{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:40:58Z","timestamp":1790959258265,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.prp.2021.153346","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T09:45:28Z","timestamp":1611740728000},"page":"153346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Esophageal squamous cell carcinoma metachronous to head and neck cancers"],"prefix":"10.1016","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0045-9140","authenticated-orcid":false,"given":"Gianluca","family":"Businello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Fassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Degasperi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Traverso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania","family":"Scarpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imerio","family":"Angriman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andromachi","family":"Kotsafti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio","family":"Castagliuolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Sbaraglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romeo","family":"Bardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0217-6523","authenticated-orcid":false,"given":"Marco","family":"Scarpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"55","key":"10.1016\/j.prp.2021.153346_bib0005","first-page":"10","article-title":"Cancer statistics, 2005","author":"Jemal","year":"2005","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.prp.2021.153346_bib0010","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0039-6109(02)00029-4","article-title":"Multimodality therapy for esophageal cancer","volume":"82","author":"Refaely","year":"2002","journal-title":"Surg. Clin. North Am."},{"issue":"23","key":"10.1016\/j.prp.2021.153346_bib0015","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1056\/NEJMra035010","article-title":"Esophageal cancer","volume":"349","author":"Enzinger","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.prp.2021.153346_bib0020","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S1470-2045(03)01167-7","article-title":"The role of surgery in the management of oesophageal cancer","volume":"4","author":"Wu","year":"2003","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.prp.2021.153346_bib0025","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/01.sla.0000197698.17794.eb","article-title":"Risk factors for complications after esophageal cancer resection: a prospective population-based study in Sweden","volume":"243","author":"Viklund","year":"2006","journal-title":"Ann. Surg."},{"key":"10.1016\/j.prp.2021.153346_bib0030","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/cam4.2688","article-title":"Risk of second primary malignancies after definitive treatment for esophageal cancer: a competing risk analysis","volume":"9","author":"Mitani","year":"2020","journal-title":"Cancer Med."},{"issue":"July (1)","key":"10.1016\/j.prp.2021.153346_bib0035","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/ijc.32101","article-title":"Trends in the risk and burden of second primary malignancy among survivors of smoking-related cancers in the United States","volume":"145","author":"Adjei Boakye","year":"2019","journal-title":"Int. J. Cancer"},{"issue":"May (10)","key":"10.1016\/j.prp.2021.153346_bib0040","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1002\/cncr.27988","article-title":"Synchronous cancers in patients with head and neck cancer: risks in the era of human papillomavirus-associated oropharyngeal cancer","volume":"119","author":"Jain","year":"2013","journal-title":"Cancer"},{"issue":"April (4)","key":"10.1016\/j.prp.2021.153346_bib0045","first-page":"e62116","article-title":"The impact of second primary malignancies on head and neck cancer survivors: a nationwide cohort study","volume":"8","author":"LJ(1)","year":"2013","journal-title":"PLoS One"},{"issue":"January(1)","key":"10.1016\/j.prp.2021.153346_bib0050","article-title":"p53 expression: a potential biomarker for risk of multiple primary malignancies in the upper aerodigestive tract","volume":"31B","author":"Gallo","year":"1995","journal-title":"Eur. J. Cancer, B, Oral Oncol."},{"issue":"25","key":"10.1016\/j.prp.2021.153346_bib0055","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1056\/NEJMoa051424","article-title":"Effector memory T cells, early metastasis, and survival in colorectal cancer","volume":"353","author":"Pag\u00e8s","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"5795","key":"10.1016\/j.prp.2021.153346_bib0060","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1126\/science.1129139","article-title":"Type, density, and location of immune cells within human colorectal tumors predict clinical outcome","volume":"313","author":"Galon","year":"2006","journal-title":"Science"},{"issue":"October(13)","key":"10.1016\/j.prp.2021.153346_bib0065","doi-asserted-by":"crossref","first-page":"6036","DOI":"10.1002\/cam4.2359","article-title":"PD-L1 expression, CD8+ and CD4+ lymphocyte rate are predictive of pathological complete response after neoadjuvant chemoradiotherapy for squamous cell cancer of the thoracic esophagus","volume":"8","author":"Fassan","year":"2019","journal-title":"Cancer Med."},{"key":"10.1016\/j.prp.2021.153346_bib0070","series-title":"AJCC Cancer Staging Manual","author":"Edge","year":"2009"},{"issue":"8","key":"10.1016\/j.prp.2021.153346_bib0075","doi-asserted-by":"crossref","DOI":"10.1007\/s11605-013-2269-3","article-title":"Complete Clinical Response After Neoadjuvant Chemoradiotherapy for Squamous Cell Cancer of the Thoracic Oesophagus: Is Surgery Always Necessary?","volume":"17","author":"Castoro","year":"2013","journal-title":"J. Gastrointest. Surg."},{"issue":"3","key":"10.1016\/j.prp.2021.153346_bib0080","doi-asserted-by":"crossref","first-page":"330","DOI":"10.5858\/arpa.2018-0043-OA","article-title":"Clinical utility of the combined positive score for programmed death Ligand-1 expression and the approval of pembrolizumab for treatment of gastric cancer","volume":"143","author":"Kulangara","year":"2019","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"3","key":"10.1016\/j.prp.2021.153346_bib0085","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s10120-013-0315-1","article-title":"High-throughput mutation profiling identifies novel molecular dysregulation in high-grade intraepithelial neoplasia and early gastric cancers","volume":"17","author":"Fassan","year":"2014","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.prp.2021.153346_bib0090","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.humpath.2018.10.024","article-title":"Human papillomavirus infection is not involved in esophageal verrucous carcinoma","volume":"85","author":"Cappellesso","year":"2019","journal-title":"Hum. Pathol."},{"issue":"April (1)","key":"10.1016\/j.prp.2021.153346_bib0095","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.celrep.2018.03.063","article-title":"Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas","volume":"3","author":"Campbell","year":"2018","journal-title":"Cell Rep."},{"issue":"June(6)","key":"10.1016\/j.prp.2021.153346_bib0100","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1017\/S0950268814000016","article-title":"Association between human papillomavirus (HPV) and oesophageal squamous cell carcinoma: a meta-analysis","volume":"142","author":"Hardefeldt","year":"2014","journal-title":"Epidemiol. Infect."},{"issue":"October(10)","key":"10.1016\/j.prp.2021.153346_bib0105","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1158\/1055-9965.EPI-18-0287","article-title":"Oral Alpha, Beta, and Gamma HPV Types and Risk of Incident Esophageal Cancer","volume":"27","author":"Agalliu","year":"2018","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.prp.2021.153346_bib0110","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13027-017-0163-4","article-title":"HPV infection and p53 and p16 expression in esophageal cancer: are they prognostic factors?","volume":"12","author":"da Costa","year":"2017","journal-title":"Infect Agent Cancer."},{"issue":"July(1)","key":"10.1016\/j.prp.2021.153346_bib0115","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3892\/ol.2017.6196","article-title":"Expression of methylation-modulated tumor-related genes in endoscopically resected early esophageal squamous neoplasia","volume":"14","author":"Hosoda","year":"2017","journal-title":"Oncol. Lett."},{"issue":"December(12)","key":"10.1016\/j.prp.2021.153346_bib0120","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1002\/hed.23231","article-title":"Impact of p16, p53, smoking, and alcohol on survival in patients with oropharyngeal squamous cell carcinoma treated with primary intensity-modulated chemoradiation","volume":"35","author":"Broglie","year":"2013","journal-title":"Head Neck"},{"issue":"1","key":"10.1016\/j.prp.2021.153346_bib0125","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1365-2249.2010.04311.x","article-title":"Association of CD8+ T cell infiltration in oesophageal carcinoma lesions with human leucocyte antigen (HLA) class I antigen expression and survival","volume":"164","author":"Tsuchikawa","year":"2011","journal-title":"Clin. Exp. Immunol."},{"issue":"March (3)","key":"10.1016\/j.prp.2021.153346_bib0130","doi-asserted-by":"crossref","first-page":"e18219","DOI":"10.1371\/journal.pone.0018219","article-title":"The accumulation and prognosis value of tumor infiltrating IL-17 producing cells in esophageal squamous cell carcinoma","volume":"31","author":"Lv","year":"2011","journal-title":"PLoS One"},{"issue":"April (7)","key":"10.1016\/j.prp.2021.153346_bib0135","first-page":"1555","article-title":"CD4+ and CD8+ T cells cooperate to improve prognosis of patients with esophageal squamous cell carcinoma","volume":"63","author":"Cho","year":"2003","journal-title":"Cancer Res."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033821000078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033821000078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:45:14Z","timestamp":1759733114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033821000078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":27,"alternative-id":["S0344033821000078"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2021.153346","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Esophageal squamous cell carcinoma metachronous to head and neck cancers","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2021.153346","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153346"}}