{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:42:23Z","timestamp":1790937743737,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.prp.2013.02.002","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T14:04:27Z","timestamp":1363183467000},"page":"215-220","source":"Crossref","is-referenced-by-count":14,"title":["C-MET is expressed in the majority of penile squamous cell carcinomas and correlates with polysomy-7 but is not associated with MET oncogene amplification, pertinent histopathologic parameters, or with cancer-specific survival"],"prefix":"10.1016","volume":"209","author":[{"given":"Sven","family":"Gunia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Erbersdobler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver W.","family":"Hakenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2013.02.002_bib0005","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/JTO.0b013e3182417da5","article-title":"Plasma cell membrane localization of c-MET predicts longer survival in patients with malignant mesothelioma: a series of 157 cases from the MESOPATH Group","volume":"7","author":"Levallet","year":"2012","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.prp.2013.02.002_bib0010","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.1200\/JCO.2011.36.7706","article-title":"Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer","volume":"29","author":"Graziano","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.prp.2013.02.002_bib0015","first-page":"1997","article-title":"Expression of the MET\/HGF receptor in normal and neoplastic human tissues","volume":"6","author":"Di Renzo","year":"1991","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2013.02.002_bib0020","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1083\/jcb.126.2.485","article-title":"Expression and functional interaction of hepatocyte growth factor-scatter factor and its receptor c-met in mammalian brain","volume":"126","author":"Jung","year":"1994","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.prp.2013.02.002_bib0025","first-page":"386","article-title":"Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma","volume":"147","author":"Humphrey","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2013.02.002_bib0030","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/311029a0","article-title":"Molecular cloning of a new transforming gene from a chemically transformed human cell line","volume":"311","author":"Cooper","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.prp.2013.02.002_bib0035","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0092-8674(86)90564-7","article-title":"Mechanism of met oncogene activation","volume":"45","author":"Park","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.prp.2013.02.002_bib0040","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/ng0597-68","article-title":"Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal cell carcinoma","volume":"16","author":"Schmidt","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.prp.2013.02.002_bib0045","first-page":"6272","article-title":"c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions","volume":"63","author":"Ma","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2013.02.002_bib0050","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/sj.onc.1209057","article-title":"Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma","volume":"25","author":"Miller","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2013.02.002_bib0055","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1158\/0008-5472.CAN-04-4603","article-title":"Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis","volume":"65","author":"Zhao","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2013.02.002_bib0060","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1517\/13543784.2011.600687","article-title":"Development of c-MET pathway inhibitors","volume":"20","author":"Liu","year":"2011","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.prp.2013.02.002_bib0065","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00595-011-0065-9","article-title":"Molecular targeted agents for gastric and gastroesophageal junction cancer","volume":"42","author":"Oshima","year":"2012","journal-title":"Surg. Today"},{"key":"10.1016\/j.prp.2013.02.002_bib0070","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000315543","article-title":"Kidney cancer pathology in the new context of targeted therapy","volume":"78","author":"Allory","year":"2011","journal-title":"Pathobiology"},{"key":"10.1016\/j.prp.2013.02.002_bib0075","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s12094-011-0719-5","article-title":"MET and VEGF: synergistic targets in castration-resistant prostate cancer","volume":"13","author":"Aftab","year":"2011","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.prp.2013.02.002_bib0080","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.eururo.2011.12.028","article-title":"Novel molecular targets for the therapy of castration-resistant prostate cancer","volume":"61","author":"Agarwal","year":"2011","journal-title":"Eur. Urol."},{"key":"10.1016\/j.prp.2013.02.002_bib0085","first-page":"7345","article-title":"A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo","volume":"63","author":"Christensen","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2013.02.002_bib0090","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1073\/pnas.0508776103","article-title":"Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752","volume":"103","author":"Smolen","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.prp.2013.02.002_bib0095","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.1158\/0008-5472.CAN-06-4443","article-title":"An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms","volume":"67","author":"Zou","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2013.02.002_bib0100","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1158\/1535-7163.MCT-07-0365","article-title":"Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma","volume":"6","author":"Christensen","year":"2007","journal-title":"Mol. Cancer. Ther."},{"key":"10.1016\/j.prp.2013.02.002_bib0105","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1158\/1535-7163.MCT-07-2045","article-title":"A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras","volume":"7","author":"Yang","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.prp.2013.02.002_bib0110","first-page":"556","article-title":"Efficacy of c-Met inhibitor for advanced prostate cancer","volume":"10","author":"Tu","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.prp.2013.02.002_bib0115","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1097\/JTO.0b013e31822591e9","article-title":"MET tyrosine kinase inhibitor Crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations","volume":"6","author":"Tanizaki","year":"2011","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.prp.2013.02.002_bib0120","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1158\/1055-9965.EPI-10-1080","article-title":"MET expression and amplification in patients with localized gastric cancer","volume":"20","author":"Janjigian","year":"2011","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.prp.2013.02.002_bib0125","doi-asserted-by":"crossref","first-page":"33","DOI":"10.5021\/ad.2011.23.1.33","article-title":"Expression of the c-Met proteins in malignant skin cancers","volume":"23","author":"Lee","year":"2011","journal-title":"Ann. Dermatol."},{"key":"10.1016\/j.prp.2013.02.002_bib0130","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1002\/ijc.25927","article-title":"Head neck squamous cell carcinoma c-Met cells display cancer stem cell properties and are responsible for cisplatin-resistance and metastasis","volume":"129","author":"Sun","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.prp.2013.02.002_bib0135","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1097\/00000478-200108000-00016","article-title":"Anatomic levels: important landmarks in penectomy specimens","volume":"25","author":"Cubilla","year":"2001","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2013.02.002_bib0140","series-title":"TNM Classification of Malignant Tumors","first-page":"225","year":"2010"},{"key":"10.1016\/j.prp.2013.02.002_bib0145","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/00000658-192102000-00001","article-title":"Squamous-cell epithelioma of the skin: a study of 256 cases","volume":"73","author":"Broders","year":"1921","journal-title":"Ann. Surg."},{"key":"10.1016\/j.prp.2013.02.002_bib0150","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1097\/PAS.0b013e3181a418ae","article-title":"Comparison of morphologic features and outcome of resected recurrent and nonrecurrent squamous cell carcinoma of the penis: a study of 81 cases","volume":"33","author":"Chaux","year":"2009","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2013.02.002_bib0155","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/00000478-199308000-00001","article-title":"Pathologic features of epidermoid carcinoma of the penis","volume":"17","author":"Cubilla","year":"1993","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2013.02.002_bib0160","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1309\/6UHNC7MAD8KWNAWC","article-title":"Recommendations for the reporting of surgically resected specimens of colorectal carcinoma: Association of Directors of Anatomic and Surgical Pathology","volume":"29","author":"Jass","year":"2008","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.prp.2013.02.002_bib0165","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1046\/j.1442-2042.2002.00424.x","article-title":"Tumor-associated tissue eosinophilia of penile cancer","volume":"9","author":"Ono","year":"2002","journal-title":"Int. J. Urol."},{"key":"10.1016\/j.prp.2013.02.002_bib0170","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1309\/AJCPKUZ69LXZGFEA","article-title":"Different HER2 expression profiles aid in the histologic differential diagnosis between urothelial carcinoma in situ (CIS) and non-CIS conditions of the (dysplasia and reactive atypia) of the urinary bladder mucosa","volume":"136","author":"Gunia","year":"2011","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.prp.2013.02.002_bib0175","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1586\/era.10.115","article-title":"Molecular biology of squamous cell carcinoma of the head and neck: relevance and therapeutic implications","volume":"10","author":"Schmitz","year":"2010","journal-title":"Expert Rev. Anticancer Ther."},{"key":"10.1016\/j.prp.2013.02.002_bib0180","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s13277-010-0021-0","article-title":"MET expressing chordomas frequently exhibit polysomy of chromosome 7 but no MET activation through sarcoma-specific gene fusions","volume":"31","author":"Grabellus","year":"2010","journal-title":"Tumour Biol."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S034403381300023X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S034403381300023X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T23:25:43Z","timestamp":1562801143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S034403381300023X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S034403381300023X"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2013.02.002","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}