{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:35:11Z","timestamp":1773293711617,"version":"3.50.1"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T00:00:00Z","timestamp":1431648000000},"content-version":"vor","delay-in-days":134,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Procedia in Vaccinology"],"published-print":{"date-parts":[[2015]]},"DOI":"10.1016\/j.provac.2015.05.003","type":"journal-article","created":{"date-parts":[[2015,5,23]],"date-time":"2015-05-23T01:41:04Z","timestamp":1432345264000},"page":"16-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Haloarchaeal Gas Vesicle Nanoparticles Displaying Salmonella Antigens as a Novel Approach to Vaccine Development"],"prefix":"10.1016","volume":"9","author":[{"given":"P.","family":"DasSarma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.D.","family":"Negi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Balakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-M.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Karan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Chakravortty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"DasSarma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.provac.2015.05.003_bib0005","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1086\/318457","article-title":"Nontyphoidal salmonellosis","volume":"32","author":"Hohmann","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.provac.2015.05.003_bib0010","volume":"vol. 9","year":"2006"},{"key":"10.1016\/j.provac.2015.05.003_bib0015","first-page":"257","article-title":"Typhoid vaccines","volume":"75","author":"WHO","year":"2000","journal-title":"Wkly Epidemiol Rec"},{"key":"10.1016\/j.provac.2015.05.003_bib0020","first-page":"49","article-title":"Typhoid vaccines","volume":"83","author":"WHO","year":"2008","journal-title":"Wkly Epidemiol Rec"},{"key":"10.1016\/j.provac.2015.05.003_bib0025","article-title":"The global burden of typhoid fever","volume":"82","author":"Crump","year":"2004","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.provac.2015.05.003_bib0030","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3201\/eid1106.041017","article-title":"International Salmonella Typhimurium DT104 infections, 1992-2001","volume":"11","author":"Helms","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.provac.2015.05.003_bib0035","first-page":"559","article-title":"Salmonella Typhimurium DT104: a virulent and drug-resistant pathogen","volume":"39","author":"Poppe","year":"1998","journal-title":"Can Vet J"},{"key":"10.1016\/j.provac.2015.05.003_bib0040","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1128\/JCM.00327-09","article-title":"Reliable means of diagnosis and serovar determination of blood-borne Salmonella strains: quick PCR amplification of unique genomic loci by novel primer sets","volume":"47","author":"Nagarajan","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.provac.2015.05.003_bib0045","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.resmic.2004.04.005","article-title":"Supplement 2002 (no.46) to the Kauffmann-White scheme","volume":"155","author":"Popoff","year":"2004","journal-title":"Res Microbiol"},{"key":"10.1016\/j.provac.2015.05.003_bib0050","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1128\/IAI.66.10.4579-4587.1998","article-title":"Evolution of host adaptation in Salmonella enterica","volume":"66","author":"Baumler","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.provac.2015.05.003_bib0055","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nrmicro1788","article-title":"Salmonellae interplay with host cells","volume":"6","author":"Haraga","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.provac.2015.05.003_bib0060","doi-asserted-by":"crossref","first-page":"6777","DOI":"10.1016\/j.vaccine.2008.09.045","article-title":"Engagement of TLR signaling as adjuvant: towards smarter vaccine and beyond","volume":"26","author":"Lahiri","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.provac.2015.05.003_bib0065","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.4049\/jimmunol.145.4.1265","article-title":"Role of CD4+ T cells and T-independent mechanisms in acquired resistance to Salmonella typhimurium infection","volume":"145","author":"Nauciel","year":"1990","journal-title":"J Immunol"},{"key":"10.1016\/j.provac.2015.05.003_bib0070","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1128\/IAI.60.2.450-454.1992","article-title":"Role of gamma interferon and tumor necrosis factor alpha in resistance to Salmonella typhimurium infection","volume":"60","author":"Nauciel","year":"1992","journal-title":"Infect Immun"},{"key":"10.1016\/j.provac.2015.05.003_bib0075","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1365-2567.2005.02140.x","article-title":"Tracking the dynamics of T-cell activation in response to Salmonella infection","volume":"114","author":"Ravindran","year":"2005","journal-title":"Immunol"},{"key":"10.1016\/j.provac.2015.05.003_bib0080","doi-asserted-by":"crossref","first-page":"7848","DOI":"10.1016\/j.vaccine.2007.08.027","article-title":"Typhoid fever vaccines: systematic review and meta-analysis of randomised controlled trials","volume":"25","author":"Fraser","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.provac.2015.05.003_bib0085","doi-asserted-by":"crossref","first-page":"5622","DOI":"10.1128\/IAI.70.10.5622-5627.2002","article-title":"Oral immunization with a Salmonella enterica serovar typhi vaccine induces specific circulating mucosa-homing CD4(+) and CD8(+) T cells in humans","volume":"70","author":"Lundin","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.provac.2015.05.003_bib0090","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1128\/IAI.68.1.46-53.2000","article-title":"Igh-6(\u2212\/\u2212) (B cell-deficient) mice fail to mount solid acquired resistance to oral challenge with virulent Salmonella enterica serovar typhimurium and show impaired Th1 T-cell responses to Salmonella antigens","volume":"68","author":"Mastroeni","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.provac.2015.05.003_bib0095","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.4049\/jimmunol.164.4.1648","article-title":"Cutting edge: role of B lymphocytes in protective immunity against Salmonella typhimurium infection","volume":"164","author":"Mittrucker","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.provac.2015.05.003_bib0100","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1472-6750-13-112","article-title":"An improved genetic system for bioengineering buoyant gas vesicle nanoparticles from Haloarchaea","volume":"13","author":"DasSarma","year":"2013","journal-title":"BMC Biotechnol"},{"key":"10.1016\/j.provac.2015.05.003_bib0105","series-title":"In: Encyclopedia of Life Sciences","article-title":"Bacterial and Archaeal Inclusions","author":"Shively","year":"2011"},{"key":"10.1016\/j.provac.2015.05.003_bib0110","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1016\/j.vaccine.2009.02.092","article-title":"sopB of Salmonella enterica serovar Typhimurium is a potential DNA vaccine candidate in conjugation with live attenuated bacteria","volume":"27","author":"Nagarajan","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.provac.2015.05.003_bib0115","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1016\/j.vaccine.2014.06.021","article-title":"Haloarchaeal gas vesicle nanoparticles displaying Salmonella SopB antigen reduce bacterial burden when administered with live attenuated bacteria","volume":"32","author":"DasSarma","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.provac.2015.05.003_bib0120","series-title":"Desk encyclopedia of microbiology","first-page":"118","article-title":"Archaea-overview","author":"DasSarma","year":"2010"},{"key":"10.1016\/j.provac.2015.05.003_bib0125","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0378-1119(92)90078-4","article-title":"Genetic transformation of a halophilic archaebacterium with a gas vesicle gene cluster restores its ability to float","volume":"119","author":"Halladay","year":"1992","journal-title":"Gene"},{"key":"10.1016\/j.provac.2015.05.003_bib0130","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1128\/jb.175.3.684-692.1993","article-title":"The rightward gas vesicle operon in Halobacterium halobium plasmid pNRC-100: identification of the gvpA and gvpC gene products by use of antibody probes and genetic analysis of the region downstream of gvpC","volume":"175","author":"Halladay","year":"1993","journal-title":"J Bacteriol"},{"key":"10.1016\/j.provac.2015.05.003_bib0135","doi-asserted-by":"crossref","first-page":"7646","DOI":"10.1128\/jb.176.24.7646-7652.1994","article-title":"Wild-type gas vesicle formation requires at least ten genes in the gvp gene cluster of Halobacterium halobium plasmid pNRC100","volume":"176","author":"DasSarma","year":"1994","journal-title":"J Bacteriol"},{"key":"10.1016\/j.provac.2015.05.003_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.1997.tb10456.x","article-title":"Genetic analysis of the gas vesicle gene cluster in haloarchaea","volume":"153","author":"DasSarma","year":"1997","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.provac.2015.05.003_bib0145","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1128\/JB.186.10.3182-3186.2004","article-title":"Complexity of gas vesicle biogenesis in Halobacterium sp. strain NRC-1: identification of five new proteins","volume":"186","author":"Shukla","year":"2004","journal-title":"J Bacteriol"},{"key":"10.1016\/j.provac.2015.05.003_bib0150","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0168-1656(01)00267-X","article-title":"Antigen presentation using novel particulate organelles from halophilic archaea","volume":"88","author":"Stuart","year":"2001","journal-title":"J Biotechnol"},{"key":"10.1016\/j.provac.2015.05.003_bib0155","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jbiotec.2004.01.005","article-title":"Cassette-based presentation of SIV epitopes with recombinant gas vesicles from halophilic archaea","volume":"114","author":"Stuart","year":"2004","journal-title":"J Biotechnol"},{"key":"10.1016\/j.provac.2015.05.003_bib0160","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1472-6750-8-9","article-title":"Recombinant gas vesicles from Halobacterium sp. displaying SIV peptides demonstrate biotechnology potential as a pathogen peptide delivery vehicle","volume":"8","author":"Sremac","year":"2008","journal-title":"BMC Biotechnol"},{"key":"10.1016\/j.provac.2015.05.003_bib0165","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1472-6750-10-54","article-title":"SIVsm Tat, Rev, and Nef1: functional characteristics of r-GV internalization on isotypes, cytokines, and intracellular degradation","volume":"10","author":"Sremac","year":"2010","journal-title":"BMC Biotechnol"},{"key":"10.1016\/j.provac.2015.05.003_bib0170","series-title":"Halophiles. In: Encyclopedia of Life Sciences","author":"DasSarma","year":"2012"},{"key":"10.1016\/j.provac.2015.05.003_bib0175","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1128\/mr.58.1.94-144.1994","article-title":"Gas vesicles","volume":"58","author":"Walsby","year":"1994","journal-title":"Micro Rev"},{"key":"10.1016\/j.provac.2015.05.003_bib0180","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nrmicro2834","article-title":"Distribution, formation, and regulation of gas vesicles","volume":"10","author":"Pfeifer","year":"2012","journal-title":"Nature Rev Microbiol"},{"key":"10.1016\/j.provac.2015.05.003_bib0185","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/S0006-3495(96)79813-2","article-title":"Direct observation of proteins secondary structure in gas vesicles by atomic force microscopy","volume":"70","author":"McMaster","year":"1996","journal-title":"Biophys J"},{"key":"10.1016\/j.provac.2015.05.003_bib0190","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0006-3495(04)74128-4","article-title":"Subunit structure of gas vesicles: a MALDI-TOF mass spectrometry study","volume":"86","author":"Belenky","year":"2004","journal-title":"Biophys J"},{"key":"10.1016\/j.provac.2015.05.003_bib0195","series-title":"Archaea: a laboratory manual \u2013 Halophiles","year":"1995"},{"key":"10.1016\/j.provac.2015.05.003_bib0200","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1101\/gr.8.11.1131","article-title":"Snapshot of a large dynamic replicon from a halophilic Archaeon: Megaplasmid or minichromosome?","volume":"8","author":"Ng","year":"1998","journal-title":"Genome Res"},{"key":"10.1016\/j.provac.2015.05.003_bib0205","doi-asserted-by":"crossref","first-page":"12176","DOI":"10.1073\/pnas.190337797","article-title":"Genome sequence of Halobacterium species NRC-1","volume":"97","author":"Ng","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.provac.2015.05.003_bib0210","series-title":"Microbial Genomes","first-page":"383","article-title":"Genome sequence of an extremely halophilic archaeon","author":"DasSarma","year":"2004"},{"key":"10.1016\/j.provac.2015.05.003_bib0215","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0580-9517(08)70030-8","article-title":"Genetic Systems for Halophilic Archaea","volume":"35","author":"Berquist","year":"2006","journal-title":"Meth Microbio"},{"key":"10.1016\/j.provac.2015.05.003_bib0220","first-page":"2647","article-title":"The minor cyanobacterial gas vesicle protein. GVPc, is attached to the outer surface of the gas vesicle","volume":"134","author":"Walsby","year":"1988","journal-title":"J Gen Microbiol"},{"key":"10.1016\/j.provac.2015.05.003_bib0225","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1021\/pr1009383","article-title":"New structural proteins of Halobacterium salinarum gas vesicle revealed by comparative proteomics analysis","volume":"10","author":"Chu","year":"2011","journal-title":"J Proteome Res"},{"key":"10.1016\/j.provac.2015.05.003_bib0230","first-page":"3013","article-title":"Structure of the gas vesicle protein GvpF from the cyanobacterium Microcystis aeruginosa","volume":"D70","author":"Xu","year":"2014","journal-title":"Acta Cryst"},{"key":"10.1016\/j.provac.2015.05.003_bib0235","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1365-2958.1995.mmi_17010147.x","article-title":"GvpCs with reduced numbers of repeating sequence elements bind to and strengthen cyanobacterial gas vesicles","volume":"17","author":"Kinsman","year":"1995","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.provac.2015.05.003_bib0240","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ijpharm.2008.04.036","article-title":"Vaccine adjuvant systems: Enhancing the efficacy of sub-unit protein antigens","volume":"364","author":"Perrie","year":"2008","journal-title":"Int J Pharm"},{"key":"10.1016\/j.provac.2015.05.003_bib0245","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.addr.2004.09.008","article-title":"Immunity in response to particulate antigen-delivery systems","volume":"57","author":"Storni","year":"2005","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.provac.2015.05.003_bib0250","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.4155\/tde.11.68","article-title":"Subunit vaccines of the future: the need for safe, customized and optimized particulate delivery systems","volume":"2","author":"Foged","year":"2011","journal-title":"Ther Del"},{"key":"10.1016\/j.provac.2015.05.003_bib0255","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.1016\/j.vaccine.2007.05.015","article-title":"Salmonella enterica serovar Typhimurium strain lacking pmrG-HM-D provides excellent protection against salmonellosis in murine typhoid model","volume":"25","author":"Negi","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.provac.2015.05.003_bib0260","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1101\/gr.190201","article-title":"Understanding the adaptation of Halobacterium species NRC-1 to its extreme environment through computational analysis of its genome sequence","volume":"11","author":"Kennedy","year":"2001","journal-title":"Genome Res"},{"key":"10.1016\/j.provac.2015.05.003_bib0265","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S0723-2020(11)80326-7","article-title":"Large deletions in class III gas vesicle-deficient mutants of Halobacterium halobium","volume":"16","author":"Ng","year":"1994","journal-title":"Syst Appl Microbiol"},{"key":"10.1016\/j.provac.2015.05.003_bib0270","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1046\/j.1365-2958.2000.01739.x","article-title":"Homologous gene knockout in the archaeon Halobacterium salinarum with ura 3 as a counterselectable marker","volume":"35","author":"Peck","year":"2000","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.provac.2015.05.003_bib0275","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1472-6750-13-3","article-title":"Cloning, overexpression, purification, and characterization of a polyextremophilic \u03b2-galactosidase from the Antarctic haloarchaeaon Halorubrum lacusprofundi","volume":"13","author":"Karan","year":"2013","journal-title":"BMC Biotechnol"},{"key":"10.1016\/j.provac.2015.05.003_bib0280","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s00253-013-5368-x","article-title":"Bioengineering radioresistance by overproduction of RPA, a mammalian-type single-stranded DNA-binding protein, in a halophilic archaeon","volume":"98","author":"Karan","year":"2014","journal-title":"Appl Microbio Biotech"},{"key":"10.1016\/j.provac.2015.05.003_bib0285","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1746-1448-2-3","article-title":"Post-genomics of the model haloarchaeon Halobacterium sp. NRC-1","volume":"2","author":"DasSarma","year":"2006","journal-title":"Saline Systems"}],"container-title":["Procedia in Vaccinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877282X15000041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877282X15000041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T21:02:29Z","timestamp":1691701349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877282X15000041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":57,"alternative-id":["S1877282X15000041"],"URL":"https:\/\/doi.org\/10.1016\/j.provac.2015.05.003","relation":{},"ISSN":["1877-282X"],"issn-type":[{"value":"1877-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Haloarchaeal Gas Vesicle Nanoparticles Displaying Salmonella Antigens as a Novel Approach to Vaccine Development","name":"articletitle","label":"Article Title"},{"value":"Procedia in Vaccinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.provac.2015.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}