{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:21:00Z","timestamp":1752549660219,"version":"3.40.5"},"reference-count":36,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.prp.2016.09.011","type":"journal-article","created":{"date-parts":[[2016,9,24]],"date-time":"2016-09-24T07:24:30Z","timestamp":1474701870000},"page":"1138-1143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["The predictive value of dendritic cells in early squamous cell carcinoma of the tongue"],"prefix":"10.1016","volume":"212","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0104-2096","authenticated-orcid":false,"given":"Ohad","family":"Hilly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia","family":"Strenov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Rath-Wolfson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Hod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yotam","family":"Shkedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aviram","family":"Mizrachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumelia","family":"Koren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Shpitzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2016.09.011_bib0005","unstructured":"Surveillance Epidemiology and End Results: database, National Cancer Institute. Available at: http:\/\/seer.cancer.gov\/statfacts\/html\/tongue.html (accessed 09.09.12)."},{"key":"10.1016\/j.prp.2016.09.011_bib0010","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tripleo.2005.07.038","article-title":"Oral squamous cell carcinoma: review of prognostic and predictive factors","volume":"102","author":"Massano","year":"2006","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"10.1016\/j.prp.2016.09.011_bib0015","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/01.pas.0000149687.90710.21","article-title":"Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival","volume":"29","author":"Brandwein-Gensler","year":"2005","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2016.09.011_bib0020","unstructured":"NCCN guidelines - version 2.2013. National Comprehensive Cancer Network Website. Available at: http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck.pdf (accessed 27.08.13)."},{"key":"10.1016\/j.prp.2016.09.011_bib0025","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","article-title":"Immunobiology of dendritic cells","volume":"18","author":"Banchereau","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.prp.2016.09.011_bib0030","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nri3712","article-title":"Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny","volume":"14","author":"Guilliams","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.prp.2016.09.011_bib0035","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1471-2105-10-70","article-title":"An improved ontological representation of dendritic cells as a paradigm for all cell types","volume":"10","author":"Masci","year":"2009","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.prp.2016.09.011_bib0040","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1177\/10454411960070010301","article-title":"Oral mucosal langerhans' cells","volume":"7","author":"Barrett","year":"1996","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.prp.2016.09.011_bib0045","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/archotol.124.6.641","article-title":"Peritumoral CD1a-positive dendritic cells are associated with improved survival in patients with tongue carcinoma","volume":"124","author":"Goldman","year":"1998","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.prp.2016.09.011_bib0050","first-page":"545","article-title":"Yamamo Y Dendritic cells in human squamous cell carcinoma of the oral cavity","volume":"22","author":"Kikuchi","year":"2002","journal-title":"Anticancer Res."},{"key":"10.1016\/j.prp.2016.09.011_bib0055","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1002\/1097-0142(20010601)91:11<2136::AID-CNCR1242>3.0.CO;2-Q","article-title":"The number of intratumoral dendritic cells and zeta-chain expression in T cells as prognostic and survival biomarkers in patients with oral carcinoma","volume":"91","author":"Reichert","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.prp.2016.09.011_bib0060","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.canlet.2007.04.003","article-title":"Distribution of dendritic cell subtypes in primary oral squamous cell carcinoma is inconsistent with a functional response","volume":"255","author":"O'Donnell","year":"2007","journal-title":"Cancer Lett."},{"key":"10.1016\/j.prp.2016.09.011_bib0065","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1007\/s10875-011-9594-7","article-title":"Nationwide survey of patients with primary immunodeficiency diseases in Japan","volume":"31","author":"Ishimura","year":"2011","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.prp.2016.09.011_bib0070","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1749-6632.2011.06322.x","article-title":"DNA repair: the link between primary immunodeficiency and cancer","volume":"1246","author":"de Miranda","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.prp.2016.09.011_bib0075","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.it.2004.03.002","article-title":"CD1a in human cancers: a new role for an old molecule","volume":"25","author":"Coventry","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.prp.2016.09.011_bib0080","doi-asserted-by":"crossref","first-page":"201","DOI":"10.5468\/ogs.2014.57.3.201","article-title":"S100 expression in dendritic cells is inversely correlated with tumor grade in endometrial carcinoma","volume":"57","author":"Lee","year":"2014","journal-title":"Obstet. Gynecol. Sci."},{"key":"10.1016\/j.prp.2016.09.011_bib0085","first-page":"1755","article-title":"Clinical significance of defective dendritic cell differentiation in cancer","volume":"6","author":"Almand","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2016.09.011_bib0090","first-page":"641","article-title":"Human sunlight-induced basal-cell-carcinoma-associated dendritic cells are deficient in T cell co-stimulatory molecules and are impaired as antigen-presenting cells","volume":"150","author":"Nestle","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2016.09.011_bib0095","first-page":"e7240","article-title":"S100 proteins as diagnostic and prognostic markers in colorectal and hepatocellular carcinoma","volume":"12","author":"Maletzki","year":"2012","journal-title":"Hepat. Mon."},{"key":"10.1016\/j.prp.2016.09.011_bib0100","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1158\/1078-0432.CCR-15-1507","article-title":"The where, the when, and the how of immune monitoring for cancer immunotherapies in the era of checkpoint inhibition","volume":"22","author":"Hegde","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2016.09.011_bib0105","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1440-1711.2005.01371.x","article-title":"Dendritic cell dysfunction in cancer: a mechanism for immunosuppression","volume":"83","author":"Pinzon-Charry","year":"2005","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.prp.2016.09.011_bib0110","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/eji.1830270326","article-title":"Interleukin-10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin-4 and granulocyte\/macrophage-colony-stimulating factor","volume":"27","author":"Buelens","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.prp.2016.09.011_bib0115","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.1182\/blood.V92.12.4778","article-title":"Inhibition of the differentiation of dendritic cells from CD34(+) progenitors by tumor cells: role of interleukin-6 and macrophage colony-stimulating factor","volume":"92","author":"Menetrier-Caux","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.prp.2016.09.011_bib0120","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nm1096-1096","article-title":"Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells","volume":"2","author":"Gabrilovich","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.prp.2016.09.011_bib0125","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.4049\/jimmunol.168.9.4333","article-title":"Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation","volume":"168","author":"Sombroek","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.prp.2016.09.011_bib0130","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.4049\/jimmunol.170.7.3488","article-title":"Gangliosides from human melanoma tumors impair dendritic cell differentiation from monocytes and induce their apoptosis","volume":"170","author":"P\u00e9guet-Navarro","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.prp.2016.09.011_bib0135","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1172\/JCI16492","article-title":"Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor","volume":"111","author":"Yang","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.prp.2016.09.011_bib0140","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0065-230X(04)92002-7","article-title":"Tumor-host immune interactions and dendritic cell dysfunction","volume":"92","author":"Yang","year":"2004","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.prp.2016.09.011_bib0145","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nm.2172","article-title":"Lipid accumulation and dendritic cell dysfunction in cancer","volume":"16","author":"Herber","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.prp.2016.09.011_bib0150","doi-asserted-by":"crossref","first-page":"989","DOI":"10.4049\/jimmunol.172.2.989","article-title":"Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species","volume":"172","author":"Kusmartsev","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.prp.2016.09.011_bib0155","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1074-7613(03)00120-1","article-title":"Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance","volume":"18","author":"Probst","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.prp.2016.09.011_bib0160","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.193.2.233","article-title":"Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells","volume":"193","author":"Dhodapkar","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.prp.2016.09.011_bib0165","first-page":"975","article-title":"Inflammatory cells infiltrating human colorectal carcinomas express HLA class II but not B7-1 and B7-2 costimulatory molecules of the T-cell activation","volume":"74","author":"Chaux","year":"1996","journal-title":"Lab. Invest."},{"key":"10.1016\/j.prp.2016.09.011_bib0170","first-page":"483","article-title":"Decreased antigen presentation by dendritic cells in patients with breast cancer","volume":"3","author":"Gabrilovich","year":"1997","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2016.09.011_bib0175","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1126\/science.1073514","article-title":"Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase","volume":"297","author":"Munn","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.prp.2016.09.011_bib0180","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/BF00157962","article-title":"A comparative study on tissue processing procedures for the immunohistochemical investigation of oral mucosal Langerhans cells","volume":"26","author":"Barrett","year":"1994","journal-title":"Histochem. J."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033816304605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033816304605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T07:10:15Z","timestamp":1601104215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033816304605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0344033816304605"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2016.09.011","relation":{},"ISSN":["0344-0338"],"issn-type":[{"type":"print","value":"0344-0338"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The predictive value of dendritic cells in early squamous cell carcinoma of the tongue","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2016.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}