{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:10:14Z","timestamp":1791263414486,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.prp.2005.11.009","type":"journal-article","created":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T09:54:49Z","timestamp":1138355689000},"page":"151-156","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic value of trophoblastic proliferation in complete hydatidiform moles in predicting persistent disease"],"prefix":"10.1016","volume":"202","author":[{"given":"L.-C.","family":"Horn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kowalzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Bilek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.E.","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Einenkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2005.11.009_bib1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0140-6736(86)90179-0","article-title":"Hydatidiform mole in England and Wales 1973\u20131983","volume":"2","author":"Bagshawe","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.prp.2005.11.009_bib2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00004347-199707000-00008","article-title":"Clinicopathologic differences between diploid and tetraploid complete hydatidiform moles","volume":"16","author":"Bewtra","year":"1997","journal-title":"Int. J. Gynecol. Pathol."},{"key":"10.1016\/j.prp.2005.11.009_bib3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1046\/j.1525-1438.1999.09904.x","article-title":"Immunohistochemical and mutational analysis of p53 tumor suppressor gene in gestational trophoblastic disease: correlation with mdm2, proliferation index, and clinicopathologic parameters","volume":"9","author":"Cheung","year":"1999","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.prp.2005.11.009_bib4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/jcp.51.2.159","article-title":"p21WAF1\/CIP1 expression in gestational trophoblastic disease: correlation with clinicopathological parameters, and Ki67 and p53 gene expression","volume":"51","author":"Cheung","year":"1998","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.prp.2005.11.009_bib5","first-page":"1","article-title":"Hydatidiform mole: diagnosis management and long-term follow up of 347 patients","volume":"45","author":"Curry","year":"1975","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.prp.2005.11.009_bib6","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0002-9378(78)90012-1","article-title":"Gestational trophoblastic neoplasms: morphologic correlates of therapeutic response","volume":"130","author":"Deligdish","year":"1978","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.prp.2005.11.009_bib7","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1471-0528.1972.tb12907.x","article-title":"The value of histological grading in the management of hydatidiform mole","volume":"79","author":"Elston","year":"1972","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.prp.2005.11.009_bib8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0020-7292(02)00063-2","article-title":"FIGO staging for gestational trophoblastic neoplasia 2000","volume":"77","year":"2002","journal-title":"Int. J. Obstet."},{"key":"10.1016\/j.prp.2005.11.009_bib9","series-title":"World Health Organization Classification of Tumors. Tumors of the breast and female genital tract","first-page":"250","article-title":"Gestational trophoblastic disease","author":"Genest","year":"2003"},{"key":"10.1016\/j.prp.2005.11.009_bib10","first-page":"402","article-title":"A clinicopathologic study of 153 cases of complete hydatidiform mole (1980\u20131990): Histologic grade lacks prognostic significance","volume":"78","author":"Genest","year":"1991","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.prp.2005.11.009_bib11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/00004347-200110000-00001","article-title":"Partial hydatidiform mole: clinicopathologic features, differential diagnosis, ploidy and molecular studies and gold standards for diagnosis","volume":"20","author":"Genest","year":"2001","journal-title":"Int. J. Gynecol. Pathol."},{"key":"10.1016\/j.prp.2005.11.009_bib12","first-page":"139","article-title":"Current management of complete and partial molar pregnancy","volume":"39","author":"Goldstein","year":"1994","journal-title":"J. Reprod. Med."},{"key":"10.1016\/j.prp.2005.11.009_bib13","unstructured":"A.H. Hertig, H. Mansell, Hydatidiform moles and choriocarcinoma. Tumors of the female sex organs, Part I, in: Atlas of Tumor Pathology, Section 9, Fascicle 33, Armed Forces Institute of Pathology, Washington, DC, 1956, pp. 7\u201327."},{"key":"10.1016\/j.prp.2005.11.009_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0002-9378(47)90445-6","article-title":"Hydatidiform mole: a pathologico-clinical correlation of 200 cases","volume":"53","author":"Hertig","year":"1947","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.prp.2005.11.009_bib15","first-page":"375","article-title":"Choriocarcinoma in extrauterine tubal pregnancy","volume":"54","author":"Horn","year":"1994","journal-title":"Geburtsh. Frauenheilk."},{"key":"10.1016\/j.prp.2005.11.009_bib16","first-page":"87","article-title":"Histologic classification and staging of gestational trophoblastic disease","volume":"143","author":"Horn","year":"1997","journal-title":"Gen. Diagn. Pathol."},{"key":"10.1016\/j.prp.2005.11.009_bib17","first-page":"1233","article-title":"Gestational trophoblastic disease \u2013 a review","volume":"63","author":"Horn","year":"2003","journal-title":"Geburtsh. Frauenheilk."},{"key":"10.1016\/j.prp.2005.11.009_bib18","first-page":"593","article-title":"Hydatidiform mole: a clinicopathologic study involving \u201cgrading\u201d as a measure of possible malignant change","volume":"1","author":"Hunt","year":"1953","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.prp.2005.11.009_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1046\/j.1365-2559.2003.01667.x","article-title":"p57kip2 is useful in the classification and differential diagnosis of complete and partial hydatidiform moles","volume":"43","author":"Jun","year":"2003","journal-title":"Histopathology"},{"key":"10.1016\/j.prp.2005.11.009_bib20","first-page":"99","article-title":"Prognostic value of histologic grading of hydatidiform moles","volume":"7","author":"Junaid","year":"1978","journal-title":"Afr. J. Med. Sci."},{"key":"10.1016\/j.prp.2005.11.009_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/00001703-200202000-00006","article-title":"Chemotherapy for trophoblastic disease: current standards","volume":"14","author":"Kendall","year":"2002","journal-title":"Curr. Opin. Obstet. Gynecol."},{"issue":"Suppl 1","key":"10.1016\/j.prp.2005.11.009_bib22","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/S0020-7292(98)80003-9","article-title":"Epidemiology and time trends of gestational trophoblastic disease in Korea","volume":"60","author":"Kim","year":"1998","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.prp.2005.11.009_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1054\/cdip.2003.0150","article-title":"Gestational trophoblastic disease: update on new immunohistochemical findings","volume":"9","author":"Lage","year":"2003","journal-title":"Curr. Diagn. Pathol."},{"key":"10.1016\/j.prp.2005.11.009_bib24","first-page":"109","article-title":"Genetic aspects of gestational trophoblastic disease: a general overview with emphasis on new approaches in determining genetic composition","volume":"143","author":"Lage","year":"1997","journal-title":"Gen. Diagn. Pathol."},{"key":"10.1016\/j.prp.2005.11.009_bib25","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/0002-9378(58)90840-8","article-title":"Hydatidiform mole: a clinical and pathological study of 72 cases with reference to their malignant tendencies","volume":"75","author":"Logan","year":"1958","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.prp.2005.11.009_bib26","first-page":"1069","article-title":"Diagnostic aspects of hydatidiform mole with persistence of polymorphic trophoblastic hyperplasia","volume":"23","author":"Makovitzky","year":"2003","journal-title":"Anticancer Res."},{"key":"10.1016\/j.prp.2005.11.009_bib27","first-page":"622","article-title":"Inter- and intrapathologist variability in the diagnosis of gestational trophoblastic neoplasia","volume":"69","author":"Messerli","year":"1987","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.prp.2005.11.009_bib28","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1046\/j.1525-1438.2003.13027.x","article-title":"Gestational trophoblastic syndrome: an audit of 112 patients. A South African experience","volume":"13","author":"Moodley","year":"2003","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.prp.2005.11.009_bib29","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/modpathol.3880432","article-title":"Immunohistochemical expression of cell cycle proteins E2F-1, Cdk-2, Cyclin E, p27(kip1), and Ki-67 in normal placenta and gestational trophoblastic disease","volume":"14","author":"Olvera","year":"2001","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.prp.2005.11.009_bib30","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0968-6053(06)80006-2","article-title":"The histological diagnosis of hydatidiform moles","volume":"1","author":"Paradinas","year":"1994","journal-title":"Curr. Diagn. Pathol."},{"key":"10.1016\/j.prp.2005.11.009_bib31","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0140-6736(00)02432-6","article-title":"Choriocarcinoma and partial hydatidiform moles","volume":"356","author":"Seckl","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.prp.2005.11.009_bib32","first-page":"1951","article-title":"Histological grading of hydatidiform moles","volume":"32","author":"Sugimori","year":"1980","journal-title":"Acta Obstet. Gynecol. Jpn."},{"key":"10.1016\/j.prp.2005.11.009_bib33","series-title":"Human Trophoblast","first-page":"135","article-title":"Complete and partial hydatidiform moles: cytogenetic and morphological aspects","author":"Szulman","year":"1984"},{"key":"10.1016\/j.prp.2005.11.009_bib34","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/gyno.2000.5839","article-title":"Gestational trophoblastic disease: a study of mode of evacuation and subsequent need for treatment with chemotherapy","volume":"78","author":"Tidy","year":"2000","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.prp.2005.11.009_bib35","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1471-0528.1967.tb14878.x","article-title":"The value of histologic grading in the prognostication of hydatidiform mole","volume":"74","author":"Tow","year":"1967","journal-title":"J. Obstet. Gynaecol. Br. Cwlth."},{"key":"10.1016\/j.prp.2005.11.009_bib36","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1006\/gyno.2000.5777","article-title":"Expression of epidermal growth factor receptor-related family products in gestational trophoblastic diseases and normal placenta and its relationship with development of postmolar tumor","volume":"77","author":"Tuncer","year":"2000","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.prp.2005.11.009_bib37","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0002-9378(16)33244-6","article-title":"Hydatidiform mole: two entities. A morphologic and cytogenetic study with some clinical considerations","volume":"127","author":"Vassilakos","year":"1977","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.prp.2005.11.009_bib38","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1006\/gyno.2002.6652","article-title":"The relationship between expression of c-ras, c-erbB-2, nm23, and p53 gene products and development of trophoblastic tumor and their predictive significance for the malignant transformation of complete hydatidiform mole","volume":"85","author":"Yang","year":"2002","journal-title":"Gynecol. Oncol."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033805002402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033805002402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T16:20:06Z","timestamp":1547828406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033805002402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0344033805002402"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2005.11.009","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}