{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:19:59Z","timestamp":1790839199636,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"First Affiliated Hospital of Guangxi Medical University"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.prp.2018.11.006","type":"journal-article","created":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T16:43:49Z","timestamp":1541868229000},"page":"177-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Clinical and prognostic value of chaperonin containing T-complex 1 subunit 3 in hepatocellular carcinoma: A Study based on microarray and RNA-sequencing with 4272 cases"],"prefix":"10.1016","volume":"215","author":[{"given":"Jia-yin","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-yu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-quan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-wu","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2018.11.006_bib0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21442","article-title":"Cancer statistics","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.prp.2018.11.006_bib0010","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1053\/j.gastro.2016.11.048","article-title":"Liver cancer cell of origin, molecular class, and effects on patient prognosis","volume":"152","author":"Sia","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.prp.2018.11.006_bib0015","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1159\/000478963","article-title":"Genome-wide association study of MKI67 expression and its clinical implications in HBV-related hepatocellular carcinoma in southern China","volume":"42","author":"Yang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.prp.2018.11.006_bib0020","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3892\/ijo.2016.3535","article-title":"Whole-genome DNA methylation and hydroxymethylation profiling for HBV-related hepatocellular carcinoma","volume":"49","author":"Ye","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.prp.2018.11.006_bib0025","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1186\/s12885-017-3895-z","article-title":"Survival benefit of hepatic resection versus transarterial chemoembolization for hepatocellular carcinoma with portal vein tumor thrombus: a systematic review and meta-analysis","volume":"17","author":"Zhang","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.prp.2018.11.006_bib0030","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1186\/s12885-017-3911-3","article-title":"Somatostatin and CXCR4 chemokine receptor expression in hepatocellular and cholangiocellular carcinomas: tumor capillaries as promising targets","volume":"17","author":"Kaemmerer","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.prp.2018.11.006_bib0035","first-page":"3558","article-title":"A proteomics-based investigation on the anticancer activity of alisertib, an Aurora kinase A inhibitor, in hepatocellular carcinoma Hep3B cells","volume":"9","author":"Zhu","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.prp.2018.11.006_bib0040","first-page":"1777","article-title":"Synergistic antitumor effects of tanshinone IIA and sorafenib or its derivative SC-1 in hepatocellular carcinoma cells","volume":"11","author":"Chiu","year":"2018","journal-title":"Oncol. Ther."},{"key":"10.1016\/j.prp.2018.11.006_bib0045","first-page":"3697","article-title":"Advances in management of hepatocellular carcinoma","volume":"17","author":"Intaraprasong","year":"2016","journal-title":"Asian Pac J Cancer."},{"key":"10.1016\/j.prp.2018.11.006_bib0050","first-page":"863","article-title":"Hepatocellular carcinoma: a comprehensive review of biomarkers, clinical aspects, and therapy","volume":"18","author":"Tunissiolli","year":"2017","journal-title":"Asian Pac J Cancer."},{"key":"10.1016\/j.prp.2018.11.006_bib0055","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.2147\/OTT.S143154","article-title":"The effects of nonsteroidal anti-inflammatory drugs in the incident and recurrent risk of hepatocellular carcinoma: a meta-analysis","volume":"10","author":"Pang","year":"2017","journal-title":"Onco. Ther."},{"key":"10.1016\/j.prp.2018.11.006_bib0060","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1053\/j.gastro.2015.05.061","article-title":"Genetic landscape and biomarkers of hepatocellular carcinoma","volume":"149","author":"Zucman-Rossi","year":"2015","journal-title":"Gastroenterology."},{"key":"10.1016\/j.prp.2018.11.006_bib0065","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0960-9822(94)00024-2","article-title":"Identification of six TCP-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin","volume":"4","author":"Kubota","year":"1994","journal-title":"Curr. Biol."},{"key":"10.1016\/j.prp.2018.11.006_bib0070","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1042\/bj3130381","article-title":"Cloning, structure and mRNA expression of human CCTG, which encodes the chaperonin subunit CCT gamma","volume":"313","author":"Walkley","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.prp.2018.11.006_bib0075","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13000-016-0596-x","article-title":"A transcriptome profile in hepatocellular carcinomas based on integrated analysis of microarray studies","volume":"12","author":"Wang","year":"2017","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.prp.2018.11.006_bib0080","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0168-8278(02)00412-9","article-title":"Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression","volume":"38","author":"Wong","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.prp.2018.11.006_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12935-016-0332-3","article-title":"Expression and diagnostic value of CCT3 and IQGAP3 in hepatocellular carcinoma","volume":"16","author":"Qian","year":"2016","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.prp.2018.11.006_bib0090","doi-asserted-by":"crossref","first-page":"8588","DOI":"10.3748\/wjg.v21.i28.8588","article-title":"Overexpression of chaperonin containing TCP1, subunit 3predicts poor prognosis in hepatocellular carcinoma","volume":"21","author":"Cui","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.prp.2018.11.006_bib0095","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.canlet.2015.12.029","article-title":"Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells","volume":"372","author":"Zhang","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.prp.2018.11.006_bib0100","doi-asserted-by":"crossref","first-page":"108333","DOI":"10.18632\/oncotarget.22659","article-title":"Clinical role and biological function of CDK5 in hepatocellular carcinoma: a study based on immunohistochemistry, RNA-seq and in vitro investigation","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2018.11.006_bib0105","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s12064-012-0162-3","article-title":"Measurement of mRNA abundance using RNA-seq data: RPKM measure is inconsistent among samples","volume":"131","author":"Wagner","year":"2012","journal-title":"Theory Biosci."},{"key":"10.1016\/j.prp.2018.11.006_bib0110","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"EdgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.prp.2018.11.006_bib0115","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2017-315068","article-title":"Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma","volume":"67","author":"Gerbes","year":"2018","journal-title":"Gut."},{"key":"10.1016\/j.prp.2018.11.006_bib0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2017.02.010","article-title":"Recent advances in hepatocellular carcinoma therapy","author":"Dutta","year":"2017","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.prp.2018.11.006_bib0125","doi-asserted-by":"crossref","first-page":"6879","DOI":"10.1158\/0008-5472.CAN-08-4700","article-title":"Intracellular beta-tubulin\/chaperonin containing TCP1-beta complex serves as a novel chemotherapeutic target against drug-resistant tumors","volume":"69","author":"Lin","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2018.11.006_bib0130","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.2174\/138945011798829339","article-title":"Heat shock proteins: a potential anticancer target","volume":"12","author":"Sankhala","year":"2011","journal-title":"Drug Targets."},{"key":"10.1016\/j.prp.2018.11.006_bib0135","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2174\/156800909789271486","article-title":"Heat shock protein 90 \u2013 a potential target in the treatment of human acute myelogenous leukemia","volume":"9","author":"Reikvam","year":"2009","journal-title":"Cancer Drug Targets."},{"key":"10.1016\/j.prp.2018.11.006_bib0140","first-page":"797","article-title":"Inhibition of cancer invasion and metastasis by targeting the molecular chaperone heat-shock protein 90","volume":"29","author":"Koga","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.prp.2018.11.006_bib0145","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/prot.24510","article-title":"Molecular determinants of the ATP hydrolysis asymmetry of the CCT chaperonin complex","volume":"82","author":"Chagoyen","year":"2014","journal-title":"Proteins Struct. Funct. Bioinform."},{"key":"10.1016\/j.prp.2018.11.006_bib0150","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2017.0192","article-title":"The substrate specificity of eukaryotic cytosolic chaperonin CCT","volume":"373","author":"Willison","year":"2018","journal-title":"Philos. Trans. R. Soc. Lond., B, Biol. Sci."},{"key":"10.1016\/j.prp.2018.11.006_bib0155","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1016\/j.jmb.2015.04.013","article-title":"The mechanism and function of group II chaperonins","volume":"427","author":"Lopez","year":"2015","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.prp.2018.11.006_bib0160","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/apm.12258","article-title":"Chaperonin containing TCP1, subunit 8 (CCT8) is upregulated in hepatocellular carcinoma and promotes HCC proliferation","volume":"122","author":"Huang","year":"2014","journal-title":"APMIS"},{"key":"10.1016\/j.prp.2018.11.006_bib0165","first-page":"9202","article-title":"Suppression of CCT3 inhibits malignant proliferation of human papillary thyroid carcinoma cell","volume":"15","author":"Shi","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.prp.2018.11.006_bib0170","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2968106","article-title":"Identification of the key genes and pathways in esophageal carcinoma","author":"Su","year":"2016","journal-title":"Gastroenterol. Res. Pract."},{"key":"10.1016\/j.prp.2018.11.006_bib0175","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/cgt.2015.48","article-title":"Integrated analysis of gene expression and genomic aberration data in osteosarcoma (OS)","volume":"22","author":"Xiong","year":"2015","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.prp.2018.11.006_bib0180","doi-asserted-by":"crossref","first-page":"111470","DOI":"10.18632\/oncotarget.22838","article-title":"Chaperonin containing TCP-1 subunit 3 is critical for gastric cancer growth","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2018.11.006_bib0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004393","article-title":"Informatics for RNA sequencing: a web resource for analysis on the cloud","volume":"11","author":"Griffith","year":"2015","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.prp.2018.11.006_bib0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001844","article-title":"Modulation of STAT3 folding and function by TRiC\/CCT chaperonin","volume":"12","author":"Kasembeli","year":"2014","journal-title":"PLoS Biol."},{"key":"10.1016\/j.prp.2018.11.006_bib0195","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.prp.2018.11.006_bib0200","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.prp.2018.11.006_bib0205","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/bioinformatics\/btu680","article-title":"Rcount: simple and flexible RNA-Seq read counting","volume":"31","author":"Schmid","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.prp.2018.11.006_bib0210","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-15-S1-S7","article-title":"Reducing bias in RNA sequencing data: a novel approach to compute counts","volume":"15","author":"Finotello","year":"2014","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.prp.2018.11.006_bib0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003494","article-title":"Universal count correction for high-throughput sequencing","volume":"10","author":"Hashimoto","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.prp.2018.11.006_bib0220","article-title":"A comparative study of techniques for differential expression analysis on RNA-Seq data","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2018.11.006_bib0225","doi-asserted-by":"crossref","first-page":"7140","DOI":"10.1158\/1078-0432.CCR-06-0484","article-title":"Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3","volume":"12","author":"Li","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2018.11.006_bib0230","first-page":"1503","article-title":"Comprehensive characterization of cancer genes in hepatocellular carcinoma genomes","volume":"15","author":"Zhang","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.prp.2018.11.006_bib0235","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13000-016-0596-x","article-title":"A transcriptome profile in hepatocellular carcinomas based on integrated analysis of microarray\u2009 studies","volume":"12","author":"Wang","year":"2017","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.prp.2018.11.006_bib0240","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.canlet.2015.12.029","article-title":"Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells","volume":"372","author":"Zhang","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.prp.2018.11.006_bib0245","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12885-018-4056-8","article-title":"MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S\/G2 cell cycle progression","volume":"18","author":"Liu","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.prp.2018.11.006_bib0250","doi-asserted-by":"crossref","first-page":"983","DOI":"10.2147\/OTT.S153814","article-title":"Kanglaite reverses multidrug resistance of HCC by inducing apoptosis and cell cycle arrest via PI3K\/AKT pathway","volume":"11","author":"Yang","year":"2018","journal-title":"Onco. Ther."},{"key":"10.1016\/j.prp.2018.11.006_bib0255","first-page":"2815","article-title":"Karyopherin subunit-\u03b1 2 expression accelerates cell cycle progression by upregulating CCNB2 and CDK1 in hepatocellular carcinoma","volume":"15","author":"Gao","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.prp.2018.11.006_bib0260","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1136\/jclinpath-2013-201907","article-title":"Immunohistochemical stains of proliferating cell nuclear antigen, insulin-like growth factor 2 and clusterin help distinguish malignant from benign liver nodular lesions","volume":"67","author":"Lai","year":"2014","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.prp.2018.11.006_bib0265","first-page":"6815","article-title":"Identification and functional analysis of a core gene module associated with hepatitis C virus-induced human hepatocellular carcinoma progression","volume":"15","author":"Bai","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.prp.2018.11.006_bib0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01616412.2018.1460701","article-title":"Gene expression microarray analysis reveals prognostic markers of survival in high grade astrocytomas","volume":"15","author":"Yang","year":"2018","journal-title":"Neurol. Res."},{"key":"10.1016\/j.prp.2018.11.006_bib0275","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.bbrc.2018.04.201","article-title":"FOXM1 promotes proliferation in human hepatocellular carcinoma cells by transcriptional activation of CCNB1","volume":"500","author":"Chai","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033818309427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033818309427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T07:27:21Z","timestamp":1720769241000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033818309427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0344033818309427"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2018.11.006","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical and prognostic value of chaperonin containing T-complex 1 subunit 3 in hepatocellular carcinoma: A Study based on microarray and RNA-sequencing with 4272 cases","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2018.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}