{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T22:16:47Z","timestamp":1781821007380,"version":"3.54.5"},"reference-count":56,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.prp.2007.12.005","type":"journal-article","created":{"date-parts":[[2008,3,6]],"date-time":"2008-03-06T18:48:09Z","timestamp":1204829289000},"page":"219-233","source":"Crossref","is-referenced-by-count":19,"title":["Gastrointestinal stromal tumors\u2014frequency, malignancy, and new prognostic factors: The experience of a single institution"],"prefix":"10.1016","volume":"204","author":[{"given":"Valentina","family":"Bertolini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Chiaravalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Klersy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Placidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Marchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Boni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Capella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2007.12.005_bib1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/01.pas.0000213307.05811.f0","article-title":"Minute gastric sclerosing stromal tumors (GIST tumorlets) are common in adults and frequently show c-KIT mutations","volume":"31","author":"Agaimy","year":"2007","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1046\/j.1440-1827.2001.01233.x","article-title":"p53 expression in gastrointestinal stromal tumors","volume":"51","author":"Al-Bozom","year":"2001","journal-title":"Pathol. Int."},{"key":"10.1016\/j.prp.2007.12.005_bib3","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1158\/1078-0432.CCR-04-2245","article-title":"Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation","volume":"11","author":"Antonescu","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2007.12.005_bib4","first-page":"124","article-title":"Prognosis of gastrointestinal stromal tumors","volume":"54","author":"Bertin","year":"2007","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.prp.2007.12.005_bib5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/00000478-199704000-00006","article-title":"Stromal tumors of the jejunum and ileum: a clinicopathologic study of 39 cases","volume":"21","author":"Brainard","year":"1997","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib6","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/S0002-9440(10)61103-0","article-title":"KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size","volume":"160","author":"Corless","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib7","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1200\/JCO.2004.05.140","article-title":"Biology of gastrointestinal stromal tumors","volume":"22","author":"Corless","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.prp.2007.12.005_bib8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00022744-200103000-00005","article-title":"Apoptosis, bcl-2 expression, and p53 expression in gastrointestinal stromal\/smooth muscle tumors","volume":"9","author":"Cunningham","year":"2001","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"10.1016\/j.prp.2007.12.005_bib9","first-page":"3034","article-title":"Approval summary: imatinib mesylate in the treatment of metastatic and\/or unresectable malignant gastrointestinal stromal tumors","volume":"8","author":"Dagher","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2007.12.005_bib10","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.ejca.2003.11.025","volume":"40","author":"Debiec-Rychter","year":"2004","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.prp.2007.12.005_bib11","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1056\/NEJMoa020461","article-title":"Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors","volume":"347","author":"Demetri","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.prp.2007.12.005_bib12","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0140-6736(06)69446-4","article-title":"Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumor after failure of imatinib: a randomised controlled trial","volume":"368","author":"Demetri","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.prp.2007.12.005_bib13","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1365-2559.2005.02071.x","article-title":"The expression of p53 and bcl-2 in gastrointestinal stromal tumors is associated with anatomical site, and p53 expression is associated with grade and clinical outcome","volume":"46","author":"Feakins","year":"2005","journal-title":"Histopathology"},{"key":"10.1016\/j.prp.2007.12.005_bib14","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1053\/hupa.2002.123545","article-title":"Diagnosis of gastrointestinal stromal tumors: a consensus approach","volume":"33","author":"Fletcher","year":"2002","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib15","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1016\/j.ejca.2005.09.009","article-title":"Incidence of gastrointestinal stromal tumors is underestimated: results of a nation-wide study","volume":"41","author":"Goettsch","year":"2005","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.prp.2007.12.005_bib16","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0046-8177(98)90402-6","article-title":"DNA ploidy and proliferative index in gastrointestinal stromal tumors","volume":"29","author":"Goldblum","year":"1998","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib17","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1158\/1078-0432.CCR-06-2328","article-title":"Approval summary: sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma","volume":"13","author":"Goodman","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2007.12.005_bib18","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1126\/science.1079666","article-title":"PDGFRA activating mutations in gastrointestinal stromal tumors","volume":"299","author":"Heinrich","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.prp.2007.12.005_bib19","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.1200\/JCO.2003.04.190","article-title":"Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor","volume":"21","author":"Heinrich","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.prp.2007.12.005_bib20","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.1200\/JCO.2006.06.2265","article-title":"Molecular correlates of imatinib resistance in gastrointestinal stromal tumors","volume":"24","author":"Heinrich","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.prp.2007.12.005_bib21","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1126\/science.279.5350.577","article-title":"Gain of function mutations of c-kit in human gastrointestinal stromal tumors","volume":"279","author":"Hirota","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.prp.2007.12.005_bib22","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.humpath.2007.03.001","article-title":"The role of KIT in the management of patients with gastrointestinal stromal tumors","volume":"38","author":"Hornick","year":"2007","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib23","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.amjsurg.2006.10.033","article-title":"Tumor size is a major determinant of recurrence in patients with resectable gastrointestinal stromal tumor","volume":"194","author":"Hsu","year":"2007","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.prp.2007.12.005_bib24","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1245\/s10434-006-9188-4","article-title":"Immunohistochemical expression of p16INK4A, Ki-67, and Mcm2 proteins in gastrointestinal stromal tumors: prognostic implications and correlations with risk stratification of NIH consensus criteria","volume":"13","author":"Huang","year":"2006","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.prp.2007.12.005_bib25","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.surg.2007.01.024","article-title":"A modification of NIH consensus criteria to better distinguish the highly lethal subset of primary localized gastrointestinal stromal tumors: a subdivision of the original high-risk group on the basis of outcome","volume":"141","author":"Huang","year":"2007","journal-title":"Surgery"},{"key":"10.1016\/j.prp.2007.12.005_bib26","first-page":"1259","article-title":"Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal","volume":"152","author":"Kindblom","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/j.semdp.2006.08.006","article-title":"KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs)","volume":"23","author":"Lasota","year":"2006","journal-title":"Semin. Diagn. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib28","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/labinvest.3700628","article-title":"Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors","volume":"87","author":"Lasota","year":"2007","journal-title":"Lab. Invest."},{"key":"10.1016\/j.prp.2007.12.005_bib29","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0002-9440(10)64946-2","article-title":"KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors","volume":"156","author":"Lux","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1053\/j.semdp.2006.09.001","article-title":"Gastrointestinal stromal tumors: pathology and prognosis at different sites","volume":"23","author":"Miettinen","year":"2006","journal-title":"Semin. Diagn. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib31","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1097\/00000478-199909000-00015","article-title":"Gastrointestinal stromal tumors\/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases","volume":"23","author":"Miettinen","year":"1999","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib32","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1097\/00000478-200002000-00007","article-title":"Gastrointestinal stromal tumors and leiomyosarcomas in the colon: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases","volume":"24","author":"Miettinen","year":"2000","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib33","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1097\/00000478-200109000-00002","article-title":"Gastrointestinal stromal tumors, intramural leiomyomas and leiomyosarcomas in the rectum and anus: clinicopathologic, immunohistochemical and molecular genetic study of 144 cases","volume":"25","author":"Miettinen","year":"2001","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib34","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1053\/hupa.2002.124123","article-title":"Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review","volume":"33","author":"Miettinen","year":"2002","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib35","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/00000478-200305000-00006","article-title":"Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the duodenum: a clinicopathologic, immunohistochemical, and molecular genetic study of 167 cases","volume":"27","author":"Miettinen","year":"2003","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib36","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/01.pas.0000146010.92933.de","article-title":"Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long term follow up","volume":"9","author":"Miettinen","year":"2005","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib37","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00000478-200604000-00008","article-title":"Gastrointestinal stromal tumors of the jejunum and ileum: a clinicopathologic, immunohistochemical, and molecular genetic study of 906 cases before imatinib with long-term follow-up","volume":"30","author":"Miettinen","year":"2006","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib38","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1158\/1078-0432.CCR-06-1745","article-title":"c-Kit\/PDGFRA gene status alterations possibly related to primary imatinib resistance in gastrointestinal stromal tumors","volume":"13","author":"Miselli","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2007.12.005_bib39","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.humpath.2005.03.012","article-title":"Prognostic significance of expressions of cell-cycle regulatory proteins in gastrointestinal stromal tumor and the relevance of the risk grade","volume":"36","author":"Nakamura","year":"2005","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib40","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/cncr.20862","article-title":"Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era","volume":"103","author":"Nilsson","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.prp.2007.12.005_bib41","first-page":"1277","article-title":"Biological analysis of gastrointestinal stromal tumors","volume":"9","author":"Noguchi","year":"2002","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.prp.2007.12.005_bib42","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/modpathol.3880099","article-title":"Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome","volume":"13","author":"Reith","year":"2000","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib43","series-title":"Atlas of Tumor Pathology. Tumors of the Intestine","first-page":"325","article-title":"Mesenchimal tumors: stromal tumors","author":"Riddell","year":"2002"},{"key":"10.1016\/j.prp.2007.12.005_bib44","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ejca.2006.07.015","article-title":"Population-based incidence and survival of gastrointestinal stromal tumors (GIST) in Girona, Spain","volume":"43","author":"Rubi\u00f2","year":"2007","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.prp.2007.12.005_bib45","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0046-8177(98)90447-6","article-title":"Immunophenotype, proliferation, DNA ploidy, and biological behavior of gastrointestinal stromal tumors: a multivariate clinicopathologic study","volume":"29","author":"Rudolph","year":"1998","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2007.12.005_bib46","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s00428-002-0673-2","article-title":"Gastrointestinal mesenchymal tumors\u2014immunophenotypic classification and survival analysis","volume":"441","author":"Rudolph","year":"2002","journal-title":"Virchows Arch."},{"key":"10.1016\/j.prp.2007.12.005_bib47","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1002\/(SICI)1097-0142(19981115)83:10<2060::AID-CNCR3>3.0.CO;2-#","article-title":"Telomerase activity in gastrointestinal stromal tumors","volume":"83","author":"Sakurai","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.prp.2007.12.005_bib48","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1600-0463.2006.apm_261.x","article-title":"Trends in incidence and survival of mesenchymal neoplasm of the digestive tract within a defined population of northern Norway","volume":"114","author":"Steigen","year":"2006","journal-title":"APMIS"},{"key":"10.1016\/j.prp.2007.12.005_bib49","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1600-0463.2007.apm_587.x","article-title":"Mutations in gastrointestinal stromal tumors\u2014a population-based study from Northern Norway","volume":"115","author":"Steigen","year":"2007","journal-title":"APMIS"},{"key":"10.1016\/j.prp.2007.12.005_bib50","doi-asserted-by":"crossref","unstructured":"S.E. Steigen, B. Straume, D. Turbin, A.K.W. Chan, S. Leung, T.O. Nielsen, S. Lindal, Clinicopathologic factors and nuclear morphometry as independent prognosticators in KIT positive gastrointestinal stromal tumor, J. Histochem. Cytochem. DOI:10.1369\/jhc.7A7333.2007.","DOI":"10.1369\/jhc.7A7333.2007"},{"key":"10.1016\/j.prp.2007.12.005_bib51","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1053\/j.gastro.2004.02.021","article-title":"A. new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient","volume":"127","author":"Tamborini","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.prp.2007.12.005_bib52","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.1038\/sj.onc.1209639","article-title":"Functional analyses and molecular modeling of two c-Kit mutations responsible for imatinib secondary resistance in GIST patients","volume":"25","author":"Tamborini","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2007.12.005_bib53","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1572-0241.2005.40709.x","article-title":"The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000","volume":"100","author":"Tran","year":"2005","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.prp.2007.12.005_bib54","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00428-007-0473-9","article-title":"Mutation analysis of gastrointestinal stromal tumors: increasing significance for risk assessment and effective targeted therapy","volume":"451","author":"Wardelmann","year":"2007","journal-title":"Virchows Arch."},{"key":"10.1016\/j.prp.2007.12.005_bib55","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/01.COC.0000018296.45892.CE","article-title":"Prognostic assessment of gastrointestinal stromal tumor","volume":"26","author":"Yan","year":"2003","journal-title":"Am. J. Clin. Oncol."},{"key":"10.1016\/j.prp.2007.12.005_bib56","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF01047461","article-title":"The assessment of cellular proliferation by immunohistochemistry: a review of currently available methods and their applications","volume":"24","author":"Yu","year":"1992","journal-title":"Histochem. J."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033807002828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033807002828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T15:11:03Z","timestamp":1557328263000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033807002828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0344033807002828"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2007.12.005","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}