{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:05:27Z","timestamp":1789009527654,"version":"build-2803163510"},"reference-count":82,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.prp.2020.153226","type":"journal-article","created":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T11:07:49Z","timestamp":1600513669000},"page":"153226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["The potential therapeutic effects of melatonin on breast cancer: An invasion and metastasis inhibitor"],"prefix":"10.1016","volume":"216","author":[{"given":"Nazila Fathi","family":"Maroufi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Ashouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Mortezania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Ashoori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Vahedian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Taher","family":"Amirzadeh-Iranaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Fattahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Kazemzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Bizzarri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Akbarzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid Reza","family":"Nejabati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Faridvand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9206-9336","authenticated-orcid":false,"given":"Mohammad-Reza","family":"Rashidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5367-9956","authenticated-orcid":false,"given":"Mohammad","family":"Nouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2020.153226_bib0005","article-title":"Sensitization of MDA-MBA231 breast cancer cell to docetaxel by myricetin loaded into biocompatible lipid nanoparticles via sub-G1 cell cycle arrest mechanism","author":"Maroufi","year":"2019","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.prp.2020.153226_bib0010","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/09674845.2018.1545554","article-title":"Influence of single nucleotide polymorphism in IL-27 and IL-33 genes on breast cancer","volume":"76","author":"Fathi Maroufi","year":"2019","journal-title":"Br. J. Biomed. Sci."},{"key":"10.1016\/j.prp.2020.153226_bib0015","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/21691401.2017.1423493","article-title":"Improved anticancer effects of epigallocatechin gallate using RGD-containing nanostructured lipid carriers","volume":"46","author":"Hajipour","year":"2018","journal-title":"Artif. Cells, Nanomed. Biotechnol."},{"key":"10.1016\/j.prp.2020.153226_bib0020","first-page":"1290","article-title":"In vivo and in vitro impact of miR-31 and miR-143 on the suppression of metastasis and invasion in breast cancer","volume":"23","author":"Soheilyfar","year":"2018","journal-title":"J. BUON"},{"key":"10.1016\/j.prp.2020.153226_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117106","article-title":"Therapeutic potentials of Apatinib in cancer treatment: possible mechanisms and clinical relevance","volume":"241","author":"Fathi Maroufi","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.prp.2020.153226_bib0030","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s12282-020-01055-6","article-title":"The apatinib inhibits breast cancer cell line MDA-MB-231 in vitro by inducing apoptosis, cell cycle arrest, and regulating nuclear factor-\u03baB (NF-\u03baB) and mitogen-activated protein kinase (MAPK) signaling pathways","volume":"27","author":"Maroufi","year":"2020","journal-title":"Breast Cancer"},{"key":"10.1016\/j.prp.2020.153226_bib0035","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16940-y","article-title":"The potential therapeutic effect of melatonin on human ovarian cancer by inhibition of invasion and migration of cancer stem cells","volume":"7","author":"Akbarzadeh","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2020.153226_bib0040","doi-asserted-by":"crossref","DOI":"10.1007\/s12020-018-1624-2","article-title":"Evaluation of melatonin and AFMK levels in women with breast cancer","author":"de Castro","year":"2018","journal-title":"Endocrine"},{"key":"10.1016\/j.prp.2020.153226_bib0045","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23020336","article-title":"Melatonin: A molecule for reducing breast cancer risk","volume":"23","author":"Gonz\u00e1lez-Gonz\u00e1lez","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.prp.2020.153226_bib0050","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1517\/14728222.2013.834890","article-title":"Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review","volume":"17","author":"Bizzarri","year":"2013","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.prp.2020.153226_bib0055","doi-asserted-by":"crossref","first-page":"39896","DOI":"10.18632\/oncotarget.16379","article-title":"Melatonin for the prevention and treatment of cancer","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2020.153226_bib0060","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1590\/s0102-865020180040000009","article-title":"Effect of melatonin on antioxidant capacity, \u0131nflammation and apoptotic cell death in lung tissue of diabetic rats","volume":"33","author":"Onk","year":"2018","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.prp.2020.153226_bib0065","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.01086","article-title":"Promising antineoplastic actions of melatonin","volume":"9","author":"Favero","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.prp.2020.153226_bib0070","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1007\/s00018-017-2612-z","article-title":"Melatonin, mitochondria, and the cancer cell","volume":"74","author":"Proietti","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.prp.2020.153226_bib0075","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18040843","article-title":"Melatonin, a full service anti-cancer agent: Inhibition of initiation, progression and metastasis","volume":"18","author":"Reiter","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.prp.2020.153226_bib0080","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF01670163","article-title":"Effect of pinealectomy and melatonin on mammary tumor growth in sprague-dawley rats under different conditions of lighting","volume":"47","author":"Aubert","year":"1980","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.prp.2020.153226_bib0085","first-page":"4432","article-title":"Melatonin inhibition and pinealectomy enhancement of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in the rat","volume":"41","author":"Tamarkin","year":"1981","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2020.153226_bib0090","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0024-3205(99)00262-3","article-title":"Melatonin increases p53 and p21WAF1 expression in MCF-7 human breast cancer cells in vitro","volume":"65","author":"Mediavilla","year":"1999","journal-title":"Life Sci."},{"key":"10.1016\/j.prp.2020.153226_bib0095","first-page":"825","article-title":"Characterization of a panel of novel anti-p21Waf1\/Cip1 monoclonal antibodies and immunochemical Analysis of p21Waf1\/Cip1 expression in normal human tissues","volume":"148","author":"Fredersdorf","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2020.153226_bib0100","doi-asserted-by":"crossref","first-page":"9308","DOI":"10.1158\/0008-5472.CAN-06-1769","article-title":"Estrogen receptor positive breast cancer metastasis: altered hormonal sensitivity and tumor aggressiveness in lymphatic vessels and lymph nodes","volume":"66","author":"Harrell","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2020.153226_bib0105","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a003178","article-title":"Hormone action in the mammary gland","volume":"2","author":"Brisken","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.prp.2020.153226_bib0110","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/frne.1999.0194","article-title":"Melatonin and mammary pathological growth","volume":"21","author":"Cos","year":"2000","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.prp.2020.153226_bib0115","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0304-3835(92)90050-6","article-title":"The growth inhibitory action of melatonin on human breast cancer cells is linked to the estrogen response system","volume":"64","author":"Hill","year":"1992","journal-title":"Cancer Lett."},{"key":"10.1016\/j.prp.2020.153226_bib0120","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/bem.36","article-title":"Studies of the interactions between melatonin and 2 Hz, 0.3 mT PEMF on the proliferation and invasion of human breast cancer cells","volume":"22","author":"Leman","year":"2001","journal-title":"Bioelectromagnetics"},{"key":"10.1016\/j.prp.2020.153226_bib0125","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1177\/1534735409353332","article-title":"Molecular mechanisms of melatonin anticancer effects","volume":"8","author":"Hill","year":"2009","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.prp.2020.153226_bib0130","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1600-079X.2008.00645.x","article-title":"Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells","volume":"46","author":"Cucina","year":"2009","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.prp.2020.153226_bib0135","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2174\/156800908784293659","article-title":"The PTEN\/PI3K\/AKT signalling pathway in cancer, therapeutic implications","volume":"8","author":"Carnero","year":"2008","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.prp.2020.153226_bib0140","first-page":"609","article-title":"Amarogentin secoiridoid inhibits in vivo cancer cell growth in xenograft mice model and induces apoptosis in human gastric cancer cells (SNU-16) through G2\/M cell cycle arrest and PI3K\/Akt signalling pathway","volume":"21","author":"Zhao","year":"2016","journal-title":"J. BUON"},{"key":"10.1016\/j.prp.2020.153226_bib0145","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/879746","article-title":"Melatonin suppresses the expression of 45S preribosomal RNA and upstream binding factor and enhances the antitumor activity of puromycin in MDA-MB-231 breast cancer cells","volume":"2013","author":"Jung","year":"2013","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"10.1016\/j.prp.2020.153226_bib0150","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1600-079X.2010.00824.x","article-title":"Melatonin and vitamin D 3 synergistically down-regulate Akt and MDM2 leading to TGF\u03b2-1-dependent growth inhibition of breast cancer cells","volume":"50","author":"Proietti","year":"2011","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.prp.2020.153226_bib0155","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0022-4804(03)00040-4","article-title":"Melatonin and vitamin D3 increase TGF-\u03b21 release and induce growth inhibition in breast cancer cell cultures","volume":"110","author":"Bizzarri","year":"2003","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.prp.2020.153226_bib0160","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1600-079X.2012.00973.x","article-title":"Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells","volume":"53","author":"Wang","year":"2012","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.prp.2020.153226_bib0165","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/onc.2010.566","article-title":"NF-\u03baB addiction and its role in cancer: One size does not fit all","volume":"30","author":"Chaturvedi","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2020.153226_bib0170","article-title":"Effect of melatonin in epithelial mesenchymal transition markers and invasive properties of breast cancer stem cells of canine and human cell lines","volume":"11","author":"Do Nascimento Gon\u00e7alves","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2020.153226_bib0175","doi-asserted-by":"crossref","DOI":"10.1186\/1477-7827-2-59","article-title":"Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion","author":"Staun-Ram","year":"2004","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.prp.2020.153226_bib0180","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12270","article-title":"Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression","author":"Borin","year":"2016","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.prp.2020.153226_bib0185","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1600-079X.2008.00600.x","article-title":"ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration","volume":"46","author":"Ort\u00edz-L\u00f3pez","year":"2009","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.prp.2020.153226_bib0190","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12467","article-title":"Increase in motility and invasiveness of MCF7 cancer cells induced by nicotine is abolished by melatonin through inhibition of ERK phosphorylation","volume":"64","author":"Proietti","year":"2018","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.prp.2020.153226_bib0195","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.3892\/ol.2017.6434","article-title":"Melatonin-induced KiSS1 expression inhibits triple-negative breast cancer cell invasiveness","volume":"14","author":"Kim","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.prp.2020.153226_bib0200","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00432-004-0629-9","article-title":"Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases","volume":"131","author":"Stark","year":"2005","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.prp.2020.153226_bib0205","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1002\/jcb.27678","article-title":"Melatonin inhibits breast cancer cell invasion through modulating DJ-1\/KLF17\/ID-1 signaling pathway","volume":"120","author":"El-Sokkary","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.prp.2020.153226_bib0210","first-page":"4383","article-title":"Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells","volume":"58","author":"Cos","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2020.153226_bib0215","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0959-8049(00)00158-1","article-title":"The E-cadherin-catenin complex in tumour metastasisstructure, function and regulation","volume":"36","author":"Beavon","year":"2000","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.prp.2020.153226_bib0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-mesenchymal transitions in development and disease","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.prp.2020.153226_bib0225","article-title":"D.A. Pires De Campos Zuccari, Effect of melatonin in epithelial mesenchymal transition markers and invasive properties of breast cancer stem cells of canine and human cell lines","author":"Do Nascimento Gon\u00e7alves","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2020.153226_bib0230","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23030518","article-title":"Melatonin and cancer hallmarks","volume":"23","author":"Talib","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.prp.2020.153226_bib0235","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1016\/S0021-9258(18)53979-X","article-title":"Activation of the human vimentin gene by the tax human T-cell leukemia virus I. Mechanisms of regulation by the NF-\u03baB transcription factor","volume":"268","author":"Lilienbaum","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.prp.2020.153226_bib0240","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1210\/me.2012-1071","article-title":"Circadian gating of epithelial-to-mesenchymal transition in breast cancer cells via melatonin- regulation of GSK3\u03b2","volume":"26","author":"Mao","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.prp.2020.153226_bib0245","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1038\/bjc.2014.40","article-title":"DJ-1 upregulates breast cancer cell invasion by repressing KLF17 expression","volume":"110","author":"Ismail","year":"2014","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.prp.2020.153226_bib0250","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/nature09557","article-title":"Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells","volume":"468","author":"Ricci-Vitiani","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.prp.2020.153226_bib0255","article-title":"Angiogenesis and anti-angiogenic therapy in gastric cancer","volume":"19","author":"Nienh\u00fcser","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.prp.2020.153226_bib0260","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/jpi.12007","article-title":"Regulation of vascular endothelial growth factor by melatonin in human breast cancer cells","volume":"54","author":"Alvarez-Garc\u00eda","year":"2013","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.prp.2020.153226_bib0265","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.acthis.2014.09.010","article-title":"Combination of Pitavastatin and melatonin shows partial antineoplastic effects in a rat breast carcinoma model","volume":"116","author":"Kubatka","year":"2014","journal-title":"Acta Histochem."},{"key":"10.1016\/j.prp.2020.153226_bib0270","doi-asserted-by":"crossref","first-page":"S254","DOI":"10.1016\/S0959-8049(12)71665-9","article-title":"1054 Evaluation of hypoxia inducible factor 1-alpha (HIF1A) after treatment with melatonin in breast cancer cell line","volume":"48","author":"Pires de Campos Zuccari","year":"2012","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.prp.2020.153226_bib0275","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2174\/1871520615666150511094201","article-title":"Melatonin regulates angiogenic factors under hypoxia in breast cancer cell lines","volume":"16","author":"Jardim-Perassi","year":"2016","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.prp.2020.153226_bib0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173282","article-title":"Inhibitory effect of melatonin on hypoxia-induced vasculogenic mimicry via suppressing epithelial-mesenchymal transition (EMT) in breast cancer stem cells","volume":"881","author":"Maroufi","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.prp.2020.153226_bib0285","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1053\/j.seminoncol.2015.01.001","article-title":"Cancer stem cells: the promise and the potential","volume":"42","author":"Ajani","year":"2015","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.prp.2020.153226_bib0290","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1126\/science.1203543","article-title":"A perspective on cancer cell metastasis","volume":"331","author":"Chaffer","year":"2011","journal-title":"Science (80-.)"},{"key":"10.1016\/j.prp.2020.153226_bib0295","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/aps.2013.27","article-title":"Understanding and targeting cancer stem cells: therapeutic implications and challenges","volume":"34","author":"Chen","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.prp.2020.153226_bib0300","doi-asserted-by":"crossref","first-page":"14759","DOI":"10.1002\/jcp.28271","article-title":"Current approaches in identification and isolation of cancer stem cells","volume":"234","author":"Akbarzadeh","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.prp.2020.153226_bib0305","article-title":"Evaluation of melatonin effect on human breast cancer stem cells using a three dimensional growth method of mammospheres","author":"Lopes","year":"2016","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.prp.2020.153226_bib0310","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0002-9440(10)65173-5","article-title":"Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry","volume":"155","author":"Maniotis","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2020.153226_bib0315","doi-asserted-by":"crossref","DOI":"10.1186\/bcr1626","article-title":"A novel role for cyclooxygenase-2 in regulating vascular channel formation by human breast cancer cells","volume":"8","author":"Basu","year":"2006","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.prp.2020.153226_bib0320","article-title":"Tumor vasculogenic mimicry formation as an unfavorable prognostic indicator in patients with breast cancer","author":"Shen","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2020.153226_bib0325","doi-asserted-by":"crossref","DOI":"10.1007\/s11033-020-05515-2","article-title":"Vascular mimicry: changing the therapeutic paradigms in cancer","author":"Fathi Maroufi","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.prp.2020.153226_bib0330","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/onc.2012.85","article-title":"CD133 + cells with cancer stem cell characteristics associates with vasculogenic mimicry in triple-negative breast cancer","volume":"32","author":"Liu","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2020.153226_bib0335","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3510970","article-title":"Melatonin inhibits reactive oxygen species-driven proliferation, epithelial-mesenchymal transition, and vasculogenic mimicry in oral cancer","volume":"2018","author":"Liu","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.prp.2020.153226_bib0340","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-017-0631-x","article-title":"Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin","volume":"16","author":"Delgado-Bellido","year":"2017","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.prp.2020.153226_bib0345","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/jcmm.12496","article-title":"Advanced research on vasculogenic mimicry in cancer","volume":"19","author":"Qiao","year":"2015","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.prp.2020.153226_bib0350","article-title":"Melatonin enhances the apoptotic effects and modulates the changes in gene expression induced by docetaxel in MCF-7 human breast cancer cells","author":"Alonso-Gonz\u00e1lez","year":"2018","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.prp.2020.153226_bib0355","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejphar.2012.02.011","article-title":"Combined effects of melatonin and all-trans retinoic acid and somatostatin on breast cancer cell proliferation and death: molecular basis for the anticancer effect of these molecules","volume":"681","author":"Margheri","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.prp.2020.153226_bib0360","doi-asserted-by":"crossref","DOI":"10.4103\/0973-1482.235349","article-title":"Synergistic effect of thymoquinone and melatonin against breast cancer implanted in mice","author":"Odeh","year":"2018","journal-title":"J. Cancer Res. Ther."},{"key":"10.1016\/j.prp.2020.153226_bib0365","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/bjc.1995.164","article-title":"Modulation of cancer endocrine therapy by melatonin: a phase II study of tamoxifen plus melatonin in metastatic breast cancer patients progressing under tamoxifen alone","volume":"71","author":"Lissoni","year":"1995","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.prp.2020.153226_bib0370","first-page":"609","article-title":"A randomized controlled trial of oral melatonin supplementation and breast cancer biomarkers","volume":"23","author":"Schernhammer","year":"2012","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.prp.2020.153226_bib0375","first-page":"660","article-title":"Evaluation of the safety and efficacy of the first-line treatment with somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide in 20 cases of breast cancer: a preliminary report","volume":"34","author":"Di Bella","year":"2013","journal-title":"Neuroendocrinol. Lett."},{"key":"10.1016\/j.prp.2020.153226_bib0380","first-page":"45","article-title":"Anti-angiogenic activity of melatonin in advanced cancer patients","volume":"22","author":"Lissoni","year":"2001","journal-title":"Neuroendocrinol. Lett."},{"key":"10.1016\/j.prp.2020.153226_bib0385","article-title":"The effect of melatonin on sleep and quality of life in patients with advanced breast cancer","author":"Innominato","year":"2016","journal-title":"Support. Care Cancer"},{"key":"10.1016\/j.prp.2020.153226_bib0390","doi-asserted-by":"crossref","DOI":"10.1007\/s10549-014-2962-2","article-title":"Effect of melatonin on depressive symptoms and anxiety in patients undergoing breast cancer surgery: a randomized, double-blind, placebo-controlled trial","author":"Hansen","year":"2014","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.prp.2020.153226_bib0395","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/1759-7714.12587","article-title":"Melatonin inhibits the proliferation of breast cancer cells induced by bisphenol A via targeting estrogen receptor-related pathways","volume":"9","author":"Wang","year":"2018","journal-title":"Thorac. Cancer"},{"key":"10.1016\/j.prp.2020.153226_bib0400","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5402\/2012\/458238","article-title":"Antioncogenic effects of transient receptor potential vanilloid 1 in the progression of transitional urothelial Cancer of human bladder","volume":"2012","author":"Santoni","year":"2012","journal-title":"ISRN Urol."},{"key":"10.1016\/j.prp.2020.153226_bib0405","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.mce.2015.11.016","article-title":"Melatonin enhances arsenic trioxide-induced cell death via sustained upregulation of Redd1 expression in breast cancer cells","volume":"422","author":"Yun","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.prp.2020.153226_bib0410","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00232-015-9855-0","article-title":"Synergic effects of doxorubicin and melatonin on apoptosis and mitochondrial oxidative stress in MCF-7 breast cancer cells: involvement of TRPV1 channels","volume":"249","author":"Ko\u015far","year":"2016","journal-title":"J. Membr. Biol."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033820320811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033820320811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:46:19Z","timestamp":1759733179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033820320811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":82,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0344033820320811"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2020.153226","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The potential therapeutic effects of melatonin on breast cancer: An invasion and metastasis inhibitor","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2020.153226","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153226"}}