{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:41:03Z","timestamp":1780461663858,"version":"3.54.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.prp.2017.05.004","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T17:17:48Z","timestamp":1495559868000},"page":"1010-1013","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Adenosquamous gallbladder carcinoma: Multigene hotspot mutational profiling reveals a monoclonal origin of the two components"],"prefix":"10.1016","volume":"213","author":[{"given":"Francesca","family":"Galuppini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Salmaso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Valentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Lanza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isacco","family":"Maretto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Nitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Rugge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Fassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2017.05.004_bib0005","series-title":"World Health Organization Classification of Tumours of the Digestive System","author":"Bosman","year":"2010"},{"key":"10.1016\/j.prp.2017.05.004_bib0010","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.amjsurg.2012.12.012","article-title":"Squamous variant of gallbladder cancer: is it different from adenocarcinoma?","volume":"206","author":"Kalayarasan","year":"2013","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.prp.2017.05.004_bib0015","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/MEG.0000000000000074","article-title":"Gallbladder cancers: associated conditions, histological types, prognosis, and prevention","volume":"26","author":"Cariati","year":"2014","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.prp.2017.05.004_bib0020","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/modpathol.2011.68","article-title":"Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas","volume":"24","author":"Roa","year":"2011","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.prp.2017.05.004_bib0025","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/jso.24065","article-title":"Squamous\/adenosquamous carcinoma of the gallbladder: analysis of 34 cases and comparison of clinicopathologic features and surgical outcomes with adenocarcinoma","volume":"112","author":"Song","year":"2015","journal-title":"J. Surg. Oncol."},{"key":"10.1016\/j.prp.2017.05.004_bib0030","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s12253-013-9693-2","article-title":"Squamous cell\/adenosquamous carcinomas and adenocarcinomas of the gallbladder: an immunohistochemistry study of prognostic markers","volume":"20","author":"Li","year":"2014","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.prp.2017.05.004_bib0035","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.3892\/mmr.2016.5851","article-title":"MCM2 and TIP30 are prognostic markers in squamous cell\/adenosquamous carcinoma and adenocarcinoma of the gallbladder","volume":"14","author":"Liu","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.prp.2017.05.004_bib0040","first-page":"2015","article-title":"Correlation of HMGB1 expression to progression and poor prognosis of adenocarcinoma and squamous cell\/adenosquamous carcinoma of gallbladder","volume":"7","author":"Shi","year":"2015","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.prp.2017.05.004_bib0045","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.3892\/ol.2014.1886","article-title":"TSG101 and PEG10 are prognostic markers in squamous cell\/adenosquamous carcinomas and adenocarcinoma of the gallbladder","volume":"7","author":"Liu","year":"2014","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.prp.2017.05.004_bib0050","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10735-013-9528-1","article-title":"ACE2 and FZD1 are prognosis markers in squamous cell\/adenosquamous carcinoma and adenocarcinoma of gallbladder","volume":"45","author":"Li","year":"2014","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.prp.2017.05.004_bib0055","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/his.12341","article-title":"Paxillin and carbonic anhydrase IX are prognostic markers in gallbladder squamous cell\/adenosquamous carcinomas and adenocarcinomas","volume":"64","author":"Liu","year":"2014","journal-title":"Histopathology"},{"key":"10.1016\/j.prp.2017.05.004_bib0060","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10147-013-0550-9","article-title":"A comparative study of clinicopathological significance FGFBP1, and WISP-2 expression between squamous cell\/adenosquamous carcinomas and adenocarcinoma of the gallbladder","volume":"19","author":"Yang","year":"2014","journal-title":"Int. J. Clin. Oncol."},{"key":"10.1016\/j.prp.2017.05.004_bib0065","doi-asserted-by":"crossref","first-page":"698","DOI":"10.4149\/neo_2013_089","article-title":"Comparative study of clinicopathological significance, BIRC7, and STC2 expression between squamous cell\/adenosquamous carcinomas and adenocarcinoma of gallbladder","volume":"60","author":"Yuan","year":"2013","journal-title":"Neoplasma"},{"issue":"2","key":"10.1016\/j.prp.2017.05.004_bib0070","first-page":"179","article-title":"Nectin-2 and DDX3 are biomarkers for metastasis and poor prognosis of squamous cell\/adenosquamous carcinomas and adenocarcinoma of gallbladder","volume":"6","author":"Miao","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.prp.2017.05.004_bib0075","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3109\/07357907.2012.756113","article-title":"CFL1 and Arp3 are biomarkers for metastasis and poor prognosis of squamous cell\/adenosquamous carcinomas and adenocarcinomas of gallbladder","volume":"31","author":"Yang","year":"2013","journal-title":"Cancer Invest."},{"key":"10.1016\/j.prp.2017.05.004_bib0080","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s13277-012-0557-2","article-title":"ILK and PRDX1 are prognostic markers in squamous cell\/adenosquamous carcinomas and adenocarcinoma of gallbladder","volume":"34","author":"Li","year":"2013","journal-title":"Tumour Biol."},{"key":"10.1016\/j.prp.2017.05.004_bib0085","doi-asserted-by":"crossref","first-page":"e104979","DOI":"10.1371\/journal.pone.0104979","article-title":"Reporting tumor molecular heterogeneity in histopathological diagnosis","volume":"9","author":"Mafficini","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2017.05.004_bib0090","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1200\/JCO.2012.47.5855","article-title":"Next-generation histopathologic diagnosis: a lesson from a hepatic carcinosarcoma","volume":"32","author":"Luchini","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.prp.2017.05.004_bib0095","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1159\/000369071","article-title":"Mixed adenoneuroendocrine carcinomas of the gastrointestinal tract: targeted next-generation sequencing suggests a monoclonal origin of the two components","volume":"100","author":"Scardoni","year":"2014","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.prp.2017.05.004_bib0100","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.humpath.2015.12.006","article-title":"Early signet ring cell carcinoma arising from colonic adenoma: the molecular profiling supports the adenoma-carcinoma sequence","volume":"50","author":"Bellan","year":"2016","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2017.05.004_bib0105","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/modpathol.3800788","article-title":"Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria","volume":"20","author":"Zen","year":"2007","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.prp.2017.05.004_bib0110","doi-asserted-by":"crossref","first-page":"e62692","DOI":"10.1371\/journal.pone.0062692","article-title":"DNA qualification workflow for next generation sequencing of histopathological samples","volume":"8","author":"Simbolo","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2017.05.004_bib0115","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1470-2045(03)01134-3","article-title":"Squamous-cell and non-squamous-cell carcinomas of the gallbladder have different risk factors","volume":"4","author":"Andrea","year":"2003","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.prp.2017.05.004_bib0120","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.dld.2010.01.014","article-title":"The original sin of oesophageal mucosa","volume":"43","author":"Fassan","year":"2011","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.prp.2017.05.004_bib0125","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s12253-013-9710-5","article-title":"Expression of cell cycle-related proteins p16, p53 and p63 as important prognostic markers in gallbladder adenocarcinoma","volume":"20","author":"Kim","year":"2014","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.prp.2017.05.004_bib0130","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s12253-013-9693-2","article-title":"Squamous cell\/adenosquamous carcinomas and adenocarcinomas of the gallbladder: an immunohistochemistry study of prognostic markers","volume":"20","author":"Li","year":"2014","journal-title":"Pathol. Oncol. Res."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033817303722?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033817303722?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T23:58:51Z","timestamp":1569369531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033817303722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0344033817303722"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2017.05.004","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adenosquamous gallbladder carcinoma: Multigene hotspot mutational profiling reveals a monoclonal origin of the two components","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2017.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}