{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:01:35Z","timestamp":1774414895797,"version":"3.50.1"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.prp.2023.154585","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:31:29Z","timestamp":1685359889000},"page":"154585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["An updated review of a novel method for examining P53 mutations in different forms of cancer"],"prefix":"10.1016","volume":"248","author":[{"given":"Navid","family":"Shomali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Kamrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadi","family":"Nasiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javad Ahmadian","family":"Heris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parviz","family":"Shahabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Mohammadinasab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahram","family":"Sadeghvand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7333-1300","authenticated-orcid":false,"given":"Morteza","family":"Akbari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2023.154585_bib1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41573-022-00571-8","article-title":"Drugging p53 in cancer: one protein, many targets","volume":"22","author":"Hassin","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.prp.2023.154585_bib2","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/S0140-6736(13)62146-7","article-title":"Ovarian cancer","volume":"384","author":"Jayson","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.prp.2023.154585_bib3","article-title":"Challenges in liver cancer and possible treatment approaches","volume":"1873","author":"Anwanwan","year":"2020","journal-title":"Biochim. Et. Biophys. Acta (BBA)-Rev. Cancer"},{"key":"10.1016\/j.prp.2023.154585_bib4","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","article-title":"A genetic model for colorectal tumorigenesis","volume":"61","author":"Fearon","year":"1990","journal-title":"cell"},{"key":"10.1016\/j.prp.2023.154585_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107355","article-title":"miR-193a-5p as a promising therapeutic candidate in colorectal cancer by reducing 5-FU and Oxaliplatin chemoresistance by targeting CXCR4","volume":"92","author":"Azar","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"1803\u20131815","key":"10.1016\/j.prp.2023.154585_bib6","article-title":"Regulation of the G2\/M transition by p53","volume":"20","author":"Taylor","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2023.154585_bib7","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/s41467-018-03599-w","article-title":"USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells","volume":"9","author":"Padmanabhan","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.prp.2023.154585_bib8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/GCO.0000000000000340","article-title":"Pathogenesis and heterogeneity of ovarian cancer","volume":"29","author":"Kroeger","year":"2017","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"10.1016\/j.prp.2023.154585_bib9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5152\/tjg.2018.17330","article-title":"Liver fibrosis","volume":"29","author":"Ayd\u0131n","year":"2018","journal-title":"Turk. J. Gastroenterol."},{"key":"10.1016\/j.prp.2023.154585_bib10","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1080\/15384101.2019.1688951","article-title":"Mutant p53 drives cancer chemotherapy resistance due to loss of function on activating transcription of PUMA","volume":"18","author":"Huang","year":"2019","journal-title":"Cell Cycle"},{"key":"10.1016\/j.prp.2023.154585_bib11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbcan.2018.06.001","article-title":"Control of metabolism by p53\u2013cancer and beyond","volume":"1870","author":"Labuschagne","year":"2018","journal-title":"Biochim. Et. Biophys. Acta (BBA)-Rev. Cancer"},{"key":"10.1016\/j.prp.2023.154585_bib12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.canlet.2020.09.023","article-title":"Targeting the p53-MDM2 pathway for neuroblastoma therapy: Rays of hope","volume":"496","author":"Zafar","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.prp.2023.154585_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1479-5876-9-97","article-title":"Protein kinase CK2\u03b1 is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes","volume":"9","author":"Zou","year":"2011","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.prp.2023.154585_bib14","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ejca.2017.06.023","article-title":"Mutant p53 as a target for cancer treatment","volume":"83","author":"Duffy","year":"2017","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.prp.2023.154585_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-08880-4","article-title":"Mutant p53 stimulates cell invasion through an interaction with Rad21 in human ovarian cancer cells","volume":"7","author":"Ahn","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2023.154585_bib16","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2147\/IJN.S282489","article-title":"p53 promoted ferroptosis in ovarian cancer cells treated with human serum incubated-superparamagnetic iron oxides","volume":"16","author":"Zhang","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.prp.2023.154585_bib17","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.3390\/molecules25071579","article-title":"Galangin, a flavonoid from lesser galangal, induced apoptosis via p53-dependent pathway in ovarian cancer cells","volume":"25","author":"Huang","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.prp.2023.154585_bib18","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.ccell.2018.05.003","article-title":"Liver cancer initiation requires p53 inhibition by CD44-enhanced growth factor signaling","volume":"33","author":"Dhar","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.prp.2023.154585_bib19","first-page":"2020","article-title":"Amarogentin inhibits liver cancer cell angiogenesis after insufficient radiofrequency ablation via affecting stemness and the p53-dependent VEGFA\/Dll4\/Notch1 pathway","author":"Zhang","year":"2020","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.prp.2023.154585_bib20","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/14728222.2019.1602608","article-title":"Therapeutic approaches for targeting receptor tyrosine kinase like orphan receptor-1 in cancer cells","volume":"23","author":"Kamrani","year":"2019","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.prp.2023.154585_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-021-02251-7","article-title":"Renaissance of armored immune effector cells, CAR-NK cells, brings the higher hope for successful cancer therapy","volume":"12","author":"Marofi","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.prp.2023.154585_bib22","first-page":"893","article-title":"Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines","volume":"5","author":"Bartek","year":"1990","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2023.154585_bib23","article-title":"Identification of genes and miRNAs associated with angiogenesis, metastasis, and apoptosis in colorectal cancer","volume":"18","author":"Pourakbari","year":"2020","journal-title":"Gene Rep."},{"key":"10.1016\/j.prp.2023.154585_bib24","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.3390\/ijms20235999","article-title":"Targeting the oncogenic p53 mutants in colorectal cancer and other solid tumors","volume":"20","author":"Li","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.prp.2023.154585_bib25","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/jmcb\/mjy075","article-title":"Mutant p53 in colon cancer","volume":"11","author":"Nakayama","year":"2019","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.prp.2023.154585_bib26","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.ygeno.2018.05.006","article-title":"The p53-signaling pathway and colorectal cancer: Interactions between downstream p53 target genes and miRNAs","volume":"111","author":"Slattery","year":"2019","journal-title":"Genomics"},{"key":"10.1016\/j.prp.2023.154585_bib27","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1158\/2326-6066.CIR-18-0686","article-title":"Immunologic recognition of a shared p53 mutated neoantigen in a patient with metastatic colorectal cancer","volume":"7","author":"Lo","year":"2019","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.prp.2023.154585_bib28","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/cbin.11243","article-title":"CD133: an emerging prognostic factor and therapeutic target in colorectal cancer","volume":"44","author":"Akbari","year":"2020","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.prp.2023.154585_bib29","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1093\/jnci\/85.18.1513","article-title":"Spectrum of mutation and frequency of allelic deletion of the p53 gene in ovarian cancer","volume":"85","author":"Kohler","year":"1993","journal-title":"JNCI: J. Natl. Cancer Inst."},{"key":"10.1016\/j.prp.2023.154585_bib30","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1016\/j.celrep.2017.02.049","article-title":"Progesterone prevents high-grade serous ovarian cancer by inducing necroptosis of p53-defective fallopian tube epithelial cells","volume":"18","author":"Wu","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.prp.2023.154585_bib31","first-page":"1771","article-title":"MicroRNA let\u20117d\u20115p rescues ovarian cancer cell apoptosis and restores chemosensitivity by regulating the p53 signaling pathway via HMGA1","volume":"54","author":"Chen","year":"2019","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.prp.2023.154585_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22638","article-title":"Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF\u20107 human breast cancer cell line","volume":"35","author":"Aborehab","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.prp.2023.154585_bib33","article-title":"Ginsenoside Rg1 improves pathological damages by activating the p21\u2013p53\u2013STK pathway in ovary and Bax\u2011Bcl2 in the uterus in premature ovarian insufficiency mouse models","volume":"23","author":"He","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.prp.2023.154585_bib34","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1158\/0008-5472.CAN-21-4390","article-title":"Constitutive activation of the tumor suppressor p53 in hepatocytes paradoxically promotes non\u2013cell autonomous liver carcinogenesis","volume":"82","author":"Makino","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2023.154585_bib35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3390\/cancers9090127","article-title":"Liver cancer: molecular characterization, clonal evolution and cancer stem cells","volume":"9","author":"Castelli","year":"2017","journal-title":"Cancers"},{"key":"10.1016\/j.prp.2023.154585_bib36","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.clinre.2017.12.006","article-title":"Molecular bases of the poor response of liver cancer to chemotherapy","volume":"42","author":"Marin","year":"2018","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"10.1016\/j.prp.2023.154585_bib37","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.3390\/ijms20092054","article-title":"The water extract of Juniperus communis L. induces cell death and sensitizes cancer cells to cytostatic drugs through p53 and PI3K\/Akt pathways","volume":"20","author":"Raasmaja","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.prp.2023.154585_bib38","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cell.2018.11.011","article-title":"p53 represses the mevalonate pathway to mediate tumor suppression","volume":"176","author":"Moon","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.prp.2023.154585_bib39","doi-asserted-by":"crossref","first-page":"83","DOI":"10.5582\/bst.2019.01272","article-title":"Overexpression of DJ-1 enhances colorectal cancer cell proliferation through the cyclin-D1\/MDM2-p53 signaling pathway","volume":"14","author":"Zhu","year":"2020","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.prp.2023.154585_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2022.100909","article-title":"The c-MYC-WDR43 signalling axis promotes chemoresistance and tumour growth in colorectal cancer by inhibiting p53 activity","volume":"66","author":"Di","year":"2023","journal-title":"Drug Resist. Update.: Rev. Comment. Antimicrob. Anticancer Chemother."},{"key":"10.1016\/j.prp.2023.154585_bib41","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1111\/cas.13951","article-title":"LUCAT1 promotes colorectal cancer tumorigenesis by targeting the ribosomal protein L40-MDM2-p53 pathway through binding with UBA52","volume":"110","author":"Zhou","year":"2019","journal-title":"Cancer Sci."},{"key":"10.1016\/j.prp.2023.154585_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112799","article-title":"GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7\/PCAF\/MDM2 axis","volume":"407","author":"Wang","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.prp.2023.154585_bib43","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1021\/acs.jafc.0c00107","article-title":"\u03b2-Sitosterol reverses multidrug resistance via bcrp suppression by inhibiting the p53-MDM2 interaction in colorectal cancer","volume":"68","author":"Wang","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.prp.2023.154585_bib44","doi-asserted-by":"crossref","first-page":"25310","DOI":"10.18632\/oncotarget.15813","article-title":"Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2023.154585_bib45","first-page":"13","article-title":"Targeting BCL-2 in cancer: advances, challenges, and perspectives","author":"Hafezi","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.prp.2023.154585_bib46","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1182\/blood.2021014304","article-title":"Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies","volume":"140","author":"Thomalla","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.prp.2023.154585_bib47","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in signaling and disease: beyond discovery and development","volume":"176","author":"Apte","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.prp.2023.154585_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/biom12020327","article-title":"Regulation of p53 function by formation of non-nuclear heterologous protein complexes","volume":"12","author":"Zavileyskiy","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.prp.2023.154585_bib49","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2174\/1389450114666140106101412","article-title":"Targeting tumor suppressor p53 for cancer therapy: strategies, challenges and opportunities","volume":"15","author":"Hong","year":"2014","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.prp.2023.154585_bib50","first-page":"6358","article-title":"p53 gene mutation spectrum in hepatocellular carcinoma","volume":"52","author":"Oda","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2023.154585_bib51","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/jmcb\/mjz006","article-title":"Small molecule activators of the p53 response","volume":"11","author":"Ladds","year":"2019","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.prp.2023.154585_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23095005","article-title":"Therapeutics Targeting p53-MDM2 Interaction to Induce Cancer Cell Death","volume":"23","author":"Koo","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.prp.2023.154585_bib53","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jcmgh.2020.04.002","article-title":"Characterization of a p53\/miR-34a\/CSF1R\/STAT3 Feedback Loop in Colorectal Cancer","volume":"10","author":"Shi","year":"2020","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.prp.2023.154585_bib54","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1038\/s41418-022-01007-x","article-title":"Targeting the miR-34a\/LRPPRC\/MDR1 axis collapse the chemoresistance in P53 inactive colorectal cancer","volume":"29","author":"Yang","year":"2022","journal-title":"Cell death Differ."},{"key":"10.1016\/j.prp.2023.154585_bib55","doi-asserted-by":"crossref","first-page":"265","DOI":"10.7150\/thno.36045","article-title":"Long noncoding RNA PiHL regulates p53 protein stability through GRWD1\/RPL11\/MDM2 axis in colorectal cancer","volume":"10","author":"Deng","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.prp.2023.154585_bib56","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/s41467-018-08225-3","article-title":"The p300\/YY1\/miR-500a-5p\/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer","volume":"10","author":"Tang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.prp.2023.154585_bib57","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.7150\/jca.18762","article-title":"ZEB1 Mediates Drug Resistance and EMT in p300-Deficient CRC","volume":"8","author":"Lazarova","year":"2017","journal-title":"J. Cancer"},{"key":"10.1016\/j.prp.2023.154585_bib58","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s13046-021-02126-y","article-title":"The novel circSLC6A6\/miR-1265\/C2CD4A axis promotes colorectal cancer growth by suppressing p53 signaling pathway","volume":"40","author":"Rong","year":"2021","journal-title":"J. Exp. Clin. Cancer Res.: CR"},{"key":"10.1016\/j.prp.2023.154585_bib59","doi-asserted-by":"crossref","first-page":"36689","DOI":"10.18632\/oncotarget.5385","article-title":"PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2023.154585_bib60","doi-asserted-by":"crossref","DOI":"10.3892\/or.2021.8037","article-title":"PRIMA\u20111(met) induces autophagy in colorectal cancer cells through upregulation of the mTOR\/AMPK\u2011ULK1\u2013Vps34 signaling cascade","volume":"45","author":"Li","year":"2021","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.prp.2023.154585_bib61","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s13045-021-01169-0","article-title":"Targeting mutant p53 for cancer therapy: direct and indirect strategies","volume":"14","author":"Hu","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.prp.2023.154585_bib62","doi-asserted-by":"crossref","first-page":"a001222","DOI":"10.1101\/cshperspect.a001222","article-title":"p53-based cancer therapy","volume":"2","author":"Lane","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.prp.2023.154585_bib63","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10549-018-4753-7","article-title":"Mutant p53 in breast cancer: potential as a therapeutic target and biomarker","volume":"170","author":"Duffy","year":"2018","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.prp.2023.154585_bib64","doi-asserted-by":"crossref","first-page":"a026260","DOI":"10.1101\/cshperspect.a026260","article-title":"p53 as an Effector or Inhibitor of Therapy Response","volume":"6","author":"Ablain","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.prp.2023.154585_bib65","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.2174\/1389450119666180115165447","article-title":"p53 as the Focus of Gene Therapy: Past, Present and Future","volume":"19","author":"Valente","year":"2018","journal-title":"Curr. Drug Targets"},{"issue":"Suppl 14","key":"10.1016\/j.prp.2023.154585_bib66","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF03326422","article-title":"p53 gene therapy for esophageal cancer","volume":"37","author":"Shimada","year":"2002","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.prp.2023.154585_bib67","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.exphem.2016.05.014","article-title":"Pharmacological activation of wild-type p53 in the therapy of leukemia","volume":"44","author":"Kojima","year":"2016","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.prp.2023.154585_bib68","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111941","article-title":"Gene Therapy Targeting p53 and KRAS for Colorectal Cancer Treatment: A Myth or the Way Forward?","volume":"22","author":"Hasbullah","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.prp.2023.154585_bib69","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3349\/ymj.2022.63.1.16","article-title":"ABT-737, a BH3 Mimetic, Enhances the Therapeutic Effects of Ionizing Radiation in K-ras Mutant Non-Small Cell Lung Cancer Preclinical Model","volume":"63","author":"Lee","year":"2022","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.prp.2023.154585_bib70","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.7150\/ijbs.64003","article-title":"CDC20 regulates the cell proliferation and radiosensitivity of P53 mutant HCC cells through the Bcl-2\/Bax pathway","volume":"17","author":"Zhao","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.prp.2023.154585_bib71","first-page":"18","article-title":"p53-based immunotherapy of cancer","author":"DeLeo","year":"1998","journal-title":"Crit. Reviews\u2122 Immunol."},{"key":"10.1016\/j.prp.2023.154585_bib72","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.trecan.2020.10.005","article-title":"Life and death decision-making by p53 and implications for cancer immunotherapy","volume":"7","author":"Liu","year":"2021","journal-title":"Trends Cancer"},{"key":"10.1016\/j.prp.2023.154585_bib73","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1007\/s11033-020-05435-1","article-title":"Role of PI3K\/AKT pathway in cancer: the framework of malignant behavior","volume":"47","author":"Jiang","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.prp.2023.154585_bib74","article-title":"p53-mediated PI3K\/AKT\/mTOR pathway played a role in PtoxDpt-induced EMT inhibition in liver cancer cell lines","volume":"2019","author":"Li","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.prp.2023.154585_bib75","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S1499-3872(16)60166-2","article-title":"Silibinin induces hepatic stellate cell cycle arrest via enhancing p53\/p27 and inhibiting Akt downstream signaling protein expression","volume":"16","author":"Ezhilarasan","year":"2017","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"10.1016\/j.prp.2023.154585_bib76","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3892\/or.2016.5299","article-title":"Gigantol attenuates the proliferation of human liver cancer HepG2 cells through the PI3K\/Akt\/NF-\u03baB signaling pathway","volume":"37","author":"Chen","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.prp.2023.154585_bib77","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0014-5793(02)02292-5","article-title":"Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction","volume":"512","author":"Choudhuri","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.prp.2023.154585_bib78","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1126\/science.285.5434.1733","article-title":"A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy","volume":"285","author":"Komarov","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.prp.2023.154585_bib79","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1080\/15384101.2019.1708575","article-title":"P53 versus inflammation: an update","volume":"19","author":"Kubra","year":"2020","journal-title":"Cell Cycle"},{"key":"10.1016\/j.prp.2023.154585_bib80","doi-asserted-by":"crossref","first-page":"a026161","DOI":"10.1101\/cshperspect.a026161","article-title":"p53 and the carcinogenicity of chronic inflammation","volume":"6","author":"Gudkov","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033823002856?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033823002856?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T04:08:52Z","timestamp":1774411732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033823002856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":80,"alternative-id":["S0344033823002856"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2023.154585","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An updated review of a novel method for examining P53 mutations in different forms of cancer","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2023.154585","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154585"}}