{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T17:18:45Z","timestamp":1786295925722,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI21C113701"],"award-info":[{"award-number":["HI21C113701"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.prp.2022.154108","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T12:05:38Z","timestamp":1662465938000},"page":"154108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Gastric cancer with Epstein-Barr virus heterogeneity: Evaluation of the frequency, clinicopathologic features, and genomic profiles"],"prefix":"10.1016","volume":"238","author":[{"given":"Han-Na","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soomin","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung-Mee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2022.154108_bib1","first-page":"769","article-title":"Epstein-Barr virus-associated gastric adenocarcinoma","volume":"140","author":"Shibata","year":"1992","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2022.154108_bib2","first-page":"1250","article-title":"Epstein-Barr virus in gastric carcinoma","volume":"143","author":"Tokunaga","year":"1993","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2022.154108_bib3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/mp.53.5.255","article-title":"Epstein-Barr virus and gastric carcinoma","volume":"53","author":"Takada","year":"2000","journal-title":"Mol. Pathol."},{"key":"10.1016\/j.prp.2022.154108_bib4","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1440-1746.2009.05775.x","article-title":"Clinicopathological and molecular characteristics of Epstein-Barr virus-associated gastric carcinoma: a meta-analysis","volume":"24","author":"Lee","year":"2009","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.prp.2022.154108_bib5","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1136\/gutjnl-2013-304531","article-title":"Improved survival of gastric cancer with tumour Epstein-Barr virus positivity: an international pooled analysis","volume":"63","author":"Camargo","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.prp.2022.154108_bib6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1053\/j.gastro.2010.04.002","article-title":"Host inflammatory response predicts survival of patients with Epstein-Barr virus-associated gastric carcinoma","volume":"139","author":"Song","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.prp.2022.154108_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/01.pas.0000176428.06629.1e","article-title":"Morphological evidence of an activated cytotoxic T-cell infiltrate in EBV-positive gastric carcinoma preventing lymph node metastases","volume":"30","author":"van Beek","year":"2006","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2022.154108_bib8","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/s41591-018-0101-z","article-title":"Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer","volume":"24","author":"Kim","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.prp.2022.154108_bib9","doi-asserted-by":"crossref","first-page":"24269","DOI":"10.18632\/oncotarget.8169","article-title":"PD-L1 is an independent prognostic predictor in gastric cancer of Western patients","volume":"7","author":"B\u00f6ger","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2022.154108_bib10","doi-asserted-by":"crossref","first-page":"32925","DOI":"10.18632\/oncotarget.9076","article-title":"Abundant PD-L1 expression in Epstein-Barr Virus-infected gastric cancers","volume":"7","author":"Derks","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2022.154108_bib11","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.humpath.2016.05.012","article-title":"PD-L1 expression is associated with massive lymphocyte infiltration and histology in gastric cancer","volume":"55","author":"Li","year":"2016","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2022.154108_bib12","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1158\/1078-0432.CCR-15-2834","article-title":"Pan-cancer immunogenomic perspective on the tumor microenvironment based on PD-L1 and CD8 T-cell infiltration","volume":"22","author":"Ock","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2022.154108_bib13","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10120-016-0631-3","article-title":"Clinicopathological features of programmed death ligand 1 expression with tumor-infiltrating lymphocyte, mismatch repair, and Epstein-Barr virus status in a large cohort of gastric cancer patients","volume":"20","author":"Kawazoe","year":"2017","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.prp.2022.154108_bib14","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.prp.2022.154108_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.critrevonc.2016.02.007","article-title":"Translating gastric cancer genomics into targeted therapies","volume":"100","author":"Ang","year":"2016","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.prp.2022.154108_bib16","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.3892\/ijo.2015.2856","article-title":"Update on Epstein-Barr virus and gastric cancer (Review","volume":"46","author":"Shinozaki-Ushiku","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.prp.2022.154108_bib17","first-page":"469","article-title":"Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration. Lymphoepithelioma-like carcinoma","volume":"139","author":"Shibata","year":"1991","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2022.154108_bib18","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1440-1827.1997.tb04509.x","article-title":"Morphological characteristics of Epstein-Barr virus-related early gastric carcinoma: a case-control study","volume":"47","author":"Arikawa","year":"1997","journal-title":"Pathol. Int."},{"key":"10.1016\/j.prp.2022.154108_bib19","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/annonc\/mdx047","article-title":"Epstein-Barr virus-associated gastric cancer reveals intratumoral heterogeneity of PIK3CA mutations","volume":"28","author":"B\u00f6ger","year":"2017","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.prp.2022.154108_bib20","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1002\/ijc.32228","article-title":"Bridging genomics and phenomics of gastric carcinoma","volume":"145","author":"Cho","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.prp.2022.154108_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13027-017-0151-8","article-title":"Prevalence and characteristics of Epstein-Barr virus-associated gastric carcinomas in Portugal","volume":"12","author":"Nogueira","year":"2017","journal-title":"Infect. Agent Cancer"},{"key":"10.1016\/j.prp.2022.154108_bib22","series-title":"PD-L1 IHC 22C3 pharmDx Interpretation Manual: Gastric Or Gastroesophageal Juction Adenocarcinoma","year":"2018"},{"key":"10.1016\/j.prp.2022.154108_bib23","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2022.154108_bib24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.21873\/cgp.20307","article-title":"High frequency of juxtamembrane domain ERBB2 mutation in gastric cancer","volume":"19","author":"Park","year":"2022","journal-title":"Cancer Genom. Proteom."},{"key":"10.1016\/j.prp.2022.154108_bib25","doi-asserted-by":"crossref","first-page":"386","DOI":"10.5483\/BMBRep.2021.54.7.045","article-title":"Paired analysis of tumor mutation burden calculated by targeted deep sequencing panel and whole exome sequencing in non-small cell lung cancer","volume":"54","author":"Park","year":"2021","journal-title":"BMB Rep."},{"key":"10.1016\/j.prp.2022.154108_bib26","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1053\/j.gastro.2009.05.001","article-title":"Meta-analysis shows that prevalence of epstein\u2013barr virus-positive gastric cancer differs based on sex and anatomic location","volume":"137","author":"Murphy","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.prp.2022.154108_bib27","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s00428-005-0066-4","article-title":"Intratumour T cells, their activation status and survival in gastric carcinomas characterised for microsatellite instability and Epstein-Barr virus infection","volume":"448","author":"Chiaravalli","year":"2006","journal-title":"Virchows Arch."},{"key":"10.1016\/j.prp.2022.154108_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2014.93","article-title":"Genomic assays for Epstein-Barr virus-positive gastric adenocarcinoma","volume":"47","author":"Gulley","year":"2015","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.prp.2022.154108_bib29","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1053\/j.gastro.2014.09.020","article-title":"Deregulation of immune response genes in patients With Epstein-Barr virus-associated gastric cancer and outcomes","volume":"148","author":"Kim","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.prp.2022.154108_bib30","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1038\/s41598-019-41177-2","article-title":"PD-L1 expression combined with microsatellite instability\/CD8+ tumor infiltrating lymphocytes as a useful prognostic biomarker in gastric cancer","volume":"9","author":"Morihiro","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2022.154108_bib31","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/MCG.0b013e318249c4b8","article-title":"Epstein-Barr virus-associated gastric carcinoma: a newly defined entity","volume":"46","author":"Chen","year":"2012","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.prp.2022.154108_bib32","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nature13480","article-title":"Comprehensive molecular characterization of gastric adenocarcinoma","volume":"513","year":"2014","journal-title":"Nature"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033822003521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033822003521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:56:30Z","timestamp":1759733790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033822003521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":32,"alternative-id":["S0344033822003521"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2022.154108","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastric cancer with Epstein-Barr virus heterogeneity: Evaluation of the frequency, clinicopathologic features, and genomic profiles","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2022.154108","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154108"}}