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Oncol."},{"key":"10.1016\/j.prp.2022.153970_bib66","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3164\/jcbn.21.141","article-title":"Inhibition of 4-nitroquinoline-1-oxide-induced oral carcinogenesis by plant products","volume":"21","author":"Manoharan","year":"1996","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.prp.2022.153970_bib67","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cbi.2008.01.010","article-title":"Chemopreventive and therapeutic modulation of green tea polyphenols on drug metabolizing enzymes in 4-Nitroquinoline 1-oxide induced oral cancer","volume":"172","author":"Srinivasan","year":"2008","journal-title":"Chem. Biol. 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