{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T20:19:34Z","timestamp":1770495574007,"version":"3.49.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.prp.2024.155463","type":"journal-article","created":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T09:47:35Z","timestamp":1720950455000},"page":"155463","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Clinicopathological significance of mutation profile detected by next generation sequencing in different metastatic organs of non-small cell lung cancers"],"prefix":"10.1016","volume":"260","author":[{"given":"Dilara","family":"Ak\u0131n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesibe","family":"Kahraman \u00c7eti\u0307n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130brahim Halil","family":"Erdo\u011fdu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130brahim","family":"Meteo\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.prp.2024.155463_bib1","first-page":"7","article-title":"Cancer statistics","volume":"68","author":"Siegel","year":"2018","journal-title":"CA: a Cancer J. Clin."},{"issue":"3","key":"10.1016\/j.prp.2024.155463_bib2","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA: a Cancer J. Clin."},{"issue":"3","key":"10.1016\/j.prp.2024.155463_bib3","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1002\/cam4.5233","article-title":"Identification of nine mutant genes and establishment of three prediction models of organ tropism metastases of non-small cell lung cancer","volume":"12","author":"Chen","year":"2023","journal-title":"Cancer Med."},{"key":"10.1016\/j.prp.2024.155463_bib4","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/cam4.4424","article-title":"Analysis of risk factors and gene mutation characteristics of different metastatic sites of lung cancer","volume":"11","author":"Wang","year":"2021","journal-title":"Cancer Med."},{"key":"10.1016\/j.prp.2024.155463_bib5","article-title":"Genetic Heterogeneity Between Paired Primary and Brain Metastases in Lung Adenocarcinoma","volume":"14","author":"Li","year":"2020","journal-title":"Clin. Med. Insight.: Oncol."},{"issue":"1","key":"10.1016\/j.prp.2024.155463_bib6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbcan.2009.11.002","article-title":"Tumour heterogeneity: Causes and consequences.","volume":"1805","author":"Marusyk","year":"2010","journal-title":"Biochim. Et. Biophys. Acta (BBA)-Rev. Cancer"},{"issue":"4","key":"10.1016\/j.prp.2024.155463_bib7","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nm.3522","article-title":"Tumour heterogeneity confounds and illuminates: assessing the implications","volume":"20","author":"Kleppe","year":"2014","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.prp.2024.155463_bib8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nrc3261","article-title":"Intra-tumour heterogeneity: a looking glass for cancer?","volume":"12","author":"Marusyk","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.prp.2024.155463_bib9","series-title":"World Health Organization Classification of Tumours, Thoracic Tumours","first-page":"19","article-title":"Classification of Tumours Editorial Board, Tumours of the lung","year":"2021"},{"issue":"3","key":"10.1016\/j.prp.2024.155463_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.currproblcancer.2020.100562","article-title":"Next generation sequencing in lung cancer: an initial experience from India","volume":"44","author":"Gupta","year":"2020","journal-title":"Curr. Probl. Cancer"},{"issue":"1","key":"10.1016\/j.prp.2024.155463_bib11","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jmoldx.2016.10.002","article-title":"Standards and guidelines for the interpretation and reporting of sequence variants in cancer: a joint consensus recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists","volume":"19","author":"Li","year":"2017","journal-title":"J. Mol. Diagn."},{"issue":"1","key":"10.1016\/j.prp.2024.155463_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.chest.2016.10.010","article-title":"The Eighth Edition Lung Cancer Stage Classification","volume":"151","author":"Detterbeck","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.prp.2024.155463_bib13","first-page":"1","article-title":"Evaluation of demographic characteristics of non-small cell metastatic lung cancer patients","volume":"5","author":"Bay\u0131r","year":"2017","journal-title":"Namik Kemal Med J."},{"issue":"3","key":"10.1016\/j.prp.2024.155463_bib14","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/modpathol.2011.215","article-title":"Molecular pathology of lung cancer: key to personalised medicine","volume":"25","author":"Cheng","year":"2012","journal-title":"Mod. Pathol."},{"issue":"4","key":"10.1016\/j.prp.2024.155463_bib15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.arbres.2014.09.019","article-title":"Lung cancer screening: fourteen year experience of the Pamplona early detection programme (P-IELCAP)","volume":"52","author":"Sanchez-Salcedo","year":"2015","journal-title":"Arch. De. Bronconeumol."},{"issue":"7","key":"10.1016\/j.prp.2024.155463_bib16","doi-asserted-by":"crossref","DOI":"10.1200\/PO.22.00546","article-title":"Cost-Effectiveness of Next-Generation Sequencing Versus Single-Gene Testing for the Molecular Diagnosis of Patients With Metastatic Non-Small-Cell Lung Cancer From the Perspective of Spanish Reference Centers","author":"Arriola","year":"2023","journal-title":"JCO Precis. Oncol."},{"issue":"3","key":"10.1016\/j.prp.2024.155463_bib17","first-page":"1","article-title":"Retrospective evaluation of our patients diagnosed with lung cancer","volume":"12","author":"Bircan","year":"2009","journal-title":"SDU Fac. Med. J."},{"issue":"7","key":"10.1016\/j.prp.2024.155463_bib18","first-page":"3105","article-title":"Decade of lung cancer in Serbia: tobacco abuse and gender differences","volume":"27","author":"Djekic Malbasa","year":"2023","journal-title":"Eur. Rev. Med Pharm. Sci."},{"issue":"9","key":"10.1016\/j.prp.2024.155463_bib19","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/2211-5463.12501","article-title":"Characterisation of genetic alterations in brain metastases from non-small cell lung cancer.","volume":"8","author":"Liao","year":"2018","journal-title":"FEBS Open Bio"},{"issue":"2)","key":"10.1016\/j.prp.2024.155463_bib20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3322\/caac.21338","volume":"66","author":"Chen","year":"2016","journal-title":"Cancer Stat. China CA: a Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.prp.2024.155463_bib21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3892\/mco.2014.410","article-title":"Specific organ metastases and survival in metastatic non-small-cell lung cancer","volume":"3","author":"Tamura","year":"2015","journal-title":"Mol. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.prp.2024.155463_bib22","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.lungcan.2014.07.020","article-title":"Metastatic sites and survival in lung cancer","volume":"86","author":"Riihimaki","year":"2014","journal-title":"Lung Cancer"},{"issue":"3","key":"10.1016\/j.prp.2024.155463_bib23","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3892\/ol.2011.535","article-title":"Application of conditional probability analysis to distant metastases from lung cancer","volume":"3","author":"Oikawa","year":"2012","journal-title":"Oncol. Lett."},{"issue":"6","key":"10.1016\/j.prp.2024.155463_bib24","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.7314\/APJCP.2013.14.6.3705","article-title":"Relationship between Epidermal Growth Factor Receptor Gene Mutations and Clinicopathological Features in Patients with Non-Small Cell Lung Cancer in Western Turkey","volume":"14","author":"Unal","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"5","key":"10.1016\/j.prp.2024.155463_bib25","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/cam4.1058","article-title":"The Effects of smoking status and smoking history on patients with brain metastases from lung cancer","volume":"6","author":"Shenker","year":"2017","journal-title":"Cancer Med."},{"issue":"6","key":"10.1016\/j.prp.2024.155463_bib26","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3747\/co.27.5995","article-title":"Comprehensive genomic profiling for non-small-cell lung cancer: health and budget impact","volume":"27","author":"Johnston","year":"2020","journal-title":"Curr. Oncol."},{"issue":"2","key":"10.1016\/j.prp.2024.155463_bib27","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3892\/ol.2016.5458","article-title":"Bone metastasis from lung cancer identified by genetic profiling","volume":"13","author":"Liu","year":"2017","journal-title":"Oncol. Lett."},{"issue":"3","key":"10.1016\/j.prp.2024.155463_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/PO.18.00213","article-title":"Use of a targeted exome next-generation sequencing panel offers therapeutic opportunity and clinical benefit in a subset of patients with advanced cancers","author":"Kopetz","year":"2019","journal-title":"JCO Precis. Oncol."},{"issue":"10026","key":"10.1016\/j.prp.2024.155463_bib29","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(16)00004-0","article-title":"Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT)","volume":"387","author":"Barlesi","year":"2016","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.prp.2024.155463_bib30","first-page":"6742","article-title":"Genomic profiling and sites of metastasis in non-small cell lung cancer (NSCLC)","volume":"83","author":"Chan","year":"2023","journal-title":"Front. Oncol."},{"issue":"11","key":"10.1016\/j.prp.2024.155463_bib31","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1111\/1759-7714.14432","article-title":"Clinical features and prognosis according to genomic mutations in primary and metastatic lesions of non-small-cell lung cancer","volume":"13","author":"Zhang","year":"2022","journal-title":"Thorac. Cancer"},{"issue":"10","key":"10.1016\/j.prp.2024.155463_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187289","article-title":"Non-small cell lung cancer (NSCLC), EGFR downstream pathway activation and TKI targeted therapies sensitivity: Effect of the plasma membrane-associated NEU3","volume":"12","author":"Forcella","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.prp.2024.155463_bib33","doi-asserted-by":"crossref","first-page":"382","DOI":"10.5152\/balkanmedj.2021.21049","article-title":"Evaluation of the mutation profile via next-generation sequencing in a Turkish population with non-small cell lung cancer","volume":"38","author":"Kahraman Cetin","year":"2021","journal-title":"Balk. Med J."},{"issue":"2","key":"10.1016\/j.prp.2024.155463_bib34","doi-asserted-by":"crossref","first-page":"815","DOI":"10.7314\/APJCP.2015.16.2.815","article-title":"Lung cancer in women, a different disease: survival differences by sex in Turkey","volume":"16","author":"Ulas","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"9","key":"10.1016\/j.prp.2024.155463_bib35","article-title":"Genetic profile of non-small cell lung cancer (NSCLC): A hospital-based survey in Jinhua","volume":"8","author":"Chen","year":"2020","journal-title":"Mol. Genet. Genom. Med."},{"issue":"4","key":"10.1016\/j.prp.2024.155463_bib36","first-page":"745","article-title":"Understanding tobacco smoke carcinogen NNK and lung tumorigenesis (review)","volume":"29","author":"Akopyan","year":"2006","journal-title":"Int. J. Oncol."},{"issue":"9","key":"10.1016\/j.prp.2024.155463_bib37","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1158\/0008-5472.CAN-20-3991","article-title":"Association between Smoking History and Tumour Mutation Burden in Advanced Non-Small Cell Lung Cancer.","volume":"81","author":"Wang","year":"2021","journal-title":"Cancer Res"},{"key":"10.1016\/j.prp.2024.155463_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.909388","article-title":"Molecular Features in Lymphatic Metastases Reflect the Metastasis Mechanism of Lymph Nodes With Non-Small-Cell Lung Cancers","volume":"10","author":"Guo","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"6406","key":"10.1016\/j.prp.2024.155463_bib39","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1126\/science.aat7171","article-title":"Minimal functional driver gene heterogeneity among untreated metastases","volume":"361","author":"Reiter","year":"2018","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.prp.2024.155463_bib40","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.jtho.2021.02.023","article-title":"Timing and origins of local and distant metastases in lung cancer","volume":"16","author":"Tang","year":"2021","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.prp.2024.155463_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.585284","article-title":"Mechanisms and future of non-small cell lung cancer metastasis","volume":"10","author":"Zhu","year":"2020","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.prp.2024.155463_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ijo.2022.5390","article-title":"Differences in actionable genomic alterations between brain metastases and non-brain metastases in patients with non-small cell lung cancer","volume":"61","author":"Nian","year":"2022","journal-title":"Int. J. Oncol."},{"issue":"9","key":"10.1016\/j.prp.2024.155463_bib43","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/gcc.23043","article-title":"Treatment outcomes and prognosis of patients with primary and gained BRAF-mutated non-small cell lung cancer: A multicenter retrospective study","volume":"61","author":"Wang","year":"2022","journal-title":"Genes, Chromosomes Cancer"},{"issue":"11","key":"10.1016\/j.prp.2024.155463_bib44","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1097\/JTO.0000000000000344","article-title":"Clinical characteristics and course of 63 patients with BRAF mutant lung cancers","volume":"9","author":"Litvak","year":"2014","journal-title":"J. Thorac. Oncol."},{"issue":"1","key":"10.1016\/j.prp.2024.155463_bib45","doi-asserted-by":"crossref","first-page":"306","DOI":"10.21474\/IJAR01\/8328","article-title":"Next-generation sequencing (NGS): our results of molecular pathology malignant solid tumour panel","volume":"7","author":"Erdogdu","year":"2019","journal-title":"Int J. Adv. Res"},{"issue":"1","key":"10.1016\/j.prp.2024.155463_bib46","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1038\/s41598-020-58819-5","article-title":"Validating a targeted next-generation sequencing assay and profiling somatic variants in Chinese non-small cell lung cancer patients","volume":"10","author":"Jiang","year":"2020","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.prp.2024.155463_bib47","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.5858\/arpa.2016-0501-RA","article-title":"Review of clinical next-generation sequencing","volume":"141","author":"Yohe","year":"2017","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.prp.2024.155463_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/6615575","article-title":"Genomic mutations of primary and metastatic lung adenocarcinoma in Chinese patients","volume":"2020","author":"Chen","year":"2020","journal-title":"J. Oncol."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033824003741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033824003741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T19:24:07Z","timestamp":1735154647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033824003741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":48,"alternative-id":["S0344033824003741"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2024.155463","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinicopathological significance of mutation profile detected by next generation sequencing in different metastatic organs of non-small cell lung cancers","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2024.155463","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155463"}}