{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:52:21Z","timestamp":1787727141224,"version":"build-2784847793"},"reference-count":105,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Postgraduate Innovative Research Project of Harbin Medical University","award":["YJSCX2016-21HYD"],"award-info":[{"award-number":["YJSCX2016-21HYD"]}]},{"name":"Foundation of Key Laboratory of Myocardial Ischemia, Ministry of Education","award":["KF201810"],"award-info":[{"award-number":["KF201810"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.prp.2018.08.014","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T12:38:33Z","timestamp":1534768713000},"page":"1524-1531","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["The role of long non-coding RNA AFAP1-AS1 in human malignant tumors"],"prefix":"10.1016","volume":"214","author":[{"given":"Daolin","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingming","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiming","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenglong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lining","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2018.08.014_bib0005","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/489046a","article-title":"ENCODE: the human encyclopaedia","volume":"489","author":"Maher","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.prp.2018.08.014_bib0010","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature11233","article-title":"Landscape of transcription in human cells","volume":"489","author":"Djebali","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.prp.2018.08.014_bib0015","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1126\/science.1231776","article-title":"Epigenetic regulation by long non-coding RNAs","volume":"338","author":"Lee","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.prp.2018.08.014_bib0020","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.biochi.2015.03.001","article-title":"Long non-coding RNA turnover","volume":"117","author":"Yoon","year":"2015","journal-title":"Biochimie"},{"key":"10.1016\/j.prp.2018.08.014_bib0025","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1534\/genetics.112.146704","article-title":"Long non-coding RNAs: past, present, and future","volume":"193","author":"Kung","year":"2013","journal-title":"Genetics"},{"key":"10.1016\/j.prp.2018.08.014_bib0030","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.prp.2018.04.003","article-title":"LncRNA-DANCR: a valuable cancer related long non-coding RNA for human cancers","volume":"214","author":"Thin","year":"2018","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2018.08.014_bib0035","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1007\/s11427-012-4413-9","article-title":"Long non-coding RNAs in cancer","volume":"55","author":"Gong","year":"2012","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.prp.2018.08.014_bib0040","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s11427-014-4669-3","article-title":"Long non-coding RNA: dancing on immune stage","volume":"57","author":"Huang","year":"2014","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.prp.2018.08.014_bib0045","first-page":"11","article-title":"Cancer statistics, 2013","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.prp.2018.08.014_bib0050","doi-asserted-by":"crossref","first-page":"917","DOI":"10.2217\/fon.13.76","article-title":"The rise and fall of cancer mortality in the USA: why does pancreatic cancer not follow the trend?","volume":"9","author":"Ma","year":"2013","journal-title":"Future Oncol."},{"key":"10.1016\/j.prp.2018.08.014_bib0055","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cell.2009.02.006","article-title":"Evolution and functions of long non-coding RNAs","volume":"136","author":"Ponting","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.prp.2018.08.014_bib0060","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12967-015-0490-4","article-title":"High expression of AFAP1-AS1 is associated with poor survival and short-term recurrence in pancreatic ductal adenocarcinoma","volume":"13","author":"Ye","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.prp.2018.08.014_bib0065","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.3892\/ijo.2015.2911","article-title":"Lithium chloride induces mesenchymal to epithelial reverting transition in primary colon cancer cell cultures","volume":"46","author":"Costabile","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.prp.2018.08.014_bib0070","doi-asserted-by":"crossref","first-page":"867","DOI":"10.3892\/mmr.2014.2316","article-title":"Overexpression of peroxiredoxin 2 inhibits TGF-\u03b21-induced epithelial-mesenchymal transition and cell migration in colorectal cancer","volume":"10","author":"Feng","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.prp.2018.08.014_bib0075","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1053\/j.gastro.2013.10.013","article-title":"Pathogenesis, diagnosis, and management of cholangiocarcinoma","volume":"145","author":"Rizvi","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.prp.2018.08.014_bib0080","first-page":"115","article-title":"Cancer statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.prp.2018.08.014_bib0085","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1349-7006.2009.01458.x","article-title":"Epidemiology of cholangiocarcinoma: an update focusing on risk factors","volume":"101","author":"Shin","year":"2010","journal-title":"Cancer Sci."},{"key":"10.1016\/j.prp.2018.08.014_bib0090","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0140-6736(12)61425-1","article-title":"Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study","volume":"381","author":"Marcellin","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.prp.2018.08.014_bib0095","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1002\/hep.27222","article-title":"Epidemiology of hepatocellular carcinoma in the United States: where are we?","volume":"60","author":"El-Serag","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.prp.2018.08.014_bib0100","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1002\/hep.28508","article-title":"Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans","volume":"63","author":"Li","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.prp.2018.08.014_bib0105","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/hep.22623","article-title":"Pathobiology of biliary epithelia and cholangiocarcinoma: proceedings of the henry M. and Lillian Stratton basic research single-topic conference","volume":"48","author":"Sirica","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.prp.2018.08.014_bib0110","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000477319","article-title":"Long noncoding RNA AFAP1-AS1 promoted tumor growth and invasion in Cholangiocarcinoma","volume":"42","author":"Lu","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.prp.2018.08.014_bib0115","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.3892\/mmr.2016.5170","article-title":"Knockdown of RHOC by shRNA suppresses invasion and migration of cholangiocellular carcinoma cells via inhibition of MMP2, MMP3, MMP9 and epithelial-mesenchymal transition","volume":"13","author":"Yang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.prp.2018.08.014_bib0120","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.biopha.2011.09.008","article-title":"Lobaplatin induces apoptosis and arrests cell cycle progression in human cholangiocarcinoma cell line RBE","volume":"66","author":"Wang","year":"2012","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.prp.2018.08.014_bib0125","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0168-8278(01)00079-4","article-title":"The role of overexpression and gene amplification of cyclin D1 in intrahepatic cholangiocarcinoma","volume":"35","author":"Sugimachi","year":"2001","journal-title":"J. Hepatol."},{"key":"10.1016\/j.prp.2018.08.014_bib0130","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.biopha.2016.10.064","article-title":"Overexpression of LncRNA AFAP1-AS1 predicts poor prognosis and promotes cells proliferation and invasion in gallbladder cancer","volume":"84","author":"Ma","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.prp.2018.08.014_bib0135","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ejso.2007.07.206","article-title":"Gallbladder carcinoma","volume":"34","author":"Miller","year":"2008","journal-title":"Eur. J. Surg. Oncol."},{"key":"10.1016\/j.prp.2018.08.014_bib0140","doi-asserted-by":"crossref","first-page":"12211","DOI":"10.3748\/wjg.v21.i43.12211","article-title":"Gallbladder carcinoma: prognostic factors and therapeutic options","volume":"21","author":"Goetze","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.prp.2018.08.014_bib0145","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1001\/jama.2015.5370","article-title":"Nonalcoholic fatty liver disease: a systematic review","volume":"313","author":"Rinella","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.prp.2018.08.014_bib0150","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.4254\/wjh.v7.i18.2147","article-title":"Strategies to increase the resectability of hepatocellular carcinoma","volume":"7","author":"She","year":"2015","journal-title":"World J. Hepatol."},{"issue":"36 Suppl","key":"10.1016\/j.prp.2018.08.014_bib0155","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/liv.13006","article-title":"The prognosis and management of inactive HBV carriers","volume":"1","author":"Invernizzi","year":"2016","journal-title":"Liver Int."},{"key":"10.1016\/j.prp.2018.08.014_bib0160","doi-asserted-by":"crossref","first-page":"7161","DOI":"10.1158\/0008-5472.CAN-14-1446","article-title":"MDM2-p53 pathway in hepatocellular carcinoma","volume":"74","author":"Meng","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2018.08.014_bib0165","doi-asserted-by":"crossref","first-page":"349","DOI":"10.15403\/jgld.2014.1121.243.mew","article-title":"Glycosylation-related diagnostic and therapeutic drug target markers in hepatocellular carcinoma","volume":"24","author":"Watson","year":"2015","journal-title":"J. Gastrointestin. Liver Dis."},{"key":"10.1016\/j.prp.2018.08.014_bib0170","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.3892\/ijo.2016.3385","article-title":"Long non-coding RNA AFAP1-AS1 indicates a poor prognosis of hepatocellular carcinoma and promotes cell proliferation and invasion via upregulation of the RhoA\/Rac2 signaling","volume":"48","author":"Zhang","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.prp.2018.08.014_bib0175","doi-asserted-by":"crossref","first-page":"9699","DOI":"10.1007\/s13277-016-4858-8","article-title":"Critical role for the long non-coding RNA AFAP1-AS1 in the proliferation and metastasis of hepatocellular carcinoma","volume":"37","author":"Lu","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.prp.2018.08.014_bib0180","first-page":"249","article-title":"Epidemiology of gastrointestinal and liver tumors","volume":"14","author":"Herszenyi","year":"2010","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"Suppl 1","key":"10.1016\/j.prp.2018.08.014_bib0185","article-title":"Gastric cancer: basic aspects","volume":"22","author":"Molina-Castro","year":"2017","journal-title":"Helicobacter"},{"key":"10.1016\/j.prp.2018.08.014_bib0190","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"Cancer J Clin."},{"key":"10.1016\/j.prp.2018.08.014_bib0195","first-page":"4039","article-title":"miR-218 Modulate hepatocellular carcinoma cell proliferation through PTEN\/AKT\/PI3K pathway and HoxA10","volume":"7","author":"Xiao","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.prp.2018.08.014_bib0200","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1007\/s10620-017-4584-0","article-title":"Long noncoding RNA AFAP1-AS1 promotes cell proliferation and apoptosis of gastric cancer cells via PTEN\/p-AKT pathway","volume":"62","author":"Guo","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.prp.2018.08.014_bib0205","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.2147\/OTT.S107188","article-title":"Long noncoding RNA AFAP1-AS1, a potential novel biomarker to predict the clinical outcome of cancer patients: a meta-analysis","volume":"9","author":"Liu","year":"2016","journal-title":"Onco. Ther."},{"key":"10.1016\/j.prp.2018.08.014_bib0210","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.prp.2018.08.014_bib0215","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.clinbiochem.2014.04.019","article-title":"Tests and investigations for colorectal cancer screening","volume":"47","author":"Carroll","year":"2014","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.prp.2018.08.014_bib0220","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3892\/mmr.2012.923","article-title":"Identification of a new protein biomarker for colorectal cancer diagnosis","volume":"6","author":"Zhai","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.prp.2018.08.014_bib0225","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1136\/gutjnl-2014-309086","article-title":"Colorectal cancer screening: a global overview of existing programmes","volume":"64","author":"Schreuders","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.prp.2018.08.014_bib0230","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.biopha.2016.04.009","article-title":"Overexpression of lncRNA AFAP1-AS1 correlates with poor prognosis and promotes tumorigenesis in colorectal cancer","volume":"81","author":"Wang","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.prp.2018.08.014_bib0235","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40659-016-0094-3","article-title":"Long non-coding RNA AFAP1-AS1 facilitates tumor growth and promotes metastasis in colorectal cancer","volume":"49","author":"Han","year":"2016","journal-title":"Biol. Res."},{"key":"10.1016\/j.prp.2018.08.014_bib0240","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0140-6736(12)60643-6","article-title":"Oesophageal carcinoma","volume":"381","author":"Pennathur","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.prp.2018.08.014_bib0245","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1056\/NEJMra1314530","article-title":"Esophageal carcinoma","volume":"371","author":"Rustgi","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.prp.2018.08.014_bib0250","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1748-717X-9-64","article-title":"Involved-field irradiation in definitive chemoradiotherapy for locally advanced esophageal squamous cell carcinoma","volume":"9","author":"Zhang","year":"2014","journal-title":"Radiat. Oncol."},{"key":"10.1016\/j.prp.2018.08.014_bib0255","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1053\/j.gastro.2013.01.019","article-title":"Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett\u2019s esophagus and esophageal adenocarcinoma","volume":"144","author":"Wu","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.prp.2018.08.014_bib0260","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1002\/cam4.848","article-title":"AFAP1-AS1 is upregulated and promotes esophageal squamous cell carcinoma cell proliferation and inhibits cell apoptosis","volume":"5","author":"Luo","year":"2016","journal-title":"Cancer Med."},{"key":"10.1016\/j.prp.2018.08.014_bib0265","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1002\/mc.22454","article-title":"High expression of long non-coding RNA AFAP1-AS1 predicts chemoradioresistance and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy","volume":"55","author":"Zhou","year":"2016","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.prp.2018.08.014_bib0270","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/S0140-6736(05)66698-6","article-title":"Nasopharyngeal carcinoma","volume":"365","author":"Wei","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.prp.2018.08.014_bib0275","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/S0140-6736(15)00055-0","article-title":"Nasopharyngeal carcinoma","volume":"387","author":"Chua","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.prp.2018.08.014_bib0280","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.semcancer.2011.12.011","article-title":"Deciphering the molecular genetic basis of NPC through molecular, cytogenetic, and epigenetic approaches","volume":"22","author":"Lo","year":"2012","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.prp.2018.08.014_bib0285","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1158\/0008-5472.CAN-03-3253","article-title":"A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma","volume":"64","author":"Xiong","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2018.08.014_bib0290","first-page":"156","article-title":"Family-based association analysis validates chromosome 3p21 as a putative nasopharyngeal carcinoma susceptibility locus","volume":"8","author":"Zeng","year":"2006","journal-title":"Genetics"},{"key":"10.1016\/j.prp.2018.08.014_bib0295","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.prp.2016.10.006","article-title":"Frequent overexpression of PDK1 in primary nasopharyngeal carcinoma is associated with poor prognosis","volume":"212","author":"Xiang","year":"2016","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2018.08.014_bib0300","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.oraloncology.2007.08.003","article-title":"Nasopharyngeal carcinoma: current management, future directions and dental implications","volume":"44","author":"Agulnik","year":"2008","journal-title":"Oral Oncol."},{"key":"10.1016\/j.prp.2018.08.014_bib0305","doi-asserted-by":"crossref","first-page":"20404","DOI":"10.18632\/oncotarget.4057","article-title":"Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma","volume":"6","author":"Bo","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2018.08.014_bib0310","doi-asserted-by":"crossref","first-page":"41166","DOI":"10.18632\/oncotarget.17083","article-title":"Serum long non-coding RNAs MALAT1, AFAP1-AS1 and AL359062 as diagnostic and prognostic biomarkers for nasopharyngeal carcinoma","volume":"8","author":"He","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2018.08.014_bib0315","doi-asserted-by":"crossref","first-page":"39001","DOI":"10.18632\/oncotarget.16545","article-title":"Co-expression of AFAP1-AS1 and PD-1 predicts poor prognosis in nasopharyngeal carcinoma","volume":"8","author":"Tang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2018.08.014_bib0320","first-page":"5","article-title":"Cancer statistics, 2015","volume":"65","author":"Siegel","year":"2015","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.prp.2018.08.014_bib0325","article-title":"Adoptive immunotherapy of cytokine-induced killer cell therapy in the treatment of non-small cell lung cancer","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2018.08.014_bib0330","first-page":"402","article-title":"The incidences and mortalities of major cancers in China, 2010","volume":"33","author":"Chen","year":"2014","journal-title":"Chin. J. Cancer"},{"key":"10.1016\/j.prp.2018.08.014_bib0335","first-page":"229","article-title":"Targeted therapy for lung cancer: present and future","volume":"3","author":"Aggarwal","year":"2014","journal-title":"Ann. Palliat. Med."},{"key":"10.1016\/j.prp.2018.08.014_bib0340","first-page":"41","article-title":"Advances on molecular mechanism of chronic inflammation-driven lung cancer induced by environmental carcinogens","volume":"41","author":"Lu","year":"2014","journal-title":"Prog. Biochem. Biophys."},{"key":"10.1016\/j.prp.2018.08.014_bib0345","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1097\/JTO.0b013e31818020eb","article-title":"The International Epidemiology of Lung Cancer: geographical distribution and secular trends","volume":"3","author":"Youlden","year":"2008","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.prp.2018.08.014_bib0350","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.3892\/mmr.2017.6989","article-title":"Dihydroartemisinin and gefitinib synergistically inhibit NSCLC cell growth and promote apoptosis via the Akt\/mTOR\/STAT3 pathway","volume":"16","author":"Jin","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.prp.2018.08.014_bib0355","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/JTO.0000000000000470","article-title":"Identification and validation of long noncoding RNA biomarkers in human non-small-cell lung carcinomas","volume":"10","author":"Yu","year":"2015","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.prp.2018.08.014_bib0360","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.biopha.2015.07.003","article-title":"The up-regulation of long non-coding RNA AFAP1-AS1 is associated with the poor prognosis of NSCLC patients","volume":"75","author":"Deng","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.prp.2018.08.014_bib0365","first-page":"2997","article-title":"Down-regulation of long non-coding RNA AFAP1-AS1 inhibits tumor cell growth and invasion in lung adenocarcinoma","volume":"9","author":"Zhuang","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.prp.2018.08.014_bib0370","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s13277-015-3860-x","article-title":"AFAP1-AS1, a long non-coding RNA upregulated in lung cancer and promotes invasion and metastasis","volume":"37","author":"Zeng","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.prp.2018.08.014_bib0375","first-page":"3497","article-title":"The identification of the biological characteristics of human ovarian cancer stem cells","volume":"18","author":"Yan","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.prp.2018.08.014_bib0380","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1056\/NEJMra041842","article-title":"Cancer of the ovary","volume":"351","author":"Cannistra","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.prp.2018.08.014_bib0385","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/bmb\/ldu034","article-title":"The molecular genetics of hereditary and sporadic ovarian cancer: implications for the future","volume":"112","author":"Al Bakir","year":"2014","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.prp.2018.08.014_bib0390","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0140-6736(11)60126-8","article-title":"Early versus delayed treatment of relapsed ovarian cancer","volume":"377","author":"Rustin","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.prp.2018.08.014_bib0395","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/1098-2388(200007\/08)19:1<3::AID-SSU2>3.0.CO;2-S","article-title":"Ovarian cancer: epidemiology, biology, and prognostic factors","volume":"19","author":"Holschneider","year":"2000","journal-title":"Semin. Surg. Oncol."},{"key":"10.1016\/j.prp.2018.08.014_bib0400","first-page":"5107","article-title":"Expression and functional role of long non-coding RNA AFAP1-AS1 in ovarian cancer","volume":"20","author":"Yang","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.prp.2018.08.014_bib0405","first-page":"7","article-title":"Cancer statistics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.prp.2018.08.014_bib0410","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s12254-017-0368-7","article-title":"ASCO 2017: highlights in breast cancer","volume":"10","author":"Bartsch","year":"2017","journal-title":"Memo"},{"key":"10.1016\/j.prp.2018.08.014_bib0415","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/cas.13463","article-title":"Breast cancer: the translation of big genomic data to cancer precision medicine","volume":"109","author":"Low","year":"2017","journal-title":"Cancer Sci."},{"key":"10.1016\/j.prp.2018.08.014_bib0420","article-title":"Up-regulated lncRNA AFAP1-AS1 indicates a poor prognosis and promotes carcinogenesis of breast cancer","author":"Ma","year":"2018","journal-title":"Breast Cancer"},{"key":"10.1016\/j.prp.2018.08.014_bib0425","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3233\/CBM-170831","article-title":"Expression analysis of AFAP1-AS1 and AFAP1 in breast cancer","volume":"22","author":"Dianatpour","year":"2018","journal-title":"Cancer Biomark"},{"key":"10.1016\/j.prp.2018.08.014_bib0430","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1136\/bjo.2008.138750","article-title":"Incidence of retinoblastoma in the USA: 1975\u20132004","volume":"93","author":"Broaddus","year":"2009","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.prp.2018.08.014_bib0435","doi-asserted-by":"crossref","DOI":"10.1038\/s41388-017-0050-x","article-title":"The management of retinoblastoma","author":"Fabian","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2018.08.014_bib0440","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s12098-017-2395-0","article-title":"Retinoblastoma","volume":"84","author":"Rao","year":"2017","journal-title":"Indian J. Pediatr."},{"key":"10.1016\/j.prp.2018.08.014_bib0445","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/107327481602300203","article-title":"Therapeutic options for retinoblastoma","volume":"23","author":"Mendoza","year":"2016","journal-title":"Cancer Control"},{"key":"10.1016\/j.prp.2018.08.014_bib0450","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180384","article-title":"LncRNA AFAP1-AS1 is a prognostic biomarker and serves as oncogenic role in retinoblastoma","volume":"38","author":"Hao","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.prp.2018.08.014_bib0455","first-page":"E359","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.prp.2018.08.014_bib0460","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.mlg.0000236095.97947.26","article-title":"Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival","volume":"116","author":"Hoffman","year":"2017","journal-title":"Laryngoscope"},{"key":"10.1016\/j.prp.2018.08.014_bib0465","first-page":"1055","article-title":"Chemoresistance of CD133+ cancer stem cells in laryngeal carcinoma","volume":"124","author":"Yang","year":"2011","journal-title":"Chin. Med. J. (Engl.)"},{"key":"10.1016\/j.prp.2018.08.014_bib0470","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1158\/1535-7163.MCT-05-0081","article-title":"Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL","volume":"4","author":"Bauer","year":"2005","journal-title":"Mol. Cancer Ther."},{"issue":"July 4","key":"10.1016\/j.prp.2018.08.014_bib0475","article-title":"Long non-coding RNA AFAP1-AS1\/miR-320a\/RBPJ axis regulates laryngeal carcinoma cell stemness and chemoresistance","author":"Yuan","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.prp.2018.08.014_bib0480","first-page":"115","article-title":"Cancer statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.prp.2018.08.014_bib0485","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.oraloncology.2017.02.015","article-title":"MicroRNAs in human tongue squamous cell carcinoma: from pathogenesis to therapeutic implications","volume":"67","author":"Karatas","year":"2017","journal-title":"Oral Oncol."},{"key":"10.1016\/j.prp.2018.08.014_bib0490","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.oooo.2016.10.006","article-title":"The emerging role of long noncoding RNAs in oral cancer","volume":"123","author":"Gomes","year":"2017","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"10.1016\/j.prp.2018.08.014_bib0495","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12943-017-0752-2","article-title":"Upregulation of the long non-coding RNA AFAP1-AS1 affects the proliferation, invasion and survival of tongue squamous cell carcinoma via the Wnt\/\u03b2-catenin signaling pathway","volume":"17","author":"Wang","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.prp.2018.08.014_bib0500","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1002\/ijc.29251","article-title":"Thyroid cancer mortality and incidence: a global overview","volume":"136","author":"La Vecchia","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.prp.2018.08.014_bib0505","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.surg.2013.07.007","article-title":"Long-term outcome of ultrasound-guided percutaneous ethanol ablation of selected \u201crecurrent\u201d neck nodal metastases in 25 patients with TNM stages III or IVA papillary thyroid carcinoma previously treated by surgery and 131I therapy","volume":"154","author":"Hay","year":"2013","journal-title":"Surgery"},{"key":"10.1016\/j.prp.2018.08.014_bib0510","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.biopha.2017.12.105","article-title":"Down-regulation of long non-coding RNA AFAP1-AS1 inhibits tumor growth, promotes apoptosis and decreases metastasis in thyroid cancer","volume":"99","author":"Dai","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.prp.2018.08.014_bib0515","doi-asserted-by":"crossref","first-page":"102346","DOI":"10.18632\/oncotarget.21830","article-title":"Long non-coding RNA AFAP1-AS1 is a novel biomarker in various cancers: a systematic review and meta-analysis based on the literature and GEO datasets","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2018.08.014_bib0520","doi-asserted-by":"crossref","first-page":"8100","DOI":"10.18632\/oncotarget.23568","article-title":"Meta-analysis of the prognostic value of long non-coding RNAAFAP1-AS1 for cancer patients in China","volume":"9","author":"Liu","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2018.08.014_bib0525","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cca.2018.03.006","article-title":"The prognostic value of high LncRNA AFAP1-AS1 expression in various cancers: a systematic review and meta-analysis containing 21 studies","volume":"481","author":"Zhou","year":"2018","journal-title":"Clin. Chim. Acta"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S034403381830712X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S034403381830712X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:36:02Z","timestamp":1759732562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S034403381830712X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":105,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S034403381830712X"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2018.08.014","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of long non-coding RNA AFAP1-AS1 in human malignant tumors","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2018.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}