{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:47:34Z","timestamp":1785160054869,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.prp.2021.153482","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T22:25:38Z","timestamp":1620858338000},"page":"153482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Degenerative nuclear atypia in pleomorphic adenoma of salivary glands: Histological and immunohistochemical observations"],"prefix":"10.1016","volume":"224","author":[{"given":"Asterios","family":"Triantafyllou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2021.153482_bib0005","series-title":"Tumors of the Peripheral Nervous System, Atlas of Tumor Pathology, third Series, fasc. 24","author":"Scheithauer","year":"1999"},{"key":"10.1016\/j.prp.2021.153482_bib0010","series-title":"Tumors of the Uterine Corpus and Gestational Trophoblastic Disease, Atlas of Tumor Pathology, third series, fasc. 3","author":"Sternberg","year":"1992"},{"key":"10.1016\/j.prp.2021.153482_bib0015","series-title":"Diagnostic Pathology and Molecular Genetics of the Thyroid","first-page":"119","article-title":"Follicular adenoma","author":"Nikiforov","year":"2012"},{"key":"10.1016\/j.prp.2021.153482_bib0020","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s004280050381","article-title":"Oncocytic myoepithelioma and pleomorphic adenoma of the salivary glands","volume":"434","author":"Sk\u00e1lov\u00e1","year":"1999","journal-title":"Virchows Arch."},{"key":"10.1016\/j.prp.2021.153482_bib0025","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s12105-014-0581-1","article-title":"Functional histology of salivary gland pleomorphic adenoma: an appraisal","volume":"9","author":"Triantafyllou","year":"2015","journal-title":"Head Neck Pathol."},{"key":"10.1016\/j.prp.2021.153482_bib0030","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00405-013-2488-y","article-title":"A perspective of comparative salivary and breast pathology. Part I: microstructural aspects, adaptations and cellular events","volume":"271","author":"Triantafyllou","year":"2014","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.prp.2021.153482_bib0035","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0030-4220(77)90410-8","article-title":"Pleomorphic adenomas of the parotid gland resembling mesenchymal tumors","volume":"44","author":"Merino","year":"1977","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"issue":"Supplement S1","key":"10.1016\/j.prp.2021.153482_bib0040","first-page":"S36","article-title":"Degenerative nuclear atypia in pleomorphic salivary adenoma: histological and immunohistochemical observations","volume":"240","author":"Triantafyllou","year":"2016","journal-title":"J. Pathol."},{"key":"10.1016\/j.prp.2021.153482_bib0045","series-title":"Tumors of the Salivary Glands. Atlas of Tumor Pathology, third series, fasc. 17","author":"Ellis","year":"1996"},{"key":"10.1016\/j.prp.2021.153482_bib0050","first-page":"652","article-title":"Atypical features in salivary gland mixed tumors: their relationship to malignant transformation","volume":"9","author":"Auclair","year":"1996","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.prp.2021.153482_bib0055","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.prp.2014.06.029","article-title":"Immunohistochemical localization of WT1 in epithelial salivary tumors","volume":"210","author":"Leader","year":"2014","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2021.153482_bib0060","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1600-0714.1997.tb00034.x","article-title":"Quantitation and localization of cycling tumor cells in pleomorphic adenomas and myoepitheliomas: an immunohistochemical analysis","volume":"26","author":"Norberg","year":"1997","journal-title":"J. Oral Pathol. Med."},{"issue":"Supplement S1","key":"10.1016\/j.prp.2021.153482_bib0065","first-page":"S21","article-title":"Immunohistochemical localisation of a calcium-activated chloride channel (DOG-1) in human epithelial salivary gland tumours: a reappraisal","volume":"250","author":"Nicholson","year":"2020","journal-title":"J. Pathol."},{"issue":"S1","key":"10.1016\/j.prp.2021.153482_bib0070","first-page":"S34","article-title":"Lysosomal activities and cellular homeostasis in epithelial tumours of salivary glands: an immunohistochemical investigation","volume":"231","author":"Ruggles","year":"2013","journal-title":"J. Pathol."},{"key":"10.1016\/j.prp.2021.153482_bib0075","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/path.1210","article-title":"Alterations of the INK4a-ARF gene locus in pleomorphic adenoma of the parotid gland","volume":"198","author":"Weber","year":"2002","journal-title":"J. Pathol."},{"key":"10.1016\/j.prp.2021.153482_bib0080","first-page":"1","article-title":"Morphogenesis of salivary gland tumors. A prerequisite to improving classification","volume":"22","author":"Dardick","year":"1987","journal-title":"Pathol. Annu."},{"key":"10.1016\/j.prp.2021.153482_bib0085","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1177\/10454411930040050201","article-title":"Current status of histogenetic and morphogenetic concepts of salivary gland tumorigenesis","volume":"4","author":"Dardick","year":"1993","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.prp.2021.153482_bib0090","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF01044960","article-title":"Mucosubstance histochemistry of pleomorphic adenoma of parotid and submandibular salivary glands of man: light and electron microscopy","volume":"23","author":"Harrison","year":"1991","journal-title":"Histochem. J."},{"key":"10.1016\/j.prp.2021.153482_bib0095","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/(SICI)1096-9896(1998100)186:2<178::AID-PATH161>3.0.CO;2-2","article-title":"Epithelial-mesenchymal transdifferentiation and extracellular matrix gene expression in pleomorphic adenomas of the parotid salivary gland","volume":"186","author":"Aigner","year":"1998","journal-title":"J. Pathol."},{"key":"10.1016\/j.prp.2021.153482_bib0100","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1136\/jcp.2005.031369","article-title":"Oncocytic change in pleomorphic adenoma: molecular evidence in support of an origin in neoplastic cells","volume":"60","author":"Di Palma","year":"2007","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.prp.2021.153482_bib0105","volume":"vol. 1","author":"Ghadially","year":"1988"},{"key":"10.1016\/j.prp.2021.153482_bib0110","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF01972195","article-title":"Proliferation of macrophages in inflammation","volume":"6","author":"Spector","year":"1976","journal-title":"Agents Actions"},{"key":"10.1016\/j.prp.2021.153482_bib0115","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/path.1711480205","article-title":"Evidence that multinucleate giant cells are examples of mononuclear phagocytic differentiation","volume":"148","author":"Papadimitriou","year":"1986","journal-title":"J. Pathol."},{"key":"10.1016\/j.prp.2021.153482_bib0120","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/dc.20951","article-title":"Pleomorphic adenoma: cytologic variations and potential diagnostic pitfalls","volume":"37","author":"Handa","year":"2009","journal-title":"Diagn. Cytopathol."},{"key":"10.1016\/j.prp.2021.153482_bib0125","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1002\/dc.24301","article-title":"Pleomorphic adenoma with bizarre myoepithelial cells: a diagnostic challenge on cytologic smear","volume":"47","author":"Taweevisit","year":"2019","journal-title":"Diagn. Cytopathol."},{"key":"10.1016\/j.prp.2021.153482_bib0130","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1046\/j.1440-1827.1999.00968.x","article-title":"An immunohistochemical study of bizarre neoplastic cells in pleomorphic adenoma: its cytological nature and proliferative activity","volume":"49","author":"Takeda","year":"1999","journal-title":"Pathol. Int."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033821001436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033821001436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:47:58Z","timestamp":1759733278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033821001436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":26,"alternative-id":["S0344033821001436"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2021.153482","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Degenerative nuclear atypia in pleomorphic adenoma of salivary glands: Histological and immunohistochemical observations","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2021.153482","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153482"}}