{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T15:00:50Z","timestamp":1777993250353,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.prp.2020.152833","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T11:37:34Z","timestamp":1579520254000},"page":"152833","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Nodular regenerative hyperplasia \u2013 An under-recognized vascular disorder of liver"],"prefix":"10.1016","volume":"216","author":[{"given":"Neha","family":"Bakshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Gulati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archana","family":"Rastogi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhijit","family":"Chougule","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chhagan","family":"Bihari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankur","family":"Jindal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2020.152833_bib0005","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/hep.1840110512","article-title":"Micronodular transformation (nodular regenerative hyperplasia) of the liver: a report of 64 cases among 2,500 autopsies and a new classification of benign hepatocellular nodules","volume":"11","author":"Wanless","year":"1990","journal-title":"Hepatology"},{"key":"10.1016\/j.prp.2020.152833_bib0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/hep.21258","article-title":"Nodular regenerative hyperplasia: not all nodules are created equal","volume":"44","author":"Reshamwala","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.prp.2020.152833_bib0015","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.3748\/wjg.v17.i11.1400","article-title":"Nodular regenerative hyperplasia: evolving concepts on underdiagnosed cause of portal hypertension","volume":"17","author":"Hartleb","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.prp.2020.152833_bib0020","first-page":"1425","article-title":"Nodular regenerative hyperplasia of the liver. A review of 14 cases","volume":"48","author":"Arvanitaki","year":"2001","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.prp.2020.152833_bib0025","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jhep.2013.08.013","article-title":"Non-cirrhotic portal hypertension - diagnosis and management","volume":"60","author":"Khanna","year":"2014","journal-title":"J Hepatolology."},{"key":"10.1016\/j.prp.2020.152833_bib0030","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.hepres.2006.07.014","article-title":"Cytokeratin-7, cytokeratin-19, and c-Kit: immunoreaction during the evolution stages of primary biliary cirrhosis","volume":"36","author":"Chatzipantelis","year":"2006","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.prp.2020.152833_bib0035","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1038\/modpathol.2010.175","article-title":"Aberrant expression of cytokeratin 7 in perivenular hepatocytes correlated with a cholestatic chemistry profile in patients with heart failure","volume":"23","author":"Pai","year":"2010","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.prp.2020.152833_bib0040","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1097\/PAS.0b013e3182254283","article-title":"Centrizonal arteries and microvessels in nonalcoholic steatohepatitis","volume":"35","author":"Gill","year":"2011","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2020.152833_bib0045","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/PAS.0000000000000099","article-title":"Aberrant centrizonal features in chronic hepatic venous outflow obstruction. Centrilobular mimicry of portal-based disease","volume":"38","author":"Krings","year":"2014","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2020.152833_bib0050","first-page":"1089","article-title":"Atrophic hepatocytes express keratin 7 in ischemia-associated liver lesions","volume":"31","author":"Delladetsima","year":"2016","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.prp.2020.152833_bib0055","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00428-017-2074-6","article-title":"In hepatic venous outflow obstruction, alcoholic liver disease, and nonalcoholic fatty liver disease, centrilobular scars, CD34+ vessels, and keratin 7+ hepatocytes are in close proximity","volume":"470","author":"Matsukuma","year":"2017","journal-title":"Virchows Arch."},{"key":"10.1016\/j.prp.2020.152833_bib0060","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1007\/s004280000364","article-title":"Immunohistochemical patterns of human liver sinusoids under different conditions of pathologic perfusion","volume":"438","author":"Theuerkauf","year":"2001","journal-title":"Virchows Arch."},{"key":"10.1016\/j.prp.2020.152833_bib0065","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1699-0463.1953.tb01513.x","article-title":"Miliary hepatocellular adenomatosis","volume":"33","author":"Ranstrom","year":"1953","journal-title":"Acta Pathol. Microbiol. Scand."},{"key":"10.1016\/j.prp.2020.152833_bib0070","first-page":"943","article-title":"Nodular regenerative hyperplasia of the liver","volume":"35","author":"Steiner","year":"1959","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2020.152833_bib0075","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1097\/MEG.0b013e3283360021","article-title":"Nodular regenerative hyperplasia of the liver: survival and associated features in a UK case series","volume":"22","author":"Morris","year":"2010","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.prp.2020.152833_bib0080","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0168-8278(91)90916-Y","article-title":"Nodular regenerative hyperplasia of the liver: an important cause of portal hypertension in non-cirrhotic patients","volume":"12","author":"Naber","year":"1991","journal-title":"J. Hepatol."},{"key":"10.1016\/j.prp.2020.152833_bib0085","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1600-0676.1989.tb00409.x","article-title":"Diffuse nodular regenerative hyperplasia of the liver (DNRH). A clinicopathologic study of 24 cases","volume":"9","author":"Colina","year":"1989","journal-title":"Liver"},{"key":"10.1016\/j.prp.2020.152833_bib0090","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/j.1440-1746.2012.07168.x","article-title":"Hepatic hemodynamics in 24 patients with nodular regenerative hyperplasia and symptomatic portal hypertension","volume":"27","author":"Bissonnette","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.prp.2020.152833_bib0095","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1136\/gut.2006.114363","article-title":"Nodular regenerative hyperplasia in patients with inflammatory bowel disease treated with azathioprine","volume":"56","author":"Vernier\u2010Massouille","year":"2007","journal-title":"Gut."},{"key":"10.1016\/j.prp.2020.152833_bib0100","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ajh.20024","article-title":"Nodular regenerative hyperplasia of the liver: an under-recognized cause of portal hypertension in hematological disorders","volume":"75","author":"Al-Mukhaizeem","year":"2004","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.prp.2020.152833_bib0105","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/457975","article-title":"Nodular regenerative hyperplasia secondary to neoadjuvant chemotherapy for colorectal liver metastases","author":"van den Broek","year":"2009","journal-title":"Case Rep. Med."},{"key":"10.1016\/j.prp.2020.152833_bib0110","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1097\/MEG.0b013e328326a00b","article-title":"Hepatic nodular regenerative hyperplasia in a patient with advanced carcinoid tumor","volume":"21","author":"Al-Hamoudia","year":"2009","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.prp.2020.152833_bib0115","first-page":"879","article-title":"Hepatocellular carcinoma and nodular regenerative hyperplasia: possible pathogenetic relationship","volume":"91","author":"Nzeako","year":"1996","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.prp.2020.152833_bib0120","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/826284","article-title":"Portal Hypertension, Nodular Regenerative Hyperplasia of the Liver, and Obstructive Portal Venopathy due to Metastatic Breast Cancer","author":"Turk","year":"2013","journal-title":"Case Rep. Pathol."},{"key":"10.1016\/j.prp.2020.152833_bib0125","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.gore.2019.05.003","article-title":"Paraneoplastic nodular regenerative hyperplasia of the liver associated with placental site trophoblastic tumor","volume":"29","author":"Dumasa","year":"2019","journal-title":"Gynecol. Oncol. Rep."},{"key":"10.1016\/j.prp.2020.152833_bib0130","article-title":"Nodular Regenerative Hyperplassia associated with primary liver malignancies","author":"Penrice","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.prp.2020.152833_bib0135","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/cld.459","article-title":"Noncirrhotic portal hypertension: pathology and nomenclature","volume":"5","author":"Kleiner","year":"2015","journal-title":"Clin. Liver Dis. (Hoboken)"},{"key":"10.1016\/j.prp.2020.152833_bib0140","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4132\/jptm.2015.09.23","article-title":"Idiopathic noncirrhotic portal hypertension: an appraisal","volume":"50","author":"Lee","year":"2016","journal-title":"J. Pathol. Transl. Med."},{"key":"10.1016\/j.prp.2020.152833_bib0145","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jhep.2013.08.013","article-title":"Non-cirrhotic portal hypertension\u2014diagnosis and management","volume":"60","author":"Khanna","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.prp.2020.152833_bib0150","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jceh.2014.07.005","article-title":"Idiopathic non-cirrhotic intrahepatic portal hypertension (NCIPH)-newer insights into pathogenesis and emerging newer treatment options","volume":"4","author":"Goel","year":"2014","journal-title":"J. Clin. Exp. Hepatol."},{"key":"10.1016\/j.prp.2020.152833_bib0155","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/hep.24422","article-title":"Idiopathic noncirrhotic portal hypertension","volume":"54","author":"Schouten","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.prp.2020.152833_bib0160","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","article-title":"Expanding consensus in portal hypertension: report of the Baveno VI consensus workshop: stratifying risk and individualizing care for portal hypertension","volume":"63","author":"de Franchis","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.prp.2020.152833_bib0165","unstructured":"Chougule A, Rastogi A, Maiwall R, Bihari C, Sood V, Sarin SK. Spectrum of histopathological changes in patients with non-cirrhotic portal fibrosis. Hepatology International. https:\/\/doi.org\/10.1007\/s12072-018-9857."},{"key":"10.1016\/j.prp.2020.152833_bib0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120299","article-title":"Diagnosing Nodular Regenerative Hyperplasia of the Liver Is Thwarted by Low Interobserver Agreement","volume":"10","author":"Jharap","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2020.152833_bib0175","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1365-2559.2012.04278.x","article-title":"Aberrant cytokeratin 7 expression of centrilobular hepatocytes: a clinicopathological study","volume":"61","author":"Matsukuma","year":"2012","journal-title":"Histopathology"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033819321223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033819321223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:39:46Z","timestamp":1759732786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033819321223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0344033819321223"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2020.152833","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nodular regenerative hyperplasia \u2013 An under-recognized vascular disorder of liver","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2020.152833","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152833"}}