{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:25:01Z","timestamp":1778700301247,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.prp.2022.154184","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T12:10:52Z","timestamp":1666267852000},"page":"154184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The spectrum of intestinal mature T- and NK-cell neoplasms in a tertiary center in Taiwan with a high frequency of perforation"],"prefix":"10.1016","volume":"240","author":[{"given":"Ren Ching","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Jung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Tsu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Han","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Yu","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia Hueimei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Hsiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Sung","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2022.154184_bib1","series-title":"IARC (Ed.), WHO Classification of Tumours. Digestive System Tumours","first-page":"373","article-title":"Haematolymphoid tumours of the digestive tract","author":"Chan","year":"2019"},{"key":"10.1016\/j.prp.2022.154184_bib2","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1200\/JCO.1994.12.8.1673","article-title":"Non-Hodgkin's lymphoma of the gastrointestinal tract: a population-based analysis of incidence, geographic distribution, clinicopathologic presentation features, and prognosis. Danish Lymphoma Study Group","volume":"12","author":"d'Amore","year":"1994","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.prp.2022.154184_bib3","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1002\/1097-0142(20001001)89:7<1586::AID-CNCR24>3.0.CO;2-1","article-title":"Malignant lymphoma in southern Taiwan according to the revised European\u2013American classification of lymphoid neoplasms","volume":"89","author":"Chuang","year":"2000","journal-title":"Cancer: Interdiscip. Int. J. Am. Cancer Soc."},{"key":"10.1016\/j.prp.2022.154184_bib4","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1002\/cncr.11415","article-title":"Primary gastrointestinal lymphoma in Japan: a clinicopathologic analysis of 455 patients with special reference to its time trends","volume":"97","author":"Nakamura","year":"2003","journal-title":"Cancer: Interdiscip. Int. J. Am. Cancer Soc."},{"key":"10.1016\/j.prp.2022.154184_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-11-321","article-title":"Multicenter retrospective analysis of 581 patients with primary intestinal non-hodgkin lymphoma from the Consortium for Improving Survival of Lymphoma (CISL)","volume":"11","author":"Kim","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.prp.2022.154184_bib6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s12185-014-1520-3","article-title":"Peripheral T cell lymphoma in Asia","volume":"99","author":"Park","year":"2014","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.prp.2022.154184_bib7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.pathol.2019.10.001","article-title":"T-and NK-cell lymphoproliferative disorders of the gastrointestinal tract: review and update","volume":"52","author":"van Vliet","year":"2020","journal-title":"Pathology"},{"key":"10.1016\/j.prp.2022.154184_bib8","unstructured":"S.H. Swerdlow, E. Campo, N.L. Haris, E.S. Jaffe, S.A. Pileri, H. Stein, J. Thiele, D.A. Arber, R.P. Hassejian, M.M.L. Beau, AttilioOrazi, R. Siebert, W.H.O. Classification of Tumours of Haematopietic and Lymphoid Tissue, IARC Lyon, 2017."},{"key":"10.1016\/j.prp.2022.154184_bib9","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1097\/PAS.0b013e3181a95c63","article-title":"NK-cell lineage predicts poor survival in primary intestinal NK-cell and T-cell lymphomas","volume":"33","author":"Chuang","year":"2009","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2022.154184_bib10","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1038\/leu.2013.41","article-title":"Type II EATL (epitheliotropic intestinal T-cell lymphoma): a neoplasm of intra-epithelial T-cells with predominant CD8\u03b1\u03b1 phenotype","volume":"27","author":"Tan","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.prp.2022.154184_bib11","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1084\/jem.20160894","article-title":"Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2","volume":"214","author":"Moffitt","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.prp.2022.154184_bib12","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/S0002-9440(10)65736-7","article-title":"Most CD56+ intestinal lymphomas are CD8+CD5-T-cell lymphomas of monomorphic small to medium size histology","volume":"153","author":"Chott","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2022.154184_bib13","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1097\/PAS.0b013e318222dfcd","article-title":"Type II enteropathy-associated T-cell lymphoma: a distinct aggressive lymphoma with frequent \u03b3\u03b4 T-cell receptor expression","volume":"35","author":"Chan","year":"2011","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2022.154184_bib14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1756-8722-6-86","article-title":"Extranodal natural killer\/T-cell lymphoma involving the gastrointestinal tract: analysis of clinical features and outcomes from the Asia Lymphoma Study Group","volume":"6","author":"Kim","year":"2013","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.prp.2022.154184_bib15","doi-asserted-by":"crossref","DOI":"10.1097\/PAS.0000000000001914","article-title":"Targeted next-generation sequencing reveals a wide morphologic and immunophenotypic spectrum of monomorphic epitheliotropic intestinal T-cell lymphoma","author":"Hang","year":"2022","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2022.154184_bib16","doi-asserted-by":"crossref","DOI":"10.3324\/haematol.2022.281226","article-title":"Monomorphic epitheliotropic intestinal T-cell lymphoma comprises morphologic and genomic heterogeneity impacting outcome","author":"Veloza","year":"2022","journal-title":"Haematologica"},{"key":"10.1016\/j.prp.2022.154184_bib17","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1200\/JCO.2013.54.8800","article-title":"Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification","volume":"32","author":"Cheson","year":"2014","journal-title":"J. Clin. Oncol.: Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.prp.2022.154184_bib18","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.humpath.2004.01.013","article-title":"Natural killer cell lymphoma of small intestine with features of enteropathy but lack of association with celiac disease","volume":"35","author":"Chuang","year":"2004","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2022.154184_bib19","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.pathol.2017.05.007","article-title":"Primary gastrointestinal anaplastic large cell lymphoma","volume":"49","author":"Lee","year":"2017","journal-title":"Pathology"},{"key":"10.1016\/j.prp.2022.154184_bib20","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/j.prp.2018.10.002","article-title":"Primary cutaneous peripheral T-cell lymphoma with a late relapse solely in the ileum mimicking monomorphic epitheliotropic intestinal T-cell lymphoma","volume":"214","author":"Pan","year":"2018","journal-title":"Pathol. -Res. Pract."},{"key":"10.1016\/j.prp.2022.154184_bib21","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.critrevonc.2010.06.006","article-title":"Enteropathy-associated T-cell lymphoma","volume":"79","author":"Ferreri","year":"2011","journal-title":"Crit. Rev. Oncol. \/Hematol."},{"key":"10.1016\/j.prp.2022.154184_bib22","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/ajh.23213","article-title":"Type II enteropathy-associated T-cell lymphoma: A multicenter analysis from the Asia Lymphoma Study Group","volume":"87","author":"Tse","year":"2012","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.prp.2022.154184_bib23","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.humpath.2009.11.020","article-title":"Enteropathy-associated T-cell lymphoma--a clinicopathologic and array comparative genomic hybridization study","volume":"41","author":"Ko","year":"2010","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2022.154184_bib24","first-page":"254","article-title":"WHO Classification of Malignant Lymphomas in Korea: Report of the Third Nationwide Study","volume":"45","author":"Kim","year":"2011","journal-title":"J. Pathol. Transl. Med"},{"key":"10.1016\/j.prp.2022.154184_bib25","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000002119","article-title":"Primary gastrointestinal lymphoma: a retrospective multicenter clinical study of 415 cases in Chinese province of Guangdong and a systematic review containing 5075 Chinese patients","volume":"94","author":"Chen","year":"2015","journal-title":"Medicine"},{"key":"10.1016\/j.prp.2022.154184_bib26","first-page":"2718","article-title":"Clinicopathological characteristics and prognostic factors of primary gastrointestinal lymphoma: a 22-year experience from South China","volume":"7","author":"Li","year":"2014","journal-title":"Int J. Clin. Exp. Pathol."},{"key":"10.1016\/j.prp.2022.154184_bib27","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/16078454.2021.1889160","article-title":"A 10-year cohort study of 175 primary gastrointestinal lymphoma cases in Thailand: clinical features and outcomes in the immunochemotherapy era","volume":"26","author":"Owattanapanich","year":"2021","journal-title":"Hematology"},{"key":"10.1016\/j.prp.2022.154184_bib28","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1078\/0344-0338-00270","article-title":"Clinicopathological features of primary intestinal lymphoma in Taiwan: a study of 21 resected cases","volume":"198","author":"Chuang","year":"2002","journal-title":"Pathol. - Res. Pract."},{"key":"10.1016\/j.prp.2022.154184_bib29","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/PAI.0000000000000226","article-title":"Primary intestinal diffuse large B-cell lymphoma in taiwan showed a relative higher rate of perforation and EBV association","volume":"24","author":"Lu","year":"2016","journal-title":"Appl. Immunohistochem. Mol. Morphol.: AIMM"},{"key":"10.1016\/j.prp.2022.154184_bib30","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1097\/PAS.0b013e3181a95c63","article-title":"NK-cell lineage predicts poor survival in primary intestinal NK-cell and T-cell lymphomas","volume":"33","author":"Chuang","year":"2009","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2022.154184_bib31","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1365-2559.2008.03140.x","article-title":"Perforation predicts poor prognosis in patients with primary intestinal diffuse large B-cell lymphoma","volume":"53","author":"Chuang","year":"2008","journal-title":"Histopathology"},{"key":"10.1016\/j.prp.2022.154184_bib32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0140-6736(78)90004-1","article-title":"Intestinal lymphoma associated with malabsorption","volume":"1","author":"Isaacson","year":"1978","journal-title":"Lancet (Lond., Engl.)"},{"key":"10.1016\/j.prp.2022.154184_bib33","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1182\/blood.V94.1.260.413k40_260_264","article-title":"Mucosal Intra-epithelial Lymphocytes in Enteropathy-Associated T-Cell Lymphoma, Ulcerative Jejunitis, and Refractory Celiac Disease Constitute a Neoplastic Population","volume":"94","author":"Bagdi","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.prp.2022.154184_bib34","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/modpathol.2011.45","article-title":"Primary intestinal T-cell and NK-cell lymphomas: a clinicopathological and molecular study from China focused on type II enteropathy-associated T-cell lymphoma and primary intestinal NK-cell lymphoma","volume":"24","author":"Sun","year":"2011","journal-title":"Mod. Pathol.: Off. J. U. S. Can. Acad. Pathol., Inc."},{"key":"10.1016\/j.prp.2022.154184_bib35","doi-asserted-by":"crossref","first-page":"12602","DOI":"10.1038\/ncomms12602","article-title":"Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations","volume":"7","author":"Roberti","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.prp.2022.154184_bib36","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.3390\/cancers12123539","article-title":"Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma in Asia Frequently Shows SETD2 Alterations","volume":"12","author":"Tomita","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.prp.2022.154184_bib37","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.3390\/cancers13215463","article-title":"Machine learning based on morphological features enables classification of primary intestinal t-cell lymphomas","volume":"13","author":"Yu","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.prp.2022.154184_bib38","doi-asserted-by":"crossref","first-page":"e541","DOI":"10.1016\/S2352-3026(20)30121-6","article-title":"Machine learning in haematological malignancies","volume":"7","author":"Radakovich","year":"2020","journal-title":"Lancet Haematol."},{"issue":"17","key":"10.1016\/j.prp.2022.154184_bib39","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1182\/blood-2008-10-185256","article-title":"Clinical differences between nasal and extranasal natural killer\/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project","volume":"113","author":"Au","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.prp.2022.154184_bib40","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1007\/s00277-019-03689-9","article-title":"Improved prognosis of extranodal NK\/T cell lymphoma, nasal type of nasal origin but not extranasal origin","volume":"98","author":"Yamaguchi","year":"2019","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.prp.2022.154184_bib41","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1600-0609.2012.01796.x","article-title":"Clinical features and prognostic model for extranasal NK\/T-cell lymphoma","volume":"89","author":"Jo","year":"2012","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.prp.2022.154184_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/PAS.0000000000000312","article-title":"Primary cutaneous NK\/T-cell lymphoma, nasal type and CD56-positive peripheral T-cell lymphoma: a cellular lineage and clinicopathologic study of 60 patients from Asia","volume":"39","author":"Takata","year":"2015","journal-title":"Am. J. Surg. Pathol."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033822004289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033822004289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:52:56Z","timestamp":1759733576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033822004289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":42,"alternative-id":["S0344033822004289"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2022.154184","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The spectrum of intestinal mature T- and NK-cell neoplasms in a tertiary center in Taiwan with a high frequency of perforation","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2022.154184","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154184"}}