{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T01:44:30Z","timestamp":1781919870571,"version":"3.54.5"},"reference-count":36,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["26460428"],"award-info":[{"award-number":["26460428"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["26670286"],"award-info":[{"award-number":["26670286"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.prp.2015.06.004","type":"journal-article","created":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T12:06:48Z","timestamp":1434197208000},"page":"657-664","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["A mutation spectrum that includes GNAS, KRAS and TP53 may be shared by mucinous neoplasms of the appendix"],"prefix":"10.1016","volume":"211","author":[{"given":"Kieko","family":"Hara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuo","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alkam","family":"Yimit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Mitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2015.06.004_bib0185","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1097\/00000478-200308000-00006","article-title":"Appendiceal mucinous neoplasms: a clinicopathologic analysis of 107 cases","volume":"27","author":"Misdraji","year":"2003","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2015.06.004_bib0190","doi-asserted-by":"crossref","first-page":"864","DOI":"10.5858\/134.6.864","article-title":"Appendiceal mucinous neoplasms","volume":"134","author":"Misdraji","year":"2010","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.prp.2015.06.004_bib0195","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3109\/00365521.2011.565070","article-title":"Ki-ras gene mutations are invariably present in low-grade mucinous tumors of the vermiform appendix","volume":"46","author":"Zauber","year":"2011","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.prp.2015.06.004_bib0200","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/modpathol.3880572","article-title":"Mucinous and nonmucinous appendiceal adenocarcinomas: different clinicopathological features but similar genetic alterations","volume":"15","author":"Kabbani","year":"2002","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.prp.2015.06.004_bib0205","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/bjc.2013.47","article-title":"Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms","volume":"108","author":"Nishikawa","year":"2013","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.prp.2015.06.004_bib0210","doi-asserted-by":"crossref","first-page":"837","DOI":"10.5858\/2002-126-0837-ENOTAA","article-title":"Epithelial neoplasms of the appendix and colorectum: an analysis of cell proliferation, apoptosis, and expression of p53, CD44, bcl-2","volume":"126","author":"Carr","year":"2002","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.prp.2015.06.004_bib0215","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jss.2012.10.053","article-title":"Kras mutations and p53 overexpression in pseudomyxoma peritonei: association with phenotype and prognosis","volume":"180","author":"Shetty","year":"2013","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.prp.2015.06.004_bib0220","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1097\/PAS.0b013e318282649b","article-title":"High-level microsatellite instability in appendiceal carcinomas","volume":"37","author":"Taggart","year":"2013","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2015.06.004_bib0225","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1097\/PAS.0b013e31806bee6d","article-title":"A comprehensive study of nondysplastic and dysplastic serrated polyps of the vermiform appendix","volume":"31","author":"Yantiss","year":"2007","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2015.06.004_bib0230","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1097\/PAS.0b013e3182299c25","article-title":"Determining the site of origin of mucinous adenocarcinoma: an immunohistochemical study of 175 cases","volume":"35","author":"Chu","year":"2011","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2015.06.004_bib0235","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1230062","article-title":"TERT promoter mutations in familial and sporadic melanoma","volume":"339","author":"Horn","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.prp.2015.06.004_bib0240","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00401-013-1195-5","article-title":"Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system","volume":"126","author":"Koelsche","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.prp.2015.06.004_bib0245","doi-asserted-by":"crossref","first-page":"E754","DOI":"10.1210\/jc.2013-3734","article-title":"TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas","volume":"99","author":"Melo","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.prp.2015.06.004_bib0250","doi-asserted-by":"crossref","first-page":"17426","DOI":"10.1073\/pnas.1310522110","article-title":"TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism","volume":"110","author":"Rachakonda","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.prp.2015.06.004_bib0255","article-title":"Low frequency of TERT promoter mutations in gastrointestinal stromal tumors (GISTs)","author":"Campanella","year":"2014","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.prp.2015.06.004_bib0260","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1073\/pnas.1303607110","article-title":"TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal","volume":"110","author":"Killela","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.prp.2015.06.004_bib0265","series-title":"WHO Classification of Tumours of the Digestive System","first-page":"122","article-title":"Adenocarcinoma of the appendix","author":"Carr","year":"2010"},{"key":"10.1016\/j.prp.2015.06.004_bib0270","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0046-8177(95)90247-3","article-title":"Pseudomyxoma peritonei in women: a clinicopathologic analysis of 30 cases with emphasis on site of origin, prognosis, and relationship to ovarian mucinous tumors of low malignant potential","volume":"26","author":"Ronnett","year":"1995","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2015.06.004_bib0275","first-page":"411","article-title":"Pseudomyxoma peritonei usually originates from the appendix: a review of the evidence","volume":"25","author":"Mukherjee","year":"2004","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"10.1016\/j.prp.2015.06.004_bib0280","first-page":"1059","article-title":"A new constitutively activating mutation of the Gs protein alpha subunit-gsp oncogene is found in human pituitary tumours","volume":"5","author":"Clememti","year":"1990","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2015.06.004_bib0285","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1365-2559.2007.02676.x","article-title":"A sensitive mutation-specific screening technique for GNAS1 mutations in cases of fibrous dysplasia: the first report of a codon 227 mutation in bone","volume":"50","author":"Idowu","year":"2007","journal-title":"Histopathology"},{"key":"10.1016\/j.prp.2015.06.004_bib0290","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/modpathol.2009.32","article-title":"GNAS1 mutations occur more commonly than previously thought in intramuscular myxoma","volume":"22","author":"Delaney","year":"2009","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.prp.2015.06.004_bib0295","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/path.4012","article-title":"Frequent activating GNAS mutations in villous adenoma of the colorectum","volume":"228","author":"Yamada","year":"2012","journal-title":"J. Pathol."},{"key":"10.1016\/j.prp.2015.06.004_bib0300","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/srep00161","article-title":"Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas","volume":"1","author":"Furukawa","year":"2011","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2015.06.004_bib0305","doi-asserted-by":"crossref","first-page":"e81706","DOI":"10.1371\/journal.pone.0081706","article-title":"GNAS and KRAS mutations are common in intraductal papillary neoplasms of the bile duct","volume":"8","author":"Sasaki","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2015.06.004_bib0310","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/gm559","article-title":"Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin","volume":"6","author":"Alakus","year":"2014","journal-title":"Genome Med."},{"key":"10.1016\/j.prp.2015.06.004_bib0315","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/j.humpath.2014.04.018","article-title":"GNAS is frequently mutated in both low-grade and high-grade disseminated appendiceal mucinous neoplasms but does not affect survival","volume":"45","author":"Singhi","year":"2014","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2015.06.004_bib0320","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1373\/clinchem.2014.225565","article-title":"Molecular profiling of appendiceal epithelial tumors using massively parallel sequencing to identify somatic mutations","volume":"60","author":"Liu","year":"2014","journal-title":"Clin. Chem."},{"key":"10.1016\/j.prp.2015.06.004_bib0325","doi-asserted-by":"crossref","first-page":"D962","DOI":"10.1093\/nar\/gks1033","article-title":"The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis","volume":"41","author":"Leroy","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.prp.2015.06.004_bib0330","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1038\/modpathol.2014.37","article-title":"Clinicopathologic and molecular analysis of disseminated appendiceal mucinous neoplasms: identification of factors predicting survival and proposed criteria for a three-tiered assessment of tumor grade","volume":"27","author":"Davison","year":"2014","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.prp.2015.06.004_bib0335","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/modpathol.2009.74","article-title":"Differential protein immunoexpression profiles in appendiceal mucinous neoplasms: a special reference to classification and predictive factors","volume":"22","author":"Yoon","year":"2009","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.prp.2015.06.004_bib0340","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1016\/j.humpath.2014.08.016","article-title":"GNAS mutation as an alternative mechanism of activation of the Wnt\/\u03b2-catenin signaling pathway in gastric adenocarcinoma of the fundic gland type","volume":"45","author":"Nomura","year":"2014","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2015.06.004_bib0345","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/path.1838","article-title":"Discriminating functional and non-functional p53 in human tumours by p53 and MDM2 immunohistochemistry","volume":"207","author":"Nenutil","year":"2005","journal-title":"J. Pathol."},{"key":"10.1016\/j.prp.2015.06.004_bib0350","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.humpath.2005.08.022","article-title":"Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and neuroendocrine cell markers in epithelial neoplasm of appendix","volume":"36","author":"Yajima","year":"2005","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2015.06.004_bib0355","first-page":"1840","article-title":"The abnormal p53 proteins expressed in CML cell lines are non-functional","volume":"7","author":"Bi","year":"1993","journal-title":"Leukemia"},{"key":"10.1016\/j.prp.2015.06.004_bib0360","first-page":"547","article-title":"Molecular and genetic characterization of a non-metastatic human esophageal cancer cell line, T.Tn expressing non-functional mutated p53","volume":"21","author":"Sakai","year":"2002","journal-title":"Int. J. Oncol."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033815001211?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033815001211?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T21:17:49Z","timestamp":1656451069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033815001211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0344033815001211"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2015.06.004","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A mutation spectrum that includes GNAS, KRAS and TP53 may be shared by mucinous neoplasms of the appendix","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2015.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}