{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:19:23Z","timestamp":1777263563750,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.prp.2019.152615","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T12:42:13Z","timestamp":1567082533000},"page":"152615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["The application of antigen receptor gene rearrangement of BIOMED-2 in the pathologic diagnosis of 348 cases with non-Hodgkin lymphoma in a single institution in Southwest of China"],"prefix":"10.1016","volume":"215","author":[{"given":"Xueni","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiubo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2019.152615_bib0005","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s12185-014-1548-4","article-title":"Infectious mononucleosis accompanied by clonal proliferation of EBV-infected cells and infection of CD8-positive cells","volume":"99","author":"Arai","year":"2014","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.prp.2019.152615_bib0010","doi-asserted-by":"crossref","first-page":"903","DOI":"10.4103\/0973-1482.157345","article-title":"Novel diagnostic biomarker for patients with Non-Hodgkin\u2019s Lymphoma by IgH gene rearrangement","volume":"12","author":"Bo","year":"2016","journal-title":"J. Cancer Res. Ther."},{"key":"10.1016\/j.prp.2019.152615_bib0015","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-62703-269-8_4","article-title":"PCR-based analysis of rearranged immunoglobulin or T-cell receptor genes by GeneScan analysis or heteroduplex analysis for clonality assessment in lymphoma diagnostics","volume":"971","author":"Boone","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.prp.2019.152615_bib0020","doi-asserted-by":"crossref","DOI":"10.1038\/s41375-019-0496-7","article-title":"Standardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic leukaemia; a EuroClonality-NGS validation study","author":"Bruggemann","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.prp.2019.152615_bib0025","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/sj.leu.2404481","article-title":"Powerful strategy for polymerase chain reaction-based clonality assessment in T-cell malignancies Report of the BIOMED-2 Concerted Action BHM4 CT98-3936","volume":"21","author":"Bruggemann","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.prp.2019.152615_bib0030","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-62703-269-8_10","article-title":"MRD detection in B-cell non-Hodgkin lymphomas using Ig gene rearrangements and chromosomal translocations as targets for real-time quantitative PCR","author":"Pott","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.prp.2019.152615_bib0035","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S1470-2045(09)70351-1","article-title":"Common misdiagnoses in lymphomas and avoidance strategies","volume":"11","author":"Chan","year":"2010","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.prp.2019.152615_bib0040","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1136\/jcp.48.11.1045","article-title":"The polymerase chain reaction in the demonstration of monoclonality in T cell lymphomas","volume":"48","author":"Diss","year":"1995","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.prp.2019.152615_bib0045","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/sj.leu.2404479","article-title":"Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936","volume":"21","author":"Evans","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.prp.2019.152615_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jcp.56.1.1","article-title":"Diagnostic role of tests for T cell receptor (TCR) genes","volume":"56","author":"Hodges","year":"2003","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.prp.2019.152615_bib0055","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2141.2007.06618.x","article-title":"A practical strategy for the routine use of BIOMED-2 PCR assays for detection of B- and T-cell clonality in diagnostic haematopathology","volume":"138","author":"Hongxiang","year":"2007","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.prp.2019.152615_bib0060","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3892\/ijo.2014.2790","article-title":"Diagnostic value of immunoglobulin \u03ba light chain gene rearrangement analysis in B-cell lymphomas","volume":"46","author":"Ira","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.prp.2019.152615_bib0065","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.humpath.2014.11.008","article-title":"Extranodal natural killer\/T-cell lymphoma, nasal type in Taiwan: a relatively higher frequency of T-cell lineage and poor survival for extranasal tumors","volume":"46","author":"Jie-Yang","year":"2015","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2019.152615_bib0070","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1365-2141.2011.08803.x","article-title":"BIOMED-2 PCR assays for IGK gene rearrangements are essential for B-cell clonality analysis in follicular lymphoma","volume":"155","author":"Karen","year":"2011","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.prp.2019.152615_bib0075","doi-asserted-by":"crossref","DOI":"10.1038\/s41375-019-0499-4","article-title":"Quality control and quantification in IG\/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS","author":"Knecht","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.prp.2019.152615_bib0080","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1046\/j.1365-2141.2002.03866.x","article-title":"Specificity of polymerase chain reaction-based clonality analysis of immunoglobulin heavy chain gene rearrangement for the detection of bone marrow infiltrate in B-cell lymphoma-associated haemophagocytic syndrome","volume":"119","author":"Kojima","year":"2002","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.prp.2019.152615_bib0085","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00345-10","article-title":"An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody","volume":"2","author":"Krause","year":"2011","journal-title":"Mbio"},{"key":"10.1016\/j.prp.2019.152615_bib0090","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.3171\/jns.2002.97.6.1390","article-title":"Analysis of immunoglobulin H gene rearrangement by polymerase chain reaction in primary central nervous system lymphoma","volume":"97","author":"Kros","year":"2002","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.prp.2019.152615_bib0095","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1038\/leu.2012.246","article-title":"EuroClonality\/BIOMED-2 guidelines for interpretation and reporting of Ig\/TCR clonality testing in suspected lymphoproliferations","volume":"26","author":"Langerak","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.prp.2019.152615_bib0100","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/sj.leu.2404482","article-title":"Polymerase chain reaction-based clonality testing in tissue samples with reactive lymphoproliferations: usefulness and pitfalls. A report of the BIOMED-2 Concerted Action BMH4-CT98-3936","volume":"21","author":"Langerak","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.prp.2019.152615_bib0105","doi-asserted-by":"crossref","first-page":"77009","DOI":"10.18632\/oncotarget.20330","article-title":"The value of detecting immunoglobulin gene rearrangements in the diagnosis of B-cell lymphoma","volume":"8","author":"Lu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2019.152615_bib0110","doi-asserted-by":"crossref","first-page":"107s","DOI":"10.1111\/1523-1747.ep12275570","article-title":"Genes encoding the T-cell antigen receptor","volume":"85","author":"Mak","year":"1985","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.prp.2019.152615_bib0115","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1309\/AJCP5W0VOCSVOBRA","article-title":"Cutaneous peripheral T-cell lymphoma associated with a proliferation of B cells","volume":"131","author":"Mattoch","year":"2009","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.prp.2019.152615_bib0120","first-page":"821","article-title":"The rapid detection of clonal T-cell proliferations in patients with lymphoid disorders","volume":"138","author":"Mccarthy","year":"1991","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2019.152615_bib0125","first-page":"173","article-title":"A simplified method of detection of clonal rearrangements of the T-cell receptor-gamma chain gene","volume":"1","author":"Mccarthy","year":"1992","journal-title":"Diagnostic Molecular Pathology the American Journal of Surgical Pathology Part B"},{"key":"10.1016\/j.prp.2019.152615_bib0130","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1136\/jcp.43.5.429","article-title":"Rapid method for distinguishing clonal from polyclonal B cell populations in surgical biopsy specimens","volume":"43","author":"Mccarthy","year":"1990","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.prp.2019.152615_bib0135","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/PAS.0b013e31824433d8","article-title":"Extranodal NK\/T-cell lymphoma, nasal type, includes cases of natural killer cell and \u03b1\u03b2, \u03b3\u03b4, and \u03b1\u03b2\/\u03b3\u03b4 T-cell origin: a comprehensive clinicopathologic and phenotypic study","volume":"36","author":"Pongpruttipan","year":"2012","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2019.152615_bib0140","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/pin.12566","article-title":"Improved clonality detection in B-cell lymphoma using a semi-nested modification of the BIOMED-2 PCR assay for IGH rearrangement: a paraffin-embedded tissue study","volume":"67","author":"Sakamoto","year":"2017","journal-title":"Pathol. Int."},{"key":"10.1016\/j.prp.2019.152615_bib0145","doi-asserted-by":"crossref","DOI":"10.1038\/s41375-019-0508-7","article-title":"Next-generation sequencing of immunoglobulin gene rearrangements for clonality assessment: a technical feasibility study by EuroClonality-NGS","author":"Scheijen","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.prp.2019.152615_bib0150","doi-asserted-by":"crossref","first-page":"494","DOI":"10.7150\/ijms.8842","article-title":"Comparison of methods for the extraction of DNA from formalin-fixed, paraffin-embedded archival tissues","volume":"11","author":"Seng\u00fcven","year":"2014","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.prp.2019.152615_bib0155","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/PAS.0b013e31826731b5","article-title":"Extranodal NK\/T-cell lymphoma, nasal type: a report of 73 cases at MD Anderson Cancer Center","volume":"37","author":"Shaoying","year":"2013","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2019.152615_bib0160","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.7150\/ijms.5342","article-title":"Analysis of immunoglobulin and T cell receptor gene rearrangement in the bone marrow of lymphoid neoplasia using BIOMED-2 multiplex polymerase chain reaction","volume":"10","author":"Shin","year":"2013","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.prp.2019.152615_bib0165","series-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow","year":"2017"},{"key":"10.1016\/j.prp.2019.152615_bib0170","doi-asserted-by":"crossref","first-page":"466","DOI":"10.2353\/jmoldx.2006.060016","article-title":"The frequency of B- and T-Cell gene rearrangements and epstein-barr virus in T-Cell lymphomas : a comparison between angioimmunoblastic T-Cell lymphoma and peripheral T-Cell lymphoma, unspecified with and without associated B-Cell proliferations","volume":"8","author":"Tan","year":"2006","journal-title":"J. Mol. Diagn."},{"key":"10.1016\/j.prp.2019.152615_bib0175","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/302575a0","article-title":"Somatic generation of antibody diversity","volume":"302","author":"Tonegawa","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.prp.2019.152615_bib0180","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936","volume":"17","author":"van Dongen","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.prp.2019.152615_bib0185","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/sj.leu.2404467","article-title":"Improved reliability of lymphoma diagnostics via PCR-based clonality testing: report of the BIOMED-2 Concerted Action BHM4-CT98-3936","volume":"21","author":"van Krieken","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.prp.2019.152615_bib0190","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1182\/blood.V69.1.79.79","article-title":"Immunoglobulin and T cell receptor gene rearrangements in human lymphoma and leukemia","volume":"69","author":"Williams","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.prp.2019.152615_bib0195","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1600-0609.2011.01597.x","article-title":"Presence of B-cell clones in T-cell lymphoma","volume":"86","author":"Zaki","year":"2011","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.prp.2019.152615_bib0200","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1002\/jmv.24526","article-title":"Identification of IgH gene rearrangement and immunophenotype in an animal model of Epstein-Barr virus-associated lymphomas","volume":"88","author":"Zhang","year":"2016","journal-title":"J. Med. Virol."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033819312506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033819312506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:38:36Z","timestamp":1759732716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033819312506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S0344033819312506"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2019.152615","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The application of antigen receptor gene rearrangement of BIOMED-2 in the pathologic diagnosis of 348 cases with non-Hodgkin lymphoma in a single institution in Southwest of China","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2019.152615","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152615"}}