{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:47:01Z","timestamp":1769608021845,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.prp.2024.155164","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T11:36:54Z","timestamp":1705923414000},"page":"155164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Reduced expression of Ankyrin-G and E-cadherin in duodenal mucosal biopsy of subjects with celiac disease"],"prefix":"10.1016","volume":"255","author":[{"given":"Nidhi","family":"Sharma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikram","family":"Narang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajit","family":"Sood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandana","family":"Midha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabyasachi","family":"Senapati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2024.155164_bib1","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMcp1113994","article-title":"Celiac disease","volume":"367","author":"Fasano","year":"2012","journal-title":"New Engl. J. Med."},{"issue":"1","key":"10.1016\/j.prp.2024.155164_bib2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/20469047.2018.1504431","article-title":"Coeliac disease","volume":"39","author":"Glissen","year":"2019","journal-title":"Paediatr. Child Health"},{"key":"10.1016\/j.prp.2024.155164_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-019-1380-z","article-title":"Celiac disease: a comprehensive current review","volume":"17","author":"Caio","year":"2019","journal-title":"BMC Med"},{"key":"10.1016\/j.prp.2024.155164_bib4","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1053\/j.gastro.2016.01.029","article-title":"Clinical and immunologic features of ultra-short celiac disease","volume":"150","author":"Mooney","year":"2016","journal-title":"Gastroenterol"},{"issue":"5","key":"10.1016\/j.prp.2024.155164_bib5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1046\/j.1365-2036.1996.66237000.x","article-title":"Management of patients with non-responsive coeliac disease","volume":"10","author":"O'Mahony","year":"1996","journal-title":"Aliment. Pharm."},{"key":"10.1016\/j.prp.2024.155164_bib6","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/ng.209","article-title":"Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder","volume":"40","author":"Ferreira","year":"2008","journal-title":"Nat. Genet"},{"issue":"1","key":"10.1016\/j.prp.2024.155164_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12920-016-0211-8","article-title":"Shared and unique common genetic determinants between pediatric and adult celiac disease","volume":"9","author":"Senapati","year":"2016","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.prp.2024.155164_bib8","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.jpsychires.2010.02.002","article-title":"Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort","volume":"44","author":"Athanasiu","year":"2010","journal-title":"J. Psychiatry Res"},{"key":"10.1016\/j.prp.2024.155164_bib9","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/ejhg.2014.137","article-title":"Evaluation of European coeliac disease risk variants in a north Indian population","volume":"23","author":"Senapati","year":"2015","journal-title":"Eur. J. Hum. Genet"},{"issue":"39","key":"10.1016\/j.prp.2024.155164_bib10","first-page":"19717","article-title":"Neurodevelopmental mutation of giant ankyrin-G disrupts a core mechanism for axon initial segment assembly","volume":"116","author":"Yang","year":"2019","journal-title":"Procn. Sci."},{"issue":"4","key":"10.1016\/j.prp.2024.155164_bib11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s10048-021-00655-4","article-title":"ANK3 related neurodevelopmental disorders: expanding the spectrum of heterozygous loss-of-function variants","volume":"22","author":"Kloth","year":"2021","journal-title":"Neurogenetics"},{"key":"10.1016\/j.prp.2024.155164_bib12","first-page":"1","article-title":"Celiac disease poses significant risk in developing depression, anxiety, headache, epilepsy, panic disorder, dysthymia: a meta-analysis","volume":"2021","author":"Sharma","year":"2021","journal-title":"Indian J. Gastroenterol"},{"issue":"2","key":"10.1016\/j.prp.2024.155164_bib13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1083\/jcb.130.2.313","article-title":"Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain","volume":"130","author":"Peters","year":"1995","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.prp.2024.155164_bib14","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1074\/jbc.M115.648386","article-title":"Ankyrin-G inhibits endocytosis of cadherin dimers","volume":"291","author":"Cadwell","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.prp.2024.155164_bib15","doi-asserted-by":"crossref","first-page":"16706","DOI":"10.1074\/jbc.M314296200","article-title":"Lateral membrane biogenesis in human bronchial epithelial cells requires 190 kDa ankyrin-G","volume":"279","author":"Kizhatil","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"36","key":"10.1016\/j.prp.2024.155164_bib16","doi-asserted-by":"crossref","first-page":"26552","DOI":"10.1074\/jbc.M703158200","article-title":"Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos","volume":"282","author":"Kizhatil","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.prp.2024.155164_bib17","first-page":"a003012","article-title":"Membrane domains based on ankyrin and spectrin associated with cell\u2013cell interactions","volume":"1","author":"Bennett","year":"2009","journal-title":"Cold Spring HarbPerspect Biol."},{"key":"10.1016\/j.prp.2024.155164_bib18","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1128\/MCB.01342-10","article-title":"A pathway for the control of anoikis-sensitivity by E-cadherin and EMT","volume":"31","author":"Kumar","year":"2011","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.prp.2024.155164_bib19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.yexcr.2017.03.061","article-title":"Interplay between tight junctions &adherens junctions","volume":"358","author":"Campbell","year":"2017","journal-title":"Exp. Cell Res."},{"issue":"8","key":"10.1016\/j.prp.2024.155164_bib20","first-page":"1","article-title":"Mechanisms regulating intestinal barrier integrity and its pathological implications","volume":"50","author":"Chelakkot","year":"2018","journal-title":"ExpMol Med."},{"issue":"6","key":"10.1016\/j.prp.2024.155164_bib21","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/MPG.0000000000000338","article-title":"Alteration of tight junction gene expression in celiac disease","volume":"58","author":"Jauregi-Miguel","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.prp.2024.155164_bib22","first-page":"402","volume":"Vol. 25","author":"Livak","year":"2001"},{"issue":"2","key":"10.1016\/j.prp.2024.155164_bib23","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nmeth.2811","article-title":"BoxPlotR: a web tool for generation of box plots","volume":"11","author":"Spitzer","year":"2014","journal-title":"Nat. Methods"},{"issue":"6130","key":"10.1016\/j.prp.2024.155164_bib24","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/328533a0","article-title":"Ankyrin binding to (Na++ K+) ATPase and implications for the organization of membrane domains in polarized cells","volume":"328","author":"Nelson","year":"1987","journal-title":"Nature"},{"issue":"4919","key":"10.1016\/j.prp.2024.155164_bib25","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1126\/science.2672330","article-title":"Morphogenesis of the polarized epithelial cell phenotype","volume":"245","author":"Rodriguez-Boulan","year":"1989","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.prp.2024.155164_bib26","first-page":"2965","article-title":"Ankyrin binds to two distinct cytoplasmic domains of Na, K-ATPase alpha subunit","volume":"91","author":"Devarajan","year":"1994","journal-title":"Procn. Sci."},{"key":"10.1016\/j.prp.2024.155164_bib27","first-page":"702","article-title":"Molecular mechanism of regulation of villus cell Na-K-ATPase in the chronically inflamed mammalian small intestine","volume":"1848","author":"Saha","year":"2015","journal-title":"BiochimBiophysActa"},{"issue":"1","key":"10.1016\/j.prp.2024.155164_bib28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1074\/jbc.M116.753616","article-title":"Ankyrin G expression regulates apical delivery of the epithelial sodium channel (ENaC)","volume":"292","author":"Klemens","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.prp.2024.155164_bib29","first-page":"393","article-title":"The role of the E-cadherin\/catenin complex in gastrointestinal cancer","volume":"62","author":"Bebruyne","year":"1999","journal-title":"Acta Gastroenterol. Beig."},{"issue":"3","key":"10.1016\/j.prp.2024.155164_bib30","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00441-014-1994-6","article-title":"Defects in the adherens junction complex (E-cadherin\/\u03b2-catenin) in inflammatory bowel disease","volume":"360","author":"Mehta","year":"2015","journal-title":"Cell Tissue Res"},{"issue":"2","key":"10.1016\/j.prp.2024.155164_bib31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1309\/AJCPS54RTFCTHGWX","article-title":"Combined loss of E-cadherin and aberrant \u03b2-catenin protein expression correlates with a poor prognosis for small intestinal adenocarcinomas","volume":"139","author":"Lee","year":"2013","journal-title":"Am. J. Clin. Pathol."},{"issue":"6","key":"10.1016\/j.prp.2024.155164_bib32","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.3892\/ol.2017.6063","article-title":"E-cadherin: a potential biomarker of colorectal cancer prognosis","volume":"13","author":"Christou","year":"2017","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.prp.2024.155164_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2012.06.005","article-title":"E-cadherin is required for intestinal morphogenesis in the mouse","volume":"371","author":"Bondow","year":"2012","journal-title":"Dev. Biol."},{"issue":"11","key":"10.1016\/j.prp.2024.155164_bib34","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.3390\/ijms20112756","article-title":"E-cadherin beyond structure: a signaling hub in colon homeostasis and disease","volume":"20","author":"Daulagala","year":"2019","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.prp.2024.155164_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12038-020-00117-3","article-title":"Human ankyrins and their contribution to disease biology: an update","volume":"45","author":"Sharma","year":"2020","journal-title":"J. Biosci."},{"issue":"1","key":"10.1016\/j.prp.2024.155164_bib36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/glia.20252","article-title":"Expression of Nav1. 6 sodium channels by Schwann cells at neuromuscular junctions: role in the motor endplate disease phenotype","volume":"53","author":"Musarella","year":"2006","journal-title":"Glia"},{"issue":"24","key":"10.1016\/j.prp.2024.155164_bib37","doi-asserted-by":"crossref","first-page":"5796","DOI":"10.1523\/JNEUROSCI.0858-17.2017","article-title":"A role for ankyrin-G in maturation and maintenance of the nodes of ranvier","volume":"37","author":"Yang","year":"2017","journal-title":"JNeurosci"},{"issue":"8","key":"10.1016\/j.prp.2024.155164_bib38","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.3390\/cells10082110","article-title":"Pathophysiological roles of abnormal axon initial segments in neurodevelopmental disorders","volume":"10","author":"Fujitani","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.prp.2024.155164_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-019-0465-9","article-title":"S100P is a molecular determinant of E-cadherin function in gastric cancer","volume":"17","author":"Carneiro","year":"2019","journal-title":"Cell Commun. Signal"},{"issue":"18","key":"10.1016\/j.prp.2024.155164_bib40","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.3390\/ijms20184452","article-title":"E-cadherin downregulation and microRNAs in sporadic intestinal-type gastric cancer","volume":"20","author":"Rossi","year":"2019","journal-title":"Int J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.prp.2024.155164_bib41","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1111\/jcmm.16348","article-title":"M1 Macrophage exosomes MiR-21a-5p aggravates inflammatory bowel disease through decreasing E-cadherin and subsequent ILC2 activation","volume":"25","author":"Lu","year":"2021","journal-title":"J. Cell Mol. Med"},{"issue":"5","key":"10.1016\/j.prp.2024.155164_bib42","first-page":"331","article-title":"Colonic fibronectin and E-cadherin in mild ulcerative colitis","volume":"122","author":"Sarpdag","year":"2021","journal-title":"BratislavskeLekarskeListy"},{"key":"10.1016\/j.prp.2024.155164_bib43","article-title":"DNA and RNA sequencing analysis revealed alterations of ANK3, PKHD1 and olfactory transduction as potential biomarker of three-year survival in gastric cancer","volume":"39","author":"Wang","year":"2021","journal-title":"J. ClinOncol"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S034403382400075X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S034403382400075X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T07:06:18Z","timestamp":1759734378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S034403382400075X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":43,"alternative-id":["S034403382400075X"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2024.155164","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced expression of Ankyrin-G and E-cadherin in duodenal mucosal biopsy of subjects with celiac disease","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2024.155164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155164"}}