{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:23:44Z","timestamp":1788261824736,"version":"build-2803163510"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020247","name":"University of Bisha","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020247","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.prp.2023.154833","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T17:21:30Z","timestamp":1695662490000},"page":"154833","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Alogliptin exhibits multifaceted effects in thioacetamide-insulted rats: A novel approach to combating hepatic inflammation and fibrogenesis"],"prefix":"10.1016","volume":"250","author":[{"given":"Osama A.","family":"Mohammed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.prp.2023.154833_bib1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.prp.2023.154833_bib2","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.prp.2023.154833_bib3","first-page":"511","article-title":"Blockade of PGE2, PGD2 receptors confers protection against prepatent schistosomiasis mansoni in mice","volume":"45","author":"Abdel-Ghany","year":"2015","journal-title":"J. Egypt. Soc. Parasitol."},{"issue":"6","key":"10.1016\/j.prp.2023.154833_bib4","doi-asserted-by":"crossref","first-page":"955","DOI":"10.3889\/oamjms.2018.167","article-title":"Liver protective effects of renin-angiotensin system inhibition have no survival benefits in hepatocellular carcinoma induced by repetitive administration of diethylnitrosamine in mice","volume":"6","author":"Saber","year":"2018","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"10.1016\/j.prp.2023.154833_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112455","article-title":"Empagliflozin adjunct with metformin for the inhibition of hepatocellular carcinoma progression: emerging approach for new application","volume":"145","author":"Abdelhamid","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.prp.2023.154833_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-04377-1","article-title":"Initiation of hepatic stellate cell activation extends into chronic liver disease","volume":"12","author":"De Smet","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.prp.2023.154833_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121697","article-title":"Androgen receptor blockade by flutamide down-regulates renal fibrosis, inflammation, and apoptosis pathways in male rats","volume":"323","author":"Allam","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.prp.2023.154833_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113409","article-title":"Canagliflozin-loaded chitosan-hyaluronic acid microspheres modulate AMPK\/NF-\u03baB\/NLRP3 axis: a new paradigm in the rectal therapy of ulcerative colitis","volume":"153","author":"Nasr","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.prp.2023.154833_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.887233","article-title":"Carbocisteine as a modulator of Nrf2\/HO-1 and NF\u03baB interplay in rats: new inspiration for the revival of an old drug for treating ulcerative colitis","volume":"13","author":"Abdelhamid","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.prp.2023.154833_bib10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.prp.2023.154833_bib11","doi-asserted-by":"crossref","first-page":"821","DOI":"10.33549\/physiolres.934755","article-title":"Hepatic stellate cell: a double-edged sword in the liver","author":"Luo","year":"2021","journal-title":"Physiol. Res. 70"},{"issue":"8","key":"10.1016\/j.prp.2023.154833_bib12","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3390\/ph16081123","article-title":"Alvespimycin exhibits potential anti-TGF-\u03b2 signaling in the setting of a proteasome activator in rats with bleomycin-induced pulmonary fibrosis: a promising novel approach","volume":"16","author":"Mohammed","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.prp.2023.154833_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114196","article-title":"Innovative challenge for the inhibition of hepatocellular carcinoma progression by combined targeting of HSP90 and STAT3\/HIF-1\u03b1 signaling","volume":"158","author":"Saber","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.prp.2023.154833_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114918","article-title":"Ganetespib (STA-9090) augments sorafenib efficacy via necroptosis induction in hepatocellular carcinoma: Implications from preclinical data for a novel therapeutic approach","volume":"164","author":"Saber","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.prp.2023.154833_bib15","doi-asserted-by":"crossref","unstructured":"R. Abdelhady, S. Saber, M.A. Abdel-Reheim, M.M.S. Alamri, J. Alfaifi, M.I. Adam, L.A. Saleh, A.I. Farag, E.A. Elmorsy, H.S. El-wakeel, Unveiling the therapeutic potential of exogenous \u03b2-hydroxybutyrate for chronic colitis in rats: Novel insights on autophagy, apoptosis, and pyroptosis, Frontiers in Pharmacology 14 1239025.","DOI":"10.3389\/fphar.2023.1239025"},{"key":"10.1016\/j.prp.2023.154833_bib16","article-title":"miRNAs as potential game-changers in retinoblastoma: future clinical and medicinal uses","author":"Doghish","year":"2023","journal-title":"Pathol. -Res. Pract."},{"key":"10.1016\/j.prp.2023.154833_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154684","article-title":"miRNAs orchestration of gallbladder cancer - particular emphasis on diagnosis, progression and drug resistance","author":"Shahin","year":"2023","journal-title":"Pathol. - Res. Pract."},{"key":"10.1016\/j.prp.2023.154833_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154763","article-title":"miRNAs driving diagnosis, prognosis and progression in Merkel cell carcinoma","volume":"249","author":"Al-Noshokaty","year":"2023","journal-title":"Pathol. - Res. Pract."},{"key":"10.1016\/j.prp.2023.154833_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154817","article-title":"Melodic maestros: unraveling the role of miRNAs in the diagnosis, progression, and drug resistance of malignant pleural mesothelioma","volume":"250","author":"Abd-Elmawla","year":"2023","journal-title":"Pathol. - Res. Pract."},{"key":"10.1016\/j.prp.2023.154833_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154704","article-title":"miRNAs driving diagnosis, progression, and drug resistance in multiple myeloma","volume":"248","author":"Elkady","year":"2023","journal-title":"Pathol. - Res. Pract."},{"key":"10.1016\/j.prp.2023.154833_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154715","article-title":"Decoding the role of miRNAs in multiple myeloma pathogenesis: a focus on signaling pathways","author":"Yehia","year":"2023","journal-title":"Pathol. - Res. Pract."},{"key":"10.1016\/j.prp.2023.154833_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154613","article-title":"miRNAs orchestration of cardiovascular diseases \u2013 particular emphasis on diagnosis, and progression","volume":"248","author":"Elsakka","year":"2023","journal-title":"Pathol. - Res. Pract."},{"key":"10.1016\/j.prp.2023.154833_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154624","article-title":"The potential role of miRNAs in the pathogenesis of cardiovascular diseases \u2013 a focus on signaling pathways interplay","volume":"248","author":"Khidr","year":"2023","journal-title":"Pathol. - Res. Pract."},{"key":"10.1016\/j.prp.2023.154833_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154790","article-title":"The interplay between toxoplasmosis and host miRNAs: mechanisms and consequences","volume":"250","author":"Doghish","year":"2023","journal-title":"Pathol. - Res. Pract."},{"issue":"3","key":"10.1016\/j.prp.2023.154833_bib25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1369\/0022155415627681","article-title":"TGF-\u03b2\/SMAD pathway and its regulation in hepatic fibrosis","volume":"64","author":"Xu","year":"2016","journal-title":"J. Histochem. Cytochem.: Off. J. Histochem. Soc."},{"key":"10.1016\/j.prp.2023.154833_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113487","article-title":"Pimitespib, an HSP90 inhibitor, augments nifuroxazide-induced disruption in the IL-6\/STAT3\/HIF-1\u03b1 autocrine loop in rats with bleomycin-challenged lungs: evolutionary perspective in managing pulmonary fibrosis","volume":"153","author":"El-Kashef","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.prp.2023.154833_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113247","article-title":"Combining the HSP90 inhibitor TAS-116 with metformin effectively degrades the NLRP3 and attenuates inflammasome activation in rats: a new management paradigm for ulcerative colitis","volume":"153","author":"Shaaban","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.prp.2023.154833_bib28","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00441-016-2445-3","article-title":"Reactive oxygen species and fibrosis: further evidence of a significant liaison","volume":"365","author":"Richter","year":"2016","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.prp.2023.154833_bib29","doi-asserted-by":"crossref","unstructured":"D. Hasan Khudhair, A.I. Al-Gareeb, H.M. Al-kuraishy, A.H. El-Kadem, E. Elekhnawy, W.A. Negm, S. Saber, S. Cavalu, A. Tirla, S.S. Alotaibi, G.E.-S. Batiha, Combination of Vitamin C and Curcumin Safeguards Against Methotrexate-Induced Acute Liver Injury in Mice by Synergistic Antioxidant Effects, 9 (2022). DOI 10.3389\/fmed.2022.866343.","DOI":"10.3389\/fmed.2022.866343"},{"issue":"7","key":"10.1016\/j.prp.2023.154833_bib30","article-title":"ROS-Nrf2 pathway mediates the development of TGF-\u03b21-induced epithelial-mesenchymal transition through the activation of Notch signaling","volume":"100","author":"Yazaki","year":"2021","journal-title":"Eur. J. Cell Biol."},{"issue":"1","key":"10.1016\/j.prp.2023.154833_bib31","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1080\/14756366.2021.1901089","article-title":"Design, synthesis, anticancer evaluation, and molecular modelling studies of novel tolmetin derivatives as potential VEGFR-2 inhibitors and apoptosis inducers","volume":"36","author":"Kassab","year":"2021","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.prp.2023.154833_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106729","article-title":"Development of pyrolo[2,3-c]pyrazole, pyrolo[2,3-d]pyrimidine and their bioisosteres as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: synthesis, biological evaluation and molecular dynamics investigations","author":"Azmy","year":"2023","journal-title":"Bioorg. Chem."},{"issue":"15","key":"10.1016\/j.prp.2023.154833_bib33","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.3390\/molecules28155812","article-title":"Antimicrobial, antibiofilm, and anticancer activities of syzygium aromaticum essential oil nanoemulsion","volume":"28","author":"Shehabeldine","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.prp.2023.154833_bib34","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.redox.2015.09.009","article-title":"Reciprocal regulation of TGF-\u03b2 and reactive oxygen species: a perverse cycle for fibrosis","volume":"6","author":"Liu","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.prp.2023.154833_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120070","article-title":"Blunting p38 MAPK\u03b1 and ERK1\/2 activities by empagliflozin enhances the antifibrotic effect of metformin and augments its AMPK-induced NF-\u03baB inactivation in mice intoxicated with carbon tetrachloride","volume":"286","author":"Abdelhamid","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.prp.2023.154833_bib36","article-title":"AKT-AMPK\u03b1-mTOR-dependent HIF-1\u03b1 activation is a new therapeutic target for cancer treatment: a novel approach to repositioning the antidiabetic drug sitagliptin for the management of hepatocellular carcinoma","volume":"12","author":"Abd El-Fattah","year":"2022"},{"issue":"2","key":"10.1016\/j.prp.2023.154833_bib37","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J. Pathol."},{"issue":"2","key":"10.1016\/j.prp.2023.154833_bib38","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.prp.2023.154833_bib39","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.prp.2023.154833_bib40","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0168-8278(01)00142-8","article-title":"Oxidative stress-related molecules and liver fibrosis","volume":"35","author":"Parola","year":"2001","journal-title":"J. Hepatol."},{"key":"10.1016\/j.prp.2023.154833_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/s41575-023-00807-x","article-title":"Hepatic inflammatory responses in liver fibrosis","author":"Hammerich","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.prp.2023.154833_bib42","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jhep.2020.04.011","article-title":"Animal models for liver disease - a practical approach for translational research","volume":"73","author":"Nevzorova","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.prp.2023.154833_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2023.104093","article-title":"Molecular mechanisms in thioacetamide-induced acute and chronic liver injury models","volume":"99","author":"Ezhilarasan","year":"2023","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.prp.2023.154833_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-42144-8","article-title":"A thioacetamide-induced liver fibrosis model for pre-clinical studies in microminipig","volume":"13","author":"Nishi","year":"2023","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.prp.2023.154833_bib45","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1007\/s00125-023-05966-9","article-title":"The future of incretins in the treatment of obesity and non-alcoholic fatty liver disease","volume":"66","author":"Andreasen","year":"2023","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.prp.2023.154833_bib46","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/jgh.13026","article-title":"Incretin-based therapies for the treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"31","author":"Carbone","year":"2016","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.prp.2023.154833_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ph14020144","article-title":"Novel potent and selective DPP-4 inhibitors: design, synthesis and molecular docking study of dihydropyrimidine phthalimide hybrids","author":"Mourad","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"1","key":"10.1016\/j.prp.2023.154833_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-57935-6","article-title":"Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis\u2013associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects","volume":"10","author":"Kawakubo","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2023.154833_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115246","article-title":"Vildagliptin, a DPP-4 inhibitor, attenuates carbon tetrachloride-induced liver fibrosis by targeting ERK1\/2, p38\u03b1, and NF-\u03baB signaling","volume":"407","author":"Khalil","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.prp.2023.154833_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-021-00625-7","article-title":"Dipeptidyl peptidase-4 (DPP4) inhibitor sitagliptin alleviates liver inflammation of diabetic mice by acting as a ROS scavenger and inhibiting the NF\u03baB pathway","volume":"7","author":"Wang","year":"2021","journal-title":"Cell Death Discov."},{"issue":"3","key":"10.1016\/j.prp.2023.154833_bib51","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00535-013-0783-4","article-title":"Dipeptidyl peptidase-4 inhibitor attenuates hepatic fibrosis via suppression of activated hepatic stellate cell in rats","volume":"49","author":"Kaji","year":"2014","journal-title":"J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.prp.2023.154833_bib52","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1517\/14656560802694713","article-title":"Alogliptin: a new, highly selective dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes","volume":"10","author":"Pratley","year":"2009","journal-title":"Expert Opin. Pharmacother."},{"issue":"2","key":"10.1016\/j.prp.2023.154833_bib53","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2146\/ajhp130131","article-title":"Alogliptin: A new dipeptidyl peptidase-4 inhibitor for the management of type 2 diabetes mellitus","volume":"71","author":"Ndefo","year":"2014","journal-title":"Am. J. Health-Syst. Pharm.: AJHP: Off. J. Am. Soc. Health-Syst. Pharm."},{"issue":"1","key":"10.1016\/j.prp.2023.154833_bib54","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1530\/JOE-13-0601","article-title":"Administration of pioglitazone alone or with alogliptin delays diabetes onset in UCD-T2DM rats","volume":"221","author":"Cummings","year":"2014","journal-title":"J. Endocrinol."},{"issue":"7","key":"10.1016\/j.prp.2023.154833_bib55","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/jsfa.4723","article-title":"Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis","volume":"92","author":"Chen","year":"2012","journal-title":"J. Sci. Food Agric."},{"issue":"5","key":"10.1016\/j.prp.2023.154833_bib56","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1021\/acs.jafc.8b05943","article-title":"Maltol mitigates thioacetamide-induced liver fibrosis through TGF-\u03b21-mediated activation of PI3K\/Akt signaling pathway","volume":"67","author":"Mi","year":"2019","journal-title":"J. Agric. Food Chem."},{"issue":"8","key":"10.1016\/j.prp.2023.154833_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/ph16081080","article-title":"STA9090 as a potential therapeutic agent for liver fibrosis by modulating the HSP90\/T\u03b2RII\/proteasome interplay: novel insights from in vitro and in vivo investigations","volume":"16","author":"Mohammed","year":"2023","journal-title":"Pharmaceuticals"},{"issue":"17","key":"10.1016\/j.prp.2023.154833_bib58","doi-asserted-by":"crossref","first-page":"25723","DOI":"10.1007\/s11356-021-17831-6","article-title":"Electrocardiographic and histopathological characterizations of diabetic cardiomyopathy in rats","volume":"29","author":"Youssef","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"6","key":"10.1016\/j.prp.2023.154833_bib59","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J. Hepatol."},{"issue":"7","key":"10.1016\/j.prp.2023.154833_bib60","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.prp.2023.154833_bib61","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.prp.2023.154833_bib62","first-page":"589","article-title":"New developments on the treatment of liver fibrosis","volume":"34","author":"Koyama","year":"2016","journal-title":"Dig. Dis. (Basel, Switz. )"},{"key":"10.1016\/j.prp.2023.154833_bib63","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6612892","article-title":"Current and emerging approaches for hepatic fibrosis treatment","volume":"2021","author":"Li","year":"2021","journal-title":"Gastroenterol. Res. Pract."},{"issue":"1","key":"10.1016\/j.prp.2023.154833_bib64","article-title":"Liver fibrosis: pathophysiology and clinical implications","volume":"13","author":"Berumen","year":"2021","journal-title":"WIREs Mech. Dis."},{"key":"10.1016\/j.prp.2023.154833_bib65","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mam.2018.09.002","article-title":"Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues","volume":"65","author":"Parola","year":"2019","journal-title":"Mol. Asp. Med."},{"issue":"4","key":"10.1016\/j.prp.2023.154833_bib66","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1055\/s-0033-1358527","article-title":"The role of gastrointestinal hormones in hepatic lipid metabolism","volume":"33","author":"Mells","year":"2013","journal-title":"Semin. liver Dis."},{"issue":"4","key":"10.1016\/j.prp.2023.154833_bib67","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.2337\/db10-1338","article-title":"Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice","volume":"60","author":"Shirakawa","year":"2011","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/j.prp.2023.154833_bib68","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s40264-019-00857-8","article-title":"Benefit-risk assessment of alogliptin for the treatment of type 2 diabetes mellitus","volume":"42","author":"Kaku","year":"2019","journal-title":"Drug Saf."},{"issue":"9","key":"10.1016\/j.prp.2023.154833_bib69","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1021\/tx3002719","article-title":"Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes","volume":"25","author":"Hajovsky","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.prp.2023.154833_bib70","series-title":"Comprehensive Toxicology (Second Edition)","first-page":"627","article-title":"9.29 - thioacetamide","author":"Mehendale","year":"2010"},{"issue":"5","key":"10.1016\/j.prp.2023.154833_bib71","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s00204-015-1543-4","article-title":"Experimental models of liver fibrosis","volume":"90","author":"Yanguas","year":"2016","journal-title":"Arch. Toxicol."},{"issue":"15","key":"10.1016\/j.prp.2023.154833_bib72","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.3748\/wjg.v19.i15.2298","article-title":"Dipeptidyl peptidase-4: a key player in chronic liver disease","volume":"19","author":"Itou","year":"2013","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.prp.2023.154833_bib73","doi-asserted-by":"crossref","DOI":"10.1186\/1475-2840-13-32","article-title":"The DPP-4 inhibitor sitagliptin attenuates the progress of atherosclerosis in apolipoprotein-E-knockout mice via AMPK- and MAPK-dependent mechanisms","volume":"13","author":"Zeng","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"issue":"8","key":"10.1016\/j.prp.2023.154833_bib74","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1139\/cjpp-2017-0680","article-title":"Vildagliptin\/pioglitazone combination improved the overall glycemic control in type I diabetic rats","volume":"96","author":"Abdelhamid","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"3","key":"10.1016\/j.prp.2023.154833_bib75","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1042\/BJ20150568","article-title":"KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity","volume":"469","author":"Dodson","year":"2015","journal-title":"Biochem. J."},{"key":"10.1016\/j.prp.2023.154833_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107963","article-title":"Telmisartan alleviates alcohol-induced liver injury by activation of PPAR-\u03b3\/ Nrf-2 crosstalk in mice","volume":"99","author":"Abdelhamid","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.prp.2023.154833_bib77","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.pharep.2019.06.006","article-title":"The hepatoprotective effect of sitagliptin against hepatic ischemia reperfusion-induced injury in rats involves Nrf-2\/HO-1 pathway","volume":"71","author":"Abdel-Gaber","year":"2019","journal-title":"Pharmacol. Rep.: PR"},{"issue":"7","key":"10.1016\/j.prp.2023.154833_bib78","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1080\/08941939.2019.1680777","article-title":"Dipeptidyl Peptidase-4 (DPP-4) inhibitor saxagliptin alleviates lipopolysaccharide-induced acute lung injury via regulating the Nrf-2\/HO-1 and NF-\u03baB pathways","volume":"34","author":"Guo","year":"2021","journal-title":"J. Invest. Surg.: Off. J. Acad. Surg. Res."},{"key":"10.1016\/j.prp.2023.154833_bib79","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.887233","article-title":"Carbocisteine as a modulator of Nrf2\/HO-1 and NF\u03baB interplay in rats: new inspiration for the revival of an old drug for treating ulcerative colitis front pharm","volume":"13","author":"Abdelhamid","year":"2022","journal-title":"Front Pharmacol."},{"issue":"1","key":"10.1016\/j.prp.2023.154833_bib80","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.prp.2023.154833_bib81","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"issue":"4","key":"10.1016\/j.prp.2023.154833_bib82","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/path.5680","article-title":"TGF-\u03b2 as a driver of fibrosis: physiological roles and therapeutic opportunities","volume":"254","author":"Budi","year":"2021","journal-title":"J. Pathol."},{"key":"10.1016\/j.prp.2023.154833_bib83","article-title":"Nanocomposite based on gold nanoparticles and carboxymethyl cellulose: synthesis, characterization, antimicrobial, and anticancer activities","volume":"77","author":"Doghish","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"46","key":"10.1016\/j.prp.2023.154833_bib84","doi-asserted-by":"crossref","first-page":"29052","DOI":"10.1039\/D1RA04345E","article-title":"Graphene oxide and its nanocomposites with EDTA or chitosan induce apoptosis in MCF-7 human breast cancer","volume":"11","author":"Doghish","year":"2021","journal-title":"RSC Adv."},{"issue":"16","key":"10.1016\/j.prp.2023.154833_bib85","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.3390\/polym14163352","article-title":"Synthesis of silver nanocomposite based on carboxymethyl cellulose: antibacterial, antifungal and anticancer activities","volume":"14","author":"Salem","year":"2022","journal-title":"Polymers"},{"issue":"1","key":"10.1016\/j.prp.2023.154833_bib86","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/14756366.2021.2015343","article-title":"New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies","volume":"37","author":"Elkady","year":"2022","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.prp.2023.154833_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154807","article-title":"Rumex vesicarius L. boosts the effectiveness of sorafenib in triple-negative breast cancer by downregulating BCl2, mTOR, and JNK, and upregulating p21 expression","volume":"250","author":"Ghanem","year":"2023","journal-title":"Pathol. - Res. Pract."},{"key":"10.1016\/j.prp.2023.154833_bib88","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/7382620","article-title":"Effect of dipeptidyl peptidase-4 (DPP-4) inhibition on biomarkers of kidney injury and vascular calcification in diabetic kidney disease: a randomized controlled trial","volume":"2021","author":"Trakarnvanich","year":"2021","journal-title":"J. Diabetes Res."},{"issue":"9","key":"10.1016\/j.prp.2023.154833_bib89","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200749R","article-title":"Ambroxol, a mucolytic agent, boosts HO-1, suppresses NF-\u03baB, and decreases the susceptibility of the inflamed rat colon to apoptosis: a new treatment option for treating ulcerative colitis","volume":"36","author":"Cavalu","year":"2022","journal-title":"FASEB J.: Off. Publ. Fed. Am. Soc. Exp. Biol."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033823005332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033823005332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T07:05:45Z","timestamp":1759734345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033823005332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":89,"alternative-id":["S0344033823005332"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2023.154833","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alogliptin exhibits multifaceted effects in thioacetamide-insulted rats: A novel approach to combating hepatic inflammation and fibrogenesis","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2023.154833","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154833"}}