{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:20:52Z","timestamp":1778498452192,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K16184"],"award-info":[{"award-number":["20K16184"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.prp.2023.154309","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T11:21:33Z","timestamp":1673868093000},"page":"154309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Transcription factor activating enhancer-binding protein 2B expression correlates with invasiveness and prognosis of extramammary Paget's disease"],"prefix":"10.1016","volume":"242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2416-8185","authenticated-orcid":false,"given":"Aya","family":"Kawaguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Akiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Ogasawara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiichiro","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Naito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Kusano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakiko","family":"Sanada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikko","family":"Muto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takekuni","family":"Nakama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohisa","family":"Yano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2023.154309_bib1","first-page":"448","article-title":"Extramammary Paget disease - clinical appearance, pathogenesis, management","volume":"9","author":"Wagner","year":"2011","journal-title":"J. der Dtsch. Dermatol. Ges. J. Ger. Soc. Dermatol.: JDDG"},{"key":"10.1016\/j.prp.2023.154309_bib2","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.7150\/jca.19127","article-title":"Chemokine receptors CXCR4 and CXCR7 are associated with tumor aggressiveness and prognosis in extramammary paget disease","volume":"8","author":"Chang","year":"2017","journal-title":"J. Cancer"},{"key":"10.1016\/j.prp.2023.154309_bib3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/1346-8138.12764","article-title":"Tumor thickness as a prognostic factor in extramammary Paget's disease","volume":"42","author":"Ito","year":"2015","journal-title":"J. Dermatol."},{"key":"10.1016\/j.prp.2023.154309_bib4","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jdermsci.2016.06.004","article-title":"A proposal for a TNM staging system for extramammary Paget disease: retrospective analysis of 301 patients with invasive primary tumors","volume":"83","author":"Ohara","year":"2016","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.prp.2023.154309_bib5","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/jdv.12156","article-title":"MUC5AC expression correlates with invasiveness and progression of extramammary Paget's disease","volume":"28","author":"Hata","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol.: JEADV"},{"key":"10.1016\/j.prp.2023.154309_bib6","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/ijc.33558","article-title":"Transcription factor AP-2beta in development, differentiation and tumorigenesis","volume":"149","author":"Raap","year":"2021","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.prp.2023.154309_bib7","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0092-8674(87)90512-5","article-title":"Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen","volume":"50","author":"Mitchell","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.prp.2023.154309_bib8","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1002\/ijc.22648","article-title":"Activator protein-2 in carcinogenesis with a special reference to breast cancer--a mini review","volume":"120","author":"Pellikainen","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.prp.2023.154309_bib9","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.ygyno.2018.03.057","article-title":"Decreased expression of TFAP2B in endometrial cancer predicts poor prognosis: a study based on TCGA data","volume":"149","author":"Wu","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.prp.2023.154309_bib10","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1002\/mc.22646","article-title":"Transcription factor AP-2\u03b2 suppresses cervical cancer cell proliferation by promoting the degradation of its interaction partner \u03b2-catenin","volume":"56","author":"Wang","year":"2017","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.prp.2023.154309_bib11","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.urology.2004.02.022","article-title":"Differential expression of activator protein-2 isoforms in renal cell carcinoma","volume":"64","author":"Oya","year":"2004","journal-title":"Urology"},{"key":"10.1016\/j.prp.2023.154309_bib12","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.molonc.2015.10.020","article-title":"Transcription factor activating protein 2 beta (TFAP2B) mediates noradrenergic neuronal differentiation in neuroblastoma","volume":"10","author":"Ikram","year":"2016","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.prp.2023.154309_bib13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1755-8794-2-53","article-title":"Verification of genes differentially expressed in neuroblastoma tumours: a study of potential tumour suppressor genes","volume":"2","author":"Thorell","year":"2009","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.prp.2023.154309_bib14","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1200\/JCO.2005.03.4934","article-title":"Subtype and prognostic classification of rhabdomyosarcoma by immunohistochemistry","volume":"24","author":"Wachtel","year":"2006","journal-title":"J. Clin. Oncol.: Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.prp.2023.154309_bib15","doi-asserted-by":"crossref","first-page":"7267","DOI":"10.1038\/sj.onc.1210525","article-title":"Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3\/FKHR","volume":"26","author":"Ebauer","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2023.154309_bib16","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/j.1365-2559.2009.03303.x","article-title":"Immunohistochemical detection of EGFR, fibrillin-2, P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics","volume":"54","author":"Grass","year":"2009","journal-title":"Histopathology"},{"key":"10.1016\/j.prp.2023.154309_bib17","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/PAS.0000000000000195","article-title":"Myogenin, AP2\u03b2, NOS-1, and HMGA2 are surrogate markers of fusion status in rhabdomyosarcoma: a report from the soft tissue sarcoma committee of the children's oncology group","volume":"38","author":"Rudzinski","year":"2014","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2023.154309_bib18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1476-4598-13-89","article-title":"TFAP2B overexpression contributes to tumor growth and a poor prognosis of human lung adenocarcinoma through modulation of ERK and VEGF\/PEDF signaling","volume":"13","author":"Fu","year":"2014","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.prp.2023.154309_bib19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41419-019-1600-7","article-title":"TFAP2B overexpression contributes to tumor growth and progression of thyroid cancer through the COX-2 signaling pathway","volume":"10","author":"Fu","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.prp.2023.154309_bib20","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.31557\/APJCP.2020.21.8.2415","article-title":"TFAP2B, AP-1 and JAZF1 Expression in Tissues of Papillary Thyroid Carcinoma Patients; Clinical, Pathological and Prognostic Values","volume":"21","author":"A","year":"2020","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.prp.2023.154309_bib21","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/j.1365-2133.2004.06053.x","article-title":"Cyclooxygenase-2 is a possible target of treatment approach in conjunction with photodynamic therapy for various disorders in skin and oral cavity","volume":"151","author":"Akita","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.prp.2023.154309_bib22","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/gyno.1995.1010","article-title":"A clinicopathologic study of 30 patients with Paget's disease of the vulva","volume":"56","author":"Kodama","year":"1995","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.prp.2023.154309_bib23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1046\/j.1365-2133.2000.03242.x","article-title":"The roswell park cancer Institute experience with extramammary Paget's disease","volume":"142","author":"Zollo","year":"2000","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.prp.2023.154309_bib24","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1002\/1097-0142(197711)40:5<2333::AID-CNCR2820400549>3.0.CO;2-#","article-title":"Progression of intraepithelial Paget's disease of the vulva to invasive carcinoma","volume":"40","author":"Hart","year":"1977","journal-title":"Cancer"},{"key":"10.1016\/j.prp.2023.154309_bib25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/apm.13086","article-title":"Expression of laminin-5 gamma 2 chain predicts invasion of extramammary Paget's disease cell","volume":"129","author":"Tohmatsu","year":"2021","journal-title":"APMIS: Acta Pathol. Microbiol. Et. Immunol. Scand."},{"key":"10.1016\/j.prp.2023.154309_bib26","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1046\/j.1440-1827.2002.01364.x","article-title":"Expression of mucin core proteins in extramammary Paget's disease","volume":"52","author":"Yoshii","year":"2002","journal-title":"Pathol. Int."},{"key":"10.1016\/j.prp.2023.154309_bib27","doi-asserted-by":"crossref","first-page":"219","DOI":"10.21873\/anticanres.14768","article-title":"Programmed Death-Ligand 1 and programmed Death-Ligand 2 expression can affect prognosis in extramammary Paget's disease","volume":"41","author":"Kawaguchi","year":"2021","journal-title":"Anticancer Res."},{"key":"10.1016\/j.prp.2023.154309_bib28","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12967-017-1150-7","article-title":"COX-2 expression positively correlates with PD-L1 expression in human melanoma cells","volume":"15","author":"Botti","year":"2017","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.prp.2023.154309_bib29","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/bjd.12249","article-title":"Human epidermal growth factor receptor 2 protein overexpression and gene amplification in extramammary Paget disease","volume":"168","author":"Tanaka","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.prp.2023.154309_bib30","doi-asserted-by":"crossref","first-page":"151","DOI":"10.5582\/bst.2011.v5.4.151","article-title":"The expression of HER-2 in extramammary Paget's disease","volume":"5","author":"Masuguchi","year":"2011","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.prp.2023.154309_bib31","doi-asserted-by":"crossref","first-page":"e654","DOI":"10.1016\/j.clbc.2021.04.010","article-title":"A 10-gene signature for predicting the response to Neoadjuvant Trastuzumab therapy in HER2-positive breast cancer","volume":"21","author":"Jia","year":"2021","journal-title":"Clin. Breast Cancer"},{"key":"10.1016\/j.prp.2023.154309_bib32","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/sj.onc.1202307","article-title":"Regulation of cyclooxygenase-2 pathway by HER2 receptor","volume":"18","author":"Vadlamudi","year":"1999","journal-title":"Oncogene"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033823000092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033823000092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:55:40Z","timestamp":1759733740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033823000092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":32,"alternative-id":["S0344033823000092"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2023.154309","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcription factor activating enhancer-binding protein 2B expression correlates with invasiveness and prognosis of extramammary Paget's disease","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2023.154309","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154309"}}