{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:42:53Z","timestamp":1777869773052,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007397","name":"Charles University","doi-asserted-by":"publisher","award":["BBMRI-CZ LM2018125"],"award-info":[{"award-number":["BBMRI-CZ LM2018125"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.prp.2021.153636","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T06:28:30Z","timestamp":1632724110000},"page":"153636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Calcific aortic valve stenosis \u2013 comparison of inflammatory lesions in the left, right, and non-coronary cusp"],"prefix":"10.1016","volume":"227","author":[{"given":"Ivo","family":"\u0160teiner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salifu","family":"Timbilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6129-9841","authenticated-orcid":false,"given":"V\u00e1clav","family":"Stejskal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2021.153636_bib1","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1161\/CIRCULATIONAHA.104.486738","article-title":"Spectrum of calcific aortic valve disease. Pathogenesis, disease progression, and treatment strategies","volume":"111","author":"Freeman","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.prp.2021.153636_bib2","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1161\/01.ATV.0000227513.13697.ac","article-title":"Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more)","volume":"26","author":"O\u2019Brien","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.prp.2021.153636_bib3","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1161\/ATVBAHA.119.313067","article-title":"Aortic valve stenosis. From basic mechanisms to novel therapeutic targets","volume":"40","author":"Goody","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.prp.2021.153636_bib4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.atherosclerosis.2020.02.016","article-title":"Innate and adaptive immunity in cardiovascular calcification","volume":"306","author":"Passos","year":"2020","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.prp.2021.153636_bib5","doi-asserted-by":"crossref","first-page":"108","DOI":"10.15420\/ecr.2015.10.2.108","article-title":"Calcific aortic valve disease: molecular mechanisms and therapeutic approaches","volume":"10","author":"Lerman","year":"2015","journal-title":"Eur. Cardiol."},{"key":"10.1016\/j.prp.2021.153636_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006339","article-title":"Valve interstitial cells: the key to understanding the pathophysiology of heart valve calcification","volume":"6","author":"Rutkovskiy","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.prp.2021.153636_bib7","doi-asserted-by":"crossref","first-page":"H141","DOI":"10.1152\/ajpheart.00100.2019","article-title":"Adaptive immune cells in calcific aortic valve disease","volume":"317","author":"Raddatz","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.prp.2021.153636_bib8","first-page":"33","article-title":"Blood vessels and lymphatics in calcific aortic stenosis \u2013 in support of its inflammatory pathogenesis","volume":"46","author":"\u0160teiner","year":"2010","journal-title":"\u010ces. Slov. Patol."},{"key":"10.1016\/j.prp.2021.153636_bib9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.prp.2012.02.009","article-title":"Calcific aortic valve stenosis: Immunohistochemical analysis of inflammatory infiltrate","volume":"208","author":"\u0160teiner","year":"2012","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2021.153636_bib10","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.prp.2017.07.016","article-title":"Mast cells in calcific aortic stenosis","volume":"214","author":"\u0160teiner","year":"2018","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2021.153636_bib11","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00428-007-0430-7","article-title":"Bone formation in cardiac valves: a histopathological study of 128 cases","volume":"450","author":"\u0160teiner","year":"2007","journal-title":"Virchows Arch."},{"key":"10.1016\/j.prp.2021.153636_bib12","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1161\/01.CIR.103.11.1522","article-title":"Bone formation and inflammation in cardiac valves","volume":"103","author":"Mohler","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.prp.2021.153636_bib13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.carpath.2005.03.005","article-title":"Cardiac valves and valvular pathology. Update on function, disease, repair, and replacement","volume":"14","author":"Schoen","year":"2005","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.prp.2021.153636_bib14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.carpath.2006.04.007","article-title":"Pathology of inflammatory native valvular heart disease","volume":"15","author":"Veinot","year":"2006","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.prp.2021.153636_bib15","series-title":"Cardiovascular Pathology","first-page":"420","author":"Silver","year":"2011"},{"key":"10.1016\/j.prp.2021.153636_bib16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.carpath.2010.12.001","article-title":"The aortic valve microenvironment and its role in calcific aortic valve disease","volume":"20","author":"Yip","year":"2011","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.prp.2021.153636_bib17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.carpath.2015.08.008","article-title":"Osseous and chondromatous metaplasia in calcific aortic valve stenosis","volume":"25","author":"Torre","year":"2016","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.prp.2021.153636_bib18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11886-019-1162-4","article-title":"Pathology of the aortic valve: aortic valve stenosis\/aortic regurgitation","volume":"21","author":"Fishbein","year":"2019","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.prp.2021.153636_bib19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/ATVBAHA.120.314287","article-title":"Human aortic valve interstitial cells display proangiogenic properties during calcific aortic valve disease","volume":"41","author":"Gendron","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.prp.2021.153636_bib20","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11883-020-0821-7","article-title":"Calcific aortic valve stenosis and atherosclerotic calcification","volume":"22","author":"de Oliveira S\u00e1","year":"2020","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.prp.2021.153636_bib21","article-title":"Hemodynamics and mechanobiology of aortic valve inflammation and calcification","volume":"2011","author":"Balachandran","year":"2011","journal-title":"Int. J. Inflam."},{"key":"10.1016\/j.prp.2021.153636_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.carpath.2021.107318","article-title":"Cellular senescence evaluated by P16INK4a immunohistochemistry is a prevalent phenomenon in advanced calcific aortic valve disease","volume":"52","author":"Oh","year":"2021","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.prp.2021.153636_bib23","doi-asserted-by":"crossref","first-page":"7434","DOI":"10.3390\/ijms21207434","article-title":"Ultrastructural pathology of atherosclerosis, calcific aortic valve disease, and bioprosthetic heart valve degeneration: commonalities and differences","volume":"21","author":"Kostyunin","year":"2020","journal-title":"IJMS"},{"key":"10.1016\/j.prp.2021.153636_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carpath.2012.06.005","article-title":"The progression of calcific aortic valve disease through injury, cell dysfunction, and disruptive biologic and physical force feedback loops","volume":"22","author":"Li","year":"2013","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.prp.2021.153636_bib25","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/j.amjcard.2004.08.013","article-title":"Mechanisms of aortic valve calcification","volume":"94","author":"Mohler","year":"2004","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.prp.2021.153636_bib26","doi-asserted-by":"crossref","first-page":"e296","DOI":"10.1161\/ATVBAHA.120.315261","article-title":"Secreted factors from proinflammatory macrophages promote an osteoblast-like phenotype in valvular interstitial cells","volume":"40","author":"Grim","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033821002971?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033821002971?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:38:42Z","timestamp":1777559922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033821002971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":26,"alternative-id":["S0344033821002971"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2021.153636","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Calcific aortic valve stenosis \u2013 comparison of inflammatory lesions in the left, right, and non-coronary cusp","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2021.153636","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153636"}}