{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:29:37Z","timestamp":1784903377060,"version":"3.55.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:00:00Z","timestamp":1631923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.prp.2021.153624","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T14:44:28Z","timestamp":1632149068000},"page":"153624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Clinicopathological and prognostic value of STAT3\/p-STAT3 in cervical cancer: A meta and bioinformatics analysis"],"prefix":"10.1016","volume":"227","author":[{"given":"Shuai","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Yan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Gang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2021.153624_bib1","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.prp.2021.153624_bib2","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1200\/JCO.2017.35.15_suppl.1567","article-title":"Incidence and survival trends of cancers diagnosed in young adults (20-39 years): A population-based study","volume":"35","author":"Olga","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.prp.2021.153624_bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/rmv.1822","article-title":"Human papillomavirus molecular biology and disease association","volume":"25","author":"Doorbar","year":"2015","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.prp.2021.153624_bib4","first-page":"203","article-title":"Meta-analysis of the value of TCT and HPV in cervical screening","volume":"20","author":"Jin","year":"2014","journal-title":"J. Oncol."},{"key":"10.1016\/j.prp.2021.153624_bib5","first-page":"56","article-title":"Progress of cervical cancer screening technology","volume":"018","author":"Chang","year":"2018","journal-title":"Chin. remedies Clin."},{"key":"10.1016\/j.prp.2021.153624_bib6","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/ng.3178","article-title":"Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism","volume":"47","author":"Hu","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.prp.2021.153624_bib7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s12094-012-0789-z","article-title":"Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis[J]","volume":"14","author":"Sonnenblick","year":"2012","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.prp.2021.153624_bib8","first-page":"358","article-title":"The expression of IL-1\u03b2, IL-6, IL-17 and the correlation between HPV infection and cervical cancer","volume":"32","author":"Zhao","year":"2017","journal-title":"Pract. J. Cancer"},{"key":"10.1016\/j.prp.2021.153624_bib9","first-page":"361","article-title":"Expression of hmga1 and CK19 protein in serum of patients with cervical cancer and its clinical significance","volume":"32","author":"Tan","year":"2017","journal-title":"Pract. J. Cancer"},{"key":"10.1016\/j.prp.2021.153624_bib10","doi-asserted-by":"crossref","first-page":"8404","DOI":"10.1038\/sj.onc.1206047","article-title":"Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells","volume":"21","author":"Rahaman","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2021.153624_bib11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3835(03)00482-8","article-title":"Blockade of constitutively activated Janus kinase\/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer","volume":"201","author":"Toyonaga","year":"2003","journal-title":"Cancer Lett."},{"key":"10.1016\/j.prp.2021.153624_bib12","first-page":"727","article-title":"Expression of IL-6 and STAT3 in cervical cancer tissues and their correlation with HPV","volume":"4","author":"Yao","year":"2019","journal-title":"J. Clin. Res."},{"key":"10.1016\/j.prp.2021.153624_bib13","first-page":"611","article-title":"The expression and clinical significance of JNK and STAT3 protein in cervical lesions","volume":"29","author":"Chen","year":"2014","journal-title":"Pract. J. Cancer"},{"key":"10.1016\/j.prp.2021.153624_bib14","first-page":"1211","article-title":"The expression and significance of RACK1 and STAT3 protein in cervical cancer","volume":"36","author":"Wan","year":"2018","journal-title":"J. Prev. Med. Chin. People\u2019S. Lib. Army"},{"key":"10.1016\/j.prp.2021.153624_bib15","first-page":"23","article-title":"The expression and significance of STAT3 and CyclinD1 in cervical cancer","volume":"49","author":"Jia","year":"2009","journal-title":"Shandong Med. J."},{"key":"10.1016\/j.prp.2021.153624_bib16","first-page":"15","article-title":"The expression and significance of STAT3 and cyclinD1 protein in cervical squamous cell carcinoma","volume":"11","author":"Wang","year":"2008","journal-title":"Shandong Med. J."},{"key":"10.1016\/j.prp.2021.153624_bib17","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1681\/ASN.2016050573","article-title":"Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury","volume":"28","author":"Huang","year":"2017","journal-title":"J. Am. Soc. Nephrol.: JASN"},{"key":"10.1016\/j.prp.2021.153624_bib18","first-page":"1650","article-title":"The expression and significance of STAT3 and Survivin in cervical cancer","volume":"8","author":"Hui","year":"2011","journal-title":"J. Mod. Oncol."},{"key":"10.1016\/j.prp.2021.153624_bib19","first-page":"569","article-title":"The expression of STAT3 in cervical intraepithelial lesions and cervical cancer and its relationship with high-risk HPV infection","volume":"42","author":"Li","year":"2020","journal-title":"Hebei Med. J."},{"key":"10.1016\/j.prp.2021.153624_bib20","first-page":"2008","article-title":"Expression and significance of Tyk2\/Stat3 in cervical squamous cell carcinoma","volume":"25","author":"Chai","year":"2009","journal-title":"J. Pract. Med."},{"key":"10.1016\/j.prp.2021.153624_bib21","unstructured":"Wang H., He JY, Li SW, Li W., Gao Q. and Cai HB: Expression and role of high mobility group protein 1, signal transducer 3 and cervical cancer stem cell marker Nanog in cervical cancer. 39: 250\u2013355, 2018."},{"key":"10.1016\/j.prp.2021.153624_bib22","first-page":"93","article-title":"Expression of miR-21 and Stat3 in cervical cancer and their clinicopathological significance","volume":"39","author":"Yang","year":"2017","journal-title":"ZHEJIANG Med. J."},{"key":"10.1016\/j.prp.2021.153624_bib23","first-page":"1","article-title":"Expression changes of miRNA-125a, STAT3, and IL-10 in cervical carcinoma tissues","volume":"58","author":"Li","year":"2018","journal-title":"Shandong Med. J."},{"key":"10.1016\/j.prp.2021.153624_bib24","first-page":"298","article-title":"Expressions of stat3 and mmp-2 in cervical cancer","volume":"26","author":"Li","year":"2011","journal-title":"Med. J. QILU"},{"key":"10.1016\/j.prp.2021.153624_bib25","first-page":"104","article-title":"Expression and clinical significance of STAT3 and HMGB1 in cervical cancer tissue","volume":"16","author":"Zheng","year":"2019","journal-title":"China Med. Her."},{"key":"10.1016\/j.prp.2021.153624_bib26","first-page":"50","article-title":"Positive expression of activated protein kinase C receptor 1, signal transducer and activator of transcription 3 protein in cervical cancer","volume":"32","author":"Ju","year":"2019","journal-title":"Med. Equip."},{"key":"10.1016\/j.prp.2021.153624_bib27","first-page":"1396","article-title":"Expressions and correlation of IL-6 and Stat3 protein in cervical carcinomas","volume":"15","author":"Shu","year":"2008","journal-title":"Precis. Radiat. Oncol."},{"key":"10.1016\/j.prp.2021.153624_bib28","first-page":"618","article-title":"Expression and clinicopathological significance of STAT3 in cervix cancer","volume":"20","author":"Nong","year":"2011","journal-title":"Prog. Obstet. Gynecol."},{"key":"10.1016\/j.prp.2021.153624_bib29","first-page":"2344","article-title":"Expression and significances of PTEN,STAT3 and CyclinD1 in cervical cancer","volume":"27","author":"Guo","year":"2011","journal-title":"Matern. Child Health Care China"},{"key":"10.1016\/j.prp.2021.153624_bib30","first-page":"1544","article-title":"Clinicopathological significance of par3 and p-STA3 expression in cervical cancer","volume":"42","author":"Guo","year":"2019","journal-title":"J. Xinjiang Med. Univ."},{"key":"10.1016\/j.prp.2021.153624_bib31","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/sj.bjc.6605212","article-title":"Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma","volume":"101","author":"Takemoto","year":"2009","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.prp.2021.153624_bib32","first-page":"221","article-title":"Expression and clinicopathological significance of P-JAK2, P-STAT3 and mutant p53 proteins in cervical lesions","volume":"44","author":"Ma","year":"2016","journal-title":"Tianjin Med. J."},{"key":"10.1016\/j.prp.2021.153624_bib33","first-page":"1405","article-title":"The expression and significance of P-STAT3 protein in cervical lesions","volume":"16","author":"Zhu","year":"2014","journal-title":"Zhejiang Clin. Mdeical J."},{"key":"10.1016\/j.prp.2021.153624_bib34","first-page":"14","article-title":"Expression and significance of P-STAT3 and Ki67 in cervical cancer","volume":"48","author":"Wang","year":"2010","journal-title":"Mod. Chin. Dr."},{"key":"10.1016\/j.prp.2021.153624_bib35","first-page":"13","article-title":"Expression changes of pSTAT3, cyclin D1 and VEGF in cervical squamous cell carcinoma","volume":"53","author":"Wang","year":"2013","journal-title":"Shandong Med. J."},{"key":"10.1016\/j.prp.2021.153624_bib36","first-page":"1533","article-title":"Association of expressions of P-STAT3 and cyclinD1 with the pathological features in cervical carcinoma","volume":"24","author":"Wang","year":"2008","journal-title":"J. PRACTICAL Med."},{"key":"10.1016\/j.prp.2021.153624_bib37","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1126\/science.7690989","article-title":"A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma","volume":"261","author":"Shuai","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.prp.2021.153624_bib38","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1038\/sj.onc.1203483","article-title":"STAT signaling head and neck cancer","volume":"19","author":"Song","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2021.153624_bib39","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1182\/blood.V88.3.809.809","article-title":"Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines","volume":"88","author":"Weber-Nordt","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.prp.2021.153624_bib40","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/(SICI)1097-0215(19981029)78:3<326::AID-IJC12>3.0.CO;2-4","article-title":"STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells","volume":"78","author":"Shinichiro","year":"1998","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.prp.2021.153624_bib41","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1038\/sj.onc.1204349","article-title":"Constitutive activation of STAT3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells","volume":"20","author":"Gareia","year":"2001","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.prp.2021.153624_bib42","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3835(03)00482-8","article-title":"Blockade of constitutively activated Janus kinase signal transducer and activator of transcription-3 pathway inhibits growth of humanpancreatic cancer [J].","volume":"201","author":"Toyonaga","year":"2003","journal-title":"Cancer Lett."},{"key":"10.1016\/j.prp.2021.153624_bib43","first-page":"945","article-title":"Activated STAT signaling in human tumors provides novelmolecular targets for therapeutic intervention","volume":"8","author":"Buettner","year":"2002","journal-title":"Clin. Cancer Res"},{"key":"10.1016\/j.prp.2021.153624_bib44","doi-asserted-by":"crossref","first-page":"8404","DOI":"10.1038\/sj.onc.1206047","article-title":"Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells","volume":"21","author":"Rahaman","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2021.153624_bib45","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3835(03)00482-8","article-title":"Blockade of constitutively activated Janus kinase\/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer","volume":"201","author":"Toyonaga","year":"2003","journal-title":"Cancer Lett."},{"key":"10.1016\/j.prp.2021.153624_bib46","first-page":"1750","article-title":"Research progress on the mechanism of abnormally high activation of STAT3 to promote tumorigenesis and development","volume":"34","author":"Yang","year":"2017","journal-title":"Chin. J. Immunol."},{"key":"10.1016\/j.prp.2021.153624_bib47","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.1038\/sj.onc.1208719","article-title":"Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways","volume":"24","author":"Xu","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2021.153624_bib48","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1038\/sj.onc.1206226","article-title":"Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway","volume":"22","author":"Wei","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2021.153624_bib49","first-page":"3074","article-title":"Research review of the relationship between STAT3 and tumor","volume":"27","author":"Zheng","year":"2015","journal-title":"Mod. J. Integr. Tradit. Chin. West. Med."},{"key":"10.1016\/j.prp.2021.153624_bib50","first-page":"11","article-title":"Expression of Stem Cell Related Transcription Factors 3, High-Mobility Group Box 1, and Stem Cell Markers Nanog and Their Significance in Cervical Cancer","volume":"39","author":"Wang","year":"2018","journal-title":"Med. J. Wuhan. Univ."},{"issue":"3","key":"10.1016\/j.prp.2021.153624_bib51","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s12094-012-0789-z","article-title":"Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis[J]","volume":"14","author":"Sonnenblick","year":"2012","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.prp.2021.153624_bib52","first-page":"430","article-title":"Expressions of STAT3, p-STAT3 and Bcl-xL in Gastric Carcinoma and Their Clinical Significance","volume":"41","author":"Zhang","year":"2014","journal-title":"Cancer Res. Prev. Treat."},{"key":"10.1016\/j.prp.2021.153624_bib53","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1038\/sj.onc.1207383","article-title":"Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis","volume":"23","author":"Xie","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2021.153624_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006975","article-title":"STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle","volume":"14","author":"Morgan","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.prp.2021.153624_bib55","first-page":"105","article-title":"Research progress on the relationship between signal transducer and activator of transcription 3 and cervical cancer","volume":"55","author":"Zhang","year":"2015","journal-title":"Shandong Med. J."},{"key":"10.1016\/j.prp.2021.153624_bib56","doi-asserted-by":"crossref","first-page":"633","DOI":"10.2353\/ajpath.2006.051109","article-title":"Signal Transducers and Activators of Transcription-3 Up-Regulates Tissue Inhibitor of Metalloproteinase-1 Expression and Decreases Invasiveness of Breast Cancer","volume":"169","author":"Dien","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2021.153624_bib57","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1136\/jcp.2004.023416","article-title":"Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors","volume":"58","author":"Kusaba","year":"2005","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.prp.2021.153624_bib58","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ejso.2013.11.012","article-title":"A meta-analysis of STAT3 and phospho-STAT3 expression and survival of patients with non-small-cell lung cancer","volume":"40","author":"Xu","year":"2014","journal-title":"Eur. J. Surg. Oncol."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033821002855?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033821002855?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:47:32Z","timestamp":1759733252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033821002855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":58,"alternative-id":["S0344033821002855"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2021.153624","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinicopathological and prognostic value of STAT3\/p-STAT3 in cervical cancer: A meta and bioinformatics analysis","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2021.153624","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153624"}}