{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:26:56Z","timestamp":1767374816940,"version":"build-2065373602"},"reference-count":19,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.prp.2020.153267","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T04:28:44Z","timestamp":1604291324000},"page":"153267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sarcomatoid Mesothelioma: A CDKN2A molecular analysis of 53 cases with immunohistochemical correlation with BAP1"],"prefix":"10.1016","volume":"216","author":[{"given":"Michael","family":"Zaleski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Kalhor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Wistuba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar A.","family":"Moran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.prp.2020.153267_bib0005","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/modpathol.2008.45","article-title":"Diagnostic importance of 9p21 homozygous deletion in malignant mesotheliomas","volume":"21","author":"Chiosea","year":"2008","journal-title":"Mod. Pathol."},{"issue":"10","key":"10.1016\/j.prp.2020.153267_bib0010","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/pin.12453","article-title":"BAP1 immunohistochemistry and p16 FISH results in combination provide higher confidence in malignant pleural mesothelioma diagnosis: ROC analysis of the two tests","volume":"66","author":"Hida","year":"2016","journal-title":"Pathol. Int."},{"issue":"5","key":"10.1016\/j.prp.2020.153267_bib0015","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1097\/PAS.0000000000000616","article-title":"BAP1 immunohistochemistry and p16 FISH in the diagnosis of sarcomatous and desmoplastic mesotheliomas","volume":"40","author":"Hwang","year":"2016","journal-title":"Am. J. Surg. Pathol."},{"issue":"6","key":"10.1016\/j.prp.2020.153267_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2019.03.006","article-title":"The importance of FISH signal cut-off values for 9p21 deletion in malignant pleural mesothelioma: Is it underestimated?","volume":"215","author":"Kulduk","year":"2019","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2020.153267_bib0025","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.humpath.2018.05.001","article-title":"BAP1 loss is unusual in well-differentiated papillary mesothelioma and may predict development of malignant mesothelioma","volume":"79","author":"Lee","year":"2018","journal-title":"Hum. Pathol."},{"issue":"5","key":"10.1016\/j.prp.2020.153267_bib0030","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1440-1827.2010.02534.x","article-title":"9p21 deletion in the diagnosis of malignant mesothelioma, using fluorescence in situ hybridization analysis","volume":"60","author":"Takeda","year":"2010","journal-title":"Pathol. Int."},{"key":"10.1016\/j.prp.2020.153267_bib0035","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.lungcan.2018.07.041","article-title":"Highlights of the 14th international mesothelioma interest group meeting: pathologic separation of benign from malignant mesothelial proliferations and histologic\/molecular analysis of malignant mesothelioma subtypes","volume":"124","author":"Churg","year":"2018","journal-title":"Lung Cancer"},{"issue":"7","key":"10.1016\/j.prp.2020.153267_bib0040","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/jcp.2010.076794","article-title":"FISH assay development for the detection of p16\/CDKN2A deletion in malignant pleural mesothelioma","volume":"63","author":"Chung","year":"2010","journal-title":"J. Clin. Pathol."},{"issue":"6","key":"10.1016\/j.prp.2020.153267_bib0045","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00428-008-0689-3","article-title":"Prognostic significance of p16\/cdkn2a loss in pleural malignant mesotheliomas","volume":"453","author":"Dacic","year":"2008","journal-title":"Virchows Arch."},{"issue":"5","key":"10.1016\/j.prp.2020.153267_bib0050","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/PAS.0000000000000176","article-title":"p16 FISH deletion in surface epithelial mesothelial proliferations is predictive of underlying invasive mesothelioma","volume":"38","author":"Hwang","year":"2014","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2020.153267_bib0055","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.humpath.2016.09.026","article-title":"BAP1 immunohistochemistry has limited prognostic utility as a complement of CDKN2A (p16) fluorescence in situ hybridization in malignant pleural mesothelioma","volume":"60","author":"McGregor","year":"2017","journal-title":"Hum. Pathol."},{"issue":"7","key":"10.1016\/j.prp.2020.153267_bib0060","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/PAS.0000000000000394","article-title":"BAP1 immunohistochemistry and p16 FISH to separate benign from malignant mesothelial proliferations","volume":"39","author":"Sheffield","year":"2015","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2020.153267_bib0065","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.anndiagpath.2016.10.010","article-title":"Usefulness of p16\/CDKN2A fluorescence in situ hybridization and BAP1 immunohistochemistry for the diagnosis of biphasic mesothelioma","volume":"26","author":"Wu","year":"2017","journal-title":"Ann. Diagn. Pathol."},{"issue":"1","key":"10.1016\/j.prp.2020.153267_bib0070","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1309\/AJCPT94JVWIHBKRD","article-title":"Diagnostic usefulness of p16\/CDKN2A FISH in distinguishing between sarcomatoid mesothelioma and fibrous pleuritis","volume":"139","author":"Wu","year":"2013","journal-title":"Am. J. Clin. Pathol."},{"year":"2006","series-title":"Molecular Genetic Testing in Surgical Pathology","author":"Pfeifer","key":"10.1016\/j.prp.2020.153267_bib0075"},{"key":"10.1016\/j.prp.2020.153267_bib0080","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.lungcan.2016.07.011","article-title":"Low homozygous\/high heterozygous deletion status by p16 FISH correlates with a better prognostic group than high homozygous deletion status in malignant pleural mesothelioma","volume":"99","author":"Hamasaki","year":"2016","journal-title":"Lung Cancer"},{"key":"10.1016\/j.prp.2020.153267_bib0085","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.lungcan.2016.12.017","article-title":"Immunohistochemical detection of MTAP and BAP1 protein loss for mesothelioma diagnosis: comparison with 9p21 FISH and BAP1 immunohistochemistry","volume":"104","author":"Hida","year":"2017","journal-title":"Lung Cancer"},{"issue":"2","key":"10.1016\/j.prp.2020.153267_bib0090","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4997\/JRCPE.2015.207","article-title":"Survival from malignant mesothelioma: where are we now?","volume":"45","author":"Marshall","year":"2015","journal-title":"J. R. Coll. Phys. Edinb."},{"issue":"6","key":"10.1016\/j.prp.2020.153267_bib0095","doi-asserted-by":"crossref","first-page":"e901","DOI":"10.1016\/j.cllc.2018.08.007","article-title":"Survival by histologic subtype of malignant pleural mesothelioma and the impact of surgical resection on overall survival","volume":"19","author":"Verma","year":"2018","journal-title":"Clin. Lung Cancer"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033820321221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033820321221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:44:47Z","timestamp":1759733087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033820321221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0344033820321221"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2020.153267","relation":{},"ISSN":["0344-0338"],"issn-type":[{"type":"print","value":"0344-0338"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sarcomatoid Mesothelioma: A CDKN2A molecular analysis of 53 cases with immunohistochemical correlation with BAP1","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2020.153267","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153267"}}