{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:45:03Z","timestamp":1762004703709},"reference-count":30,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.prp.2015.05.007","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T02:21:33Z","timestamp":1432866093000},"page":"641-645","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["A switch from epithelial to mesenchymal properties correlates with lymphovascular invasion in squamous cell carcinoma of the penis"],"prefix":"10.1016","volume":"211","author":[{"given":"Matthias","family":"May","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Brookman-May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Burger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Otto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Br\u00fcndl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knut","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Denzinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2015.05.007_bib0155","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1242\/jcs.1993.Supplement_17.23","article-title":"Molecular mechanisms leading to loss of differentiation and gain of invasiveness in epithelial cells","volume":"117","author":"Birchmeier","year":"1993","journal-title":"J. Cell Sci. Suppl."},{"key":"10.1016\/j.prp.2015.05.007_bib0160","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI200320530","article-title":"Epithelial\u2013mesenchymal transition and its implications for fibrosis","volume":"112","author":"Kalluri","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.prp.2015.05.007_bib0165","doi-asserted-by":"crossref","first-page":"e714","DOI":"10.1038\/cddis.2013.244","article-title":"TGF-\u03b21 regulates cell fate during epithelial\u2013mesenchymal transition by upregulating survivin","volume":"4","author":"Lee","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.prp.2015.05.007_bib0170","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1746-1596-8-99","article-title":"Combined aberrant expression of E-cadherin and S100A4, but not \u03b2-catenin is associated with disease-free survival and overall survival in colorectal cancer patients","volume":"8","author":"Lee","year":"2013","journal-title":"Diagn. Pathol."},{"issue":"April","key":"10.1016\/j.prp.2015.05.007_bib0175","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.prp.2013.02.002","article-title":"C-MET is expressed in the majority of penile squamous cell carcinomas and correlates with polysomy-7 but is not associated with MET oncogene amplification, pertinent histopathologic parameters, or with cancer-specific survival","volume":"209","author":"Gunia","year":"2013","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2015.05.007_bib0180","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1083\/jcb.200601018","article-title":"The epithelial\u2013mesenchymal transition: new insights in signaling, development, and disease","volume":"172","author":"Lee","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.prp.2015.05.007_bib0185","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1083\/jcb.130.2.393","article-title":"Identification and characterization of a fibroblast marker: FSP1","volume":"130","author":"Strutz","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.prp.2015.05.007_bib0190","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/B978-0-12-394311-8.00014-5","article-title":"Cadherins and epithelial-to-mesenchymal transition","volume":"116","author":"Gheldof","year":"2013","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.prp.2015.05.007_bib0195","first-page":"103","article-title":"ASA status and age predict adverse events after abdominal surgery","volume":"16","author":"Hall","year":"1996","journal-title":"J. Qual. Clin. Pract."},{"key":"10.1016\/j.prp.2015.05.007_bib0200","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/00000658-192102000-00001","article-title":"Squamous-cell epithelioma of the skin: a study of 256 cases","volume":"73","author":"Broders","year":"1921","journal-title":"Ann. Surg."},{"key":"10.1016\/j.prp.2015.05.007_bib0205","year":"2009"},{"key":"10.1016\/j.prp.2015.05.007_bib0210","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1053\/j.semdp.2011.06.001","article-title":"New pathologic entities in penile carcinomas: an update of the 2004 World Health Organization classification","volume":"29","author":"Chaux","year":"2012","journal-title":"Semin. Diagn. Pathol."},{"key":"10.1016\/j.prp.2015.05.007_bib0215","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/annonc\/mdt286","article-title":"Penile cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"24","author":"Van Poppel","year":"2013","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.prp.2015.05.007_bib0220","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/bju.12449","article-title":"Should centralized histopathological review in penile cancer be the global standard?","volume":"114","author":"Tang","year":"2014","journal-title":"BJU Int."},{"key":"10.1016\/j.prp.2015.05.007_bib0225","doi-asserted-by":"crossref","first-page":"651","DOI":"10.18632\/oncotarget.199","article-title":"Epithelial and mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget","volume":"7","author":"Zlobec","year":"2010","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2015.05.007_bib0230","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jdermsci.2013.07.001","article-title":"Epithelial to mesenchymal transition markers are associated with an increased metastatic risk in primary cutaneous squamous cell carcinomas but are attenuated in lymph node metastases","volume":"72","author":"Toll","year":"2013","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.prp.2015.05.007_bib0235","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1600-0714.2011.01041.x","article-title":"Tumor budding correlates with poor prognosis and epithelial\u2013mesenchymal transition in tongue squamous cell carcinoma","volume":"40","author":"Wang","year":"2011","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.prp.2015.05.007_bib0240","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.amjoto.2010.11.018","article-title":"Snail as a novel marker for regional metastasis in head and neck squamous cell carcinoma","volume":"33","author":"Mendelsohn","year":"2012","journal-title":"Am. J. Otolarynol."},{"key":"10.1016\/j.prp.2015.05.007_bib0245","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-2559.2006.02551.x","article-title":"Tumor budding in colorectal carcinoma","volume":"50","author":"Prall","year":"2007","journal-title":"Histopathology"},{"key":"10.1016\/j.prp.2015.05.007_bib0250","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.prp.2014.09.013","article-title":"Analysis of a cytoskeleton-associated kinase PEAK1 and E-cadherin in gastric cancer","volume":"210","author":"Guo","year":"2014","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2015.05.007_bib0255","doi-asserted-by":"crossref","first-page":"5814","DOI":"10.1158\/1078-0432.CCR-10-0230","article-title":"Expression of snail in upper urinary tract urothelial carcinoma: prognostic significance and implications for tumor invasion","volume":"16","author":"Kosaka","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2015.05.007_bib0260","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0344-0338(98)80129-5","article-title":"Nuclear overexpression of the oncoprotein \u03b2-catenin in colorectal cancer is localized predominantly at the invasion front","volume":"194","author":"Brabletz","year":"1998","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2015.05.007_bib0265","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000084505","article-title":"Transforming growth factor-beta signaling during epithelial\u2013mesenchymal transformation: implications for embryogenesis and tumor metastasis","volume":"179","author":"Nawshad","year":"2005","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.prp.2015.05.007_bib0270","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1023\/A:1024090116451","article-title":"Mechanisms in epithelial plasticity and metastasis: insights from 3D cultures and expression profiling","volume":"7","author":"Jechlinger","year":"2002","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"10.1016\/j.prp.2015.05.007_bib0275","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-\u03b2 signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.prp.2015.05.007_bib0280","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1083\/jcb.200710067","article-title":"Slug is a direct Notch target required for initiation of cardiac cushion cellularization","volume":"182","author":"Niessen","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.prp.2015.05.007_bib0285","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.1091\/mbc.E08-05-0506","article-title":"Snail and slug promote epithelial\u2013mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3","volume":"19","author":"Medici","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.prp.2015.05.007_bib0290","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1242\/jcs.028282","article-title":"Snail is required for TGFbeta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells","volume":"121","author":"Kokudo","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.prp.2015.05.007_bib0295","doi-asserted-by":"crossref","first-page":"594","DOI":"10.6004\/jnccn.2013.0075","article-title":"Penile cancer: clinical practice guidelines in oncology","volume":"11","author":"Clark","year":"2013","journal-title":"J. Natl. Compr. Canc. Netw."},{"key":"10.1016\/j.prp.2015.05.007_bib0300","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1200\/jco.2015.33.7_suppl.383","article-title":"Receipt of inguinal lymph node dissection in patients with T2 penile cancer: results from the National Cancer Database","volume":"33","author":"Haseebuddin","year":"2015","journal-title":"J. Clin. Oncol."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033815001016?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033815001016?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T07:46:50Z","timestamp":1717919210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033815001016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0344033815001016"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2015.05.007","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A switch from epithelial to mesenchymal properties correlates with lymphovascular invasion in squamous cell carcinoma of the penis","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2015.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}