{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:32:10Z","timestamp":1784752330136,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.prp.2020.153280","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T17:21:46Z","timestamp":1604596906000},"page":"153280","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Relationship between HER2 expression and tumor interstitial angiogenesis in primary gastric cancer and its effect on prognosis"],"prefix":"10.1016","volume":"217","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7551-5899","authenticated-orcid":false,"given":"Fang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqing","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibo","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3924-6350","authenticated-orcid":false,"given":"Zihao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2834-3625","authenticated-orcid":false,"given":"Shuyao","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-114X","authenticated-orcid":false,"given":"Yueping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"66","key":"10.1016\/j.prp.2020.153280_bib0005","first-page":"271","article-title":"Cancer treatment and survivorship statistics, 2016","author":"Miller","year":"2016","journal-title":"CA Cancer J Clin. C.C."},{"issue":"10","key":"10.1016\/j.prp.2020.153280_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jnci\/djw166","article-title":"The efficacy and safety of first-line chemotherapy in advanced esophagogastric cancer: a network meta-analysis","volume":"108","author":"Ter Veer","year":"2016","journal-title":"J. Natl. Cancer Inst."},{"issue":"3","key":"10.1016\/j.prp.2020.153280_bib0015","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s10120-014-0402-y","article-title":"HER2 screening data from ToGA: targeting HER2 in gastric and gastroesophageal junction cancer","volume":"18","author":"Van Cutsem","year":"2015","journal-title":"Gastric Cancer"},{"issue":"1","key":"10.1016\/j.prp.2020.153280_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10120-013-0252-z","article-title":"HER2-positive gastric cancer","volume":"17","author":"Boku","year":"2014","journal-title":"Gastric Cancer"},{"issue":"3","key":"10.1016\/j.prp.2020.153280_bib0025","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s10120-015-0518-8","article-title":"Clinicopathological factors associated with HER2 status in gastric cancer: results from a prospective multicenter observational cohort study in a Japanese population (JFMC44-1101)","volume":"19","author":"Matsusaka","year":"2016","journal-title":"Gastric Cancer"},{"issue":"1","key":"10.1016\/j.prp.2020.153280_bib0030","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s10120-013-0239-9","article-title":"Evaluation of HER2-based biology in 1,006 cases of gastric cancer in a Japanese population","volume":"17","author":"Aizawa","year":"2014","journal-title":"Gastric Cancer"},{"issue":"11","key":"10.1016\/j.prp.2020.153280_bib0035","doi-asserted-by":"crossref","first-page":"80290","DOI":"10.1371\/journal.pone.0080290","article-title":"HER2 status in gastric and gastroesophageal junction cancer assessed by local and central laboratories: chinese results of the HER-EAGLE study","volume":"8","author":"Huang","year":"2013","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.prp.2020.153280_bib0040","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1093\/annonc\/mdt232","article-title":"HER2 status in gastric cancers: a retrospective analysis from four Chinese representative clinical centers and assessment of its prognostic significance","volume":"24","author":"Sheng","year":"2013","journal-title":"Ann. Oncol."},{"issue":"3","key":"10.1016\/j.prp.2020.153280_bib0045","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00404-016-4277-5","article-title":"The expression of Foxp3 and TLR4 in cervical cancer: association with immune escape and clinical pathology","volume":"295","author":"Zhang","year":"2017","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.prp.2020.153280_bib0050","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7813729","article-title":"A feasible method of angiogenesis assessment in gastric Cancer Using 3D microvessel density","volume":"2018","author":"Zhang","year":"2018","journal-title":"Stem Cells Int."},{"issue":"23","key":"10.1016\/j.prp.2020.153280_bib0055","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.3748\/wjg.v22.i23.5422","article-title":"Endocan-expressing microvessel density as a prognostic factor for survival in human gastric cancer","volume":"22","author":"Chang","year":"2016","journal-title":"World J. Gastroenterol."},{"issue":"42","key":"10.1016\/j.prp.2020.153280_bib0060","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000012854","article-title":"The relationship between HER2 overexpression and angiogenesis in gastric cancer","volume":"97","author":"Ciesielski","year":"2018","journal-title":"Med. (Baltimore)."},{"key":"10.1016\/j.prp.2020.153280_bib0065","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4103\/cytojournal.cytojournal_19_17","article-title":"Not all neck mass fine-needle aspirations with squamous cells are squamous cell carcinoma; report of a case of recurrent thyroid carcinoma with papillary and squamous components","volume":"15","author":"Dennis","year":"2018","journal-title":"Cytojournal"},{"issue":"1","key":"10.1016\/j.prp.2020.153280_bib0070","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.clbc.2018.09.012","article-title":"Phase 1b study of trebananib plus paclitaxel and trastuzumab in patients with HER2-Positive locally recurrent or metastatic breast Cancer","volume":"19","author":"Kaufman","year":"2019","journal-title":"Clin. Breast Cancer"},{"issue":"42","key":"10.1016\/j.prp.2020.153280_bib0075","doi-asserted-by":"crossref","first-page":"e12854","DOI":"10.1097\/MD.0000000000012854","article-title":"The relationship between HER2 overexpression and angiogenesis in gastric cancer","volume":"97","author":"Ciesielski","year":"2018","journal-title":"Med. (Baltimore)"},{"issue":"1","key":"10.1016\/j.prp.2020.153280_bib0080","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12967-018-1550-3","article-title":"Polyethylene glycol-conjugated HER2-targeted peptides as a nuclear imaging probe for HER2-overexpressed gastric cancer detection in vivo","volume":"16","author":"Guan","year":"2018","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.prp.2020.153280_bib0085","first-page":"9","article-title":"Analysis of HER2 expression and gene amplification in adenocarcinoma of the stomach and the gastro-oesophageal junction: rationale for the Belgian way of working","volume":"75","author":"Jouret-Mourin","year":"2012","journal-title":"Acta Gastroenterol. Belg."},{"issue":"8","key":"10.1016\/j.prp.2020.153280_bib0090","first-page":"528","article-title":"Guideline recommendations for, H.E.R.D.i.G.C.G., [Guidelines for HER2 detection in gastric cancer(2016)]","volume":"45","year":"2016","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"issue":"2","key":"10.1016\/j.prp.2020.153280_bib0095","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.annpat.2011.03.001","article-title":"[HER2 and gastric cancer. Recommendations for clinical practice in 2011]","volume":"31","author":"Penault-Llorca","year":"2011","journal-title":"Ann. Pathol."},{"issue":"24","key":"10.1016\/j.prp.2020.153280_bib0100","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/jnci\/84.24.1875","article-title":"Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma","volume":"84","author":"Weidner","year":"1992","journal-title":"J. Natl. Cancer Inst."},{"issue":"23","key":"10.1016\/j.prp.2020.153280_bib0105","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.3748\/wjg.v22.i23.5406","article-title":"Association of HER2 status with prognosis in gastric cancer patients undergoing R0 resection: a large-scale multicenter study in China","volume":"22","author":"Shen","year":"2016","journal-title":"World J. Gastroenterol."},{"issue":"10","key":"10.1016\/j.prp.2020.153280_bib0110","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1097\/PAS.0b013e3182635987","article-title":"Evaluation of reliability of FISH versus brightfield dual-probe in situ hybridization (BDISH) for frontline assessment of HER2 status in breast cancer samples in a community setting: influence of poor tissue preservation","volume":"36","author":"Schiavon","year":"2012","journal-title":"Am. J. Surg. Pathol."},{"issue":"6801","key":"10.1016\/j.prp.2020.153280_bib0115","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"Carmeliet","year":"2000","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.prp.2020.153280_bib0120","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.prp.2017.11.001","article-title":"Clinicopathological significance and prognostic role of microvessel density in gastric cancer: a meta-analysis","volume":"213","author":"Hong","year":"2017","journal-title":"Pathol. Res. Pract."},{"issue":"8","key":"10.1016\/j.prp.2020.153280_bib0125","doi-asserted-by":"crossref","first-page":"919","DOI":"10.2217\/bmm-2016-0026","article-title":"Relationship between microvessel density and cancer stem cells in tumor angiogenesis: a meta-analysis","volume":"10","author":"Lan","year":"2016","journal-title":"Biomark. Med."},{"issue":"8","key":"10.1016\/j.prp.2020.153280_bib0130","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1111\/cas.13288","article-title":"High-mobility group box-1 contributes tumor angiogenesis under interleukin-8 mediation during gastric cancer progression","volume":"108","author":"Chung","year":"2017","journal-title":"Cancer Sci."},{"issue":"6","key":"10.1016\/j.prp.2020.153280_bib0135","article-title":"MACC-1 promotes endothelium-dependent angiogenesis in gastric Cancer by activating TWIST1\/VEGF-A signal pathway","volume":"11","author":"Wang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2020.153280_bib0140","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1186\/s12885-016-2351-9","article-title":"Helicobacter pylori promotes angiogenesis depending on Wnt\/beta-catenin-mediated vascular endothelial growth factor via the cyclooxygenase-2 pathway in gastric cancer","volume":"16","author":"Liu","year":"2016","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.prp.2020.153280_bib0145","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/annonc\/mdp532","article-title":"HER2\/neu expression correlates with vascular endothelial growth factor-C and lymphangiogenesis in lymph node-positive breast cancer","volume":"21","author":"Schoppmann","year":"2010","journal-title":"Ann. Oncol."},{"issue":"4","key":"10.1016\/j.prp.2020.153280_bib0150","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s10120-014-0430-7","article-title":"Multicenter large-scale study of prognostic impact of HER2 expression in patients with resectable gastric cancer","volume":"18","author":"Kurokawa","year":"2015","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.prp.2020.153280_bib0155","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1186\/1471-2407-14-823","article-title":"Lauren classification combined with HER2 status is a better prognostic factor in Chinese gastric cancer patients","volume":"14","author":"Qiu","year":"2014","journal-title":"BMC Cancer"},{"issue":"11","key":"10.1016\/j.prp.2020.153280_bib0160","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3748\/wjg.v17.i11.1501","article-title":"Clinicopathologic significance of HER-2\/neu protein expression and gene amplification in gastric carcinoma","volume":"17","author":"Yan","year":"2011","journal-title":"World J. Gastroenterol."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S034403382032135X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S034403382032135X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:43:34Z","timestamp":1759733014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S034403382032135X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":32,"alternative-id":["S034403382032135X"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2020.153280","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relationship between HER2 expression and tumor interstitial angiogenesis in primary gastric cancer and its effect on prognosis","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2020.153280","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153280"}}