{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:48:16Z","timestamp":1786996096932,"version":"build-2736575974"},"reference-count":18,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T00:00:00Z","timestamp":1622332800000},"content-version":"am","delay-in-days":302,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.prp.2020.153028","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T02:55:17Z","timestamp":1590029717000},"page":"153028","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["An immunohistochemical analysis of CD3, PD-L1, and CTLA-4 expression in carcinosarcomas of the gynecological tract and their metastases"],"prefix":"10.1016","volume":"216","author":[{"given":"Georgia","family":"Karpathiou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Chauleur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Dal Col","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maroa","family":"Dridi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirine","family":"Hathroubi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousa","family":"Mobarki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Peoc'h","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2020.153028_bib0005","series-title":"WHO Classification of Tumours of the Female Reproductive Organs","year":"2014"},{"key":"10.1016\/j.prp.2020.153028_bib0010","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1038\/modpathol.2015.137","article-title":"A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus","volume":"29","author":"McCluggage","year":"2016","journal-title":"Mod. Pathol."},{"issue":"3","key":"10.1016\/j.prp.2020.153028_bib0015","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ccell.2017.02.010","article-title":"Integrated molecular characterization of uterine carcinosarcoma","volume":"31","author":"Cherniack","year":"2017","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.prp.2020.153028_bib0020","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ygyno.2017.05.003","article-title":"Immunotherapy for gynecological cancers: opportunities abound","volume":"145","author":"Nelson","year":"2017","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.prp.2020.153028_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2019.152782","article-title":"The immune checkpoints CTLA-4 and PD-L1 in carcinomas of the uterine cervix","volume":"216","author":"Karpathiou","year":"2020","journal-title":"Pathol. Res. Pract."},{"issue":"8","key":"10.1016\/j.prp.2020.153028_bib0030","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s00262-018-2189-x","article-title":"Expression of CD3, PD-L1 and CTLA-4 in mammary and extra-mammary Paget disease","volume":"67","author":"Karpathiou","year":"2018","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.prp.2020.153028_bib0035","unstructured":"FDA. https:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm560167.htm."},{"issue":"12","key":"10.1016\/j.prp.2020.153028_bib0040","doi-asserted-by":"crossref","first-page":"19310","DOI":"10.18632\/oncotarget.14242","article-title":"Prognostic impact of immune microenvironment in laryngeal and pharyngeal squamous cell carcinoma: immune cell subtypes, immuno-suppressive pathways and clinicopathologic characteristics","volume":"8","author":"Karpathiou","year":"2017","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.prp.2020.153028_bib0045","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.pathol.2016.01.005","article-title":"p16 and p53 expression status in head and neck squamous cell carcinoma: a correlation with histological, histoprognostic and clinical parameters","volume":"48","author":"Karpathiou","year":"2016","journal-title":"Pathology"},{"issue":"1","key":"10.1016\/j.prp.2020.153028_bib0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170879","article-title":"Clinical significance of programmed death Ligand\u20111 and intra-tumoral CD8+ t lymphocytes in ovarian carcinosarcoma. Shridhar V, ed","volume":"12","author":"Zhu","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.prp.2020.153028_bib0055","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/ijc.30537","article-title":"Distinct molecular landscapes between endometrioid and nonendometrioid uterine carcinomas","volume":"140","author":"Jones","year":"2017","journal-title":"Int. J. Cancer"},{"issue":"2","key":"10.1016\/j.prp.2020.153028_bib0060","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jtho.2016.11.2228","article-title":"PD-L1 immunohistochemistry assays for lung Cancer: results from phase 1 of the blueprint PD-L1 IHC assay comparison project","volume":"12","author":"Hirsch","year":"2017","journal-title":"J. Thorac. Oncol."},{"issue":"4","key":"10.1016\/j.prp.2020.153028_bib0065","doi-asserted-by":"crossref","first-page":"341","DOI":"10.5858\/arpa.2015-0506-SA","article-title":"Programmed death Ligand-1 immunohistochemistry\u2014 a new challenge for pathologists: a perspective from members of the pulmonary pathology society","volume":"140","author":"Sholl","year":"2016","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"7","key":"10.1016\/j.prp.2020.153028_bib0070","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1097\/JTO.0000000000000526","article-title":"Programmed death-ligand 1 immunohistochemistry in lung cancer: in what state is this art?","volume":"10","author":"Kerr","year":"2015","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.prp.2020.153028_bib0075","series-title":"IASLC ATLAS OF PD-L1 Immunohistochemistry Testing in Lung Cancer","author":"TSAO","year":"2017"},{"issue":"4","key":"10.1016\/j.prp.2020.153028_bib0080","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000452277","article-title":"Malignant mixed m\u00fcllerian tumour of the uterus: analysis of 44 cases","volume":"92","author":"Grasso","year":"2017","journal-title":"Oncology"},{"issue":"1","key":"10.1016\/j.prp.2020.153028_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00004347-199001000-00001","article-title":"Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus. A Gynecologic Oncology Group pathologic study of 203 cases","volume":"9","author":"Silverberg","year":"1990","journal-title":"Int. J. Gynecol. Pathol."},{"issue":"1","key":"10.1016\/j.prp.2020.153028_bib0090","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s10147-015-0859-7","article-title":"Prognostic factors in patients with uterine carcinosarcoma: a multi-institutional retrospective study from the Japanese Gynecologic Oncology Group","volume":"21","author":"Harano","year":"2016","journal-title":"Int. J. Clin. Oncol."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033820308748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033820308748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:41:17Z","timestamp":1759732877000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033820308748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0344033820308748"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2020.153028","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An immunohistochemical analysis of CD3, PD-L1, and CTLA-4 expression in carcinosarcomas of the gynecological tract and their metastases","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2020.153028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153028"}}