{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:17:19Z","timestamp":1759796239430,"version":"build-2065373602"},"reference-count":53,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.prp.2020.152819","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T11:47:43Z","timestamp":1578656863000},"page":"152819","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical features associated with high pathological grade in primary thyroid lymphoma"],"prefix":"10.1016","volume":"216","author":[{"given":"Antonio","family":"Travaglino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirella","family":"Pace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Varricchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Insabato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Picardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Severino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Pane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Staibano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Mascolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"May (5)","key":"10.1016\/j.prp.2020.152819_bib0005","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/00000478-200005000-00001","article-title":"Malignant lymphoma of the thyroid gland: a clinicopathologic study of 108 cases","volume":"24","author":"Derringer","year":"2000","journal-title":"Am. J. Surg. Pathol."},{"issue":"February (2)","key":"10.1016\/j.prp.2020.152819_bib0010","doi-asserted-by":"crossref","first-page":"317","DOI":"10.7863\/ultra.34.2.317","article-title":"Primary thyroid lymphoma has different sonographic and color Doppler features compared to nodular goiter","volume":"34","author":"Wang","year":"2015","journal-title":"J. Ultrasound Med."},{"issue":"November (5)","key":"10.1016\/j.prp.2020.152819_bib0015","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.3906\/sag-1611-91","article-title":"Eleven patients with primary thyroid lymphoma: a single center experience","volume":"47","author":"Bostanc\u0131","year":"2017","journal-title":"Turk. J. Med. Sci."},{"key":"10.1016\/j.prp.2020.152819_bib0020","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11864-004-0021-7","article-title":"Primary thyroid lymphomas","volume":"5","author":"Widder","year":"2004","journal-title":"Curr. Treat. Options Oncol."},{"issue":"August (2)","key":"10.1016\/j.prp.2020.152819_bib0025","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/ajcp\/112.2.263","article-title":"Malignant lymphoma of the thyroid. A 30-year clinicopathologic experience and an evaluation of the presence of Epstein-Barr virus","volume":"112","author":"Lam","year":"1999","journal-title":"Am. J. Clin. Pathol."},{"issue":"August (4)","key":"10.1016\/j.prp.2020.152819_bib0030","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.1365-2303.2001.00338.x","article-title":"Fine needle aspiration cytology of primary lymphoma of the thyroid: a report of 17 cases","volume":"12","author":"Sangalli","year":"2001","journal-title":"Cytopathology"},{"issue":"January (1)","key":"10.1016\/j.prp.2020.152819_bib0035","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1210\/jcem.87.1.8156","article-title":"Primary thyroid lymphoma is a heterogeneous disease","volume":"87","author":"Thieblemont","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"June (3)","key":"10.1016\/j.prp.2020.152819_bib0040","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0720-048X(02)00134-1","article-title":"Primary thyroid lymphoma: CT findings","volume":"46","author":"Kim","year":"2003","journal-title":"Eur. J. Radiol."},{"issue":"December 9","key":"10.1016\/j.prp.2020.152819_bib0045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1742-6413-2-21","article-title":"Fine needle aspiration cytology of primary thyroid lymphoma: a report of ten cases","volume":"2","author":"Gupta","year":"2005","journal-title":"Cytojournal"},{"issue":"October (10)","key":"10.1016\/j.prp.2020.152819_bib0050","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1080\/10428190600783395","article-title":"High incidence of mucosa-associated lymphoid tissue in primary thyroid lymphoma: a clinicopathologic study of 18 cases in the Korean population","volume":"47","author":"Cho","year":"2006","journal-title":"Leuk. Lymphoma"},{"issue":"December (12)","key":"10.1016\/j.prp.2020.152819_bib0055","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1038\/modpathol.3800692","article-title":"Deviated VH4 immunoglobulin gene usage is found among thyroid mucosa-associated lymphoid tissue lymphomas, similar to the usage at other sites, but is not found in thyroid diffuse large B-cell lymphomas","volume":"19","author":"Sato","year":"2006","journal-title":"Mod. Pathol."},{"issue":"2","key":"10.1016\/j.prp.2020.152819_bib0060","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF02698041","article-title":"Outcomes of primary thyroid non-Hodgkin\u2019s lymphoma: a series of nine consecutive cases","volume":"24","author":"Colovi\u0107","year":"2007","journal-title":"Med. Oncol."},{"issue":"March (3)","key":"10.1016\/j.prp.2020.152819_bib0065","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/10428190601149562","article-title":"HLA associations, microsatellite instability and epigenetic changes in thyroid lymphoma in Chinese","volume":"48","author":"Wy","year":"2007","journal-title":"Leuk. Lymphoma"},{"issue":"November-December (6)","key":"10.1016\/j.prp.2020.152819_bib0070","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1177\/030089160909500613","article-title":"Surgical treatment of primitive thyroid lymphoma","volume":"95","author":"Avenia","year":"2009","journal-title":"Tumori."},{"issue":"3","key":"10.1016\/j.prp.2020.152819_bib0075","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1507\/endocrj.K08E-355","article-title":"Clinical characteristics of primary thyroid lymphoma in Koreans","volume":"56","author":"Hwang","year":"2009","journal-title":"Endocr. J."},{"issue":"January (1)","key":"10.1016\/j.prp.2020.152819_bib0080","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/annonc\/mdq310","article-title":"Treatment results and prognostic factors in primary thyroid lymphoma patients: a rare cancer network study","volume":"22","author":"Onal","year":"2011","journal-title":"Ann. Oncol."},{"issue":"April (2)","key":"10.1016\/j.prp.2020.152819_bib0085","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1365-2141.2011.08606.x","article-title":"Clinicopathological features of 171 cases of primary thyroid lymphoma: a long-term study involving 24553 patients with Hashimoto\u2019s disease","volume":"153","author":"Watanabe","year":"2011","journal-title":"Br. J. Haematol."},{"issue":"June (6)","key":"10.1016\/j.prp.2020.152819_bib0090","first-page":"2075","article-title":"Primary thyroid lymphoma: the 40 year experience of a UK lymphoma treatment centre","volume":"40","author":"Alzouebi","year":"2012","journal-title":"Int. J. Oncol."},{"issue":"December (4)","key":"10.1016\/j.prp.2020.152819_bib0095","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3857\/roj.2013.31.4.177","article-title":"Patterns of care and treatment outcomes for primary thyroid lymphoma: a single institution study","volume":"31","author":"Cha","year":"2013","journal-title":"Radiat. Oncol. J."},{"issue":"September (9)","key":"10.1016\/j.prp.2020.152819_bib0100","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/RLU.0b013e31829b2686","article-title":"Is 18F-FDG PET\/CT useful for distinguishing between primary thyroid lymphoma and chronic thyroiditis?","volume":"38","author":"Nakadate","year":"2013","journal-title":"Clin. Nucl. Med."},{"issue":"January (1)","key":"10.1016\/j.prp.2020.152819_bib0105","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3109\/00016489.2013.831994","article-title":"Characteristic ultrasound features of mucosa-associated lymphoid tissue lymphoma of the salivary and thyroid gland","volume":"134","author":"Orita","year":"2014","journal-title":"Acta Otolaryngol."},{"issue":"August (8)","key":"10.1016\/j.prp.2020.152819_bib0110","first-page":"4427","article-title":"Hypothyroidism after radiotherapy for primary thyroid lymphoma","volume":"34","author":"Ishibashi","year":"2014","journal-title":"Anticancer Res."},{"issue":"December (6)","key":"10.1016\/j.prp.2020.152819_bib0115","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4174\/astr.2015.89.6.295","article-title":"Clinicopathological characteristics and treatment outcomes of 38 cases of primary thyroid lymphoma: a multicenter study","volume":"89","author":"Chai","year":"2015","journal-title":"Ann. Surg. Treat. Res."},{"issue":"October-December (4)","key":"10.1016\/j.prp.2020.152819_bib0120","first-page":"546","article-title":"Evaluation of primary thyroid lymphoma by ultrasonography combined with contrast-enhanced ultrasonography: a pilot study","volume":"52","author":"Wei","year":"2015","journal-title":"Indian J. Cancer"},{"issue":"July (7)","key":"10.1016\/j.prp.2020.152819_bib0125","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s40618-015-0250-6","article-title":"12 cases of primary thyroid lymphoma in China","volume":"38","author":"Yang","year":"2015","journal-title":"J. Endocrinol. Invest."},{"issue":"October 10","key":"10.1016\/j.prp.2020.152819_bib0130","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.2147\/CMAR.S155170","article-title":"Clinicopathological characteristics and prognostic factors for primary thyroid lymphoma: report on 28 Chinese patients and results of a population-based study","volume":"10","author":"Chen","year":"2018","journal-title":"Cancer Manage. Res."},{"issue":"February (2)","key":"10.1016\/j.prp.2020.152819_bib0135","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1210\/jc.2017-01478","article-title":"Long-term outcomes of 107 cases of primary thyroid mucosa-associated lymphoid tissue lymphoma at a single medical institution in Japan","volume":"103","author":"Watanabe","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"December (12)","key":"10.1016\/j.prp.2020.152819_bib0140","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1038\/modpathol.3800501","article-title":"Hodgkin\u2019s lymphoma of the thyroid: a clinicopathologic study of five cases and review of the literature","volume":"18","author":"Wang","year":"2005","journal-title":"Mod. Pathol."},{"issue":"April (2)","key":"10.1016\/j.prp.2020.152819_bib0145","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/bjh.12255","article-title":"Primary peripheral T-cell lymphoma, not otherwise specified of the thyroid with autoimmune thyroiditis","volume":"161","author":"Yoshida","year":"2013","journal-title":"Br. J. Haematol."},{"year":"2019","series-title":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) \u2013 B-Cell Lymphomas","author":"Zelenetz","key":"10.1016\/j.prp.2020.152819_bib0150"},{"issue":"July (1)","key":"10.1016\/j.prp.2020.152819_bib0155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00404-019-05167-z","article-title":"Treatments and overall survival in patients with Krukenberg tumor","volume":"300","author":"Lionetti","year":"2019","journal-title":"Arch. Gynecol. Obstet."},{"issue":"February","key":"10.1016\/j.prp.2020.152819_bib0160","article-title":"Management of women with atypical polypoid adenomyoma of the uterus: a quantitative systematic review","author":"Raffone","year":"2019","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"June","key":"10.1016\/j.prp.2020.152819_bib0165","first-page":"1","article-title":"Diabetes mellitus and responsiveness of endometrial hyperplasia and early endometrial cancer to conservative treatment","volume":"5","author":"Raffone","year":"2019","journal-title":"Gynecol. Endocrinol."},{"issue":"April (4)","key":"10.1016\/j.prp.2020.152819_bib0170","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/apm.12938","article-title":"PTEN immunohistochemistry in endometrial hyperplasia: which are the optimal criteria for the diagnosis of precancer?","volume":"127","author":"Travaglino","year":"2019","journal-title":"APMIS"},{"issue":"1","key":"10.1016\/j.prp.2020.152819_bib0175","doi-asserted-by":"crossref","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst. Rev."},{"issue":"March (3)","key":"10.1016\/j.prp.2020.152819_bib0180","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/aogs.13512","article-title":"PAX2 in endometrial carcinogenesis and in differential diagnosis of endometrial hyperplasia. A systematic review and meta-analysis of diagnostic accuracy","volume":"98","author":"Raffone","year":"2019","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"June (6)","key":"10.1016\/j.prp.2020.152819_bib0185","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/apm.12945","article-title":"Complexity of glandular architecture should be reconsidered in the classification and management of endometrial hyperplasia","volume":"127","author":"Travaglino","year":"2019","journal-title":"APMIS."},{"issue":"April (5)","key":"10.1016\/j.prp.2020.152819_bib0190","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/ajcp\/aqy178","article-title":"Immunohistochemical nuclear expression of \u03b2-Catenin as a surrogate of CTNNB1 exon 3 mutation in endometrial Cancer","volume":"151","author":"Travaglino","year":"2019","journal-title":"Am. J. Clin. Pathol."},{"issue":"June","key":"10.1016\/j.prp.2020.152819_bib0195","article-title":"Diabetes mellitus is associated with occult Cancer in endometrial hyperplasia","author":"Raffone","year":"2019","journal-title":"Pathol. Oncol. Res."},{"issue":"September (9)","key":"10.1016\/j.prp.2020.152819_bib0200","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/apm.12977","article-title":"Diagnostic and prognostic value of ARID1A in endometrial hyperplasia: a novel marker of occult cancer","volume":"127","author":"Raffone","year":"2019","journal-title":"APMIS"},{"issue":"August 12","key":"10.1016\/j.prp.2020.152819_bib0205","article-title":"Nuclear expression of \u03b2-catenin in endometrial hyperplasia as marker of premalignancy","author":"Travaglino","year":"2019","journal-title":"APMIS"},{"issue":"12","key":"10.1016\/j.prp.2020.152819_bib0210","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.7863\/jum.2007.26.12.1761","article-title":"Primary thyroid lymphoma: role of ultrasound-guided needle biopsy","volume":"26","author":"Kwak","year":"2007","journal-title":"J. Ultrasound Med."},{"issue":"1","key":"10.1016\/j.prp.2020.152819_bib0215","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000369443","article-title":"Cytological findings for the diagnosis of primary thyroid mucosa-associated lymphoid tissue lymphoma by fine needle aspiration","volume":"59","author":"Kaba","year":"2015","journal-title":"Acta Cytol."},{"key":"10.1016\/j.prp.2020.152819_bib0220","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1089\/thy.2011.0228","article-title":"Co-occurrence of papillary thyroid carcinoma and primary lymphoma of the thyroid in a patient with long-standing Hashimoto\u2019s thyroiditis","volume":"22","author":"Cheng","year":"2012","journal-title":"Thyroid"},{"issue":"March-April (2)","key":"10.1016\/j.prp.2020.152819_bib0225","first-page":"153","article-title":"Clinicopathologic characteristics and treatment of marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)","volume":"66","author":"Raderer","year":"2016","journal-title":"CA Cancer J. Clin."},{"issue":"November (4)","key":"10.1016\/j.prp.2020.152819_bib0230","first-page":"232","article-title":"Does nodule size predict compressive symptoms in patients with thyroid nodules?","volume":"3","author":"Eng","year":"2014","journal-title":"Gland Surg."},{"issue":"October","key":"10.1016\/j.prp.2020.152819_bib0235","article-title":"Hashimoto thyroiditis in primary thyroid non-hodgkin lymphoma","author":"Travaglino","year":"2019","journal-title":"Am. J. Clin. Pathol."},{"issue":"November","key":"10.1016\/j.prp.2020.152819_bib0240","article-title":"Prevalence of Chlamydia psittaci, Chlamydia pneumoniae, and Chlamydia trachomatis determined by molecular testing in ocular adnexa lymphoma specimens","author":"Travaglino","year":"2019","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.prp.2020.152819_bib0245","article-title":"Sj\u00f6gren syndrome in primary salivary gland lymphoma: a systematic review and meta-analysis","author":"Travaglino","year":"2019","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.prp.2020.152819_bib0250","first-page":"389","article-title":"Lactic dehydrogenase in human neoplastic tissues","volume":"24","author":"Goldman","year":"1964","journal-title":"Cancer Res."},{"issue":"October (1)","key":"10.1016\/j.prp.2020.152819_bib0255","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12905-018-0662-5","article-title":"Increased LDH5\/LDH1 ratio in preoperative diagnosis of uterine sarcoma with inconclusive MRI and LDH total activity but suggestive CT scan: a case report","volume":"18","author":"Mollo","year":"2018","journal-title":"BMC Womens Health"},{"issue":"August (2)","key":"10.1016\/j.prp.2020.152819_bib0260","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.critrevonc.2012.12.009","article-title":"Diffuse large B-cell lymphoma","volume":"87","author":"Martelli","year":"2013","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"September","key":"10.1016\/j.prp.2020.152819_bib0265","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.leukres.2017.07.006","article-title":"Clinical characteristics and prognosis of primary Waldeyer\u2019s ring and lymph node diffuse large B-cell lymphoma in the rituximab era","volume":"60","author":"Jing","year":"2017","journal-title":"Leuk. Res."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033819326822?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033819326822?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:39:49Z","timestamp":1759732789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033819326822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0344033819326822"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2020.152819","relation":{},"ISSN":["0344-0338"],"issn-type":[{"type":"print","value":"0344-0338"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical features associated with high pathological grade in primary thyroid lymphoma","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2020.152819","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152819"}}