{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:33:32Z","timestamp":1784604812633,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571767"],"award-info":[{"award-number":["81571767"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81171538"],"award-info":[{"award-number":["81171538"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.prp.2017.09.014","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T07:46:36Z","timestamp":1510299996000},"page":"296-302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Study on expression of p16 and human papillomavirus 16 and 18 (E6) in OLP and its malignant transformation"],"prefix":"10.1016","volume":"214","author":[{"given":"Ting","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingjiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2017.09.014_bib0005","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/000163501750266774","article-title":"Immune mechanisms in oral lichen planus","volume":"59","author":"Thornhill","year":"2001","journal-title":"Acta Odontol. Scand."},{"key":"10.1016\/j.prp.2017.09.014_bib0010","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3109\/00016357.2014.914570","article-title":"Malignant transformation of oral lichen planus by a chronic inflammatory process. Use of topical corticosteroids to prevent this progression","volume":"72","author":"Otero-Rey","year":"2014","journal-title":"Acta Odontol. Scand."},{"key":"10.1016\/j.prp.2017.09.014_bib0015","doi-asserted-by":"crossref","first-page":"45","DOI":"10.14219\/jada.2013.10","article-title":"The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review","volume":"145","author":"Fitzpatrick","year":"2014","journal-title":"J. Am. Dent. Assoc."},{"key":"10.1016\/j.prp.2017.09.014_bib0020","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1601-0825.2010.01750.x","article-title":"PLENARY ABSTRACT: the malignant potential of oral lichen planus","volume":"16","author":"Holmstrup","year":"2010","journal-title":"Oral Dis."},{"key":"10.1016\/j.prp.2017.09.014_bib0025","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s004280000368","article-title":"p16 alterations and retinoblastoma protein expression in squamous cell carcinoma and neighboring dysplasia from the upper aerodigestive tract","volume":"438","author":"Ambrosch","year":"2001","journal-title":"Virchows Arch."},{"key":"10.1016\/j.prp.2017.09.014_bib0030","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2334\/josnusd.52.239","article-title":"Detection of nucleoproteins in squamous cell carcinoma, and dysplastic and normal mucosa in the oral cavity by methyl green-pyronin staining","volume":"52","author":"Mohtasham","year":"2010","journal-title":"J. Oral Sci."},{"key":"10.1016\/j.prp.2017.09.014_bib0035","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.anndiagpath.2014.03.009","article-title":"Immunohistochemical expression of p16 protein in oral squamous cell carcinoma and lichen planus","volume":"18","author":"Salehinejad","year":"2014","journal-title":"Ann. Diagn. Pathol."},{"key":"10.1016\/j.prp.2017.09.014_bib0040","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/366704a0","article-title":"A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D\/CDK4","volume":"366","author":"Serrano","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.prp.2017.09.014_bib0045","first-page":"283","article-title":"Relation between human papillomavirus positivity and p16 expression in head and neck carcinomas\u2014a tissue microarray study","volume":"27","author":"Konig","year":"2007","journal-title":"Anticancer Res."},{"key":"10.1016\/j.prp.2017.09.014_bib0050","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/excr.2000.5149","article-title":"p16(MTS-1\/CDKN2\/INK4a) in cancer progression","volume":"264","author":"Rocco","year":"2001","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.prp.2017.09.014_bib0055","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3233\/CBM-130355","article-title":"A systematic review of hypermethylation of p16 gene in esophageal cancer","volume":"13","author":"Xu","year":"2013","journal-title":"Cancer Biomark."},{"key":"10.1016\/j.prp.2017.09.014_bib0060","doi-asserted-by":"crossref","first-page":"797","DOI":"10.4103\/0970-9290.152208","article-title":"Promoter hypermethylation patterns of P16, DAPK and MGMT in oral squamous cell carcinoma: a systematic review and meta-analysis","volume":"25","author":"Don","year":"2014","journal-title":"Indian J. Dent. Res."},{"key":"10.1016\/j.prp.2017.09.014_bib0065","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1368-8375(01)00048-3","article-title":"Expression of cell cycle control proteins in normal epithelium, premalignant and malignant lesions of oral cavity","volume":"38","author":"Shintani","year":"2002","journal-title":"Oral Oncol."},{"key":"10.1016\/j.prp.2017.09.014_bib0070","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1600-0714.2010.01001.x","article-title":"Overexpression of cdk4 and p16 in oral lichen planus supports the concept of premalignancy","volume":"40","author":"Poomsawat","year":"2011","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.prp.2017.09.014_bib0075","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1054\/ijom.2002.0443","article-title":"Human papillomavirus type 16 and 18 DNA in oral squamous cell carcinoma and normal mucosa","volume":"33","author":"Zhang","year":"2004","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.prp.2017.09.014_bib0080","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.7314\/APJCP.2015.16.15.6193","article-title":"Roles of human papillomaviruses and p16 in oral cancer","volume":"16","author":"Sritippho","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.prp.2017.09.014_bib0085","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/idj.12125","article-title":"Role of human papilloma virus-16 in the pathogenesis of oral lichen planus\u2014an immunohistochemical study","volume":"65","author":"Pol","year":"2015","journal-title":"Int. Dent. J."},{"key":"10.1016\/j.prp.2017.09.014_bib0090","doi-asserted-by":"crossref","first-page":"e170","DOI":"10.4317\/medoral.16.e170","article-title":"Prevalence of herpes simplex, Epstein Barr and human papilloma viruses in oral lichen planus","author":"Yildirim","year":"2011","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"10.1016\/j.prp.2017.09.014_bib0095","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4103\/0973-029X.164528","article-title":"Prevalence of human papillomavirus in oral lichen planus in an Iranian cohort","volume":"19","author":"Sahebjamiee","year":"2015","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"10.1016\/j.prp.2017.09.014_bib0100","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tripleo.2010.11.007","article-title":"Oral lichen planus: malignant transformation and human papilloma virus: a review of potential clinical implications","volume":"111","author":"Gorsky","year":"2011","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"issue":"Suppl. 1","key":"10.1016\/j.prp.2017.09.014_bib0105","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/s12105-012-0367-2","article-title":"Biology of human papillomavirus infections in head and neck carcinogenesis","volume":"6","author":"Rautava","year":"2012","journal-title":"Head Neck Pathol."},{"key":"10.1016\/j.prp.2017.09.014_bib0110","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1601-0825.1997.tb00025.x","article-title":"The high risk human papillomaviruses and oral cancer: evidence for and against a causal relationship","volume":"3","author":"Sugerman","year":"1997","journal-title":"Oral Dis."},{"key":"10.1016\/j.prp.2017.09.014_bib0115","first-page":"13","article-title":"Absence of high-risk HPV 16 and 18 in Chinese patients with oral squamous cell carcinoma and oral potentially malignant disorders","volume":"20","author":"Chen","year":"2016","journal-title":"Virol. J."},{"key":"10.1016\/j.prp.2017.09.014_bib0120","first-page":"17","article-title":"Human papilloma virus in oral squamous cell carcinoma \u2013 the enigma unravelled","volume":"19","author":"Khot","year":"2016","journal-title":"Chin. J. Dent. Res."},{"key":"10.1016\/j.prp.2017.09.014_bib0125","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00432-010-0886-8","article-title":"Significant association of high-risk human papillomavirus (HPV) but not of p53 polymorphisms with oral squamous cell carcinomas in Malaysia","volume":"137","author":"Saini","year":"2011","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.prp.2017.09.014_bib0130","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1743-7563.2009.01200.x","article-title":"Human papillomavirus infection and premalignant lesions of the oral cavity: a cross-sectional study in Allahabad, North India","volume":"5","author":"Debanth","year":"2009","journal-title":"Asia-Pac. J. Clin. Oncol."},{"key":"10.1016\/j.prp.2017.09.014_bib0135","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1750-9378-6-4","article-title":"The role of human papillomavirus in the pathogenesis of head & neck squamous cell carcinoma: an overview","volume":"6","author":"Pannone","year":"2011","journal-title":"Infect. Agents Cancer"},{"key":"10.1016\/j.prp.2017.09.014_bib0140","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1002\/ijc.28534","article-title":"P16(INK4A) immunostaining is a strong indicator for high-risk-HPV-associated oropharyngeal carcinomas and dysplasias, but is unreliable to predict low-risk-HPV-infection in head and neck papillomas and laryngeal dysplasias","volume":"134","author":"Mooren","year":"2014","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.prp.2017.09.014_bib0145","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1097\/PAS.0b013e3181e84652","article-title":"p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status","volume":"34","author":"Lewis","year":"2010","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2017.09.014_bib0150","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1159\/000331047","article-title":"Usefulness of CINtec(R) PLUS p16\/Ki-67 double-staining in cytological screening of cervical cancer","volume":"55","author":"Yoshida","year":"2011","journal-title":"Acta Cytol."},{"key":"10.1016\/j.prp.2017.09.014_bib0155","first-page":"717","article-title":"5.Histopathological analysis of oral lichen planus with malignant transformation","volume":"51","author":"Gao","year":"2016","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"10.1016\/j.prp.2017.09.014_bib0160","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1365-2559.2010.03671.x","article-title":"Immunohistochemical expression of p16(INK4A) protein as a helpful marker of a subset of potentially malignant oral epithelial lesions: study on a series with long-term follow-up","volume":"57","author":"Montebugnoli","year":"2010","journal-title":"Histopathology"},{"key":"10.1016\/j.prp.2017.09.014_bib0165","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.canlet.2011.02.039","article-title":"p16(INK4a)\/CDKN2 expression and its relationship with oral squamous cell carcinoma is our current knowledge enough?","volume":"306","author":"Perez-Sayans","year":"2011","journal-title":"Cancer Lett."},{"key":"10.1016\/j.prp.2017.09.014_bib0170","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4103\/2231-0762.131269","article-title":"Analysis of human papilloma virus in oral squamous cell carcinoma using p16: an immunohistochemical study","volume":"4","author":"Patil","year":"2014","journal-title":"J. Int. Soc. Prev. Commun. Dent."},{"key":"10.1016\/j.prp.2017.09.014_bib0175","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ijc.1174","article-title":"Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri","volume":"92","author":"Klaes","year":"2001","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.prp.2017.09.014_bib0180","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1758-3284-1-22","article-title":"Role of human papillomavirus and its detection in potentially malignant and malignant head and neck lesions: updated review","volume":"1","author":"Chaudhary","year":"2009","journal-title":"Head Neck Oncol."},{"key":"10.1016\/j.prp.2017.09.014_bib0185","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.ijom.2010.05.007","article-title":"Cancer genes alterations and HPV infection in oral squamous cell carcinoma","volume":"39","author":"Popovic","year":"2010","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.prp.2017.09.014_bib0190","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1399-302X.2009.00516.x","article-title":"Progressive increase of human papillomavirus carriage rates in potentially malignant and malignant oral disorders with increasing malignant potential","volume":"24","author":"Szarka","year":"2009","journal-title":"Oral Microbiol. Immunol."},{"key":"10.1016\/j.prp.2017.09.014_bib0195","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00430-002-0161-y","article-title":"Human papillomavirus 6\/11, 16 and 18 in oral carcinomas and benign oral lesions","volume":"192","author":"Ostwald","year":"2003","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.prp.2017.09.014_bib0200","first-page":"82","article-title":"Human papilloma virus as a possible factor in the pathogenesis of oral lichen planus","volume":"6","author":"Razavi","year":"2009","journal-title":"Dent. Res. J. (Isfahan)"},{"key":"10.1016\/j.prp.2017.09.014_bib0205","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1600-0714.1990.tb00841.x","article-title":"Human papillomavirus in erosive lichen planus","volume":"19","author":"Jontell","year":"1990","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.prp.2017.09.014_bib0210","doi-asserted-by":"crossref","first-page":"e0161339","DOI":"10.1371\/journal.pone.0161339","article-title":"The magnitude of the association between human papillomavirus and oral lichen planus: a meta-analysis","volume":"11","author":"Ma","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2017.09.014_bib0215","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.oraloncology.2012.04.009","article-title":"Human papillomavirus in oral atrophic lichen planus lesions","volume":"48","author":"Mattila","year":"2012","journal-title":"Oral Oncol."},{"key":"10.1016\/j.prp.2017.09.014_bib0220","first-page":"3435","article-title":"Frequency and role of HPV in the progression of epithelial dysplasia to oral cancer","volume":"30","author":"Angiero","year":"2010","journal-title":"Anticancer Res."},{"key":"10.1016\/j.prp.2017.09.014_bib0225","doi-asserted-by":"crossref","first-page":"398","DOI":"10.4149\/neo_2012_052","article-title":"Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16(INK4a) expression, and HPV status","volume":"59","author":"Laco","year":"2012","journal-title":"Neoplasma"},{"key":"10.1016\/j.prp.2017.09.014_bib0230","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1002\/cncr.25033","article-title":"Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience","volume":"116","author":"Singhi","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.prp.2017.09.014_bib0235","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.tripleo.2005.10.069","article-title":"Expression of p16(INK4A), p53, and Rb proteins are independent from the presence of human papillomavirus genes in oral squamous cell carcinoma","volume":"102","author":"Nemes","year":"2006","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033817305010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033817305010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T14:20:52Z","timestamp":1719584452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033817305010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S0344033817305010"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2017.09.014","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study on expression of p16 and human papillomavirus 16 and 18 (E6) in OLP and its malignant transformation","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2017.09.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}