{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:16:59Z","timestamp":1779340619512,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.prp.2020.153149","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T21:55:03Z","timestamp":1596059703000},"page":"153149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Roles of estrogen receptor \u03b1 and \u03b2 in the regulation of proliferation in endometrial carcinoma"],"prefix":"10.1016","volume":"216","author":[{"given":"Guanli","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2020.153149_bib0005","first-page":"271","article-title":"Cancer treatment and survivorship statistics, 2016","volume":"66","author":"Miller","year":"2016","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.prp.2020.153149_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108327","article-title":"Fatostatin inhibits the development of endometrial carcinoma in endometrial carcinoma cells and a xenograft model by targeting lipid metabolism","author":"Yao","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.prp.2020.153149_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-3127-9_1","article-title":"The Estrogen Receptors: An overview from different perspectives","volume":"1366","author":"Eyster","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.prp.2020.153149_bib0020","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s11626-019-00328-5","article-title":"Repression of insulin gene transcription by indirect genomic signaling via the estrogen receptor in pancreatic beta cells","volume":"55","author":"Sekido","year":"2019","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.prp.2020.153149_bib0025","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.mce.2015.01.035","article-title":"miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets","volume":"418","author":"Klinge","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.prp.2020.153149_bib0030","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1186\/s12885-017-3601-1","article-title":"Differential expression of estrogen receptor subtypes and variants in ovarian cancer: effects on cell invasion, proliferation and prognosis","volume":"17","author":"Chan","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.prp.2020.153149_bib0035","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bioorg.2017.02.011","article-title":"Estrogen receptor agonists\/antagonists in breast cancer therapy: a critical review","volume":"71","author":"Jameera Begam","year":"2017","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.prp.2020.153149_bib0040","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1159\/000489687","article-title":"MiR-301a-3p suppresses estrogen signaling by directly inhibiting esr1 in eralpha positive breast cancer","volume":"46","author":"Lettlova","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.prp.2020.153149_bib0045","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.steroids.2018.02.007","article-title":"The ER-alpha36\/EGFR signaling loop promotes growth of hepatocellular carcinoma cells","volume":"134","author":"You","year":"2018","journal-title":"Steroids."},{"key":"10.1016\/j.prp.2020.153149_bib0050","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1073\/pnas.0308319100","article-title":"Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D","volume":"101","author":"Strom","year":"2004","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.prp.2020.153149_bib0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044787","article-title":"Potential role of estrogen receptor beta as a tumor suppressor of epithelial ovarian cancer","volume":"7","author":"Bossard","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2020.153149_bib0060","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2478\/v10039-012-0055-1","article-title":"Expression of estrogen receptors (alpha, beta), cyclooxygenase-2 and aromatase in normal endometrium and endometrioid cancer of uterus","volume":"58","author":"Knapp","year":"2013","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.prp.2020.153149_bib0065","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.2147\/OTT.S160014","article-title":"Immunohistochemical expression of hormone receptors, Ki-67, endoglin (CD105), claudins 3 and 4, MMP-2 and -9 in endometrial polyps and endometrial cancer type I","volume":"11","author":"Peres","year":"2018","journal-title":"Onco. Ther."},{"key":"10.1016\/j.prp.2020.153149_bib0070","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00004347-200204000-00007","article-title":"Expression of COX-2, Ki-67, cyclin D1, and P21 in endometrial endometrioid carcinomas","volume":"21","author":"Cao","year":"2002","journal-title":"Int. J. Gynecol. Pathol."},{"key":"10.1016\/j.prp.2020.153149_bib0075","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.bbrc.2016.08.058","article-title":"Dixdc1 targets CyclinD1 and p21 via PI3K pathway activation to promote Schwann cell proliferation after sciatic nerve crush","volume":"478","author":"Wu","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.prp.2020.153149_bib0080","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.7150\/ijbs.40173","article-title":"Knockdown of SMAD3 inhibits the growth and enhances the radiosensitivity of lung adenocarcinoma via p21 in vitro and in vivo","volume":"16","author":"Niu","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.prp.2020.153149_bib0085","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.21037\/jtd.2016.08.82","article-title":"Prognostic value of immunohistochemical markers in malignant thymic epithelial tumors","volume":"8","author":"Leisibach","year":"2016","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.prp.2020.153149_bib0090","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3892\/mmr.2013.1774","article-title":"Expression and significance of Wnt signaling components and their target genes in breast carcinoma","volume":"9","author":"He","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.prp.2020.153149_bib0095","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.steroids.2011.02.038","article-title":"Estrogen receptor-beta activation in combination with letrozole blocks the growth of breast cancer tumors resistant to letrozole therapy","volume":"76","author":"Nair","year":"2011","journal-title":"Steroids."},{"key":"10.1016\/j.prp.2020.153149_bib0100","doi-asserted-by":"crossref","first-page":"15639","DOI":"10.1038\/srep15639","article-title":"Metformin attenuates testosterone-induced prostatic hyperplasia in rats: a pharmacological perspective","volume":"5","author":"Mosli","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2020.153149_bib0105","doi-asserted-by":"crossref","first-page":"40765","DOI":"10.18632\/oncotarget.16582","article-title":"Expression of estrogen receptors and androgen receptor and their clinical significance in gastric cancer","volume":"8","author":"Tang","year":"2017","journal-title":"Oncotarget."},{"key":"10.1016\/j.prp.2020.153149_bib0110","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.bbrc.2020.01.164","article-title":"Hepatic CD147 knockout modulates liver steatosis and up-regulates autophagy in high-fat-diet-induced NAFLD mice","volume":"524","author":"Lou","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.prp.2020.153149_bib0115","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1039\/C8TX00029H","article-title":"The role of IP3R-SOCCs in Cr(vi)-induced cytosolic Ca(2+) overload and apoptosis in L-02 hepatocytes","volume":"7","author":"Liang","year":"2018","journal-title":"Toxicol Res (Camb)."},{"key":"10.1016\/j.prp.2020.153149_bib0120","doi-asserted-by":"crossref","first-page":"E2702","DOI":"10.3390\/nu11112702","article-title":"Curcumin ameliorates nonalcoholic fatty liver disease through inhibition of O-GlcNAcylation","volume":"11","author":"Lee","year":"2019","journal-title":"Nutrients."},{"key":"10.1016\/j.prp.2020.153149_bib0125","article-title":"Levonorgestrel-releasing intrauterine system for atypical endometrial hyperplasia","volume":"Cd009458","author":"Luo","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.prp.2020.153149_bib0130","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1476-4598-6-24","article-title":"The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention","volume":"6","author":"Alao","year":"2007","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.prp.2020.153149_bib0135","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.mce.2015.08.009","article-title":"Inhibitory role of ERbeta on anterior pituitary cell proliferation by controlling the expression of proteins related to cell cycle progression","volume":"415","author":"Perez","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.prp.2020.153149_bib0140","doi-asserted-by":"crossref","first-page":"6368","DOI":"10.1111\/jcmm.13963","article-title":"Metformin inhibits growth and prolactin secretion of pituitary prolactinoma cells and xenografts","volume":"22","author":"Gao","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.prp.2020.153149_bib0145","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.3892\/or.2016.4675","article-title":"Anticancer effect of metformin on estrogen receptor-positive and tamoxifen-resistant breast cancer cell lines","volume":"35","author":"Kim","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.prp.2020.153149_bib0150","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bbrc.2015.03.178","article-title":"Metformin inhibits the proliferation of human prostate cancer PC-3 cells via the downregulation of insulin-like growth factor 1 receptor","volume":"461","author":"Kato","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.prp.2020.153149_bib0155","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1002\/pros.23000","article-title":"Metformin represses androgen-dependent and androgen-independent prostate cancers by targeting androgen receptor","volume":"75","author":"Wang","year":"2015","journal-title":"Prostate."},{"key":"10.1016\/j.prp.2020.153149_bib0160","doi-asserted-by":"crossref","first-page":"E3816","DOI":"10.1073\/pnas.1702211114","article-title":"Estrogen receptor \u03b2, a regulator of androgen receptor signaling in the mouse ventral prostate","volume":"114","author":"Wu","year":"2017","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.prp.2020.153149_bib0165","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.3892\/ol.2017.6544","article-title":"Involvement of estrogen receptor \u03b2 in androgen receptor-induced growth inhibition in prostate cancer PC-3 cells","volume":"14","author":"Xiao","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.prp.2020.153149_bib0170","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12986-020-00446-y","article-title":"Crucial role of androgen receptor in resistance and endurance trainings-induced muscle hypertrophy through IGF-1\/IGF-1R- PI3K\/Akt- mTOR pathway","volume":"17","author":"Yin","year":"2020","journal-title":"Nutr Metab (Lond)."},{"key":"10.1016\/j.prp.2020.153149_bib0175","doi-asserted-by":"crossref","first-page":"4949","DOI":"10.3892\/ol.2017.6877","article-title":"Role of metformin in inhibiting estrogen-induced proliferation and regulating ERalpha and ERbeta expression in human endometrial cancer cells","volume":"14","author":"Zhang","year":"2017","journal-title":"Oncol. Lett."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033820320045?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033820320045?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:45:31Z","timestamp":1759733131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033820320045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0344033820320045"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2020.153149","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles of estrogen receptor \u03b1 and \u03b2 in the regulation of proliferation in endometrial carcinoma","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2020.153149","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153149"}}