{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T04:52:58Z","timestamp":1774414378242,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006694","name":"Associazione Italiana Contro le Leucemie - Linfomi e Mieloma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012100","name":"Associazione Italiana Contro le Leucemie-Linfomi e Mieloma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012100","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.prp.2023.154661","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T11:14:45Z","timestamp":1688210085000},"page":"154661","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Different patterns of mast cell distribution in B-cell non-Hodgkin lymphomas"],"prefix":"10.1016","volume":"248","author":[{"given":"Diego","family":"Guidolin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Tamma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Annese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Tortorella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Ingravallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Gaudio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pellegrino","family":"Musto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgina","family":"Specchia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Ribatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2023.154661_bib1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1159\/000069515","article-title":"Mast cells in basal cell carcinoma express VEGF, IL-8 and RANTES","volume":"130","author":"Aoki","year":"2003","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.prp.2023.154661_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v012.i06","article-title":"Spatstat: an R package for analyzing spatial point patterns","volume":"12","author":"Baddeley","year":"2005","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.prp.2023.154661_bib3","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.1182\/blood-2011-01-293050","article-title":"The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications","volume":"117","author":"Campo","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.prp.2023.154661_bib4","first-page":"61","article-title":"The roles of mast cells in anticancer immunity","author":"Dalton","year":"2012","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.prp.2023.154661_bib5","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.jaci.2009.01.044","article-title":"Vascular endothelial growth factors synthesized byhuman lung mast cells exert angiogenic effects","volume":"123","author":"Detoraki","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.prp.2023.154661_bib6","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1002\/ajh.24200","article-title":"Follicular lymphoma: 2015 update on diagnosis and management","volume":"90","author":"Freedman","year":"2015","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.prp.2023.154661_bib7","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nri2327","article-title":"Immunomodulatory mast cells: negative, as well as positive regulators of the immunity","volume":"8","author":"Galli","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.prp.2023.154661_bib8","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/sj.bjc.6605912","article-title":"How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine","volume":"103","author":"Gerlinger","year":"2010","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.prp.2023.154661_bib9","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.canlet.2008.07.032","article-title":"Tumoral mast cells exhibit a common spatial distribution","volume":"273","author":"Guidolin","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.prp.2023.154661_bib10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10238-016-0407-4","article-title":"Non-random spatial relationships between mast cells and microvessels in human endometrial carcinoma","volume":"17","author":"Guidolin","year":"2017","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.prp.2023.154661_bib11","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10238-017-0452-7","article-title":"Spatial distribution of mast cells around vessels and glands in human gastric carcinoma","volume":"17","author":"Guidolin","year":"2017","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.prp.2023.154661_bib12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/978-1-0716-0916-3_7","article-title":"Spatial statistics-based image analysis methods for the study of vascular morphogenesis","volume":"2206","author":"Guidolin","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.prp.2023.154661_bib13","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s10238-021-00716-w","article-title":"Different spatial distributions of inflammatory cells in the tumor microenvironment of ABC and GBC subgroups of diffuse large B cell lymphoma","volume":"21","author":"Guidolin","year":"2021","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.prp.2023.154661_bib14","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/ijc.2910180520","article-title":"Mast cells and tumor angiogenesis","volume":"18","author":"Kessler","year":"1976","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.prp.2023.154661_bib15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10555-011-9286-z","article-title":"The significant role of mast cells in cancer","volume":"30","author":"Khazaie","year":"2011","journal-title":"Cancer Metastas Rev."},{"key":"10.1016\/j.prp.2023.154661_bib16","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.bpj.2009.05.039","article-title":"On the use of Ripley\u2019s K-function and its derivatives to analyze domain size","volume":"97","author":"Kiskowski","year":"2009","journal-title":"Biophys. J."},{"key":"10.1016\/j.prp.2023.154661_bib17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s12016-019-08753-w","article-title":"Role of mast cells in haping tumor microenvironment","volume":"58","author":"Komi","year":"2020","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.prp.2023.154661_bib18","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1073\/pnas.91.9.3739","article-title":"Mast cells synthesize, store, and release nerve growth factor","volume":"91","author":"Leon","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.prp.2023.154661_bib19","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1158\/2326-6066.CIR-13-0119","article-title":"Mast cells: potential positive and negative roles in tumor biology","volume":"1","author":"Marichal","year":"2013","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.prp.2023.154661_bib20","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ccell.2020.03.007","article-title":"Intratumor heterogeneity: the Rosetta stone of therapy resistance","volume":"37","author":"Marusyk","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.prp.2023.154661_bib21","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/nrc2013","article-title":"Cancer as an evolutionary and ecological process","volume":"6","author":"Merlo","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.prp.2023.154661_bib22","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.4049\/jimmunol.151.6.3261","article-title":"Human mast cells produce IL-8","volume":"151","author":"M\u00f6ller","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.prp.2023.154661_bib23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature09807","article-title":"Tumour evolution inferred by single-cell sequencing","volume":"472","author":"Navin","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.prp.2023.154661_bib24","first-page":"564","article-title":"Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma","volume":"147","author":"Qu","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2023.154661_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1937-6448(09)75004-X","article-title":"The controversial role of mast cells in tumor growth","volume":"275","author":"Ribatti","year":"2009","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.prp.2023.154661_bib26","series-title":"Mast Cells and Tumours","author":"Ribatti","year":"2011"},{"key":"10.1016\/j.prp.2023.154661_bib27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.canlet.2018.07.005","article-title":"The dual role of mast cells in tumor fate","volume":"433","author":"Ribatti","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.prp.2023.154661_bib28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.imlet.2013.05.003","article-title":"Mast Cells and macrophages exert beneficial and detrimental effects on tumor progression and angiogenesis","volume":"152","author":"Ribatti","year":"2013","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.prp.2023.154661_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.yexcr.2014.11.014","article-title":"Tryptase, a novel angiogenic factor stored in mast cell granules","volume":"332","author":"Ribatti","year":"2015","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.prp.2023.154661_bib30","article-title":"A double-edged sword in tumor angiogenesis and progression. Dual roles of mast cells, macrophages, and neutrophils","volume":"240","author":"Ribatti","year":"2022","journal-title":"Pathol. Res Pr."},{"key":"10.1016\/j.prp.2023.154661_bib31","series-title":"Spatial Statistics","author":"Ripley","year":"1981"},{"key":"10.1016\/j.prp.2023.154661_bib32","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/annonc\/mdn666","article-title":"Angiogenesis and antiangiogenic therapy in non-Hodgkin\u2019s lymphoma","volume":"20","author":"Ruan","year":"2009","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.prp.2023.154661_bib33","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.3390\/app9163271","article-title":"The accuracy of determining cluster size by analyzing Ripley\u2019s K function in single molecule localization microscopy","volume":"9","author":"Ruan","year":"2019","journal-title":"Appl. Sci."},{"key":"10.1016\/j.prp.2023.154661_bib34","volume":"6","author":"Russ","year":"2011"},{"key":"10.1016\/j.prp.2023.154661_bib35","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.prp.2023.154661_bib36","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.21873\/anticanres.14886","article-title":"Tumor cell microenvironment and microvessel density analysis in MALT type lymphoma","volume":"41","author":"Tamma","year":"2021","journal-title":"Anticancer Res."},{"key":"10.1016\/j.prp.2023.154661_bib37","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3390\/jcm11051257","article-title":"Tumor microenvironment and microvascular density in follicular lymphoma","volume":"11","author":"Tamma","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.prp.2023.154661_bib38","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1073\/pnas.88.10.4220","article-title":"Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1","volume":"88","author":"Walsh","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.prp.2023.154661_bib39","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1007\/s00262-012-1276-7","article-title":"Mast cells impair the development of protective anti-tumor immunity","volume":"61","author":"Wasiuk","year":"2012","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.prp.2023.154661_bib40","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.hoc.2008.07.011","article-title":"Marginal zone lymphomas","volume":"22","author":"Zucca","year":"2008","journal-title":"Hematol. Oncol. Clin. N. Am."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033823003618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033823003618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T03:55:06Z","timestamp":1774410906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033823003618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":40,"alternative-id":["S0344033823003618"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2023.154661","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Different patterns of mast cell distribution in B-cell non-Hodgkin lymphomas","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2023.154661","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154661"}}