{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:51:12Z","timestamp":1780404672393,"version":"3.54.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018289","name":"The Shinnihon Foundation of Advanced Medical Treatment Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005865","name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008670","name":"Terumo Foundation for Life Sciences and Arts","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008889","name":"UBE Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008889","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020109","name":"Fukuoka Public Health Promotion Organization Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.prp.2024.155420","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T07:10:23Z","timestamp":1718867423000},"page":"155420","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Wnt\/\u03b2-catenin-YAP axis in the pathogenesis of primary intraosseous carcinoma NOS, deriving from odontogenic keratocyst"],"prefix":"10.1016","volume":"260","author":[{"given":"Yusuke","family":"Nakako","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Kami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Moriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari J.","family":"Kurppa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiina","family":"Heikinheimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Yoshiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamotsu","family":"Kiyoshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2024.155420_bib1","series-title":"WHO classification of odontogenic and maxillofacial bone tumours. WHO classification of Head and Neck Tumours","first-page":"204","author":"El-Nagger","year":"2017"},{"key":"10.1016\/j.prp.2024.155420_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/froh.2021.775707","article-title":"Malignant odontogenic tumours: a systematic review of cases reported in literature","volume":"2","author":"Marin","year":"2021","journal-title":"Front Oral. Health"},{"key":"10.1016\/j.prp.2024.155420_bib3","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1600-0714.2011.01058.x","article-title":"Primary intraosseous squamous cell carcinoma arising in an odontogenic cyst: a clinicopathologic analysis of 116 reported cases","volume":"40","author":"Bodner","year":"2011","journal-title":"J. Oral. Pathol. Med."},{"key":"10.1016\/j.prp.2024.155420_bib4","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/s12105-020-01234-z","article-title":"Primary intraosseous squamous cell carcinoma involving the jaw bones, a systematic review and update","volume":"15","author":"de Morais","year":"2021","journal-title":"Head. Neck Pathol."},{"key":"10.1016\/j.prp.2024.155420_bib5","first-page":"331","article-title":"Malignant transformation in odontogenic keratocysts. Case report","volume":"7","author":"Keszler","year":"2002","journal-title":"Med Oral."},{"key":"10.1016\/j.prp.2024.155420_bib6","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1053\/joms.2001.19297","article-title":"Squamous cell carcinoma in a maxillary odontogenic keratocyst","volume":"59","author":"Makowski","year":"2001","journal-title":"J. Oral. Maxillofac. Surg."},{"key":"10.1016\/j.prp.2024.155420_bib7","doi-asserted-by":"crossref","first-page":"81571","DOI":"10.18632\/oncotarget.13147","article-title":"Epigenetic upregulation of ARL4C, due to DNA hypomethylation in the 3\u2032-untranslated region, promotes tumorigenesis of lung squamous cell carcinoma","volume":"7","author":"Fujii","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2024.155420_bib8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/path.5814","article-title":"RAF1-MEK\/ERK pathway-dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation","volume":"256","author":"Fujii","year":"2022","journal-title":"J. Pathol."},{"key":"10.1016\/j.prp.2024.155420_bib9","article-title":"Stepwise activation of p63 and the MEK\/ERK pathway induces the expression of ARL4C to promote oral squamous cell carcinoma cell proliferation","volume":"246","author":"Alkhatib","year":"2023","journal-title":"Pathol. Res. Pr."},{"key":"10.1016\/j.prp.2024.155420_bib10","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/path.5553","article-title":"YAP signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation","volume":"253","author":"Hasegawa","year":"2021","journal-title":"J. Pathol."},{"key":"10.1016\/j.prp.2024.155420_bib11","article-title":"Clear cell squamous cell carcinoma of the tongue exhibits characteristics as an undifferentiated squamous cell carcinoma","volume":"235","author":"Hasegawa","year":"2022","journal-title":"Pathol. Res. Pr."},{"key":"10.1016\/j.prp.2024.155420_bib12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bbrc.2022.09.012","article-title":"Wnt signaling promotes tooth germ development through YAP1-TGF-\u03b2 signaling","volume":"630","author":"Nagano","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.prp.2024.155420_bib13","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1038\/s41598-019-39686-1","article-title":"Wnt\/\u03b2-catenin signaling, which is activated in odontomas, reduces Sema3A expression to regulate odontogenic epithelial cell proliferation and tooth germ development","volume":"9","author":"Fujii","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2024.155420_bib14","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1038\/onc.2014.402","article-title":"Arl4c expression in colorectal and lung cancers promotes tumorigenesis and may represent a novel therapeutic target","volume":"34","author":"Fujii","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2024.155420_bib15","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s41374-019-0357-z","article-title":"The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation","volume":"100","author":"Fujii","year":"2020","journal-title":"Lab Invest"},{"key":"10.1016\/j.prp.2024.155420_bib16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbrc.2023.09.014","article-title":"Arl4c is involved in tooth germ development through osteoblastic\/ameloblastic differentiation","volume":"679","author":"Truong","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.prp.2024.155420_bib17","first-page":"3889","article-title":"Low-grade myofibroblastic sarcoma arising in the tip of the tongue with intravascular invasion: a case report","volume":"16","author":"Mikami","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.prp.2024.155420_bib18","article-title":"The Semaphorin 3A-AKT axis-mediated cell proliferation in salivary gland morphogenesis and adenoid cystic carcinoma pathogenesis","volume":"236","author":"Fujii","year":"2022","journal-title":"Pathol. Res. Pr."},{"key":"10.1016\/j.prp.2024.155420_bib19","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/embj.201386942","article-title":"A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures","volume":"33","author":"Matsumoto","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.prp.2024.155420_bib20","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1172\/JCI84658","article-title":"CKAP4 is a Dickkopf1 receptor and is involved in tumor progression","volume":"126","author":"Kimura","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.prp.2024.155420_bib21","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.oraloncology.2011.03.015","article-title":"Emergence of keratin 17 vs. loss of keratin 13: their reciprocal immunohistochemical profiles in oral carcinoma in situ","volume":"47","author":"Mikami","year":"2011","journal-title":"Oral. Oncol."},{"key":"10.1016\/j.prp.2024.155420_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0161163","article-title":"Keratin 17 is induced in oral cancer and facilitates tumor growth","volume":"11","author":"Khanom","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2024.155420_bib23","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s00432-017-2398-2","article-title":"GLI-mediated Keratin 17 expression promotes tumor cell growth through the anti-apoptotic function in oral squamous cell carcinomas","volume":"143","author":"Mikami","year":"2017","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.prp.2024.155420_bib24","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nrm2221","article-title":"Filling out the hippo pathway","volume":"8","author":"Saucedo","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.prp.2024.155420_bib25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.prp.2024.155420_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4624890","article-title":"Expression of YAP\/TAZ in keratocystic odontogenic tumors and its possible association with proliferative behavior","author":"Man","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.prp.2024.155420_bib27","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/\u03b2-Catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.prp.2024.155420_bib28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/pin.13325","article-title":"The role of Wnt, ARL4C, and Sema3A in developmental process and disease pathogenesis","volume":"73","author":"Fujii","year":"2023","journal-title":"Pathol. Int."},{"key":"10.1016\/j.prp.2024.155420_bib29","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00432-005-0027-y","article-title":"Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma","volume":"131","author":"Iwai","year":"2005","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.prp.2024.155420_bib30","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.oraloncology.2004.04.011","article-title":"Expression of adenomatous polyposis coli (APC) in tumorigenesis of human oral squamous cell carcinoma","volume":"40","author":"Tsuchiya","year":"2004","journal-title":"Oral. Oncol."},{"key":"10.1016\/j.prp.2024.155420_bib31","first-page":"1001","article-title":"Correlation between protein expression and epigenetic and mutation changes of Wnt pathway-related genes in oral cancer","volume":"23","author":"Yeh","year":"2003","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.prp.2024.155420_bib32","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1128\/MCB.22.4.1172-1183.2002","article-title":"Wnt\/\u03b2-catenin\/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway","volume":"22","author":"Jho","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.prp.2024.155420_bib33","article-title":"The Wnts","volume":"3","author":"Miller","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.prp.2024.155420_bib34","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/gb-2012-13-10-173","article-title":"Balance of DNA methylation and demethylation in cancer development","volume":"13","author":"Song","year":"2012","journal-title":"Genome Biol."},{"key":"10.1016\/j.prp.2024.155420_bib35","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7150\/ijbs.11218","article-title":"DNA methylation, its mediators and genome integrity","volume":"11","author":"Meng","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.prp.2024.155420_bib36","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1038\/bjc.2011.497","article-title":"Notch signalling in cancer progression and bone metastasis","volume":"105","author":"Sethi","year":"2011","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.prp.2024.155420_bib37","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/pin.12461","article-title":"Notch signaling in oral squamous neoplasia","volume":"66","author":"Sakamoto","year":"2016","journal-title":"Pathol. Int"},{"key":"10.1016\/j.prp.2024.155420_bib38","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41392-019-0100-7","article-title":"The \u03b2-catenin\/YAP signaling axis is a key regulator of melanoma-associated fibroblasts","volume":"4","author":"Liu","year":"2019","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.prp.2024.155420_bib39","doi-asserted-by":"crossref","first-page":"11730","DOI":"10.1074\/jbc.M111.327767","article-title":"Wnt\/\u03b2-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells","volume":"287","author":"Konsavage","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.prp.2024.155420_bib40","doi-asserted-by":"crossref","first-page":"588","DOI":"10.2337\/diabetes.52.3.588","article-title":"Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo","volume":"52","author":"Ring","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.prp.2024.155420_bib41","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/S1471-4914(02)02314-6","article-title":"Epigenomics and epigenetic therapy of cancer","volume":"8","author":"Brown","year":"2002","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.prp.2024.155420_bib42","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/hmg\/10.7.687","article-title":"Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer","volume":"10","author":"Baylin","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.prp.2024.155420_bib43","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/cncr.22087","article-title":"Elevated mRNA levels of DNA methyltransferase-1 as an independent prognostic factor in primary nonsmall cell lung cancer","volume":"107","author":"Kim","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.prp.2024.155420_bib44","doi-asserted-by":"crossref","first-page":"15805","DOI":"10.1073\/pnas.0707628104","article-title":"MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B","volume":"104","author":"Fabbri","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.prp.2024.155420_bib45","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.lungcan.2006.10.022","article-title":"Alteration of DNA methyltransferases contributes to 5\u2032CpG methylation and poor prognosis in lung cancer","volume":"55","author":"Lin","year":"2007","journal-title":"Lung Cancer"},{"key":"10.1016\/j.prp.2024.155420_bib46","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1158\/0008-5472.CAN-09-4161","article-title":"Dysregulation of p53\/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer","volume":"70","author":"Lin","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2024.155420_bib47","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1186\/1471-2164-15-1079","article-title":"Genes suppressed by DNA methylation in non-small cell lung cancer reveal the epigenetics of epithelial-mesenchymal transition","volume":"15","author":"Lin","year":"2014","journal-title":"BMC Genom."},{"key":"10.1016\/j.prp.2024.155420_bib48","series-title":"Odontogenic tumours. WHO classification of Head and Neck Tumours","first-page":"306","author":"Barnes","year":"2005"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033824003315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033824003315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T19:22:31Z","timestamp":1735154551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033824003315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":48,"alternative-id":["S0344033824003315"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2024.155420","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wnt\/\u03b2-catenin-YAP axis in the pathogenesis of primary intraosseous carcinoma NOS, deriving from odontogenic keratocyst","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2024.155420","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"155420"}}