{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:24:43Z","timestamp":1740140683586,"version":"3.37.3"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["202102021165"],"award-info":[{"award-number":["202102021165"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020757","name":"Guangzhou First People's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020757","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702879"],"award-info":[{"award-number":["81702879"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021A1515110094"],"award-info":[{"award-number":["2021A1515110094"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.prp.2024.155264","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T02:59:55Z","timestamp":1710385195000},"page":"155264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["ADAM22 acts as a novel predictive biomarker for unfavorable prognosis and facilitates metastasis via PI3K\/AKT signaling pathway in nasopharyngeal carcinoma"],"prefix":"10.1016","volume":"256","author":[{"given":"Kaixiong","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.prp.2024.155264_bib1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.canlet.2016.01.040","article-title":"Global trends in incidence and mortality of nasopharyngeal carcinoma","volume":"374","author":"Tang","year":"2016","journal-title":"Cancer Lett."},{"issue":"10192","key":"10.1016\/j.prp.2024.155264_bib2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","article-title":"Nasopharyngeal carcinoma","volume":"394","author":"Chen","year":"2019","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.prp.2024.155264_bib3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"issue":"10","key":"10.1016\/j.prp.2024.155264_bib4","first-page":"450","article-title":"Subdivision of M category for nasopharyngeal carcinoma with synchronous metastasis: time to expand the M categorization system","volume":"34","author":"Shen","year":"2015","journal-title":"Chin. J. Cancer"},{"key":"10.1016\/j.prp.2024.155264_bib5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1471-2407-12-98","article-title":"Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence","volume":"12","author":"Ho","year":"2012","journal-title":"BMC Cancer"},{"issue":"4","key":"10.1016\/j.prp.2024.155264_bib6","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.4143\/crt.2018.688","article-title":"Patterns of failure and survival trends in 3,808 patients with stage II nasopharyngeal carcinoma diagnosed from 1990 to 2012: a large-scale retrospective cohort study","volume":"51","author":"Sun","year":"2019","journal-title":"Cancer Res Treat."},{"key":"10.1016\/j.prp.2024.155264_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1748-717X-9-87","article-title":"Local failure patterns for patients with nasopharyngeal carcinoma after intensity-modulated radiotherapy","volume":"9","author":"Li","year":"2014","journal-title":"Radiat. Oncol."},{"issue":"17","key":"10.1016\/j.prp.2024.155264_bib8","doi-asserted-by":"crossref","first-page":"6147","DOI":"10.1002\/cam4.3301","article-title":"Pattern and prognosis of distant metastases in nasopharyngeal carcinoma: a large-population retrospective analysis","volume":"9","author":"Qu","year":"2020","journal-title":"Cancer Med"},{"issue":"1","key":"10.1016\/j.prp.2024.155264_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0009-9260(78)80160-3","article-title":"Distant metastases in nasopharyngeal carcinoma","volume":"29","author":"Khor","year":"1978","journal-title":"Clin. Radio."},{"issue":"4","key":"10.1016\/j.prp.2024.155264_bib10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s11684-018-0656-6","article-title":"Epithelial-to-mesenchymal transition in cancer: complexity and opportunities","volume":"12","author":"Zhang","year":"2018","journal-title":"Front Med"},{"issue":"2","key":"10.1016\/j.prp.2024.155264_bib11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","article-title":"New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer","volume":"20","author":"Dongre","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.prp.2024.155264_bib12","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"344","key":"10.1016\/j.prp.2024.155264_bib13","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2005189","article-title":"Signaling mechanisms of the epithelial-mesenchymal transition","volume":"7","author":"Gonzalez","year":"2014","journal-title":"Sci. Signal"},{"key":"10.1016\/j.prp.2024.155264_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.988458","article-title":"Epithelial-mesenchymal transition classification of circulating tumor cells predicts clinical outcomes in progressive nasopharyngeal carcinoma","volume":"12","author":"Wei","year":"2022","journal-title":"Front Oncol."},{"issue":"1","key":"10.1016\/j.prp.2024.155264_bib15","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1186\/s13046-019-1463-x","article-title":"NOTCH2 negatively regulates metastasis and epithelial-Mesenchymal transition via TRAF6\/AKT in nasopharyngeal carcinoma","volume":"38","author":"Zou","year":"2019","journal-title":"J. Exp. Clin. Cancer Res"},{"issue":"9","key":"10.1016\/j.prp.2024.155264_bib16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.5732\/cjc.011.10314","article-title":"Serglycin in human cancers","volume":"30","author":"Li","year":"2011","journal-title":"Chin. J. Cancer"},{"issue":"2","key":"10.1016\/j.prp.2024.155264_bib17","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.semcdb.2008.11.002","article-title":"The \"a disintegrin and metalloprotease\" (ADAM) family of sheddases: physiological and cellular functions","volume":"20","author":"Reiss","year":"2009","journal-title":"Semin Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.prp.2024.155264_bib18","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1349-7006.2007.00434.x","article-title":"ADAMs in cancer cell proliferation and progression","volume":"98","author":"Mochizuki","year":"2007","journal-title":"Cancer Sci."},{"issue":"8","key":"10.1016\/j.prp.2024.155264_bib19","doi-asserted-by":"crossref","first-page":"720","DOI":"10.2174\/156800908786733478","article-title":"ADAM proteins - therapeutic potential in cancer","volume":"8","author":"Lu","year":"2008","journal-title":"Curr. Cancer Drug Targets"},{"issue":"5","key":"10.1016\/j.prp.2024.155264_bib20","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/01.jnen.0000229240.51490.d3","article-title":"Metalloproteinase disintegrins ADAM8 and ADAM19 are highly regulated in human primary brain tumors and their expression levels and activities are associated with invasiveness","volume":"65","author":"Wildeboer","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"8","key":"10.1016\/j.prp.2024.155264_bib21","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1158\/1078-0432.CCR-06-2092","article-title":"ADAM-17 expression in breast cancer correlates with variables of tumor progression","volume":"13","author":"McGowan","year":"2007","journal-title":"Clin. Cancer Res"},{"issue":"1-2","key":"10.1016\/j.prp.2024.155264_bib22","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11010-011-1018-8","article-title":"ADAM17 regulates prostate cancer cell proliferation through mediating cell cycle progression by EGFR\/PI3K\/AKT pathway","volume":"359","author":"Lin","year":"2012","journal-title":"Mol. Cell Biochem"},{"key":"10.1016\/j.prp.2024.155264_bib23","doi-asserted-by":"crossref","first-page":"6175","DOI":"10.1038\/ncomms7175","article-title":"ADAM8 as a drug target in pancreatic cancer","volume":"6","author":"Schlomann","year":"2015","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.prp.2024.155264_bib24","doi-asserted-by":"crossref","first-page":"6634","DOI":"10.1038\/s41598-022-10608-y","article-title":"ADAM12 is an independent predictor of poor prognosis in liver cancer","volume":"12","author":"Du","year":"2022","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.prp.2024.155264_bib25","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/jso.21781","article-title":"ADAM 10 is associated with gastric cancer progression and prognosis of patients","volume":"103","author":"Wang","year":"2011","journal-title":"J. Surg. Oncol."},{"issue":"11","key":"10.1016\/j.prp.2024.155264_bib26","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1111\/cas.12800","article-title":"Effects of ADAM10 upregulation on progression, migration, and prognosis of nasopharyngeal carcinoma","volume":"106","author":"You","year":"2015","journal-title":"Cancer Sci."},{"issue":"12","key":"10.1016\/j.prp.2024.155264_bib27","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.4161\/cc.28921","article-title":"Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis","volume":"13","author":"Bao","year":"2014","journal-title":"Cell Cycle"},{"issue":"3","key":"10.1016\/j.prp.2024.155264_bib28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/path.2487","article-title":"The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma","volume":"217","author":"Bose","year":"2009","journal-title":"J. Pathol."},{"issue":"3","key":"10.1016\/j.prp.2024.155264_bib29","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S1470-2045(18)30080-9","article-title":"Development and validation of a gene expression-based signature to predict distant metastasis in locoregionally advanced nasopharyngeal carcinoma: a retrospective, multicentre, cohort study","volume":"19","author":"Tang","year":"2018","journal-title":"Lancet Oncol."},{"issue":"1","key":"10.1016\/j.prp.2024.155264_bib30","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s13046-018-0953-6","article-title":"EBV-miR-BART8-3p induces epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma cells through activating NF-kappaB and Erk1\/2 pathways.","volume":"37","author":"Lin","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"12","key":"10.1016\/j.prp.2024.155264_bib31","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1158\/1541-7786.MCR-17-0134","article-title":"Genomic analysis of nasopharyngeal carcinoma reveals TME-based subtypes","volume":"15","author":"Zhang","year":"2017","journal-title":"Mol. Cancer Res"},{"key":"10.1016\/j.prp.2024.155264_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.746763","article-title":"A novel seven gene signature-based prognostic model to predict distant metastasis of lymph node-negative triple-negative breast cancer","volume":"11","author":"Peng","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.prp.2024.155264_bib33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-3-030-22254-3_2","article-title":"Current perspectives on nasopharyngeal carcinoma","volume":"1164","author":"Lee","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.prp.2024.155264_bib34","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.2147\/IJGM.S352330","article-title":"Identification of DTL as related biomarker and immune infiltration characteristics of nasopharyngeal carcinoma via comprehensive strategies","volume":"15","author":"Wang","year":"2022","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.prp.2024.155264_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3934704","article-title":"Differentially infiltrated identification of novel diagnostic biomarkers associated with immune infiltration in nasopharyngeal carcinoma","volume":"2022","author":"Gao","year":"2022","journal-title":"Dis. Markers"},{"issue":"20","key":"10.1016\/j.prp.2024.155264_bib36","doi-asserted-by":"crossref","first-page":"7404","DOI":"10.1002\/cam4.4228","article-title":"Key radioresistance regulation models and marker genes identified by integrated transcriptome analysis in nasopharyngeal carcinoma","volume":"10","author":"Sun","year":"2021","journal-title":"Cancer Med."},{"issue":"2","key":"10.1016\/j.prp.2024.155264_bib37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/15384047.2019.1670521","article-title":"RNA-Seq analysis of peripheral blood mononuclear cells reveals unique transcriptional signatures associated with radiotherapy response of nasopharyngeal carcinoma and prognosis of head and neck cancer","volume":"21","author":"Liu","year":"2020","journal-title":"Cancer Biol. Ther."},{"issue":"48","key":"10.1016\/j.prp.2024.155264_bib38","article-title":"Screening and identification of key biomarkers in nasopharyngeal carcinoma: Evidence from bioinformatic analysis","volume":"98","author":"Zhang","year":"2019","journal-title":"Med. (Baltim.)"},{"issue":"35","key":"10.1016\/j.prp.2024.155264_bib39","article-title":"Bioinformatics analysis identifies potential biomarkers involved in the metastasis of locoregionally advanced nasopharyngeal carcinoma","volume":"101","author":"Hu","year":"2022","journal-title":"Med. (Baltim.)"},{"issue":"12","key":"10.1016\/j.prp.2024.155264_bib40","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1002\/jcp.25797","article-title":"Epithelial-mesenchymal transition (EMT): a biological process in the development, stem cell differentiation, and tumorigenesis","volume":"232","author":"Chen","year":"2017","journal-title":"J. Cell Physiol."},{"issue":"4","key":"10.1016\/j.prp.2024.155264_bib41","first-page":"509","article-title":"Molecular mechanisms of epithelial to mesenchymal transition in tumor metastasis","volume":"66","author":"Nieszporek","year":"2019","journal-title":"Acta Biochim Pol."},{"key":"10.1016\/j.prp.2024.155264_bib42","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.biopha.2017.11.034","article-title":"ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR\/ERK signaling pathway","volume":"97","author":"Wang","year":"2018","journal-title":"Biomed. Pharm."},{"issue":"12","key":"10.1016\/j.prp.2024.155264_bib43","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1158\/0008-5472.CAN-20-3892","article-title":"Induction of ADAM10 by radiation therapy drives fibrosis, resistance, and epithelial-to-mesenchyal transition in pancreatic cancer","volume":"81","author":"Mueller","year":"2021","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.prp.2024.155264_bib44","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/s41419-018-1204-7","article-title":"Annexin A1-suppressed autophagy promotes nasopharyngeal carcinoma cell invasion and metastasis by PI3K\/AKT signaling activation","volume":"9","author":"Zhu","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.prp.2024.155264_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.617621","article-title":"YBX3 mediates the metastasis of nasopharyngeal carcinoma via PI3K\/AKT signaling","volume":"11","author":"Fan","year":"2021","journal-title":"Front. Oncol."},{"issue":"11","key":"10.1016\/j.prp.2024.155264_bib46","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.4161\/cbt.8.11.8539","article-title":"ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation","volume":"8","author":"Zheng","year":"2009","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.prp.2024.155264_bib47","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/msb.2011.67","article-title":"Toward an understanding of the protein interaction network of the human liver","volume":"7","author":"Wang","year":"2011","journal-title":"Mol. Syst. Biol."},{"issue":"4","key":"10.1016\/j.prp.2024.155264_bib48","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/emm.2004.47","article-title":"The role of Rho GTPases in the regulation of the rearrangement of actin cytoskeleton and cell movement","volume":"36","author":"Begum","year":"2004","journal-title":"Exp. Mol. Med."},{"issue":"9","key":"10.1016\/j.prp.2024.155264_bib49","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.4049\/jimmunol.1901494","article-title":"Rac2 regulates the migration of T lymphoid progenitors to the thymus during zebrafish embryogenesis","volume":"204","author":"Lu","year":"2020","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.prp.2024.155264_bib50","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1182\/bloodadvances.2020001665","article-title":"Inhibition of B-cell receptor signaling disrupts cell adhesion in mantle cell lymphoma via RAC2","volume":"5","author":"Wu","year":"2021","journal-title":"Blood Adv."},{"issue":"5","key":"10.1016\/j.prp.2024.155264_bib51","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S1074-7613(00)80207-1","article-title":"Rac2 stimulates Akt activation affecting BAD\/Bcl-XL expression while mediating survival and actin function in primary mast cells","volume":"12","author":"Yang","year":"2000","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.prp.2024.155264_bib52","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/15384101.2016.1259039","article-title":"RAC2-P38 MAPK-dependent NADPH oxidase activity is associated with the resistance of quiescent cells to ionizing radiation","volume":"16","author":"Pei","year":"2017","journal-title":"Cell Cycle"},{"issue":"1","key":"10.1016\/j.prp.2024.155264_bib53","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.yexcr.2003.08.010","article-title":"Rac regulates integrin-mediated endothelial cell adhesion and migration on laminin-8","volume":"292","author":"Fujiwara","year":"2004","journal-title":"Exp. Cell Res."},{"issue":"18","key":"10.1016\/j.prp.2024.155264_bib54","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1182\/blood-2018-11-886028","article-title":"Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects","volume":"133","author":"Hsu","year":"2019","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.prp.2024.155264_bib55","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s12916-020-01806-4","article-title":"ADAM22\/LGI1 complex as a new actionable target for breast cancer brain metastasis","volume":"18","author":"Charmsaz","year":"2020","journal-title":"BMC Med."},{"key":"10.1016\/j.prp.2024.155264_bib56","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/B978-0-12-416673-8.00014-9","article-title":"ADAM22 as a prognostic and therapeutic drug target in the treatment of endocrine-resistant breast cancer","volume":"93","author":"Bolger","year":"2013","journal-title":"Vitam. Horm."},{"issue":"5","key":"10.1016\/j.prp.2024.155264_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/toxins8050155","article-title":"ADAM and ADAMTS family proteins and snake venom metalloproteinases: a structural overview","volume":"8","author":"Takeda","year":"2016","journal-title":"Toxins (Basel)"},{"issue":"1","key":"10.1016\/j.prp.2024.155264_bib58","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbapap.2011.04.009","article-title":"Snake venom metalloproteinases: structure, function and relevance to the mammalian ADAM\/ADAMTS family proteins","volume":"1824","author":"Takeda","year":"2012","journal-title":"Biochim Biophys. Acta"},{"issue":"1","key":"10.1016\/j.prp.2024.155264_bib59","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1042\/CS20180906","article-title":"ADAM8 in invasive cancers: links to tumor progression, metastasis, and chemoresistance","volume":"133","author":"Conrad","year":"2019","journal-title":"Clin. Sci. (Lond. )"},{"issue":"9","key":"10.1016\/j.prp.2024.155264_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11091218","article-title":"ADAM17: an emerging therapeutic target for lung cancer","volume":"11","author":"Saad","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"20","key":"10.1016\/j.prp.2024.155264_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21207790","article-title":"An overview of ADAM9: structure, activation, and regulation in human diseases","volume":"21","author":"Chou","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.prp.2024.155264_bib62","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1559-0275-8-9","article-title":"The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?","volume":"8","author":"Duffy","year":"2011","journal-title":"Clin. Proteom."},{"issue":"19","key":"10.1016\/j.prp.2024.155264_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910378","article-title":"A disintegrin and metalloproteinase (ADAM) family: their significance in malignant tumors of the central nervous system (CNS)","volume":"22","author":"Lukaszewicz-Zajac","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"20","key":"10.1016\/j.prp.2024.155264_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21207624","article-title":"Role of cadherins in cancer-a review","volume":"21","author":"Kaszak","year":"2020","journal-title":"Int. J. Mol. Sci."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033824001754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033824001754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T08:59:04Z","timestamp":1731401944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033824001754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":64,"alternative-id":["S0344033824001754"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2024.155264","relation":{},"ISSN":["0344-0338"],"issn-type":[{"type":"print","value":"0344-0338"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ADAM22 acts as a novel predictive biomarker for unfavorable prognosis and facilitates metastasis via PI3K\/AKT signaling pathway in nasopharyngeal carcinoma","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2024.155264","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"155264"}}