{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T06:32:22Z","timestamp":1789281142622,"version":"build-2803163510"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.prp.2022.154266","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T19:50:04Z","timestamp":1670529004000},"page":"154266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Association of PD-L1 and p16 expression with clinicopathological parameters in oral cavity and oropharyngeal squamous cell carcinoma"],"prefix":"10.1016","volume":"241","author":[{"given":"Richa","family":"Kareer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4630-016X","authenticated-orcid":false,"given":"Sana","family":"Ahuja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neena","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2022.154266_bib1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.coms.2014.01.001","article-title":"Epidemiologic trends in head and neck cancer and aids in diagnosis","volume":"26","author":"Vigneswaran","year":"2014","journal-title":"Oral Maxillofac. Surg. Clin. North Am."},{"key":"10.1016\/j.prp.2022.154266_bib2","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.prp.2022.154266_bib3","first-page":"430","article-title":"Epidemiological profile of head and neck cancer patients in Western Uttar Pradesh and analysis of distributions of risk factors in relation to site of tumor","volume":"13","author":"Alam","year":"2017","journal-title":"J. Cancer Res. Ther."},{"key":"10.1016\/j.prp.2022.154266_bib4","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.4103\/ijmpo.ijmpo_252_17","article-title":"Head and neck squamous cell carcinoma in young adults: a hospital-based study","volume":"40","author":"Sharma","year":"2019","journal-title":"Indian J. Med. Paediatr. Oncol."},{"key":"10.1016\/j.prp.2022.154266_bib5","first-page":"7","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.prp.2022.154266_bib6","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jobcr.2017.08.003","article-title":"Human papillomavirus associated head and neck squamous cell carcinoma: controversies and new concepts","volume":"7","author":"Husain","year":"2017","journal-title":"J. Oral Biol. Craniofac. Res."},{"key":"10.1016\/j.prp.2022.154266_bib7","first-page":"51","article-title":"Significance of p16 in site-specific HPV positive and HPV Negative head and neck squamous cell carcinoma","volume":"2","author":"Stephen","year":"2013","journal-title":"Cancer Clin. Oncol."},{"key":"10.1016\/j.prp.2022.154266_bib8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13045-019-0779-5","article-title":"Immune checkpoint inhibitors of PD-L1 as cancer therapeutics","volume":"12","author":"Akinleye","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.prp.2022.154266_bib9","doi-asserted-by":"crossref","first-page":"FSO768","DOI":"10.2144\/fsoa-2021-0039","article-title":"Increased PD-L1 and p16 expression are common in oropharyngeal squamous cell carcinoma","volume":"7","author":"Shestakova","year":"2021","journal-title":"Future Sci. OA"},{"key":"10.1016\/j.prp.2022.154266_bib10","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1177\/1724600819884722","article-title":"Expression of PD-1\/PD-L1 in head and neck squamous cell carcinoma and its clinical significance","volume":"34","author":"Chen","year":"2019","journal-title":"Int J. Biol. Markers"},{"key":"10.1016\/j.prp.2022.154266_bib11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3390\/ijms18020459","article-title":"Programmed death ligand 1 (PD-L1) tumor expression is associated with a better prognosis and diabetic disease in triple negative breast cancer patients","volume":"18","author":"Botti","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.prp.2022.154266_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0269136","article-title":"Differences in PD-L1 expression between oral and oropharyngeal squamous cell carcinoma","volume":"17","author":"Blatt","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2022.154266_bib13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12943-018-0928-4","article-title":"Role of the tumor microenvironment in PD-L1\/PD-1-mediated tumor immune escape","volume":"18","author":"Jiang","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.prp.2022.154266_bib14","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.immuni.2018.03.014","article-title":"Regulation and function of the PD-L1 checkpoint","volume":"48","author":"Sun","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.prp.2022.154266_bib15","doi-asserted-by":"crossref","first-page":"550","DOI":"10.3389\/fimmu.2016.00550","article-title":"The PD1:PD-L1\/2 pathway from discovery to clinical implementation","volume":"7","author":"Bardhan","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prp.2022.154266_bib16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13045-018-0592-6","article-title":"Gut microbiome modulates efficacy of immune checkpoint inhibitors","volume":"11","author":"Yi","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.prp.2022.154266_bib17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s13273-019-0017-9","article-title":"P16 expression and its association with PD-L1 expression and FOXP3-positive tumor infiltrating lymphocytes in head and neck squamous cell carcinoma","volume":"15","author":"Kim","year":"2019","journal-title":"Mol. Cell Toxicol."},{"key":"10.1016\/j.prp.2022.154266_bib18","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1158\/1535-7163.MCT-17-0504","article-title":"A correlative analysis of PD-L1, PD-1, PD-L2, EGFR, HER2, and HER3 expression in oropharyngeal squamous cell carcinoma","volume":"17","author":"Steuer","year":"2018","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.prp.2022.154266_bib19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.oraloncology.2019.03.012","article-title":"Significant association of PD-L1 expression with human papillomavirus positivity and its prognostic impact in oropharyngeal cancer","volume":"92","author":"Hong","year":"2019","journal-title":"Oral. Oncol."},{"key":"10.1016\/j.prp.2022.154266_bib20","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1158\/0008-5472.CAN-12-2384","article-title":"Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma","volume":"73","author":"Lyford-Pike","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2022.154266_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2022.153934","article-title":"The clinicopathological significance of PD-L1 expression assessed by the combined positive score (CPS) in head and neck squamous cell carcinoma","volume":"236","author":"Wusiman","year":"2022","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2022.154266_bib22","article-title":"Determining PD-L1 expression in head and neck squamous cell carcinoma using immunohistochemistry","author":"Mishra","year":"2021","journal-title":"Indian J. Cancer"},{"key":"10.1016\/j.prp.2022.154266_bib23","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20203669","article-title":"PD-L1 expression in anogenital and oropharyngeal squamous cell carcinomas associated with different clinicopathological features, HPV status and prognosis: a meta-analysis","volume":"41","author":"Qin","year":"2021","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.prp.2022.154266_bib24","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/his.13646","article-title":"PD-1 and PD-L1 expression in HNSCC primary cancer and related lymph node metastasis - impact on clinical outcome","volume":"73","author":"Schneider","year":"2018","journal-title":"Histopathology"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033822005106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033822005106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:55:14Z","timestamp":1759733714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033822005106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":24,"alternative-id":["S0344033822005106"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2022.154266","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of PD-L1 and p16 expression with clinicopathological parameters in oral cavity and oropharyngeal squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2022.154266","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154266"}}