{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:33:02Z","timestamp":1770269582978,"version":"3.49.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.prp.2023.154719","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T07:15:03Z","timestamp":1690442103000},"page":"154719","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2"],"prefix":"10.1016","volume":"249","author":[{"given":"Tong","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Pt 2","key":"10.1016\/j.prp.2023.154719_bib1","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.semcancer.2021.05.025","article-title":"Microbes in lung cancer initiation, treatment, and outcome: boon or bane?","volume":"86","author":"Guo","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"3","key":"10.1016\/j.prp.2023.154719_bib2","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"10","key":"10.1016\/j.prp.2023.154719_bib3","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/cac2.12359","article-title":"Non-small cell lung cancer in China","volume":"42","author":"Chen","year":"2022","journal-title":"Cancer Commun. (Lond.)"},{"issue":"1","key":"10.1016\/j.prp.2023.154719_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ccm.2019.10.001","article-title":"Lung cancer 2020: epidemiology, etiology, and prevention","volume":"41","author":"Bade","year":"2020","journal-title":"Clin. Chest Med."},{"issue":"1","key":"10.1016\/j.prp.2023.154719_bib5","first-page":"7","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"issue":"8","key":"10.1016\/j.prp.2023.154719_bib6","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/resp.14295","article-title":"Lung cancer screening-marching along","volume":"27","author":"Fong","year":"2022","journal-title":"Respirology"},{"issue":"8","key":"10.1016\/j.prp.2023.154719_bib7","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.mayocp.2019.01.013","article-title":"Non-small cell lung cancer: epidemiology, screening, diagnosis, and treatment","volume":"94","author":"Duma","year":"2019","journal-title":"Mayo Clin. Proc."},{"issue":"3","key":"10.1016\/j.prp.2023.154719_bib8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.mcna.2018.12.006","article-title":"Lung cancer","volume":"103","author":"Nasim","year":"2019","journal-title":"Med. Clin. North Am."},{"issue":"9","key":"10.1016\/j.prp.2023.154719_bib9","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.7150\/ijbs.70958","article-title":"VEGF\/VEGFR-targeted therapy and immunotherapy in non-small cell lung cancer: targeting the tumor microenvironment","volume":"18","author":"Zhao","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"12","key":"10.1016\/j.prp.2023.154719_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23126836","article-title":"Role of nano-miRNAs in diagnostics and therapeutics","volume":"23","author":"Coradduzza","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"13","key":"10.1016\/j.prp.2023.154719_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23137167","article-title":"MicroRNA-based diagnosis and therapy","volume":"23","author":"Ho","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.prp.2023.154719_bib12","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s13238-014-0093-5","article-title":"MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1","volume":"5","author":"Song","year":"2014","journal-title":"Protein Cell"},{"issue":"2","key":"10.1016\/j.prp.2023.154719_bib13","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.bbrc.2018.04.124","article-title":"MiR-139-5p suppresses osteosarcoma cell growth and invasion through regulating DNMT1","volume":"503","author":"Shi","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.prp.2023.154719_bib14","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41388-020-01486-7","article-title":"Mesenchymal stem cells-derived exosomal microRNA-139-5p restrains tumorigenesis in bladder cancer by targeting PRC1","volume":"40","author":"Jia","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2023.154719_bib15","article-title":"MiR-139-5p inhibits the development of gastric cancer through targeting TPD52","volume":"2022","author":"Li","year":"2022","journal-title":"J. Health Eng."},{"key":"10.1016\/j.prp.2023.154719_bib16","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.biopha.2018.09.029","article-title":"Downregulation of miR-139-5p promotes prostate cancer progression through regulation of SOX5","volume":"109","author":"Yang","year":"2019","journal-title":"Biomed. Pharm."},{"issue":"6","key":"10.1016\/j.prp.2023.154719_bib17","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1007\/s10528-022-10204-9","article-title":"MiR-139-5p\/ENAH affects progression of hepatocellular carcinoma cells","volume":"60","author":"Zhang","year":"2022","journal-title":"Biochem. Genet."},{"issue":"1","key":"10.1016\/j.prp.2023.154719_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s12967-021-02880-9","article-title":"Mir-139-5p inhibits glioma cell proliferation and progression by targeting GABRA1","volume":"19","author":"Wang","year":"2021","journal-title":"J. Transl. Med."},{"issue":"7","key":"10.1016\/j.prp.2023.154719_bib19","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.7150\/ijbs.40338","article-title":"MiR-139-5p negatively regulates PMP22 to repress cell proliferation by targeting the NF-kappaB signaling pathway in gastric cancer","volume":"16","author":"Hou","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.prp.2023.154719_bib20","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1177\/0300060518815379","article-title":"Expression and clinical significance of miR-139-5p in non-small cell lung cancer","volume":"47","author":"Yong-Hao","year":"2019","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.prp.2023.154719_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/2563085","article-title":"Diagnostic MicroRNA biomarker discovery for non-small-cell lung cancer adenocarcinoma by integrative bioinformatics analysis","volume":"2017","author":"Shao","year":"2017","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.prp.2023.154719_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s13045-020-00990-3","article-title":"Targeting the Wnt\/beta-catenin signaling pathway in cancer","volume":"13","author":"Zhang","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.prp.2023.154719_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104794","article-title":"Targeting the beta-catenin signaling for cancer therapy","volume":"160","author":"Zhang","year":"2020","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.prp.2023.154719_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12943-020-1133-9","article-title":"lncRNA JPX\/miR-33a-5p\/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt\/beta-catenin signaling","volume":"19","author":"Pan","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.prp.2023.154719_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109495","article-title":"The involvement of miR-150\/beta-catenin axis in colorectal cancer progression","volume":"121","author":"He","year":"2020","journal-title":"Biomed. Pharm."},{"issue":"1","key":"10.1016\/j.prp.2023.154719_bib26","first-page":"101","article-title":"MiRNA-155 promotes the invasion of colorectal cancer SW-480 cells through regulating the Wnt\/beta-catenin","volume":"22","author":"Liu","year":"2018","journal-title":"Eur. Rev. Med. Pharm. Sci."},{"key":"10.1016\/j.prp.2023.154719_bib27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/1471-2407-7-149","article-title":"Therapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice","volume":"7","author":"Zhang","year":"2007","journal-title":"BMC Cancer"},{"issue":"14","key":"10.1016\/j.prp.2023.154719_bib28","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.7150\/ijbs.47203","article-title":"miRNA-based biomarkers, therapies, and resistance in cancer","volume":"16","author":"He","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"10","key":"10.1016\/j.prp.2023.154719_bib29","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nrg2634","article-title":"Causes and consequences of microRNA dysregulation in cancer","volume":"10","author":"Croce","year":"2009","journal-title":"Nat. Rev. Genet."},{"issue":"4","key":"10.1016\/j.prp.2023.154719_bib30","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/ijc.31363","article-title":"MiR-483-5p and miR-139-5p promote aggressiveness by targeting N-myc downstream-regulated gene family members in adrenocortical cancer","volume":"143","author":"Agosta","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.prp.2023.154719_bib31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/ijms21051723","article-title":"Regulatory mechanism of MicroRNA expression in cancer","volume":"21","author":"Ali Syeda","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.prp.2023.154719_bib32","doi-asserted-by":"crossref","first-page":"5768","DOI":"10.1111\/jcmm.13866","article-title":"The novel regulatory role of lncRNA-miRNA-mRNA axis in cardiovascular diseases","volume":"22","author":"Huang","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.prp.2023.154719_bib33","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/1476-4598-13-124","article-title":"microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer","volume":"13","author":"Zhang","year":"2014","journal-title":"Mol. Cancer"},{"issue":"12","key":"10.1016\/j.prp.2023.154719_bib34","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1261\/rna.042143.113","article-title":"miR-139-5p is a regulator of metastatic pathways in breast cancer","volume":"19","author":"Krishnan","year":"2013","journal-title":"RNA"},{"issue":"3","key":"10.1016\/j.prp.2023.154719_bib35","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/febs.14186","article-title":"Bax, Bak and beyond - mitochondrial performance in apoptosis","volume":"285","author":"Pena-Blanco","year":"2018","journal-title":"FEBS J."},{"issue":"2","key":"10.1016\/j.prp.2023.154719_bib36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrc.2015.17","article-title":"Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies","volume":"16","author":"Delbridge","year":"2016","journal-title":"Nat. Rev. Cancer"},{"issue":"4","key":"10.1016\/j.prp.2023.154719_bib37","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.tcb.2016.11.004","article-title":"Bax and Bak pores: are we closing the circle?","volume":"27","author":"Cosentino","year":"2017","journal-title":"Trends Cell Biol."},{"issue":"2","key":"10.1016\/j.prp.2023.154719_bib38","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/cdd.2013.139","article-title":"Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis","volume":"21","author":"Westphal","year":"2014","journal-title":"Cell Death Differ."},{"issue":"2","key":"10.1016\/j.prp.2023.154719_bib39","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/cbin.11509","article-title":"miR-139-5p upregulation alleviated spontaneous recurrent epileptiform discharge-induced oxidative stress and apoptosis in rat hippocampal neurons via regulating the Notch pathway","volume":"45","author":"Zhao","year":"2021","journal-title":"Cell Biol. Int."},{"issue":"3","key":"10.1016\/j.prp.2023.154719_bib40","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1096\/fj.201902626R","article-title":"Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p\/Bmi-1 axis in human bladder cancer cells","volume":"34","author":"Wang","year":"2020","journal-title":"FASEB J."},{"issue":"27","key":"10.1016\/j.prp.2023.154719_bib41","doi-asserted-by":"crossref","first-page":"10606","DOI":"10.1074\/jbc.RA118.001730","article-title":"Histone demethylase JMJD1A promotes colorectal cancer growth and metastasis by enhancing Wnt\/beta-catenin signaling","volume":"293","author":"Peng","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.prp.2023.154719_bib42","first-page":"3433","article-title":"Aberrant localization of beta-catenin correlates with overexpression of its target gene in human papillary thyroid cancer","volume":"87","author":"Ishigaki","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"43","key":"10.1016\/j.prp.2023.154719_bib43","doi-asserted-by":"crossref","first-page":"70323","DOI":"10.18632\/oncotarget.11855","article-title":"ATAD2 is an epigenetic reader of newly synthesized histone marks during DNA replication","volume":"7","author":"Koo","year":"2016","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.prp.2023.154719_bib44","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1158\/1541-7786.MCR-09-0095","article-title":"Deregulated E2F and the AAA+ coregulator ANCCA drive proto-oncogene ACTR\/AIB1 overexpression in breast cancer","volume":"8","author":"Hsia","year":"2010","journal-title":"Mol. Cancer Res."},{"issue":"21","key":"10.1016\/j.prp.2023.154719_bib45","doi-asserted-by":"crossref","first-page":"8491","DOI":"10.1158\/0008-5472.CAN-09-2131","article-title":"ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors","volume":"69","author":"Ciro","year":"2009","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.prp.2023.154719_bib46","doi-asserted-by":"crossref","first-page":"787","DOI":"10.7150\/thno.78840","article-title":"ATPase family AAA domain-containing protein 2 (ATAD2): from an epigenetic modulator to cancer therapeutic target","volume":"13","author":"Fu","year":"2023","journal-title":"Theranostics"},{"issue":"8","key":"10.1016\/j.prp.2023.154719_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/biom12081040","article-title":"Tumor-promoting ATAD2 and its preclinical challenges","volume":"12","author":"Liu","year":"2022","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.prp.2023.154719_bib48","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13046-021-01905-x","article-title":"ATAD2 interacts with C\/EBPbeta to promote esophageal squamous cell carcinoma metastasis via TGF-beta1\/Smad3 signaling","volume":"40","author":"Cao","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"6559","key":"10.1016\/j.prp.2023.154719_bib49","doi-asserted-by":"crossref","first-page":"eabc1048","DOI":"10.1126\/science.abc1048","article-title":"Developmental chromatin programs determine oncogenic competence in melanoma","volume":"373","author":"Baggiolini","year":"2021","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.prp.2023.154719_bib50","doi-asserted-by":"crossref","first-page":"19059","DOI":"10.1002\/jcp.28545","article-title":"Overexpression of microRNA-186 inhibits angiogenesis in retinoblastoma via the Hedgehog signaling pathway by targeting ATAD2","volume":"234","author":"Wu","year":"2019","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.prp.2023.154719_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120592","article-title":"MicroRNA-217 modulates pancreatic cancer progression via targeting ATAD2","volume":"301","author":"Dutta","year":"2022","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.prp.2023.154719_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112241","article-title":"MicroRNA-302 represses epithelial-mesenchymal transition and cisplatin resistance by regulating ATAD2 in ovarian carcinoma","volume":"396","author":"Ge","year":"2020","journal-title":"Exp. Cell Res."},{"issue":"6","key":"10.1016\/j.prp.2023.154719_bib53","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180240","article-title":"Tamoxifen attenuates dialysate-induced peritoneal fibrosis by inhibiting GSK-3beta\/beta-catenin axis activation","volume":"38","author":"Yan","year":"2018","journal-title":"Biosci. Rep."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033823004193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033823004193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T07:05:00Z","timestamp":1759734300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033823004193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":53,"alternative-id":["S0344033823004193"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2023.154719","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2023.154719","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"154719"}}