{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:57:50Z","timestamp":1791295070578,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Imhotep scientific partnership, supported by the French ministries of Foreign Affairs, of Higher Education and Research and the Egyptian Academy of Scientific Research and Technology"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Prostaglandins & Other Lipid Mediators"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.prostaglandins.2015.09.002","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T19:03:01Z","timestamp":1441738981000},"page":"46-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"PA","title":["Ex vivo relaxations of pulmonary arteries induced by prostacyclin mimetics are highly dependent of the precontractile agents"],"prefix":"10.1016","volume":"121","author":[{"given":"Chabha","family":"Benyahia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulsev","family":"Ozen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Orie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agatha","family":"Ledwozyw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"Louedec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira M.","family":"Senbel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Silverstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Danel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Longrois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie H.","family":"Clapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Norel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6k\u00e7e","family":"Topal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.prostaglandins.2015.09.002_bib0005","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.1172\/JCI60658","article-title":"Molecular pathogenesis of pulmonary arterial hypertension","volume":"122","author":"Rabinovitch","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.prostaglandins.2015.09.002_bib0010","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.prostaglandins.2013.07.001","article-title":"A comparative study of PGI2 mimetics used clinically on the vasorelaxation of human pulmonary arteries and veins, role of the DP-receptor","volume":"107","author":"Benyahia","year":"2013","journal-title":"Prostaglandins Other Lipid Mediat."},{"issue":"6","key":"10.1016\/j.prostaglandins.2015.09.002_bib0015","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0090-6980(87)90113-4","article-title":"Relaxation of isolated human pulmonary muscle preparations with prostacyclin (PGI2) and its analogs","volume":"33","author":"Haye-Legrand","year":"1987","journal-title":"Prostaglandins"},{"issue":"4","key":"10.1016\/j.prostaglandins.2015.09.002_bib0020","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/sj.bjp.0705843","article-title":"Prostacyclin release and receptor activation: differential control of human pulmonary venous and arterial tone","volume":"142","author":"Norel","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.prostaglandins.2015.09.002_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.prostaglandins.2013.07.003","article-title":"Differential actions of the prostacyclin analogues treprostinil and iloprost and the selexipag metabolite, MRE-269 (ACT-333679) in rat small pulmonary arteries and veins","volume":"106","author":"Orie","year":"2013","journal-title":"Prostaglandins Other Lipid Mediat."},{"issue":"1","key":"10.1016\/j.prostaglandins.2015.09.002_bib0030","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bcp.2012.03.012","article-title":"Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist","volume":"84","author":"Whittle","year":"2012","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.prostaglandins.2015.09.002_bib0035","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1056\/NEJM199207093270202","article-title":"An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension","volume":"327","author":"Christman","year":"1992","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.prostaglandins.2015.09.002_bib0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0167-5273(99)00062-5","article-title":"Plasma endothelin-1 levels in patients with left-to-right shunt with or without pulmonary hypertension","volume":"70","author":"Tutar","year":"1999","journal-title":"Int. J. Cardiol."},{"issue":"11","key":"10.1016\/j.prostaglandins.2015.09.002_bib0045","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1253\/jcj.45.1243","article-title":"The distribution of plasma norepinephrine concentration and the relation of plasma norepinephrine concentration to pulmonary arterial pressure in heart disease","volume":"45","author":"Kondo","year":"1981","journal-title":"Jpn. Circ. J."},{"issue":"6","key":"10.1016\/j.prostaglandins.2015.09.002_bib0050","first-page":"967","article-title":"Bosentan, sildenafil, and their combination in the monocrotaline model of pulmonary hypertension in rats","volume":"231","author":"Clozel","year":"2006","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"1","key":"10.1016\/j.prostaglandins.2015.09.002_bib0055","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cardiores.2005.08.004","article-title":"Evidence that inward rectifier K+ channels mediate relaxation by the PGI2 receptor agonist cicaprost via a cyclic AMP-independent mechanism","volume":"69","author":"Orie","year":"2006","journal-title":"Cardiovasc. Res"},{"key":"10.1016\/j.prostaglandins.2015.09.002_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2015.04.007","article-title":"The mechanistic basis of prostacyclin and its stable analogues in pulmonary arterial hypertension: role of membrane versus nuclear receptors","author":"Clapp","year":"2015","journal-title":"Prostaglandins Other Lipid Mediat."},{"issue":"51","key":"10.1016\/j.prostaglandins.2015.09.002_bib0065","doi-asserted-by":"crossref","first-page":"53036","DOI":"10.1074\/jbc.M405002200","article-title":"Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation","volume":"279","author":"WilsonSJ","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"35","key":"10.1016\/j.prostaglandins.2015.09.002_bib0070","doi-asserted-by":"crossref","first-page":"21670","DOI":"10.1016\/S0021-9258(18)45792-4","article-title":"Prostaglandin endoperoxide\/thromboxane A2 receptor desensitization. Cross-talk with adenylate cyclase in human platelets","volume":"265","author":"Murray","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.prostaglandins.2015.09.002_bib0075","unstructured":"K.C.C. Chow, H. Wise, An excess of prostanoid EP3 receptor decreases hetero-oligomerisation with thromboxane A2 receptor. Abstract book of the 15th World Congress of Pharmacology, 2006."},{"issue":"6","key":"10.1016\/j.prostaglandins.2015.09.002_bib0080","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.plefa.2006.04.002","article-title":"Investigation of the pronounced synergism between prostaglandin E2 and other constrictor agents on rat femoral artery","volume":"74","author":"Hung","year":"2006","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"issue":"4","key":"10.1016\/j.prostaglandins.2015.09.002_bib0085","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00005344-199704000-00015","article-title":"Relaxant actions of nonprostanoid prostacyclin mimetics on human pulmonary artery","volume":"29","author":"Jones","year":"1997","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"2","key":"10.1016\/j.prostaglandins.2015.09.002_bib0090","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1388-1981(99)00164-X","article-title":"The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs","volume":"1483","author":"Abramovitz","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.prostaglandins.2015.09.002_bib0095","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1161\/01.STR.0000119753.05670.F1","article-title":"Potassium channel dysfunction in cerebral arteries of insulin-resistant rats is mediated by reactive oxygen species","volume":"35","author":"Erd\u00f6s","year":"2004","journal-title":"Stroke"},{"issue":"10","key":"10.1016\/j.prostaglandins.2015.09.002_bib0100","doi-asserted-by":"crossref","first-page":"e46735","DOI":"10.1371\/journal.pone.0046735","article-title":"Statins and selective inhibition of Rho kinase protect small conductance calcium-activated potassium channel function (K(Ca) 2.3) in cerebral arteries","volume":"7","author":"McNeish","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.prostaglandins.2015.09.002_bib0105","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1465-9921-8-4","article-title":"Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs","volume":"8","author":"Schermuly","year":"2007","journal-title":"Respir. Res."},{"issue":"3","key":"10.1016\/j.prostaglandins.2015.09.002_bib0110","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/cvr\/cvp143","article-title":"Endothelin-I and angiotensin II inhibit arterial voltage-gated K+ channels through different protein kinase C isoenzymes","volume":"83","author":"Rainbow","year":"2009","journal-title":"Cardiovasc. Res."},{"issue":"3","key":"10.1016\/j.prostaglandins.2015.09.002_bib0115","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1124\/jpet.112.197152","article-title":"Differential effects of Selexipag [corrected] and prostacyclin analogs in rat pulmonary artery","volume":"343","author":"Morrison","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.prostaglandins.2015.09.002_bib0120","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ejphar.2010.12.005","article-title":"Role of prostanoid IP and EP receptors in mediating vasorelaxant responses to PGI2 analogues in rat tail artery: evidence for Gi\/o modulation via EP3 receptors","volume":"654","author":"Orie","year":"2011","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.prostaglandins.2015.09.002_bib0125","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1476-5381.2010.01039.x","article-title":"Interaction of prostanoid EP3 and TP receptors in guinea-pig isolated aorta: contractile self-synergism of 11-deoxy-16,16-dimethyl PGE2","volume":"162","author":"Jones","year":"2011","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.prostaglandins.2015.09.002_bib0130","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.plefa.2006.04.002","article-title":"Investigation of the pronounced synergism between prostaglandin E2 and other constrictor agents on rat femoral artery","volume":"74","author":"Hung","year":"2006","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"2","key":"10.1016\/j.prostaglandins.2015.09.002_bib0135","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/S0022-3565(24)37684-0","article-title":"Characterization of the role of N-linked glycosylation on the cell signaling and expression of the human thromboxane A2 receptor alpha and beta isoforms","volume":"286","author":"Walsh","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.prostaglandins.2015.09.002_bib0140","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1124\/pr.110.003517","article-title":"International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress","volume":"63","author":"Woodward","year":"2011","journal-title":"Pharmacol. Rev."},{"issue":"3","key":"10.1016\/j.prostaglandins.2015.09.002_bib0145","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.1476-5381.2009.00351.x","article-title":"Intermolecular cross-talk between the prostaglandin E2 receptor (EP) 3 of subtype and thromboxane A2 receptor signalling in human erythroleukaemic cells","volume":"158","author":"Reid","year":"2009","journal-title":"Br. J. Pharmacol."}],"container-title":["Prostaglandins & Other Lipid Mediators"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098882315300095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098882315300095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T14:06:36Z","timestamp":1748613996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1098882315300095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":29,"alternative-id":["S1098882315300095"],"URL":"https:\/\/doi.org\/10.1016\/j.prostaglandins.2015.09.002","relation":{},"ISSN":["1098-8823"],"issn-type":[{"value":"1098-8823","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ex vivo relaxations of pulmonary arteries induced by prostacyclin mimetics are highly dependent of the precontractile agents","name":"articletitle","label":"Article Title"},{"value":"Prostaglandins & Other Lipid Mediators","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prostaglandins.2015.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}