{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:24:47Z","timestamp":1779143087294,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.prp.2023.154327","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T02:28:11Z","timestamp":1674181691000},"page":"154327","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["HPV virus and biomarkers of resistance to chemoradiation in circulating tumor cells from patients with squamous cell carcinoma of the anus"],"prefix":"10.1016","volume":"243","author":[{"given":"Anna Paula Carreta","family":"Ruano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"de Jesus Ferreira Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexcia Camila","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline Aparecida","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Henrique Pereira","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emne Ali","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Barberan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virg\u00edlio","family":"Souza e Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziele","family":"Bovolim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcilei E.C.","family":"Buim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"da Silva Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel P.","family":"Riechelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmilla Thom\u00e9 Domingos","family":"Chinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.prp.2023.154327_bib1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.prp.2023.154327_bib2","unstructured":"INCA. Accessed February 15, 2022. https:\/\/www.inca.gov.br\/tipos-de-cancer\/cancer-anal."},{"issue":"16","key":"10.1016\/j.prp.2023.154327_bib3","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1001\/jama.299.16.1914","article-title":"Mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal","volume":"299","author":"Fluorouracil","year":"2008","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.prp.2023.154327_bib4","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S1470-2045(13)70086-X","article-title":"Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): a randomised, phase 3, open-label, 2\u00d72 factorial trial","volume":"14","author":"James","year":"2013","journal-title":"Lancet Oncol."},{"issue":"3","key":"10.1016\/j.prp.2023.154327_bib5","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ijrobp.2019.06.2544","article-title":"Executive summary of the American Radium Society appropriate use criteria for treatment of anal cancer","volume":"105","author":"Russo","year":"2019","journal-title":"Int J. Radiat. Oncol."},{"issue":"4","key":"10.1016\/j.prp.2023.154327_bib6","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S1470-2045(17)30104-3","article-title":"Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study","volume":"18","author":"Morris","year":"2017","journal-title":"Lancet Oncol."},{"issue":"3","key":"10.1016\/j.prp.2023.154327_bib7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.6004\/jnccn.2021.0012","article-title":"Colon cancer, version 2.2021, NCCN clinical practice guidelines in oncology","volume":"19","author":"Benson","year":"2021","journal-title":"J. Natl. Compr. Cancer Netw."},{"issue":"36","key":"10.1016\/j.prp.2023.154327_bib8","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.1200\/JCO.2005.04.6136","article-title":"High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma","volume":"24","author":"Licitra","year":"2006","journal-title":"J. Clin. Oncol."},{"issue":"17","key":"10.1016\/j.prp.2023.154327_bib9","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1200\/JCO.2013.52.3464","article-title":"Human papillomavirus genotyping and p16 expression as prognostic factors for patients with american joint committee on cancer stages I to III carcinoma of the anal canal","volume":"32","author":"Serup-Hansen","year":"2014","journal-title":"J. Clin. Oncol."},{"issue":"16","key":"10.1016\/j.prp.2023.154327_bib10","doi-asserted-by":"crossref","first-page":"8057","DOI":"10.7150\/thno.59677","article-title":"Emerging role of circulating tumor cells in immunotherapy","volume":"11","author":"Rzhevskiy","year":"2021","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.prp.2023.154327_bib11","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1002\/ijc.24442","article-title":"Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes","volume":"125","author":"Abbasi","year":"2009","journal-title":"Int. J. Cancer"},{"issue":"4","key":"10.1016\/j.prp.2023.154327_bib12","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.dnarep.2009.01.005","article-title":"The ubiquitin receptor Rad23: At the crossroads of nucleotide excision repair and proteasomal degradation","volume":"8","author":"Dantuma","year":"2009","journal-title":"DNA Repair (Amst.)"},{"issue":"6","key":"10.1016\/j.prp.2023.154327_bib13","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.3390\/cells10061539","article-title":"Molecular and dynamic evaluation of proteins related to resistance to neoadjuvant treatment with chemoradiotherapy in circulating tumor cells of patients with locally advanced rectal cancer","volume":"10","author":"Silva","year":"2021","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.prp.2023.154327_bib14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.5301\/JBM.2012.9584","article-title":"Thymidylate synthase expression and prognosis in colorectal cancer: a meta-analysis of colorectal cancer survival data","volume":"27","author":"Chen","year":"2012","journal-title":"Int. J. Biol. Markers"},{"issue":"6","key":"10.1016\/j.prp.2023.154327_bib15","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1002\/ijc.29495","article-title":"Thymidylate synthase expression in circulating tumor cells: a new tool to predict 5\u2013fluorouracil resistance in metastatic colorectal cancer patients","volume":"137","author":"Abdallah","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.prp.2023.154327_bib16","doi-asserted-by":"crossref","first-page":"e478s","DOI":"10.6061\/clinics\/2018\/e478s","article-title":"DNA repair pathways and cisplatin resistance: an intimate relationship","volume":"73","author":"Rocha","year":"2018","journal-title":"Clinics"},{"issue":"2","key":"10.1016\/j.prp.2023.154327_bib17","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/JTO.0b013e31823c5c16","article-title":"Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches","volume":"7","author":"Krebs","year":"2012","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.prp.2023.154327_bib18","article-title":"HPV16 E6\/E7 expression in circulating tumor cells in oropharyngeal squamous cell cancers: a pilot study","volume":"14","author":"Economopoulou","year":"2019"},{"issue":"8","key":"10.1016\/j.prp.2023.154327_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers12082229","article-title":"Identification of cancer-associated circulating cells in anal cancer patients","volume":"12","author":"Carter","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.prp.2023.154327_bib20","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/path.5249","article-title":"Plasma Epstein\u2013Barr virus DNA as an archetypal circulating tumour DNA marker","volume":"247","author":"Lam","year":"2019","journal-title":"J. Pathol."},{"issue":"6","key":"10.1016\/j.prp.2023.154327_bib21","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa1701717","article-title":"Analysis of plasma epstein\u2013barr virus DNA to screen for nasopharyngeal cancer","volume":"377","author":"Chan","year":"2017","journal-title":"N. Engl. J. Med"},{"issue":"21","key":"10.1016\/j.prp.2023.154327_bib22","doi-asserted-by":"crossref","first-page":"5857","DOI":"10.1158\/1078-0432.CCR-19-2384","article-title":"HPV sequencing facilitates ultrasensitive detection of HPV circulating tumor DNA","volume":"27","author":"Leung","year":"2021","journal-title":"Clin. Cancer Res."},{"issue":"7","key":"10.1016\/j.prp.2023.154327_bib23","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1158\/1078-0432.CCR-18-2984","article-title":"Clinical validity of HPV circulating tumor DNA in advanced anal carcinoma: an ancillary study to the EPITOPES-HPV02 trial","volume":"25","author":"Bernard-Tessier","year":"2019","journal-title":"Clin. Cancer Res"},{"issue":"22","key":"10.1016\/j.prp.2023.154327_bib24","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1158\/1078-0432.CCR-18-0922","article-title":"Prognostic impact of residual HPV ctDNA detection after chemoradiotherapy for anal squamous cell carcinoma","volume":"24","author":"Cabel","year":"2018","journal-title":"Clin. Cancer Res"},{"issue":"11","key":"10.1016\/j.prp.2023.154327_bib25","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1097\/PAS.0000000000001769","article-title":"p16 immunoreactivity correlates with morphologic diagnosis of HPV-associated anal intraepithelial neoplasia","volume":"45","author":"Liu","year":"2021","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2023.154327_bib26","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejca.2021.07.041","article-title":"Prognostic value of high-risk human papillomavirus DNA and p16INK4a immunohistochemistry in patients with anal cancer: an individual patient data meta-analysis","volume":"157","author":"Obermueller","year":"2021","journal-title":"Eur. J. Cancer"},{"issue":"11","key":"10.1016\/j.prp.2023.154327_bib27","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1002\/ijc.23837","article-title":"Characterization of humoral immune responses against p16, p53, HPV16 E6 and HPV16 E7 in patients with HPV-associated cancers","volume":"123","author":"Reuschenbach","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.prp.2023.154327_bib28","unstructured":"CLINICAL TRIALS. Accessed March 14, 2022. https:\/\/clinicaltrials.gov\/ct2\/results?cond=Cancer&term=PD-L1&cntry=&state=&city=&dist=."},{"key":"10.1016\/j.prp.2023.154327_bib29","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.omto.2020.05.001","article-title":"Histone deacetylase inhibitor sensitizes ERCC1-high non-small-cell lung cancer cells to cisplatin via regulating miR-149","volume":"17","author":"He","year":"2020","journal-title":"Mol. Ther. - Oncolytics"},{"issue":"15","key":"10.1016\/j.prp.2023.154327_bib30","doi-asserted-by":"crossref","first-page":"24303","DOI":"10.18632\/oncotarget.13286","article-title":"ERCC1-expressing circulating tumor cells as a potential diagnostic tool for monitoring response to platinum-based chemotherapy and for predicting post-therapeutic outcome of ovarian cancer","volume":"8","author":"Chebouti","year":"2017","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.prp.2023.154327_bib31","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/ijc.30082","article-title":"Souza e Silva V, et al. MRP1 expression in CTCs confers resistance to irinotecan-based chemotherapy in metastatic colorectal cancer","volume":"139","author":"Abdallah","year":"2016","journal-title":"Int. J. Cancer"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033823000274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033823000274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:53:47Z","timestamp":1759733627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033823000274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":31,"alternative-id":["S0344033823000274"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2023.154327","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HPV virus and biomarkers of resistance to chemoradiation in circulating tumor cells from patients with squamous cell carcinoma of the anus","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2023.154327","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154327"}}