{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:02:50Z","timestamp":1773028970954,"version":"3.50.1"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T00:00:00Z","timestamp":1739059200000},"content-version":"am","delay-in-days":345,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.prp.2024.155109","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T15:17:54Z","timestamp":1706800674000},"page":"155109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Immunohistochemical detection of cancer genetic abnormalities"],"prefix":"10.1016","volume":"255","author":[{"given":"Minh-Khang","family":"Le","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunio","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2268-0302","authenticated-orcid":false,"given":"Tetsuo","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.prp.2024.155109_bib1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"7381","key":"10.1016\/j.prp.2024.155109_bib2","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nature10762","article-title":"Clonal evolution in cancer","volume":"481","author":"Greaves","year":"2012","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.prp.2024.155109_bib3","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41580-020-0237-9","article-title":"Guidelines and definitions for research on epithelial\u2013mesenchymal transition","volume":"21","author":"Yang","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.prp.2024.155109_bib4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/1568009613666131126115012","article-title":"The role of E-Cadherin down-regulation in oral cancer: CDH1 gene expression and epigenetic blockage","volume":"14","author":"Pannone","year":"2014","journal-title":"Curr. Cancer Drug Targets"},{"issue":"2","key":"10.1016\/j.prp.2024.155109_bib5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/PAI.0000000000000181","article-title":"Immunohistochemistry as a surrogate for molecular testing: a review","volume":"23","author":"Swanson","year":"2015","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"issue":"5","key":"10.1016\/j.prp.2024.155109_bib6","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/1066896913502529","article-title":"The utility of immunohistochemistry for providing genetic information on tumors","volume":"21","author":"Chan","year":"2013","journal-title":"Int J. Surg. Pathol."},{"issue":"5","key":"10.1016\/j.prp.2024.155109_bib7","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.3892\/or.2013.2677","article-title":"Oncogenic chromosomal translocations and human cancer (Review)","volume":"30","author":"Zheng","year":"2013","journal-title":"Oncol. Rep."},{"issue":"10","key":"10.1016\/j.prp.2024.155109_bib8","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.3390\/ijms21103718","article-title":"Ntrk fusions, from the diagnostic algorithm to innovative treatment in the era of precision medicine","volume":"21","author":"Marino","year":"2020","journal-title":"Int J. Mol. Sci."},{"issue":"3-4","key":"10.1016\/j.prp.2024.155109_bib9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1615\/CritRevOncog.v7.i3-4.30","article-title":"Implication of cyclin D1 in malignant lymphoma","volume":"7","author":"Callanan","year":"1996","journal-title":"Crit. Rev. Oncog."},{"key":"10.1016\/j.prp.2024.155109_bib10","first-page":"1234","article-title":"Burkitt\u2019s lymphoma","volume":"Vol 379","author":"Molyneux","year":"2012"},{"issue":"8","key":"10.1016\/j.prp.2024.155109_bib11","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.tig.2006.06.007","article-title":"Gene amplification in cancer","volume":"22","author":"Albertson","year":"2006","journal-title":"Trends Genet."},{"key":"10.1016\/j.prp.2024.155109_bib12","unstructured":"HER2 overexpression of breast cancers in Hong Kong shows good concordance with HER2 amplification by fluorescence in-situ hybridisation study | HKMJ. Accessed June 22, 2021. \u3008https:\/\/www.hkmj.org\/abstracts\/v14n4\/333.htm\u3009."},{"issue":"7","key":"10.1016\/j.prp.2024.155109_bib13","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/modpathol.2011.47","article-title":"HER2 amplification, overexpression and score criteria in esophageal adenocarcinoma","volume":"24","author":"Hu","year":"2011","journal-title":"Mod. Pathol."},{"issue":"10","key":"10.1016\/j.prp.2024.155109_bib14","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1097\/PAS.0b013e3180581fff","article-title":"Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR","volume":"31","author":"Sirvent","year":"2007","journal-title":"Am. J. Surg. Pathol."},{"issue":"3","key":"10.1016\/j.prp.2024.155109_bib15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.lungcan.2009.07.014","article-title":"Protein overexpression and gene amplification of epidermal growth factor receptor in nonsmall cell lung carcinomas: comparison of four commercially available antibodies by immunohistochemistry and fluorescence in situ hybridization study","volume":"68","author":"Lee","year":"2010","journal-title":"Lung Cancer"},{"issue":"1","key":"10.1016\/j.prp.2024.155109_bib16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10549-015-3379-2","article-title":"Angiosarcoma and atypical vascular lesions of the breast: diagnostic and prognostic role of MYC gene amplification and protein expression","volume":"151","author":"Fraga-Guedes","year":"2015","journal-title":"Breast Cancer Res Treat."},{"issue":"30","key":"10.1016\/j.prp.2024.155109_bib17","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.1200\/JCO.2007.13.4296","article-title":"Polysomy 17 in breast cancer: clinicopathologic significance and impact on HER-2 testing","volume":"26","author":"vanden Bempt","year":"2008","journal-title":"J. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.prp.2024.155109_bib18","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1158\/1078-0432.CCR-04-2256","article-title":"Polysomy 17 in HER-2\/neu status elaboration in breast cancer: effect on daily practice","volume":"11","author":"Ma","year":"2005","journal-title":"Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.prp.2024.155109_bib19","doi-asserted-by":"crossref","first-page":"641","DOI":"10.21873\/invivo.11106","article-title":"Chromosome 7 multiplication in EGFR-positive lung carcinomas based on tissue microarray analysis","volume":"31","author":"Tsiambas","year":"2017","journal-title":"Vivo (Brooklyn)"},{"issue":"2","key":"10.1016\/j.prp.2024.155109_bib20","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001107","article-title":"Mutant p53 gain-of-function in cancer","volume":"2","author":"Oren","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"3","key":"10.1016\/j.prp.2024.155109_bib21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0964-1955(95)00095-X","article-title":"p53 overexpression in head and neck squamous cell carcinoma: review of the literature","volume":"32","author":"Raybaud-Diog\u00e8ne","year":"1996","journal-title":"Eur. J. Cancer B Oral. Oncol."},{"issue":"6","key":"10.1016\/j.prp.2024.155109_bib22","first-page":"1569","article-title":"P53 mutations in oral cavity carcinoma","volume":"23","author":"Ragos","year":"2018","journal-title":"J. BUON"},{"issue":"1","key":"10.1016\/j.prp.2024.155109_bib23","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1097\/PGP.0000000000000488","article-title":"Interpretation of P53 immunohistochemistry in endometrial carcinomas: toward increased reproducibility","volume":"38","author":"K\u00f6bel","year":"2019","journal-title":"Int. J. Gynecol. Pathol."},{"issue":"4","key":"10.1016\/j.prp.2024.155109_bib24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/cjp2.53","article-title":"Optimized p53 immunohistochemistry is an accurate predictor of TP53 mutation in ovarian carcinoma","volume":"2","author":"K\u00f6bel","year":"2016","journal-title":"J. Pathol. Clin. Res."},{"issue":"1","key":"10.1016\/j.prp.2024.155109_bib25","doi-asserted-by":"crossref","first-page":"1000334","DOI":"10.1371\/journal.pgen.1000334","article-title":"Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in the colon","volume":"5","author":"Zhang","year":"2009","journal-title":"PLoS Genet"},{"issue":"9","key":"10.1016\/j.prp.2024.155109_bib26","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/modpathol.2011.85","article-title":"Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: An immunohistochemical and nucleotide sequencing analysis","volume":"24","author":"Yemelyanova","year":"2011","journal-title":"Mod. Pathol."},{"issue":"4","key":"10.1016\/j.prp.2024.155109_bib27","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.jtho.2016.12.019","article-title":"BAP1 is altered by copy number loss, mutation, and\/or loss of protein expression in more than 70% of malignant peritoneal mesotheliomas","volume":"12","author":"Leblay","year":"2017","journal-title":"J. Thorac. Oncol."},{"issue":"12","key":"10.1016\/j.prp.2024.155109_bib28","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/cup.13530","article-title":"BRCA1-associated protein (BAP1)-inactivated melanocytic tumors","volume":"46","author":"Zhang","year":"2019","journal-title":"J. Cutan. Pathol."},{"issue":"2","key":"10.1016\/j.prp.2024.155109_bib29","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/his.12927","article-title":"Utility of ATRX immunohistochemistry in diagnosis of adult diffuse gliomas","volume":"69","author":"Ikemura","year":"2016","journal-title":"Histopathology"},{"issue":"4","key":"10.1016\/j.prp.2024.155109_bib30","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/PAS.0000000000000797","article-title":"SMARCB1 (INI-1)-deficient sinonasal carcinoma","volume":"41","author":"Agaimy","year":"2017","journal-title":"Am. J. Surg. Pathol."},{"issue":"4","key":"10.1016\/j.prp.2024.155109_bib31","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/cas.13173","article-title":"Oncogenic roles of SMARCB1\/INI1 and its deficient tumors","volume":"108","author":"Kohashi","year":"2017","journal-title":"Cancer Sci."},{"issue":"5","key":"10.1016\/j.prp.2024.155109_bib32","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/PAS.0000000000001428","article-title":"SMARCA4-deficient sinonasal carcinoma: a series of 10 cases expanding the genetic spectrum of SWI\/SNF-driven sinonasal malignancies","volume":"44","author":"Agaimy","year":"2020","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2024.155109_bib33","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.humpath.2020.06.002","article-title":"E-cadherin immunohistochemical expression in invasive lobular carcinoma of the breast: correlation with morphology and CDH1 somatic alterations","volume":"102","author":"Grabenstetter","year":"2020","journal-title":"Hum. Pathol."},{"issue":"7","key":"10.1016\/j.prp.2024.155109_bib34","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/s41379-019-0209-9","article-title":"The molecular mechanisms underlying reduced E-cadherin expression in invasive ductal carcinoma of the breast: high throughput analysis of large cohorts","volume":"32","author":"Alsaleem","year":"2019","journal-title":"Mod. Pathol."},{"issue":"8","key":"10.1016\/j.prp.2024.155109_bib35","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1097\/PAS.0b013e31825d532d","article-title":"Loss of retinoblastoma protein expression in spindle cell\/pleomorphic lipomas and cytogenetically related tumors: an immunohistochemical study with diagnostic implications","volume":"36","author":"Chen","year":"2012","journal-title":"Am. J. Surg. Pathol."},{"issue":"1","key":"10.1016\/j.prp.2024.155109_bib36","first-page":"97","article-title":"Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma","volume":"465","author":"Creytens","year":"2014","journal-title":"Virchows Arch."},{"key":"10.1016\/j.prp.2024.155109_bib37","article-title":"Myxoid pleomorphic liposarcoma-a clinicopathologic, immunohistochemical, molecular genetic and epigenetic study of 12 cases, suggesting a possible relationship with conventional pleomorphic liposarcoma","author":"D","year":"2021","journal-title":"Mod. Pathol."},{"issue":"8","key":"10.1016\/j.prp.2024.155109_bib38","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1136\/jclinpath-2018-205095","article-title":"Smad4\/DPC4","volume":"71","author":"McCarthy","year":"2018","journal-title":"J. Clin. Pathol."},{"issue":"OCTOBER2016","key":"10.1016\/j.prp.2024.155109_bib39","article-title":"TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions","volume":"5","author":"Shirole","year":"2016","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.prp.2024.155109_bib40","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1177\/0300985810379432","article-title":"The pathologist\u2019s slide reveals more than meets the eye: loss of heterozygosity and cancer biology","volume":"48","author":"Couto","year":"2011","journal-title":"Vet. Pathol."},{"issue":"1","key":"10.1016\/j.prp.2024.155109_bib41","doi-asserted-by":"crossref","DOI":"10.1186\/bcr416","article-title":"E-cadherin and loss of heterozygosity at chromosome 16 in breast cancinogenesis: different genetic pathways in ductal and lobular breast cancer?","volume":"4","author":"Cleton-Jansen","year":"2002","journal-title":"Breast Cancer Res."},{"issue":"1","key":"10.1016\/j.prp.2024.155109_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-19402-8","article-title":"Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients","volume":"11","author":"Fernando","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.prp.2024.155109_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/s41379-021-00854-2","article-title":"Loss of expression of YAP1C-terminus as an ancillary marker for epithelioid hemangioendothelioma variant with YAP1-TFE3 fusion and other YAP1-related vascular neoplasms","author":"Anderson","year":"2021","journal-title":"Mod. Pathol."},{"issue":"5307","key":"10.1016\/j.prp.2024.155109_bib44","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1126\/science.275.5307.1787","article-title":"Activation of \u03b2-catenin-Tcf signaling in colon cancer by mutations in \u03b2-catenin or APC","volume":"275","author":"Morin","year":"1997","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.prp.2024.155109_bib45","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1038\/s41379-018-0080-0","article-title":"Nuclear \u03b2-catenin localization and mutation of the CTNNB1 gene: a context-dependent association","volume":"31","author":"Kim","year":"2018","journal-title":"Mod. Pathol."},{"issue":"7","key":"10.1016\/j.prp.2024.155109_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers12071851","article-title":"Desmoid-type fibromatosis","volume":"12","author":"Garcia-Ortega","year":"2020","journal-title":"Cancers"},{"issue":"9","key":"10.1016\/j.prp.2024.155109_bib47","first-page":"1839","article-title":"Value of epithelioid morphology and PDGFRA immunostaining pattern for prediction of PDGFRA mutated genotype in gastrointestinal stromal tumors (GISTs)","volume":"6","author":"Agaimy","year":"2013","journal-title":"Int J. Clin. Exp. Pathol."},{"issue":"1","key":"10.1016\/j.prp.2024.155109_bib48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/PAP.0000000000000047","article-title":"Anaplastic large cell lymphomas: ALK positive, ALK negative, and primary cutaneous","volume":"22","author":"Xing","year":"2015","journal-title":"Adv. Anat. Pathol."},{"issue":"5","key":"10.1016\/j.prp.2024.155109_bib49","first-page":"1125","article-title":"Development of c-kit immunopositive interstitial cells of Cajal in the human stomach","volume":"14","author":"Radenkovic","year":"2010","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.prp.2024.155109_bib50","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.trecan.2017.11.006","article-title":"Gastrointestinal stromal tumors: the GIST of precision medicine","volume":"4","author":"L","year":"2018","journal-title":"Trends Cancer"},{"issue":"3","key":"10.1016\/j.prp.2024.155109_bib51","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.bbadis.2003.12.011","article-title":"High expression of both mutant and wild-type alleles of c-kit in gastrointestinal stromal tumors","volume":"1688","author":"Th\u00e9ou","year":"2004","journal-title":"Biochim Biophys. Acta"},{"issue":"10","key":"10.1016\/j.prp.2024.155109_bib52","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1053\/S0046-8177(03)00339-3","article-title":"Calretinin expression in human normal and neoplastic tissues: a tissue microarray analysis on 5233 tissue samples","volume":"34","author":"Lugli","year":"2003","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2024.155109_bib53","article-title":"Posttranscriptional regulation controls calretinin expression in malignant pleural mesothelioma","volume":"8","author":"J","year":"2017","journal-title":"Front Genet"},{"issue":"5","key":"10.1016\/j.prp.2024.155109_bib54","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1053\/j.semdp.2015.02.010","article-title":"BRAF V600E mutation-specific antibody: a review","volume":"32","author":"Ritterhouse","year":"2015","journal-title":"Semin Diagn. Pathol."},{"issue":"10","key":"10.1016\/j.prp.2024.155109_bib55","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1097\/PAI.0000000000000702","article-title":"Determining IDH-mutational status in gliomas using IDH1-R132H antibody and polymerase chain reaction","volume":"27","author":"Gondim","year":"2019","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"issue":"1","key":"10.1016\/j.prp.2024.155109_bib56","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12022-016-9466-z","article-title":"Detecting N-RAS Q61R mutated thyroid neoplasias by immunohistochemistry","volume":"28","author":"Crescenzi","year":"2017","journal-title":"Endocr. Pathol."},{"issue":"4","key":"10.1016\/j.prp.2024.155109_bib57","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/his.12992","article-title":"BRAFV600E and NRASQ61L\/Q61R mutation analysis in metastatic melanoma using immunohistochemistry: a study of 754 cases highlighting potential pitfalls and guidelines for interpretation and reporting","volume":"69","author":"Kakavand","year":"2016","journal-title":"Histopathology"},{"issue":"1","key":"10.1016\/j.prp.2024.155109_bib58","doi-asserted-by":"crossref","DOI":"10.1186\/s13000-015-0359-0","article-title":"NRAS Q61R, BRAF V600E immunohistochemistry: a concomitant tool for mutation screening in melanomas","volume":"10","author":"Uguen","year":"2015","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.prp.2024.155109_bib59","first-page":"922","article-title":"A novel SS18-SSX fusion-specific antibody for the diagnosis of synovial sarcoma","volume":"Vol 44","author":"Baranov","year":"2020"},{"issue":"4","key":"10.1016\/j.prp.2024.155109_bib60","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/s41379-020-00719-0","article-title":"Immunohistochemical detection of PAX-FOXO1 fusion proteins in alveolar rhabdomyosarcoma using breakpoint specific monoclonal antibodies","volume":"34","author":"Azorsa","year":"2021","journal-title":"Mod. Pathol."},{"issue":"23-24","key":"10.1016\/j.prp.2024.155109_bib61","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.drudis.2011.09.007","article-title":"What makes a good drug target?","volume":"16","author":"Gashaw","year":"2011","journal-title":"Drug Discov. Today"},{"issue":"7","key":"10.1016\/j.prp.2024.155109_bib62","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.5858\/2006-130-1026-IAQAOP","article-title":"Immunohistochemistry and quantitative analysis of protein expression","volume":"130","author":"Cregger","year":"2006","journal-title":"Arch. Pathol. Lab Med."},{"issue":"4","key":"10.1016\/j.prp.2024.155109_bib63","doi-asserted-by":"crossref","first-page":"413","DOI":"10.21614\/chirurgia.112.4.413","article-title":"Hormone therapy in breast cancer","volume":"112","author":"Dr\u01ceg\u01cenescu","year":"2017","journal-title":"Chirurgia"},{"issue":"1","key":"10.1016\/j.prp.2024.155109_bib64","first-page":"1","article-title":"Microsatellite instability: a review of what the oncologist should know","volume":"20","author":"Li","year":"2020","journal-title":"Cancer Cell Int"},{"issue":"9","key":"10.1016\/j.prp.2024.155109_bib65","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1200\/JCO.2016.71.3495","article-title":"Enzalutamide for the treatment of androgen receptor-expressing triple-negative breast cancer","volume":"36","author":"Traina","year":"2018","journal-title":"J. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.prp.2024.155109_bib66","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/PAI.0000000000000126","article-title":"Predictive biomarkers and companion diagnostics. The future of immunohistochemistry: \u201cin situ proteomics,\u201d or just a \u201cstain\u201d?","volume":"22","author":"Taylor","year":"2014","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"issue":"11","key":"10.1016\/j.prp.2024.155109_bib67","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1097\/PAS.0000000000000911","article-title":"Pan-Trk immunohistochemistry is an efficient and reliable screen for the detection of NTRK fusions","volume":"41","author":"Hechtman","year":"2017","journal-title":"Am. J. Surg. Pathol."},{"issue":"10","key":"10.1016\/j.prp.2024.155109_bib68","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1097\/PAS.0000000000000263","article-title":"BRAF V600E immunohistochemistry is reliable in primary and metastatic colorectal carcinoma regardless of treatment status and shows high intratumoral homogeneity","volume":"38","author":"Bledsoe","year":"2014","journal-title":"Am. J. Surg. Pathol."},{"issue":"6","key":"10.1016\/j.prp.2024.155109_bib69","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1586\/14737159.2016.1172963","article-title":"Profile of Ventana ALK (D5F3) companion diagnostic assay for non-small-cell lung carcinomas","volume":"16","author":"Conde","year":"2016","journal-title":"Expert Rev. Mol. Diagn."},{"issue":"3","key":"10.1016\/j.prp.2024.155109_bib70","doi-asserted-by":"crossref","first-page":"92828","DOI":"10.1371\/journal.pone.0092828","article-title":"Accurate and economical detection of ALK positive lung adenocarcinoma with semiquantitative immunohistochemical screening","volume":"9","author":"Zhou","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2024.155109_bib71","first-page":"9","article-title":"Pharmacogenomics and personalized medicine dovepress targeted therapies with companion diagnostics in the management of breast cancer: current perspectives","volume":"2016","author":"Myers","year":"2016","journal-title":"Pharmgenomics Pers. Med."},{"issue":"1","key":"10.1016\/j.prp.2024.155109_bib72","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/FTD.0000000000000460","article-title":"Companion and complementary diagnostics-focus on PD-L1 expression assays for PD-1\/PD-L1checkpoint inhibitors in non-small cell lung cancer","volume":"40","author":"Hersom","year":"2018","journal-title":"Ther. Drug Monit."},{"issue":"11","key":"10.1016\/j.prp.2024.155109_bib73","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1056\/NEJMoa1613683","article-title":"Pembrolizumab as second-line therapy for advanced urothelial carcinoma","volume":"376","author":"Bellmunt","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"10031","key":"10.1016\/j.prp.2024.155109_bib74","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/S0140-6736(16)00561-4","article-title":"Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial","volume":"387","author":"Rosenberg","year":"2016","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.prp.2024.155109_bib75","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/gcc.20886","article-title":"A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites","volume":"50","author":"C","year":"2011","journal-title":"Genes Chromosomes Cancer"},{"issue":"2","key":"10.1016\/j.prp.2024.155109_bib76","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng.2509","article-title":"Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing","volume":"45","author":"DR","year":"2013","journal-title":"Nat. Genet"},{"issue":"3","key":"10.1016\/j.prp.2024.155109_bib77","first-page":"175","article-title":"Frequency of ERG-positive prostate carcinoma in Polands","volume":"64","author":"K","year":"2013","journal-title":"Pol. J. Pathol."},{"issue":"7","key":"10.1016\/j.prp.2024.155109_bib78","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1097\/PAS.0b013e318198d666","article-title":"Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody","volume":"33","author":"Haack","year":"2009","journal-title":"Am. J. Surg. Pathol."},{"issue":"2","key":"10.1016\/j.prp.2024.155109_bib79","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/gcc.22700","article-title":"Immunohistochemical correlates of recurrent genetic alterations in sarcomas","volume":"58","author":"Anderson","year":"2019","journal-title":"Genes Chromosomes Cancer"},{"issue":"9","key":"10.1016\/j.prp.2024.155109_bib80","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1097\/PAS.0b013e3182960fa7","article-title":"ROS1 immunohistochemistry for detection of ROS1-rearranged lung adenocarcinomas","volume":"37","author":"LM","year":"2013","journal-title":"Am. J. Surg. Pathol."},{"issue":"4","key":"10.1016\/j.prp.2024.155109_bib81","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1177\/1093526617698263","article-title":"BCOR-CCNB3 undifferentiated sarcoma-does immunohistochemistry help in the identification?","volume":"20","author":"Ludwig","year":"2017","journal-title":"Pedia Dev. Pathol."},{"issue":"1","key":"10.1016\/j.prp.2024.155109_bib82","article-title":"Immunohistochemical and molecular detection of the expression of FGF23 in phosphaturic mesenchymal tumors including the non-phosphaturic variant","volume":"11","author":"E","year":"2016","journal-title":"Diagn. Pathol."},{"issue":"2","key":"10.1016\/j.prp.2024.155109_bib83","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/PAS.0000000000001564","article-title":"DDIT3 immunohistochemistry Is a Useful Tool for the diagnosis of myxoid liposarcoma","volume":"45","author":"JV","year":"2021","journal-title":"Am. J. Surg. Pathol."},{"issue":"5","key":"10.1016\/j.prp.2024.155109_bib84","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1097\/PAS.0000000000000965","article-title":"BCOR-CCNB3 fusion positive sarcomas: a clinicopathologic and molecular analysis of 36 cases with comparison to morphologic spectrum and clinical behavior of other round cell sarcomas","volume":"42","author":"Kao","year":"2018","journal-title":"Am. J. Surg. Pathol."},{"issue":"23","key":"10.1016\/j.prp.2024.155109_bib85","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.1158\/1078-0432.CCR-14-1182","article-title":"AMACR amplification in myxofibrosarcomas: a mechanism of overexpression that promotes cell proliferation with therapeutic relevance","volume":"20","author":"CF","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2024.155109_bib86","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.humpath.2017.10.013","article-title":"The utility of SDHB and FH immunohistochemistry in patients evaluated for hereditary paraganglioma-pheochromocytoma syndromes","volume":"71","author":"Udager","year":"2018","journal-title":"Hum. Pathol."},{"issue":"1","key":"10.1016\/j.prp.2024.155109_bib87","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0002-9440(10)64703-7","article-title":"Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas: a new marker of DPC4 inactivation","volume":"156","author":"Wilentz","year":"2000","journal-title":"Am. J. Pathol."},{"issue":"10","key":"10.1016\/j.prp.2024.155109_bib88","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1038\/leu.2009.124","article-title":"Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications","volume":"23","author":"Falini","year":"2009","journal-title":"Leukemia"},{"issue":"9","key":"10.1016\/j.prp.2024.155109_bib89","article-title":"Four methods to analyze H3K27M mutation in diffuse midline gliomas","volume":"216","author":"H","year":"2020","journal-title":"Pathol. Res. Pract."},{"issue":"1","key":"10.1016\/j.prp.2024.155109_bib90","article-title":"Histone H3.3 mutation in giant cell tumor of bone: an update in pathology","volume":"53","author":"H","year":"2020","journal-title":"Med. Mol. Morphol."},{"issue":"12","key":"10.1016\/j.prp.2024.155109_bib91","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s40263-019-00684-6","article-title":"Novel IDH1-targeted glioma therapies","volume":"33","author":"Karpel-Massler","year":"2019","journal-title":"CNS Drugs"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033824000207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033824000207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T07:08:47Z","timestamp":1759734527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033824000207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":91,"alternative-id":["S0344033824000207"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2024.155109","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunohistochemical detection of cancer genetic abnormalities","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2024.155109","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155109"}}