{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:02:57Z","timestamp":1788015777122,"version":"build-2784847793"},"reference-count":147,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.prp.2024.155479","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T16:28:01Z","timestamp":1721492881000},"page":"155479","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Targeting the Akt signaling pathway: Exploiting curcumin's anticancer potential"],"prefix":"10.1016","volume":"261","author":[{"given":"Mahdieh","family":"Aliyari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Isaac","family":"Hashemy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh Fatemeh","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirali","family":"Reihani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Kesharwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2024.155479_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.semcancer.2015.02.006","article-title":"editors. Sustained proliferation in cancer: mechanisms and novel therapeutic targets","author":"Feitelson","year":"2015","journal-title":"Semin. Cancer Biol."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ctrv.2003.07.007","article-title":"PI3K\/Akt signalling pathway and cancer","volume":"30","author":"Vara","year":"2004","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.prp.2024.155479_bib3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fonc.2014.00064","article-title":"Targeting PI3K\/Akt\/mTOR signaling in cancer","volume":"4","author":"Porta","year":"2014","journal-title":"Front. Oncol."},{"issue":"5600","key":"10.1016\/j.prp.2024.155479_bib4","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1126\/science.1075762","article-title":"The protein kinase complement of the human genome","volume":"298","author":"Manning","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.prp.2024.155479_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0065-230X(05)94002-5","article-title":"JR. Activation of AKT kinases in cancer: implications for therapeutic targeting","volume":"94","author":"Bellacosa","year":"2005","journal-title":"Adv. Cancer Res."},{"issue":"3","key":"10.1016\/j.prp.2024.155479_bib6","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4161\/cbt.3.3.703","article-title":"A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities","volume":"3","author":"Bellacosa","year":"2004","journal-title":"Cancer Biol. Ther."},{"issue":"17","key":"10.1016\/j.prp.2024.155479_bib7","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1101\/gad.913901","article-title":"Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene.","volume":"15","author":"Chen","year":"2001","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1172\/JCI16885","article-title":"Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2\/PKB\u03b2","volume":"112","author":"Garofalo","year":"2003","journal-title":"J. Clin. Investig."},{"issue":"35","key":"10.1016\/j.prp.2024.155479_bib9","doi-asserted-by":"crossref","first-page":"12865","DOI":"10.1073\/pnas.1408472111","article-title":"Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates","volume":"111","author":"Lee","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"15","key":"10.1016\/j.prp.2024.155479_bib10","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1038\/onc.2010.556","article-title":"Akt1 deletion prevents lung tumorigenesis by mutant K-ras","volume":"30","author":"Hollander","year":"2011","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.prp.2024.155479_bib11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.pharmthera.2007.02.002","article-title":"Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: two approaches with therapeutic potential in the treatment of neurodegenerative disease","volume":"114","author":"Burke","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.prp.2024.155479_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2019.109468","article-title":"The PI3K\/Akt\/mTOR pathway in polycystic kidney disease: a complex interaction with polycystins and primary cilium","volume":"66","author":"Margaria","year":"2020","journal-title":"Cell. Signal."},{"issue":"10","key":"10.1016\/j.prp.2024.155479_bib13","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.cellsig.2011.05.004","article-title":"Akt signalling in health and disease","volume":"23","author":"Hers","year":"2011","journal-title":"Cell. Signal."},{"key":"10.1016\/j.prp.2024.155479_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114244","article-title":"Targeting PI3K\/AKT signaling pathway in obesity","volume":"159","author":"Savova","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.prp.2024.155479_bib15","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1023\/B:APPT.0000045801.15585.dd","article-title":"PI3K-Akt pathway: its functions and alterations in human cancer","volume":"9","author":"Osaki","year":"2004","journal-title":"Apoptosis"},{"issue":"8","key":"10.1016\/j.prp.2024.155479_bib16","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1073\/pnas.93.8.3636","article-title":"Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA","volume":"93","author":"Cheng","year":"1996","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"19","key":"10.1016\/j.prp.2024.155479_bib17","doi-asserted-by":"crossref","first-page":"7002","DOI":"10.1158\/0008-5472.CAN-04-1399","article-title":"Deregulated Akt3 activity promotes development of malignant melanoma","volume":"64","author":"Stahl","year":"2004","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib18","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.bbcan.2019.03.003","article-title":"Targeting PI3K signaling in cancer: challenges and advances","volume":"1871","author":"De Santis","year":"2019","journal-title":"Biochim. Et. Biophys. Acta (BBA)-Rev. Cancer"},{"issue":"1","key":"10.1016\/j.prp.2024.155479_bib19","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41392-021-00828-5","article-title":"Targeting PI3K\/Akt signal transduction for cancer therapy","volume":"6","author":"He","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"8","key":"10.1016\/j.prp.2024.155479_bib20","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1023\/A:1016091631721","article-title":"Natural products as a resource for new drugs","volume":"13","author":"Clark","year":"1996","journal-title":"Pharm. Res."},{"issue":"25","key":"10.1016\/j.prp.2024.155479_bib21","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.3748\/wjg.v20.i25.8082","article-title":"Oxidative stress as a crucial factor in liver diseases","volume":"20","author":"Cicho\u017c-Lach","year":"2014","journal-title":"World J. Gastroenterol.: WJG"},{"key":"10.1016\/j.prp.2024.155479_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.603235","article-title":"Curcumin nanoparticle enhances the anticancer effect of cisplatin by inhibiting PI3K\/AKT and JAK\/STAT3 pathway in rat ovarian carcinoma induced by DMBA","volume":"11","author":"Sandhiutami","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.prp.2024.155479_bib23","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.4251\/wjgo.v16.i4.1437","article-title":"Curcumin inhibits the growth and invasion of gastric cancer by regulating long noncoding RNA AC022424. 2","volume":"16","author":"Wang","year":"2024","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1016\/j.prp.2024.155479_bib24","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.ejmech.2012.12.062","article-title":"Recent advances in natural products from plants for treatment of liver diseases","volume":"63","author":"Zhang","year":"2013","journal-title":"Eur. J. Med. Chem."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4103\/2225-4110.110411","article-title":"Recent advances in the herbal treatment of non-alcoholic Fatty liver disease","volume":"3","author":"Xiao","year":"2013","journal-title":"J. Tradit. Complement. Med."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib26","doi-asserted-by":"crossref","first-page":"278","DOI":"10.2174\/138920112799095310","article-title":"B. Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD)","volume":"13","author":"Sun Kim","year":"2012","journal-title":"Curr. Pharm. Biotechnol."},{"issue":"11-12","key":"10.1016\/j.prp.2024.155479_bib27","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.nut.2016.04.007","article-title":"Lipid-modifying effects of nutraceuticals: an evidence-based approach","volume":"32","author":"Sahebkar","year":"2016","journal-title":"Nutrition"},{"key":"10.1016\/j.prp.2024.155479_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106414","article-title":"Polyphenols and atherosclerosis: a critical review of clinical effects on LDL oxidation","volume":"184","author":"Ahmadi","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.prp.2024.155479_bib29","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/biof.1713","article-title":"Pulmonary fibrosis: therapeutic and mechanistic insights into the role of phytochemicals","volume":"47","author":"Hosseini","year":"2021","journal-title":"BioFactors"},{"key":"10.1016\/j.prp.2024.155479_bib30","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.phrs.2017.03.023","article-title":"Regulation of PCSK9 by nutraceuticals","volume":"120","author":"Momtazi","year":"2017","journal-title":"Pharmacol. Res."},{"issue":"3-4","key":"10.1016\/j.prp.2024.155479_bib31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.phymed.2009.05.020","article-title":"Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo","volume":"17","author":"Iranshahi","year":"2010","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.prp.2024.155479_bib32","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.3892\/etm.2015.2749","article-title":"Biological and therapeutic activities, and anticancer properties of curcumin","volume":"10","author":"Perrone","year":"2015","journal-title":"Exp. Ther. Med."},{"issue":"3","key":"10.1016\/j.prp.2024.155479_bib33","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3390\/molecules21030264","article-title":"Curcumin and health","volume":"21","author":"Pulido-Moran","year":"2016","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib34","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1159\/000369738","article-title":"Effects of three kinds of curcuminoids on anti-oxidative system and membrane deformation of human peripheral blood erythrocytes in high glucose levels","volume":"35","author":"Yang","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.prp.2024.155479_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116034","article-title":"Targeted therapies of curcumin focus on its therapeutic benefits in cancers and human health: molecular signaling pathway-based approaches and future perspectives","volume":"170","author":"Islam","year":"2024","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.prp.2024.155479_bib36","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ejmech.2018.12.016","article-title":"The therapeutic potential of curcumin: a review of clinical trials","volume":"163","author":"Salehi","year":"2019","journal-title":"Eur. J. Med Chem."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib37","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00394-019-01916-7","article-title":"Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial","volume":"59","author":"Cicero","year":"2020","journal-title":"Eur. J. Nutr."},{"issue":"5","key":"10.1016\/j.prp.2024.155479_bib38","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1002\/jcp.27362","article-title":"Curcumin nanofibers for the purpose of wound healing","volume":"234","author":"Fereydouni","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"22","key":"10.1016\/j.prp.2024.155479_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24224029","article-title":"The effect of curcumin on the differentiation of mesenchymal stem cells into mesodermal lineage","volume":"24","author":"Gorabi","year":"2019","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.prp.2024.155479_bib40","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1002\/ptr.7737","article-title":"Curcumin-piperine co-supplementation and human health: a comprehensive review of preclinical and clinical studies","volume":"37","author":"Heidari","year":"2023","journal-title":"Phytother. Res."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib41","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/jcp.27096","article-title":"Evidence of curcumin and curcumin analogue effects in skin diseases: a narrative review","volume":"234","author":"Panahi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.prp.2024.155479_bib42","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bioorg.2011.11.004","article-title":"Synthesis and anti-inflammatory properties of some aromatic and heterocyclic aromatic curcuminoids","volume":"40","author":"Khan","year":"2012","journal-title":"Bioorg. Chem."},{"issue":"5","key":"10.1016\/j.prp.2024.155479_bib43","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s10787-019-00607-3","article-title":"Curcumin: a modulator of inflammatory signaling pathways in the immune system","volume":"27","author":"Kahkhaie","year":"2019","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.prp.2024.155479_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctim.2020.102322","article-title":"Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial","volume":"49","author":"Saberi-Karimian","year":"2020","journal-title":"Complement Ther Med"},{"key":"10.1016\/j.prp.2024.155479_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2018.12.005","article-title":"Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent","volume":"66","author":"Mohammadi","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.prp.2024.155479_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104353","article-title":"Targeting regulatory T cells by curcumin: a potential for cancer immunotherapy","volume":"147","author":"Shafabakhsh","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"8-9","key":"10.1016\/j.prp.2024.155479_bib47","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.foodres.2005.02.021","article-title":"Separation and determination of the physico-chemical characteristics of curcumin, demethoxycurcumin and bisdemethoxycurcumin","volume":"38","author":"P\u00e9ret-Almeida","year":"2005","journal-title":"Food Res. Int."},{"key":"10.1016\/j.prp.2024.155479_bib48","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/978-0-387-46401-5_16","article-title":"Cardioprotective effects of curcumin","author":"Miriyala","year":"2007","journal-title":"Mol. Targets Ther. Uses curcumin Health Dis."},{"key":"10.1016\/j.prp.2024.155479_bib49","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.jff.2013.12.008","article-title":"Antioxidant effects of bioavailability-enhanced curcuminoids in patients with solid tumors: a randomized double-blind placebo-controlled trial","volume":"6","author":"Panahi","year":"2014","journal-title":"J. Funct. Foods"},{"issue":"1","key":"10.1016\/j.prp.2024.155479_bib50","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/biof.1566","article-title":"Effects of curcumin on mitochondria in neurodegenerative diseases","volume":"46","author":"Bagheri","year":"2020","journal-title":"BioFactors"},{"issue":"6","key":"10.1016\/j.prp.2024.155479_bib51","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1002\/jcp.26249","article-title":"Curcumin, hemostasis, thrombosis, and coagulation","volume":"233","author":"Keihanian","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"4-5","key":"10.1016\/j.prp.2024.155479_bib52","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.clinbiochem.2009.10.057","article-title":"Improvement in oxidative stress and antioxidant parameters in \u03b2-thalassemia\/Hb E patients treated with curcuminoids","volume":"43","author":"Kalpravidh","year":"2010","journal-title":"Clin. Biochem."},{"issue":"11","key":"10.1016\/j.prp.2024.155479_bib53","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.2174\/1389201017666160721123109","article-title":"Wound healing effects of curcumin: a short review","volume":"17","author":"Tejada","year":"2016","journal-title":"Curr. Pharm. Biotechnol."},{"issue":"10","key":"10.1016\/j.prp.2024.155479_bib54","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.3390\/nu11102376","article-title":"Curcumin and cancer","volume":"11","author":"Giordano","year":"2019","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.prp.2024.155479_bib55","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.3390\/biomedicines9091086","article-title":"The role of curcumin in cancer treatment","volume":"9","author":"Zoi","year":"2021","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.prp.2024.155479_bib56","doi-asserted-by":"crossref","first-page":"262","DOI":"10.2174\/1570161116666180209113014","article-title":"Anti-angiogenic activity of curcumin in cancer therapy: a narrative review","volume":"17","author":"Shakeri","year":"2019","journal-title":"Curr. Vasc. Pharmacol."},{"issue":"10","key":"10.1016\/j.prp.2024.155479_bib57","doi-asserted-by":"crossref","first-page":"6785","DOI":"10.1002\/jcp.26538","article-title":"Phytosomal curcumin inhibits tumor growth in colitis-associated colorectal cancer","volume":"233","author":"Marjaneh","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.prp.2024.155479_bib58","first-page":"1616","article-title":"The effect of curcumin on hypoxia in the tumour microenvironment as a regulatory factor in cancer","volume":"19","author":"Zahedi","year":"2023","journal-title":"Arch. Med. Sci."},{"issue":"7","key":"10.1016\/j.prp.2024.155479_bib59","first-page":"988","article-title":"S. Hitting the golden TORget: curcumin\u2019s effects on mTOR signaling","volume":"13","author":"Beevers","year":"2013","journal-title":"Anti-Cancer Agents Med. Chem. Former. Curr. Med. Chem.\u00a0Anti-Cancer Agents"},{"issue":"7","key":"10.1016\/j.prp.2024.155479_bib60","doi-asserted-by":"crossref","first-page":"967","DOI":"10.2174\/1871520611313070001","article-title":"Inhibition of PI3K\/Akt\/mTOR signaling by natural products","volume":"13","author":"Huang","year":"2013","journal-title":"Anti\u00a0Cancer Agents Med. Chem."},{"issue":"18","key":"10.1016\/j.prp.2024.155479_bib61","doi-asserted-by":"crossref","first-page":"8260","DOI":"10.1039\/D1FO01073E","article-title":"Curcumin enhances the membrane trafficking of the sodium iodide symporter and augments radioiodine uptake in dedifferentiated thyroid cancer cells via suppression of the PI3K-AKT signaling pathway","volume":"12","author":"Zhang","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.prp.2024.155479_bib62","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5946670","article-title":"Curcumin inhibits papillary thyroid cancer cell proliferation by regulating lncRNA LINC00691","volume":"2022","author":"Li","year":"2022","journal-title":"Anal. Cell. Pathol."},{"issue":"16","key":"10.1016\/j.prp.2024.155479_bib63","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1080\/14786419.2015.1074229","article-title":"Combinatorial anticancer effects of curcumin and sorafenib towards thyroid cancer cells via PI3K\/Akt and ERK pathways","volume":"30","author":"Zhang","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.prp.2024.155479_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2021.105254","article-title":"Curcumin induces autophagic cell death in human thyroid cancer cells","volume":"78","author":"Zhang","year":"2022","journal-title":"Toxicol. Vitr."},{"issue":"1","key":"10.1016\/j.prp.2024.155479_bib65","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1038\/s41598-023-30888-2","article-title":"The curcumin analogue PAC has potent anti-anaplastic thyroid cancer effects","volume":"13","author":"Al-Mohanna","year":"2023","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib66","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.gene.2014.06.006","article-title":"Curcumin inhibits the invasion of thyroid cancer cells via down-regulation of PI3K\/Akt signaling pathway","volume":"546","author":"Xu","year":"2014","journal-title":"Gene"},{"issue":"5","key":"10.1016\/j.prp.2024.155479_bib67","first-page":"5075","article-title":"Curcumin inhibits the development of non\u2011small cell lung cancer by inhibiting autophagy and apoptosis","volume":"14","author":"Wang","year":"2017","journal-title":"Exp. Ther. Med."},{"issue":"3","key":"10.1016\/j.prp.2024.155479_bib68","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2478\/acph-2020-0029","article-title":"Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K\/AKT\/mTOR signaling pathway","volume":"70","author":"Wang","year":"2020","journal-title":"Acta Pharm."},{"issue":"3","key":"10.1016\/j.prp.2024.155479_bib69","first-page":"1523","article-title":"Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K\/Akt\/mTOR pathway","volume":"39","author":"Liu","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.prp.2024.155479_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/mto.2016.18","article-title":"Curcumin inhibited HGF-induced EMT and angiogenesis through regulating c-Met dependent PI3K\/Akt\/mTOR signaling pathways in lung cancer","volume":"3","author":"Jiao","year":"2016","journal-title":"Mol. Ther. Oncolytics"},{"issue":"5","key":"10.1016\/j.prp.2024.155479_bib71","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.3892\/or.2015.4258","article-title":"Curcumin inhibits cell proliferation and induces apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of PI3K\/Akt signaling pathway","volume":"34","author":"Jin","year":"2015","journal-title":"Oncol. Rep."},{"issue":"19","key":"10.1016\/j.prp.2024.155479_bib72","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.3390\/ijms20194891","article-title":"Curcumin-gene expression response in hormone dependent and independent metastatic prostate cancer cells","volume":"20","author":"Katta","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.prp.2024.155479_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcb.10495","article-title":"Inhibition of cell survival signal protein kinase B\/Akt by curcumin in human prostate cancer cells","volume":"89","author":"Chaudhary","year":"2003","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.prp.2024.155479_bib74","first-page":"905","article-title":"Involvement of Bcl-2 family members, phosphatidylinositol 3\u2032-kinase\/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer","volume":"30","author":"Shankar","year":"2007","journal-title":"Int. J. Oncol."},{"issue":"30","key":"10.1016\/j.prp.2024.155479_bib75","doi-asserted-by":"crossref","first-page":"8635","DOI":"10.1016\/j.biomaterials.2014.06.040","article-title":"Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer","volume":"35","author":"Yallapu","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.prp.2024.155479_bib76","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2741\/e798","article-title":"Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer","volume":"9","author":"Banerjee","year":"2017","journal-title":"Front. Biosci."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib77","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1080\/01635581.2022.2139398","article-title":"Curcumin represses colorectal cancer cell proliferation by triggering ferroptosis via PI3K\/Akt\/mTOR signaling","volume":"75","author":"Chen","year":"2023","journal-title":"Nutr. Cancer"},{"issue":"8","key":"10.1016\/j.prp.2024.155479_bib78","first-page":"3185","article-title":"Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt\/mTOR signaling","volume":"29","author":"Johnson","year":"2009","journal-title":"Anticancer Res"},{"issue":"8","key":"10.1016\/j.prp.2024.155479_bib79","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000037264","article-title":"Curcumin suppresses metastasis of triple-negative breast cancer cells by modulating EMT signaling pathways: an integrated study of bioinformatics analysis","volume":"103","author":"Chen","year":"2024","journal-title":"Medicine"},{"issue":"7","key":"10.1016\/j.prp.2024.155479_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e28807","article-title":"Transcriptomics and metabonomics study on the effect of exercise combined with curcumin supplementation on breast cancer in mice","volume":"10","author":"Guo","year":"2024","journal-title":"Heliyon"},{"issue":"6","key":"10.1016\/j.prp.2024.155479_bib81","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3103\/S0095452723060087","article-title":"Synergistic anti-cancer potential of phenethyl isothiocyanate and curcumin induces apoptosis and G2\/M cell cycle arrest in HER2-positive breast cancer cells","volume":"57","author":"Sirigiripeta","year":"2023","journal-title":"Cytol. Genet."},{"issue":"18","key":"10.1016\/j.prp.2024.155479_bib82","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6528\/ab6d20","article-title":"GANT61 and curcumin-loaded PLGA nanoparticles for GLI1 and PI3K\/Akt-mediated inhibition in breast adenocarcinoma","volume":"31","author":"Borah","year":"2020","journal-title":"Nanotechnology"},{"issue":"1","key":"10.1016\/j.prp.2024.155479_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12935-014-0126-4","article-title":"The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K\/Akt-SKP2-Cip\/Kips pathway","volume":"14","author":"Jia","year":"2014","journal-title":"Cancer Cell Int."},{"issue":"6","key":"10.1016\/j.prp.2024.155479_bib84","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.3892\/ol.2017.6053","article-title":"Anticancer effect of curcumin inhibits cell growth through miR-21\/PTEN\/Akt pathway in breast cancer cell","volume":"13","author":"Wang","year":"2017","journal-title":"Oncol. Lett."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib85","doi-asserted-by":"crossref","first-page":"178","DOI":"10.4161\/cbt.6.2.3577","article-title":"Curcumin induces G2\/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK","volume":"6","author":"Weir","year":"2007","journal-title":"Cancer Biol. Ther."},{"issue":"3","key":"10.1016\/j.prp.2024.155479_bib86","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317694302","article-title":"Demethoxycurcumin inhibited human epithelia ovarian cancer cells\u2019 growth via up-regulating miR-551a","volume":"39","author":"Du","year":"2017","journal-title":"Tumor Biol."},{"issue":"10","key":"10.1016\/j.prp.2024.155479_bib87","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.3109\/13880209.2016.1139601","article-title":"Curcumin induced apoptosis via PI3K\/Akt-signalling pathways in SKOV3 cells","volume":"54","author":"Yu","year":"2016","journal-title":"Pharm. Biol."},{"issue":"4","key":"10.1016\/j.prp.2024.155479_bib88","doi-asserted-by":"crossref","first-page":"767","DOI":"10.4314\/tjpr.v20i4.15","article-title":"Effect of curcumin on the viability of SKOV3 cells and its probable mechanism of action","volume":"20","author":"Dan","year":"2021","journal-title":"Trop. J. Pharm. Res."},{"key":"10.1016\/j.prp.2024.155479_bib89","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1007\/s00404-019-05058-3","article-title":"Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT\/mTOR\/p70S6K pathway in human ovarian cancer cells","volume":"299","author":"Liu","year":"2019","journal-title":"Arch. Gynecol. Obstet."},{"issue":"8","key":"10.1016\/j.prp.2024.155479_bib90","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.7314\/APJCP.2014.15.8.3363","article-title":"Induction of microRNA-9 mediates cytotoxicity of curcumin against SKOV3 ovarian cancer cells","volume":"15","author":"Zhao","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib91","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2174\/1568009053202081","article-title":"Induction of apoptosis by curcumin and its implications for cancer therapy","volume":"5","author":"Karunagaran","year":"2005","journal-title":"Curr. Cancer Drug Targets"},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib92","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/ecam\/nem043","article-title":"Curcumin in cell death processes: a challenge for CAM of age-related pathologies","volume":"4","author":"Salvioli","year":"2007","journal-title":"Evid. -Based Complement. Altern. Med."},{"key":"10.1016\/j.prp.2024.155479_bib93","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1007\/s00595-017-1527-5","article-title":"Neoadjuvant CapeOx therapy followed by sphincter-preserving surgery for lower rectal cancer","volume":"47","author":"Hata","year":"2017","journal-title":"Surg. Today"},{"issue":"8","key":"10.1016\/j.prp.2024.155479_bib94","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1097\/MEG.0000000000000892","article-title":"Incidence and predictors of adenoma after surgery for colorectal cancer","volume":"29","author":"Marques-Antunes","year":"2017","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.prp.2024.155479_bib95","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1097\/01.sla.0000220040.66012.a9","article-title":"Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma","volume":"243","author":"Rychahou","year":"2006","journal-title":"Ann. Surg."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib96","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.surg.2005.05.012","article-title":"Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)","volume":"138","author":"Rychahou","year":"2005","journal-title":"Surgery"},{"key":"10.1016\/j.prp.2024.155479_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-017-0661-7","article-title":"Curcumin synergizes with 5-fluorouracil by impairing AMPK\/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice","volume":"36","author":"Zhang","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.prp.2024.155479_bib98","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125013","article-title":"Characterization of differentially expressed genes involved in pathways associated with gastric cancer","volume":"10","author":"Li","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2024.155479_bib99","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/1479-5876-11-225","article-title":"Long non-coding RNA expression profile in human gastric cancer and its clinical significances","volume":"11","author":"Song","year":"2013","journal-title":"J. Transl. Med"},{"issue":"4","key":"10.1016\/j.prp.2024.155479_bib100","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.4251\/wjgo.v16.i4.1437","article-title":"Curcumin inhibits the growth and invasion of gastric cancer by regulating long noncoding RNA AC022424.2","volume":"16","author":"Wang","year":"2024","journal-title":"World J. Gastrointest. Oncol."},{"issue":"11","key":"10.1016\/j.prp.2024.155479_bib101","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1002\/tox.23905","article-title":"Curcumin inhibits esophageal squamous cell carcinoma progression through down-regulating the circNRIP1\/miR-532-3p\/AKT pathway","volume":"38","author":"Luo","year":"2023","journal-title":"Environ. Toxicol."},{"issue":"4","key":"10.1016\/j.prp.2024.155479_bib102","doi-asserted-by":"crossref","DOI":"10.1177\/15593258231203585","article-title":"Curcumin's Dose-Dependent Attenuation of Gastric Cancer Cell Progression Via the PI3K Pathway Blockade","volume":"21","author":"Xi","year":"2023","journal-title":"Dose Response"},{"issue":"6","key":"10.1016\/j.prp.2024.155479_bib103","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.clon.2010.05.004","article-title":"Thyroid cancer epidemiology and prognostic variables","volume":"22","author":"Sipos","year":"2010","journal-title":"Clin. Oncol."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib104","doi-asserted-by":"crossref","first-page":"R43","DOI":"10.1530\/JOE-17-0266","article-title":"Key signaling pathways in thyroid cancer","volume":"235","author":"Zaballos","year":"2017","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.prp.2024.155479_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.sempedsurg.2020.150920","article-title":"Papillary and follicular thyroid cancer in children and adolescents: current approach and future directions","author":"Bauer","year":"2020","journal-title":"Semin. Pediatr. Surg."},{"issue":"5","key":"10.1016\/j.prp.2024.155479_bib106","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1089\/thy.1999.9.421","article-title":"An overview of the management of papillary and follicular thyroid carcinoma","volume":"9","author":"MAZZAFERRI","year":"1999","journal-title":"Thyroid"},{"issue":"1","key":"10.1016\/j.prp.2024.155479_bib107","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12906-018-2125-9","article-title":"Effects of different extracts of curcumin on TPC1 papillary thyroid cancer cell line","volume":"18","author":"Perna","year":"2018","journal-title":"BMC Complement. Altern. Med."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib108","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s12020-014-0380-1","article-title":"PI3K\/Akt\/mTOR signaling in medullary thyroid cancer: a promising molecular target for cancer therapy","volume":"48","author":"Manfredi","year":"2015","journal-title":"Endocrine"},{"issue":"8","key":"10.1016\/j.prp.2024.155479_bib109","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ctrv.2015.06.005","article-title":"PI3K\/Akt\/mTOR: a promising therapeutic target for non-medullary thyroid carcinoma","volume":"41","author":"Petrulea","year":"2015","journal-title":"Cancer Treat. Rev."},{"issue":"3","key":"10.1016\/j.prp.2024.155479_bib110","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3803\/EnM.2019.34.3.215","article-title":"Radioactive iodine-refractory differentiated thyroid cancer and redifferentiation therapy","volume":"34","author":"Liu","year":"2019","journal-title":"Endocrinol. Metab. (Seoul. )"},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib111","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1158\/0008-5472.CAN-05-2708","article-title":"Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice","volume":"66","author":"Khor","year":"2006","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.prp.2024.155479_bib112","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1021\/mp400101k","article-title":"Synergistic interaction of paclitaxel and curcumin with cyclodextrin polymer complexation in human cancer cells","volume":"10","author":"Boztas","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.prp.2024.155479_bib113","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5946670","article-title":"Curcumin inhibits papillary thyroid cancer cell proliferation by regulating lncRNA LINC00691","volume":"2022","author":"Li","year":"2022","journal-title":"Anal. Cell. Pathol."},{"issue":"6","key":"10.1016\/j.prp.2024.155479_bib114","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA: a Cancer J. Clin."},{"key":"10.1016\/j.prp.2024.155479_bib115","article-title":"Advances in the management of castration resistant prostate cancer","volume":"355","author":"Ritch","year":"2016","journal-title":"Bmj"},{"issue":"3","key":"10.1016\/j.prp.2024.155479_bib116","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3390\/nu12030679","article-title":"Mechanism of anti-cancer activity of curcumin on androgen-dependent and androgen-independent prostate cancer","volume":"12","author":"Abd. Wahab","year":"2020","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.prp.2024.155479_bib117","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc839","article-title":"The phosphatidylinositol 3-kinase\u2013AKT pathway in human cancer","volume":"2","author":"Vivanco","year":"2002","journal-title":"Nat. Rev. Cancer"},{"issue":"7","key":"10.1016\/j.prp.2024.155479_bib118","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/ijc.22862","article-title":"Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion","volume":"121","author":"Shukla","year":"2007","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.prp.2024.155479_bib119","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s12263-009-0152-3","article-title":"Chemopreventive potential of curcumin in prostate cancer","volume":"5","author":"Teiten","year":"2010","journal-title":"Genes Nutr."},{"issue":"12","key":"10.1016\/j.prp.2024.155479_bib120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21124507","article-title":"The PI3K-AKT-mTOR pathway and prostate cancer: at the crossroads of AR, MAPK, and WNT signaling","volume":"21","author":"Shorning","year":"2020","journal-title":"Int J. Mol. Sci."},{"issue":"23","key":"10.1016\/j.prp.2024.155479_bib121","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.4161\/cc.6.23.4951","article-title":"Linkage of curcumin-induced cell cycle arrest and apoptosis by cyclin-dependent kinase inhibitor p21\/WAF1\/CIP1","volume":"6","author":"Srivastava","year":"2007","journal-title":"Cell Cycle"},{"issue":"9","key":"10.1016\/j.prp.2024.155479_bib122","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1158\/1535-7163.MCT-07-2400","article-title":"Curcumin inhibits Akt\/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism","volume":"7","author":"Yu","year":"2008","journal-title":"Mol. Cancer Ther."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib123","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1124\/jpet.106.117721","volume":"321","author":"Deeb","year":"2007","journal-title":"J. Pharm. Exp. Ther."},{"issue":"12","key":"10.1016\/j.prp.2024.155479_bib124","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144293","article-title":"Combination of \u03b1-tomatine and curcumin inhibits growth and induces apoptosis in human prostate cancer cells","volume":"10","author":"Huang","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.prp.2024.155479_bib125","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1158\/0008-5472.CAN-06-3066","article-title":"Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K\/mTOR\/ETS2 pathway","volume":"67","author":"Li","year":"2007","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib126","first-page":"91","article-title":"Lung cancer: nw biological insights and recent therapeutic advances","volume":"61","author":"Ramalingam","year":"2011","journal-title":"CA: a Cancer J. Clin."},{"issue":"10","key":"10.1016\/j.prp.2024.155479_bib127","doi-asserted-by":"crossref","first-page":"6530","DOI":"10.1002\/jcp.26620","article-title":"The versatile role of curcumin in cancer prevention and treatment: a focus on PI3K\/AKT pathway","volume":"233","author":"Hamzehzadeh","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.prp.2024.155479_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2022.101364","article-title":"The PI3K\/Akt\/mTOR pathway in lung cancer; oncogenic alterations, therapeutic opportunities, challenges, and a glance at the application of nanoparticles","volume":"18","author":"Sanaei","year":"2022","journal-title":"Transl. Oncol."},{"issue":"3","key":"10.1016\/j.prp.2024.155479_bib129","first-page":"1523","article-title":"Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K\/Akt\/mTOR pathway","volume":"39","author":"Liu","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.prp.2024.155479_bib130","doi-asserted-by":"crossref","first-page":"16018","DOI":"10.1038\/mto.2016.18","article-title":"Curcumin inhibited HGF-induced EMT and angiogenesis through regulating c-Met dependent PI3K\/Akt\/mTOR signaling pathways in lung cancer","volume":"3","author":"Jiao","year":"2016","journal-title":"Mol. Ther. Oncolytics"},{"issue":"7","key":"10.1016\/j.prp.2024.155479_bib131","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.3390\/ijms20071611","article-title":"The roles of MicroRNA in lung cancer","volume":"20","author":"Wu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"38","key":"10.1016\/j.prp.2024.155479_bib132","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.1038\/sj.onc.1209615","article-title":"RB and cell cycle progression","volume":"25","author":"Giacinti","year":"2006","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.prp.2024.155479_bib133","first-page":"342","article-title":"PI3K\/Akt\/mTOR inhibitors in breast cancer","volume":"12","author":"Lee","year":"2015","journal-title":"Cancer Biol. Med"},{"issue":"1","key":"10.1016\/j.prp.2024.155479_bib134","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12935-014-0126-4","article-title":"The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K\/Akt-SKP2-Cip\/Kips pathway","volume":"14","author":"Jia","year":"2014","journal-title":"Cancer Cell Int"},{"issue":"1","key":"10.1016\/j.prp.2024.155479_bib135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-4598-9-12","article-title":"miR-21: an oncomir on strike in prostate cancer","volume":"9","author":"Folini","year":"2010","journal-title":"Mol. Cancer"},{"issue":"11","key":"10.1016\/j.prp.2024.155479_bib136","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1261\/rna.1034808","article-title":"MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis","volume":"14","author":"Yan","year":"2008","journal-title":"Rna"},{"issue":"6","key":"10.1016\/j.prp.2024.155479_bib137","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.3892\/ol.2017.6053","article-title":"Anticancer effect of curcumin inhibits cell growth through miR-21\/PTEN\/Akt pathway in breast cancer cell","volume":"13","author":"Wang","year":"2017","journal-title":"Oncol. Lett."},{"issue":"4","key":"10.1016\/j.prp.2024.155479_bib138","first-page":"284","article-title":"Ovarian cancer statistics, 2018","volume":"68","author":"Torre","year":"2018","journal-title":"CA: a Cancer J. Clin."},{"key":"10.1016\/j.prp.2024.155479_bib139","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2147\/IJWH.S197604","article-title":"Ovarian cancer in the world: epidemiology and risk factors","author":"Momenimovahed","year":"2019","journal-title":"Int. J. Women'S. Health"},{"issue":"1","key":"10.1016\/j.prp.2024.155479_bib140","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ygyno.2015.02.003","article-title":"The PI3K\/AKT\/mTOR pathway as a therapeutic target in ovarian cancer","volume":"137","author":"Mabuchi","year":"2015","journal-title":"Gynecol. Oncol."},{"issue":"6","key":"10.1016\/j.prp.2024.155479_bib141","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1007\/s00404-019-05058-3","article-title":"Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT\/mTOR\/p70S6K pathway in human ovarian cancer cells","volume":"299","author":"Liu","year":"2019","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.prp.2024.155479_bib142","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00441-015-2307-4","article-title":"MicroRNA in ovarian function","volume":"363","author":"Maalouf","year":"2016","journal-title":"Cell Tissue Res."},{"issue":"8","key":"10.1016\/j.prp.2024.155479_bib143","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.7314\/APJCP.2014.15.8.3363","article-title":"Induction of microRNA-9 mediates cytotoxicity of curcumin against SKOV3 ovarian cancer cells","volume":"15","author":"Zhao","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"1","key":"10.1016\/j.prp.2024.155479_bib144","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4161\/cbt.9.1.10392","article-title":"Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer","volume":"9","author":"Bayet-Robert","year":"2010","journal-title":"Cancer Biol. Ther."},{"issue":"2","key":"10.1016\/j.prp.2024.155479_bib145","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1177\/1078155211416530","article-title":"Effect of imatinib therapy with and without turmeric powder on nitric oxide levels in chronic myeloid leukemia","volume":"18","author":"Ghalaut","year":"2012","journal-title":"J. Oncol. Pharm. Pr."},{"issue":"Supplement 1","key":"10.1016\/j.prp.2024.155479_bib146","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1182\/blood-2018-99-112295","article-title":"A phase II study of curcumin and vitamin D in previously untreated patients with early stage chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)","volume":"132","author":"William","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.prp.2024.155479_bib147","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1182\/blood-2018-99-112295","article-title":"A phase II study of curcumin and vitamin D in previously untreated patients with early stage chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)","volume":"132","author":"William","year":"2018","journal-title":"Blood"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S034403382400390X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S034403382400390X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:12:42Z","timestamp":1723680762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S034403382400390X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":147,"alternative-id":["S034403382400390X"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2024.155479","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the Akt signaling pathway: Exploiting curcumin's anticancer potential","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2024.155479","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155479"}}