{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:43:14Z","timestamp":1788964994845,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.prp.2020.152948","type":"journal-article","created":{"date-parts":[[2020,4,5]],"date-time":"2020-04-05T01:36:26Z","timestamp":1586050586000},"page":"152948","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Primary signet ring cell carcinoma of the breast: A rare entity with unique biological behavior\u2014A clinical study based on pure signet ring cell carcinoma cohort"],"prefix":"10.1016","volume":"216","author":[{"given":"Tong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2020.152948_bib0005","series-title":"WHO Classification of Tumours of the Digestive System, 4th Ed. World Health Organization Classification of Tumours","first-page":"417","author":"Bosman","year":"2010"},{"key":"10.1016\/j.prp.2020.152948_bib0010","series-title":"Tumors of the Breast and Female Genital Organs","first-page":"30","article-title":"Invasive breast carcinoma","author":"Ellis IO","year":"2003"},{"key":"10.1016\/j.prp.2020.152948_bib0015","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/17474124.2018.1416291","article-title":"Survival in signet ring cell carcinoma varies based on primary tumor location: a Surveillance, Epidemiology, and End Results database analysis","volume":"12","author":"Wu","year":"2018","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.prp.2020.152948_bib0020","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s11605-009-1127-9","article-title":"Clinicopathologic features of gastric carcinoma with signet ring cell histology","volume":"14","author":"Zhang","year":"2010","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.prp.2020.152948_bib0025","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.2147\/CMAR.S188622","article-title":"State of the art for gastric signet ring cell carcinoma: from classification, prognosis, and genomic characteristics to specified treatments","volume":"11","author":"Machlowska","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.prp.2020.152948_bib0030","first-page":"251","article-title":"Gastric cancer: classification, histology and application of molecular pathology","volume":"3","author":"Hu","year":"2012","journal-title":"J. Gastrointest. Oncol."},{"key":"10.1016\/j.prp.2020.152948_bib0035","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s004320000195","article-title":"Gastric adenocarcinoma: pathomorphology and molecular pathology","volume":"127","author":"Werner","year":"2001","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.prp.2020.152948_bib0040","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/1097-0142(197602)37:2<828::AID-CNCR2820370231>3.0.CO;2-N","article-title":"Signet-ring cell carcinoma of the breast. The mucinous variant of infiltrating lobular carcinoma?","volume":"37","author":"Steinbrecher","year":"1976","journal-title":"Cancer"},{"key":"10.1016\/j.prp.2020.152948_bib0045","first-page":"245","article-title":"Signet-ring cell variant of invasive lobular carcinoma of the breast. A clinicopathologic study of 11 cases","volume":"118","author":"Eltorky","year":"1994","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.prp.2020.152948_bib0050","article-title":"Poorer prognosis of primary signet-ring cell carcinoma of the breast compared with mucinous carcinoma","volume":"11","author":"Wu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2020.152948_bib0055","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13000-016-0584-1","article-title":"Prognostic significance of mucin expression profiles in breast carcinoma with signet ring cells: a clinicopathological study","volume":"11","author":"Ohashi","year":"2016","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.prp.2020.152948_bib0060","first-page":"4615","article-title":"The prognostic value of the 8th edition of the american joint committee on Cancer (AJCC) staging system in HER2-Enriched subtype breast Cancer, a retrospective analysis","volume":"37","author":"Zhou","year":"2017","journal-title":"Anticancer Res."},{"key":"10.1016\/j.prp.2020.152948_bib0065","series-title":"StatPearls","article-title":"Mammography BI RADS grading","author":"Barazi","year":"2019"},{"key":"10.1016\/j.prp.2020.152948_bib0070","doi-asserted-by":"crossref","first-page":"11921","DOI":"10.1038\/s41598-019-48488-4","article-title":"Predicting breast Cancer in breast imaging reporting and data system (BI-RADS) ultrasound category 4 or 5 lesions: a nomogram combining radiomics and BI-RADS","volume":"9","author":"Luo","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2020.152948_bib0075","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2214\/AJR.09.4110","article-title":"Revised RECIST guideline version 1.1: what oncologists want to know and what radiologists need to know","volume":"195","author":"Nishino","year":"2010","journal-title":"AJR Am. J. Roentgenol."},{"issue":"2015","key":"10.1016\/j.prp.2020.152948_bib0080","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1093\/annonc\/mdv221","article-title":"Tailoring therapies--improving the management of early breast cancer: st gallen international expert consensus on the primary therapy of early breast Cancer","volume":"26","author":"Coates","year":"2015","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.prp.2020.152948_bib0085","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10549-016-3947-0","article-title":"Descriptive epidemiology of breast cancer in China: incidence, mortality, survival and prevalence","volume":"159","author":"Li","year":"2016","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.prp.2020.152948_bib0090","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/jso.21307","article-title":"Characteristics and prognosis for molecular breast cancer subtypes in Chinese women","volume":"100","author":"Zhao","year":"2009","journal-title":"J. Surg. Oncol."},{"key":"10.1016\/j.prp.2020.152948_bib0095","first-page":"908","article-title":"S. O, Mucinous carcinoma of the breast","year":"1941","journal-title":"Surg. Gynecol. Obstet."},{"key":"10.1016\/j.prp.2020.152948_bib0100","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/ajcp\/73.1.31","article-title":"Signet-ring cell carcinoma of the breast: a clinicopathologic study of 24 cases","volume":"73","author":"Hull","year":"1980","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.prp.2020.152948_bib0105","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1002\/1097-0142(19811015)48:8<1830::AID-CNCR2820480821>3.0.CO;2-H","article-title":"Signet ring carcinoma of the female breast: a clinicopathologic analysis of 24 cases","volume":"48","author":"Merino","year":"1981","journal-title":"Cancer"},{"key":"10.1016\/j.prp.2020.152948_bib0110","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10549-007-9809-z","article-title":"A retrospective review with long term follow up of 11,400 cases of pure mucinous breast carcinoma","volume":"111","author":"Di Saverio","year":"2008","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.prp.2020.152948_bib0115","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1440-1827.2006.02030.x","article-title":"Pleomorphic lobular carcinoma in situ of the breast composed almost entirely of signet ring cells","volume":"56","author":"Fadare","year":"2006","journal-title":"Pathol. Int."},{"key":"10.1016\/j.prp.2020.152948_bib0120","first-page":"64","article-title":"The significance of signet ring cells in infiltrating lobular carcinoma of the breast","volume":"119","author":"Frost","year":"1995","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.prp.2020.152948_bib0125","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1097\/PAI.0000000000000366","article-title":"Invasive duct carcinoma of the breast with dominant signet-ring cell differentiation: a microsatellite stable tumor with aggressive behavior","volume":"25","author":"Chatterjee","year":"2017","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"10.1016\/j.prp.2020.152948_bib0130","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4103\/0970-9371.117646","article-title":"Pure primary signet ring cell carcinoma breast: a rare cytological diagnosis","volume":"30","author":"Sandhu","year":"2013","journal-title":"J. Cytol."},{"key":"10.1016\/j.prp.2020.152948_bib0135","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3727\/096504011X12935427587966","article-title":"The risk factors and prognosis of bilateral primary breast cancer: a comparative study with unilateral breast cancer","volume":"19","author":"Wang","year":"2011","journal-title":"Oncol. Res."},{"key":"10.1016\/j.prp.2020.152948_bib0140","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1158\/1055-9965.EPI-17-0531","article-title":"Emerging trends in family history of breast Cancer and associated risk","volume":"26","author":"Shiyanbola","year":"2017","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.prp.2020.152948_bib0145","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10549-017-4325-2","article-title":"Family history and risk of breast cancer: an analysis accounting for family structure","volume":"165","author":"Brewer","year":"2017","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.prp.2020.152948_bib0150","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0002-9440(10)65385-0","article-title":"A. Nagafuchi, alpha-catenin-deficient F9 cells differentiate into signet ring cells","volume":"154","author":"Maeno","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2020.152948_bib0155","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1023\/A:1010648919150","article-title":"Mammographic finding as predictor of survival in 1-9 mm invasive breast cancers. Worse prognosis for cases presenting as calcifications alone","volume":"67","author":"Thurfjell","year":"2001","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.prp.2020.152948_bib0160","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3892\/ol.2017.6112","article-title":"Mammographic calcification can predict outcome in women with breast cancer treated with breast-conserving surgery","volume":"14","author":"Qi","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.prp.2020.152948_bib0165","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/S0140-6736(02)09088-8","article-title":"Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial","volume":"359","author":"Baum","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.prp.2020.152948_bib0170","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pathol.2016.09.064","article-title":"A potential pitfall in evaluating HER2 immunohistochemistry for gastric signet ring cell carcinomas","volume":"49","author":"Woo","year":"2017","journal-title":"Pathology"},{"key":"10.1016\/j.prp.2020.152948_bib0175","first-page":"516","article-title":"Signet ring variant of lobular carcinoma of the breast: a clinicopathologic and immunohistochemical study","volume":"6","author":"Raju","year":"1993","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.prp.2020.152948_bib0180","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1034\/j.1600-0463.2000.d01-84.x","article-title":"The role of cytokeratins 20 and 7 and estrogen receptor analysis in separation of metastatic lobular carcinoma of the breast and metastatic signet ring cell carcinoma of the gastrointestinal tract","volume":"108","author":"Tot","year":"2000","journal-title":"APMIS"},{"key":"10.1016\/j.prp.2020.152948_bib0185","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1002\/1097-0142(20010601)91:11<1973::AID-CNCR1222>3.0.CO;2-A","article-title":"The importance of MUC1 cellular localization in patients with breast carcinoma: an immunohistologic study of 71 patients and review of the literature","volume":"91","author":"Rahn","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.prp.2020.152948_bib0190","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/ijc.28981","article-title":"Colorectal signet-ring cell carcinoma: benefit from adjuvant chemotherapy but a poor prognostic factor","volume":"136","author":"Hugen","year":"2015","journal-title":"Int. J. Cancer"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S034403382030042X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S034403382030042X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:41:42Z","timestamp":1759732902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S034403382030042X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S034403382030042X"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2020.152948","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Primary signet ring cell carcinoma of the breast: A rare entity with unique biological behavior\u2014A clinical study based on pure signet ring cell carcinoma cohort","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2020.152948","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152948"}}