{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:18:10Z","timestamp":1791919090890,"version":"4.3.4"},"reference-count":415,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.prp.2024.155546","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T20:29:41Z","timestamp":1724358581000},"page":"155546","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Novel drug delivery systems in colorectal cancer: Advances and future prospects"],"prefix":"10.1016","volume":"262","author":[{"given":"Raj","family":"Kamal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Awasthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Shabab","family":"Mir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Dua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/mco.2021.2433","article-title":"General insight into cancer: an overview of colorectal cancer","volume":"15","author":"Alzahrani","year":"2021","journal-title":"Mol. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3390\/ijms18010197","article-title":"Colorectal carcinoma: a general overview and future perspectives in colorectal cancer","volume":"18","author":"M\u00e1rmol","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.prp.2024.155546_bib3","doi-asserted-by":"crossref","DOI":"10.3332\/ecancer.2015.520","article-title":"Biology of colorectal cancer","volume":"9","author":"Arvelo","year":"2015","journal-title":"Ecancermedicalscience"},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib4","first-page":"31","article-title":"Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells","volume":"6","author":"Testa","year":"2018","journal-title":"Med. Sci."},{"issue":"14","key":"10.1016\/j.prp.2024.155546_bib5","doi-asserted-by":"crossref","first-page":"17773","DOI":"10.18632\/oncotarget.7402","article-title":"Cell-surface markers for colon adenoma and adenocarcinoma","volume":"7","author":"Sewda","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2024.155546_bib6","unstructured":"Vinik, A., Hughes, M.S., Feliberti, E., Perry, R.R., Casellini, C., Sinesi, M., et al. (2018). Carcinoid tumors. Endotext [Internet] ."},{"issue":"03","key":"10.1016\/j.prp.2024.155546_bib7","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1055\/s-0039-1694704","article-title":"Gastrointestinal stromal tumors of small intestine","volume":"5","author":"Huda","year":"2019","journal-title":"Surg. J."},{"key":"10.1016\/j.prp.2024.155546_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.808964","article-title":"Tumor-infiltrating lymphocytes in colorectal cancer: the fundamental indication and application on immunotherapy","volume":"12","author":"Bai","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prp.2024.155546_bib9","series-title":"Treatment of cancer","first-page":"434","article-title":"Soft tissue sarcomas","author":"DeLaney","year":"2020"},{"issue":"9","key":"10.1016\/j.prp.2024.155546_bib10","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.3390\/cancers13092025","article-title":"A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis","volume":"13","author":"Sawicki","year":"2021","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.gpb.2022.07.002","article-title":"Gut microbiome in colorectal cancer: clinical diagnosis and treatment","volume":"21","author":"Liu","year":"2023","journal-title":"Genom., Proteom. Bioinforma."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib12","first-page":"175","article-title":"Global pattern and trends of colorectal cancer survival: a systematic review of population-based registration data","volume":"19","author":"Jiang","year":"2022","journal-title":"Cancer Biol. Med."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib13","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA: A Cancer J. Clin."},{"issue":"10","key":"10.1016\/j.prp.2024.155546_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101174","article-title":"Global colorectal cancer burden in 2020 and projections to 2040","volume":"14","author":"Xi","year":"2021","journal-title":"Transl. Oncol."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib15","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/gutjnl-2022-327736","article-title":"Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN","volume":"72","author":"Morgan","year":"2023","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.prp.2024.155546_bib16","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41577-021-00534-x","article-title":"The inflammatory pathogenesis of colorectal cancer","volume":"21","author":"Schmitt","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib17","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.1038\/s41467-020-19288-6","article-title":"Immune modulatory effects of oncogenic KRAS in cancer","volume":"11","author":"Hamarsheh","year":"2020","journal-title":"Nat. Commun."},{"issue":"61","key":"10.1016\/j.prp.2024.155546_bib18","doi-asserted-by":"crossref","first-page":"6623","DOI":"10.18632\/oncotarget.27304","article-title":"The multifaceted anti-cancer effects of BRAF-inhibitors","volume":"10","author":"Croce","year":"2019","journal-title":"Oncotarget"},{"issue":"8","key":"10.1016\/j.prp.2024.155546_bib19","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/cac2.12295","article-title":"Cytokine-and chemokine-induced inflammatory colorectal tumor microenvironment: emerging avenue for targeted therapy","volume":"42","author":"Bhat","year":"2022","journal-title":"Cancer Commun."},{"key":"10.1016\/j.prp.2024.155546_bib20","article-title":"Molecular network of colorectal cancer and current therapeutic options","volume":"12","author":"Huang","year":"2022","journal-title":"Front. Oncol."},{"issue":"12","key":"10.1016\/j.prp.2024.155546_bib21","doi-asserted-by":"crossref","first-page":"a022277","DOI":"10.1101\/cshperspect.a022277","article-title":"TGF-\u03b2 family signaling in tumor suppression and cancer progression","volume":"9","author":"Seoane","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/diseases9040079","article-title":"Exploring the inflammatory pathogenesis of colorectal cancer","volume":"9","author":"Khalyfa","year":"2021","journal-title":"Diseases"},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib23","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.3892\/or.2016.4660","article-title":"Role of the tumor microenvironment in tumor progression and the clinical applications","volume":"35","author":"Yuan","year":"2016","journal-title":"Oncol. Rep."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib24","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3390\/ijms22010130","article-title":"Molecular mechanisms of colon cancer progression and metastasis: recent insights and advancements","volume":"22","author":"Malki","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib25","first-page":"101","article-title":"Role of gut microbiota in the pathogenesis of colorectal cancer; a review article","volume":"11","author":"Jahani-Sherafat","year":"2018","journal-title":"Gastroenterol. Hepatol. bed bench"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/gastro\/gox031","article-title":"Dysbiosis of gut microbiota in promoting the development of colorectal cancer","volume":"6","author":"Zou","year":"2018","journal-title":"Gastroenterol. Rep."},{"key":"10.1016\/j.prp.2024.155546_bib27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fcell.2018.00056","article-title":"Underlying causes and therapeutic targeting of the inflammatory tumor microenvironment","volume":"6","author":"Comen","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.prp.2024.155546_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3128933","article-title":"Tumor-associated inflammation: The tumor-promoting immunity in the early stages of tumorigenesis","volume":"2022","author":"Bi","year":"2022","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.prp.2024.155546_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104052","article-title":"Bacterial biofilm in colorectal cancer: What is the real mechanism of action?","volume":"142","author":"Mirzaei","year":"2020","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.prp.2024.155546_bib30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/bs.pmbts.2020.02.004","article-title":"Oral and intestinal bacterial exotoxins: potential linked to carcinogenesis","volume":"171","author":"Silbergleit","year":"2020","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib31","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4251\/wjgo.v14.i2.375","article-title":"Microbiome and colorectal carcinogenesis: Linked mechanisms and racial differences","volume":"14","author":"Tortora","year":"2022","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1016\/j.prp.2024.155546_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.807648","article-title":"Potential role of the gut microbiome in colorectal cancer progression","volume":"12","author":"Kim","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prp.2024.155546_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.792546","article-title":"Proteomimetics of natural regulators of JAK\u2013STAT pathway: novel therapeutic perspectives","volume":"8","author":"La Manna","year":"2022","journal-title":"Front. Mol. Biosci."},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib34","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1007\/s11033-021-06458-y","article-title":"Cross-talk between non-coding RNAs and PI3K\/AKT\/mTOR pathway in colorectal cancer","volume":"48","author":"Moafian","year":"2021","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12935-021-02402-z","article-title":"MALAT1-related signaling pathways in colorectal cancer","volume":"22","author":"Xu","year":"2022","journal-title":"Cancer Cell Int."},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib36","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.clcc.2016.09.012","article-title":"The role of cyclooxygenase-2 in colorectal carcinogenesis","volume":"16","author":"Liu","year":"2017","journal-title":"Clin. Colorectal Cancer"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib37","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12943-022-01616-7","article-title":"Wnt signaling in colorectal cancer: Pathogenic role and therapeutic target","volume":"21","author":"Zhao","year":"2022","journal-title":"Mol. Cancer"},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib38","first-page":"2266","article-title":"Correlation of ERK\/MAPK signaling pathway with proliferation and apoptosis of colon cancer cells","volume":"17","author":"Zhou","year":"2019","journal-title":"Oncol. Lett."},{"issue":"23","key":"10.1016\/j.prp.2024.155546_bib39","doi-asserted-by":"crossref","first-page":"5822","DOI":"10.3390\/ijms20235822","article-title":"Transforming growth factor-\u03b2 signaling pathway in colorectal cancer and its tumor microenvironment","volume":"20","author":"Itatani","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib40","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.molmed.2016.02.003","article-title":"Mismatch repair and colon cancer: mechanisms and therapies explored","volume":"22","author":"Li","year":"2016","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.prp.2024.155546_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2019.144132","article-title":"Role of the NF-\u03baB signaling pathway in the pathogenesis of colorectal cancer","volume":"726","author":"Soleimani","year":"2020","journal-title":"Gene"},{"issue":"10","key":"10.1016\/j.prp.2024.155546_bib42","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1158\/0008-5472.CAN-15-1605","article-title":"Intracrine VEGF signaling mediates the activity of prosurvival pathways in human colorectal cancer cells","volume":"76","author":"Bhattacharya","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2024.155546_bib43","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.biopha.2018.11.082","article-title":"Therapeutic potential of targeting the Wnt\/\u03b2-catenin signaling pathway in colorectal cancer","volume":"110","author":"Cheng","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"8","key":"10.1016\/j.prp.2024.155546_bib44","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1002\/ijc.29800","article-title":"The N otch pathway in colorectal cancer","volume":"138","author":"Vinson","year":"2016","journal-title":"Int. J. Cancer"},{"issue":"9","key":"10.1016\/j.prp.2024.155546_bib45","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.3390\/cancers13092125","article-title":"The role of p53 signaling in colorectal cancer","volume":"13","author":"Liebl","year":"2021","journal-title":"Cancers"},{"issue":"11","key":"10.1016\/j.prp.2024.155546_bib46","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1158\/1541-7786.MCR-19-0429","article-title":"A complex role for calcium signaling in colorectal cancer development and progression","volume":"17","author":"Wang","year":"2019","journal-title":"Mol. Cancer Res."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib47","first-page":"583","article-title":"Oleanolic acid inhibits colorectal cancer angiogenesis by blocking the VEGFR2 signaling pathway","volume":"18","author":"Niu","year":"2018","journal-title":"Anti-Cancer Agents Med. Chem. Former. Curr. Med. Chem. -Anti-Cancer Agents"},{"key":"10.1016\/j.prp.2024.155546_bib48","first-page":"123","article-title":"RAF-MEK-ERK pathway in cancer evolution and treatment","volume":"Vol. 85","author":"Ullah","year":"2022"},{"key":"10.1016\/j.prp.2024.155546_bib49","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.2147\/OTT.S139639","article-title":"Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy","author":"Wu","year":"2017","journal-title":"OncoTargets Ther."},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib50","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41419-020-2467-3","article-title":"The autophagy-independent role of BECN1 in colorectal cancer metastasis through regulating STAT3 signaling pathway activation","volume":"11","author":"Hu","year":"2020","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib51","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41419-018-0695-6","article-title":"FSTL1 interacts with VIM and promotes colorectal cancer metastasis via activating the focal adhesion signalling pathway","volume":"9","author":"Gu","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.prp.2024.155546_bib52","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3389\/fphar.2020.00273","article-title":"Atractylenolide I induces apoptosis and suppresses glycolysis by blocking the JAK2\/STAT3 signaling pathway in colorectal cancer cells","volume":"11","author":"Li","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.prp.2024.155546_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152806","article-title":"Tumour necrosis factor-\u03b1 (TNF-\u03b1) enhances dietary carcinogen-induced DNA damage in colorectal cancer epithelial cells through activation of JNK signaling pathway","volume":"457","author":"Alotaibi","year":"2021","journal-title":"Toxicology"},{"issue":"16","key":"10.1016\/j.prp.2024.155546_bib54","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.3390\/cancers13164072","article-title":"Epigenetic alterations upstream and downstream of p53 signaling in colorectal carcinoma","volume":"13","author":"Tomicic","year":"2021","journal-title":"Cancers"},{"issue":"11","key":"10.1016\/j.prp.2024.155546_bib55","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.7150\/ijbs.59404","article-title":"Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells","volume":"17","author":"Wei","year":"2021","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib56","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1021\/acs.jafc.0c07166","article-title":"Lysosome-mediated cytotoxic autophagy contributes to tea polysaccharide-induced colon cancer cell death via mTOR-TFEB signaling","volume":"69","author":"Zhou","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.prp.2024.155546_bib57","first-page":"63","article-title":"Metabolic pathways regulating colorectal cancer initiation and progression","volume":"Vol. 98","author":"La Vecchia","year":"2020"},{"issue":"11","key":"10.1016\/j.prp.2024.155546_bib58","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/mc.22883","article-title":"Functional significance of Hippo\/YAP signaling for drug resistance in colorectal cancer","volume":"57","author":"Song","year":"2018","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.prp.2024.155546_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174041","article-title":"PI3K\/Akt\/GSK-3\u03b2 signal pathway is involved in P2X7 receptor-induced proliferation and EMT of colorectal cancer cells","volume":"899","author":"Zhang","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.prp.2024.155546_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.111981","article-title":"Protective effect of Shaoyao Decoction against colorectal cancer via the Keap1\u2013Nrf2\u2013ARE signaling pathway","volume":"241","author":"Wang","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.prp.2024.155546_bib61","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biochi.2018.11.003","article-title":"Role of adenomatous polyposis coli (APC) gene mutations in the pathogenesis of colorectal cancer; current status and perspectives","volume":"157","author":"Aghabozorgi","year":"2019","journal-title":"Biochimie"},{"key":"10.1016\/j.prp.2024.155546_bib62","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cellsig.2019.05.009","article-title":"Estrogen receptor alpha regulates the Wnt\/\u03b2-catenin signaling pathway in colon cancer by targeting the NOD-like receptors","volume":"61","author":"Liu","year":"2019","journal-title":"Cell. Signal."},{"key":"10.1016\/j.prp.2024.155546_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13578-019-0361-4","article-title":"Signaling pathways involved in colorectal cancer progression","volume":"9","author":"Koveitypour","year":"2019","journal-title":"Cell Biosci."},{"key":"10.1016\/j.prp.2024.155546_bib64","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s11033-018-4294-5","article-title":"A natural flavonoid lawsonaringenin induces cell cycle arrest and apoptosis in HT-29 colorectal cancer cells by targeting multiple signalling pathways","volume":"45","author":"Anwar","year":"2018","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib65","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2015.12.009","article-title":"Estrogen receptor beta as target for colorectal cancer prevention","volume":"372","author":"Williams","year":"2016","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib66","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/cancers9050052","article-title":"Epidermal growth factor receptor cell proliferation signaling pathways","volume":"9","author":"Wee","year":"2017","journal-title":"Cancers"},{"key":"10.1016\/j.prp.2024.155546_bib67","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3389\/fonc.2020.01501","article-title":"Steroid 5\u03b1-reductase type I induces cell viability and migration via nuclear factor-\u03baB\/vascular endothelial growth factor signaling pathway in colorectal cancer","volume":"10","author":"Wei","year":"2020","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib68","doi-asserted-by":"crossref","DOI":"10.1038\/srep18949","article-title":"BRAFV600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells","volume":"6","author":"Sueda","year":"2016","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.prp.2024.155546_bib69","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1111\/jcmm.12908","article-title":"C-Jun N-terminal kinase signalling pathway in response to cisplatin","volume":"20","author":"Yan","year":"2016","journal-title":"J. Cell. Mol. Med."},{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib70","first-page":"4519","article-title":"Axon guidance pathway genes are associated with schizophrenia risk","volume":"16","author":"Wang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.prp.2024.155546_bib71","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3389\/fphar.2017.00267","article-title":"The epigenomics of embryonic pathway signaling in colorectal cancer","volume":"8","author":"Balch","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.prp.2024.155546_bib72","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1080\/15592294.2016.1190894","article-title":"Aberrant DNA methylation of WNT pathway genes in the development and progression of CIMP-negative colorectal cancer","volume":"11","author":"Galamb","year":"2016","journal-title":"Epigenetics"},{"issue":"38","key":"10.1016\/j.prp.2024.155546_bib73","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1038\/onc.2017.116","article-title":"Stromal-derived IGF2 promotes colon cancer progression via paracrine and autocrine mechanisms","volume":"36","author":"Unger","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2024.155546_bib74","doi-asserted-by":"crossref","DOI":"10.1017\/erm.2021.13","article-title":"Tumour microenvironment: a non-negligible driver for epithelial\u2212 mesenchymal transition in colorectal cancer","volume":"23","author":"Han","year":"2021","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.prp.2024.155546_bib75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-019-1408-4","article-title":"Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246\/SPRED2\/MAPK signaling pathway","volume":"38","author":"Peng","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.prp.2024.155546_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2023.103920","article-title":"Cancer stem cells in colorectal cancer: signaling pathways involved in stemness and therapy resistance","author":"Ebrahimi","year":"2023","journal-title":"Crit. Rev. Oncol. \/Hematol."},{"key":"10.1016\/j.prp.2024.155546_bib77","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ebiom.2018.09.021","article-title":"Profiles of alternative splicing in colorectal cancer and their clinical significance: a study based on large-scale sequencing data","volume":"36","author":"Xiong","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.prp.2024.155546_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110148","article-title":"SPIB acts as a tumor suppressor by activating the NFkB and JNK signaling pathways through MAP4K1 in colorectal cancer cells","volume":"88","author":"Zhao","year":"2021","journal-title":"Cell. Signal."},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib79","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/mc.22539","article-title":"Emerging links among chromosome instability (CIN), cancer, and aging","volume":"56","author":"Rao","year":"2017","journal-title":"Mol. Carcinog."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib80","doi-asserted-by":"crossref","first-page":"10998","DOI":"10.1080\/21655979.2022.2066926","article-title":"Luteolin impacts deoxyribonucleic acid repair by modulating the mitogen-activated protein kinase pathway in colorectal cancer","volume":"13","author":"Song","year":"2022","journal-title":"Bioengineered"},{"issue":"10","key":"10.1016\/j.prp.2024.155546_bib81","doi-asserted-by":"crossref","first-page":"290","DOI":"10.4251\/wjgo.v10.i10.290","article-title":"Inhibiting focal adhesion kinase: A potential target for enhancing therapeutic efficacy in colorectal cancer therapy","volume":"10","author":"Jeong","year":"2018","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1016\/j.prp.2024.155546_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108708","article-title":"Collagen facilitates the colorectal cancer stemness and metastasis through an integrin\/PI3K\/AKT\/Snail signaling pathway","volume":"114","author":"Wu","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib83","doi-asserted-by":"crossref","first-page":"11390","DOI":"10.1080\/21655979.2021.2008694","article-title":"Proto-oncogene tyrosine-protein kinase SRC (Src) inhibition in microglia relieves neuroinflammation in neuropathic pain mouse models","volume":"12","author":"Cai","year":"2021","journal-title":"Bioengineered"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib84","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/jcp.29880","article-title":"Long noncoding RNA EPB41L4A-AS1 functions as an oncogene by regulating the Rho\/ROCK pathway in colorectal cancer","volume":"236","author":"Bin","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib85","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3390\/cancers12030665","article-title":"Rac1 signaling: from intestinal homeostasis to colorectal cancer metastasis","volume":"12","author":"Kotelevets","year":"2020","journal-title":"Cancers"},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib86","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1159\/000443117","article-title":"MicroRNA-124 (MiR-124) inhibits cell proliferation, metastasis and invasion in colorectal cancer by downregulating Rho-associated protein kinase 1 (ROCK1)","volume":"38","author":"Zhou","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib87","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.bbamcr.2018.02.002","article-title":"Protein Kinase C-\u03b6 stimulates colorectal cancer cell carcinogenesis via PKC-\u03b6\/Rac1\/Pak1\/\u03b2-Catenin signaling cascade","volume":"1865","author":"Islam","year":"2018","journal-title":"Biochim. Et. Biophys. Acta (BBA)-Mol. Cell Res."},{"key":"10.1016\/j.prp.2024.155546_bib88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2019.04.009","article-title":"Nitric oxide and interactions with reactive oxygen species in the development of melanoma, breast, and colon cancer: a redox signaling perspective","volume":"89","author":"Monteiro","year":"2019","journal-title":"Nitric Oxide"},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib89","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/mc.21841","article-title":"JAK\/STAT\/SOCS-signaling pathway and colon and rectal cancer","volume":"52","author":"Slattery","year":"2013","journal-title":"Mol. Carcinog."},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib90","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3390\/ijms17050759","article-title":"A comparative analysis of genetic and epigenetic events of breast and ovarian cancer related to tumorigenesis","volume":"17","author":"Longacre","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib91","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41392-020-0110-5","article-title":"Targeting cancer stem cell pathways for cancer therapy","volume":"5","author":"Yang","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib92","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1053\/j.gastro.2009.12.065","article-title":"The chromosomal instability pathway in colon cancer","volume":"138","author":"Pino","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.prp.2024.155546_bib93","unstructured":"ElRuz, R., Gupta, I., & Allouch, A. (2020). Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements."},{"key":"10.1016\/j.prp.2024.155546_bib94","doi-asserted-by":"crossref","DOI":"10.1177\/15330338231178403","article-title":"Recent advancements, limitations, and future perspectives of the use of personalized medicine in treatment of colon cancer","volume":"22","author":"Dey","year":"2023","journal-title":"Technol. Cancer Res. Treat."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib95","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/1758834014530023","article-title":"The PI3K\/AKT\/mTOR pathway in breast cancer: targets, trials and biomarkers","volume":"6","author":"Paplomata","year":"2014","journal-title":"Ther. Adv. Med Oncol."},{"key":"10.1016\/j.prp.2024.155546_bib96","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fonc.2014.00064","article-title":"Targeting PI3K\/Akt\/mTOR signaling in cancer","volume":"4","author":"Porta","year":"2014","journal-title":"Front Oncol."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib97","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","article-title":"PI3K\/AKT\/mTOR signaling transduction pathway and targeted therapies in cancer","volume":"22","author":"Glaviano","year":"2023","journal-title":"Mol. Cancer"},{"issue":"8","key":"10.1016\/j.prp.2024.155546_bib98","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1097\/JTO.0b013e31825493eb","article-title":"Development of PI3K\/AKT\/mTOR pathway inhibitors and their application in personalized therapy for non\u2013small-cell lung cancer","volume":"7","author":"Papadimitrakopoulou","year":"2012","journal-title":"J. Thorac. Oncol."},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib99","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0092-8674(00)81433-6","article-title":"Cyclooxygenase regulates angiogenesis induced by colon cancer cells","volume":"93","author":"Tsujii","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.prp.2024.155546_bib100","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5958429","article-title":"Proinflammatory Cytokines IL-6 and TNF-\u03b1 Increased Telomerase Activity through NF-\u03baB\/STAT1\/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells","volume":"2017","author":"Chung","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.prp.2024.155546_bib101","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/215158","article-title":"The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies","volume":"2010","author":"Sobolewski","year":"2010","journal-title":"Int J. Cell Biol."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib102","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2478\/jvetres-2019-0030","article-title":"Significance of Cyclooxygenase-2 in Oncogenesis","volume":"63","author":"Szweda","year":"2019","journal-title":"J. Vet. Res"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib103","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41392-022-00934-y","article-title":"Notch signaling pathway: architecture, disease, and therapeutics","volume":"7","author":"Zhou","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib104","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1152\/physrev.00005.2017","article-title":"Notch signaling in development, tissue homeostasis, and disease","volume":"97","author":"Siebel","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.prp.2024.155546_bib105","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2415489","article-title":"The notch pathway in breast cancer progression","volume":"2018","author":"Kontomanolis","year":"2018","journal-title":"Sci. World J."},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib106","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/S0002-9440(10)61116-9","article-title":"Altered Notch ligand expression in human liver disease: further evidence for a role of the notch signaling pathway in hepatic neovascularization and biliary ductular defects","volume":"160","author":"Nijjar","year":"2002","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib107","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13045-023-01439-z","article-title":"The Notch signaling pathway: a potential target for cancer immunotherapy","volume":"16","author":"Li","year":"2023","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib108","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41392-023-01559-5","article-title":"Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies","volume":"8","author":"Jing","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib109","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032962","article-title":"Understanding the roles of the hedgehog signaling pathway during T-cell lymphopoiesis and in T-cell acute lymphoblastic leukemia (T-ALL)","volume":"24","author":"Martelli","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib110","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13045-021-01111-4","article-title":"MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies","volume":"14","author":"Ahmadi","year":"2021","journal-title":"J. Hematol. Oncol."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib111","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008722","article-title":"Multiple functions of BCL-2 family proteins","volume":"5","author":"Hardwick","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib112","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41392-022-00934-y","article-title":"Notch signaling pathway: architecture, disease, and therapeutics","volume":"7","author":"Zhou","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"21","key":"10.1016\/j.prp.2024.155546_bib113","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232113431","article-title":"Role of non-coding RNAs in colorectal cancer: focus on long non-coding RNAs","volume":"23","author":"Lulli","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.prp.2024.155546_bib114","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2019.00556","article-title":"Non-canonical hedgehog signaling pathway in cancer: activation of GLI transcription factors beyond smoothened. [Review]","volume":"10","author":"Pietrobono","year":"2019","journal-title":"Front. Genet."},{"issue":"14","key":"10.1016\/j.prp.2024.155546_bib115","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.3390\/cancers13143410","article-title":"Hedgehog\/GLI signaling pathway: transduction, regulation, and implications for disease","volume":"13","author":"Sigafoos","year":"2021","journal-title":"Cancers"},{"issue":"19","key":"10.1016\/j.prp.2024.155546_bib116","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.3390\/ijms20194915","article-title":"Insulin-Like Growth Factor 2 (IGF2) Signaling in Colorectal Cancer\u2014From Basic Research to Potential Clinical Applications","volume":"20","author":"Kasprzak","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"19","key":"10.1016\/j.prp.2024.155546_bib117","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194915","article-title":"Insulin-Like Growth Factor 2 (IGF2) Signaling in Colorectal Cancer-From Basic Research to Potential Clinical Applications","volume":"20","author":"Kasprzak","year":"2019","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.prp.2024.155546_bib118","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.27155","article-title":"IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1","volume":"6","author":"Dai","year":"2017","journal-title":"Elife"},{"issue":"12","key":"10.1016\/j.prp.2024.155546_bib119","doi-asserted-by":"crossref","first-page":"6434","DOI":"10.3390\/ijms22126434","article-title":"Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer","volume":"22","author":"Kasprzak","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"13","key":"10.1016\/j.prp.2024.155546_bib120","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.3390\/ijms20133208","article-title":"Basic Concepts on the Role of Nuclear Factor Erythroid-Derived 2-Like 2 (Nrf2) in Age-Related Diseases","volume":"20","author":"Francisqueti-Ferron","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib121","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.bcp.2012.11.016","article-title":"The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation","volume":"85","author":"Bryan","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.prp.2024.155546_bib122","series-title":"Molecular Nutrition and Diabetes","first-page":"331","article-title":"Chapter 27 - NRF2-Mediated Gene Regulation and Glucose Homeostasis","author":"Yagishita","year":"2016"},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib123","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1667\/RR15101.1","article-title":"Defenses against pro-oxidant forces-Maintenance of cellular and genomic integrity and longevity","volume":"190","author":"Murray","year":"2018","journal-title":"Radiat. Res."},{"issue":"12","key":"10.1016\/j.prp.2024.155546_bib124","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.plaphy.2010.08.016","article-title":"Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants","volume":"48","author":"Gill","year":"2010","journal-title":"Plant Physiol. Biochem."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib125","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.imr.2016.07.004","article-title":"Reactive oxygen species and antioxidant defense in human gastrointestinal diseases","volume":"5","author":"Patlevi\u010d","year":"2016","journal-title":"Integr. Med. Res."},{"issue":"1-2","key":"10.1016\/j.prp.2024.155546_bib126","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.mrgentox.2008.09.015","article-title":"The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress","volume":"674","author":"Lim\u00f3n-Pacheco","year":"2009","journal-title":"Mutat. Res. \/Genet. Toxicol. Environ. Mutagen."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib127","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/metabo13040573","article-title":"Antioxidants as protection against reactive oxidative stress in inflammatory bowel disease","volume":"13","author":"Jarmakiewicz-Czaja","year":"2023","journal-title":"Metabolites"},{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib128","doi-asserted-by":"crossref","first-page":"620","DOI":"10.4254\/wjh.v13.i6.620","article-title":"Glutathione-S-transferases genes-promising predictors of hepatic dysfunction","volume":"13","author":"Prysyazhnyuk","year":"2021","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.prp.2024.155546_bib129","first-page":"1","article-title":"The importance of polymorphisms in the genes encoding glutathione S-transferase isoenzymes in development of selected cancers and cardiovascular diseases","author":"Grussy","year":"2023","journal-title":"Mol. Biol. Rep."},{"issue":"30","key":"10.1016\/j.prp.2024.155546_bib130","doi-asserted-by":"crossref","first-page":"21224","DOI":"10.18632\/oncotarget.25031","article-title":"GSTM1, GSTT1, and GSTP1 polymorphisms and colorectal cancer risk in Polish nonsmokers","volume":"9","author":"Klusek","year":"2018","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib131","first-page":"219","article-title":"GST gene polymorphisms and the risk of colorectal cancer development","volume":"18","author":"Klusek","year":"2014","journal-title":"Conte Oncol."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib132","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010013","article-title":"The multifaceted role of epoxide hydrolases in human health and disease","volume":"22","author":"Gautheron","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.prp.2024.155546_bib133","first-page":"59","article-title":"Chapter Two - Microtubule Plus-End Tracking Proteins and Their Roles in Cell Division","volume":"Vol. 309","author":"Ferreira","year":"2014"},{"key":"10.1016\/j.prp.2024.155546_bib134","series-title":"Investigating the mechanisms of pathogenesis underlying inherited colorectal adenomatous polyposis","author":"Azzopardi","year":"2009"},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib135","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1053\/j.gastro.2011.12.001","article-title":"Dysregulation of Wnt\/\u03b2-catenin signaling in gastrointestinal cancers","volume":"142","author":"White","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.prp.2024.155546_bib136","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fmolb.2020.00122","article-title":"Mismatch repair pathway, genome stability and cancer","volume":"7","author":"Pe\u0107ina-\u0160laus","year":"2020","journal-title":"Front Mol. Biosci."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib137","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/cr.2007.115","article-title":"Mechanisms and functions of DNA mismatch repair","volume":"18","author":"Li","year":"2008","journal-title":"Cell Res."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib138","doi-asserted-by":"crossref","first-page":"a012633","DOI":"10.1101\/cshperspect.a012633","article-title":"Postreplicative mismatch repair","volume":"5","author":"Jiricny","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib139","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/cr.2007.115","article-title":"Mechanisms and functions of DNA mismatch repair","volume":"18","author":"Li","year":"2008","journal-title":"Cell Res"},{"key":"10.1016\/j.prp.2024.155546_bib140","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2022.146791","article-title":"MALAT1 in colorectal cancer: Its implication as a diagnostic, prognostic, and predictive biomarker","author":"Cervena","year":"2022","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib141","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbadis.2014.11.013","article-title":"MALAT1 promotes colorectal cancer cell proliferation\/migration\/invasion via PRKA kinase anchor protein 9","volume":"1852","author":"Yang","year":"2015","journal-title":"Biochim. Et. Biophys. Acta (BBA)-Mol. Basis Dis."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib142","article-title":"SOX9: An emerging driving factor from cancer progression to drug resistance","volume":"1875","author":"Panda","year":"2021","journal-title":"Biochim. Et. Biophys. Acta (BBA)-Rev. Cancer"},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib143","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/cbdd.14006","article-title":"Multiple function of lncRNA MALAT1 in cancer occurrence and progression","volume":"101","author":"Malakoti","year":"2023","journal-title":"Chem. Biol. Drug Des."},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib144","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4291\/wjgp.v3.i3.71","article-title":"Molecular signaling mechanisms of apoptosis in hereditary non-polyposis colorectal cancer","volume":"3","author":"Hassen","year":"2012","journal-title":"World J. Gastrointest. Pathophysiol."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib145","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/CEJ.0000000000000019","article-title":"Mismatch repair pathway","volume":"23","author":"Sameer","year":"2014","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.prp.2024.155546_bib146","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1385\/1-59259-328-3:059","article-title":"Hereditary colon cancer genes","author":"Grady","year":"2003","journal-title":"Tumor Suppressor Genes.: Vol. 1: Pathw. Isol. Strateg."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib147","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1146\/annurev.genom.3.022502.103043","article-title":"Genetic and epigenetic alterations in colon cancer","volume":"3","author":"Grady","year":"2002","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib148","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/cr.2008.1","article-title":"Homologous recombination in DNA repair and DNA damage tolerance","volume":"18","author":"Li","year":"2008","journal-title":"Cell Res."},{"issue":"10","key":"10.1016\/j.prp.2024.155546_bib149","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1101\/gad.1415606","article-title":"Genetics and biology of pancreatic ductal adenocarcinoma","volume":"20","author":"Hezel","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.prp.2024.155546_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105135","article-title":"Targeting gut barrier dysfunction with phytotherapies: Effective strategy against chronic diseases","volume":"161","author":"Dey","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib151","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1158\/1055-9965.EPI-10-0843","article-title":"Genetic variation in the TGF-\u03b2 signaling pathway and colon and rectal cancer risk","volume":"20","author":"Slattery","year":"2011","journal-title":"Cancer Epidemiol., Biomark. Prev."},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib152","first-page":"1635","article-title":"Role of miR\u201134 in gastric cancer: From bench to bedside","volume":"42","author":"Xiong","year":"2019","journal-title":"Oncol. Rep."},{"issue":"11","key":"10.1016\/j.prp.2024.155546_bib153","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1002\/ibd.21281","article-title":"Role of transforming growth factor-\u03b2 in inflammatory bowel disease and colitis-associated colon cancer","volume":"16","author":"Feagins","year":"2010","journal-title":"Inflamm. bowel Dis."},{"issue":"11, Part B","key":"10.1016\/j.prp.2024.155546_bib154","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.bbamcr.2018.05.015","article-title":"Calcium signaling and the therapeutic targeting of cancer cells","volume":"1865","author":"Bong","year":"2018","journal-title":"Biochim. Et. Biophys. Acta (BBA) - Mol. Cell Res."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib155","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13020179","article-title":"Deciphering the Role of Ca(2+) Signalling in Cancer Metastasis: From the Bench to the Bedside.","volume":"13","author":"Alharbi","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.prp.2024.155546_bib156","series-title":"The Detection of Biomarkers","first-page":"1","article-title":"Introduction to biomarkers","author":"Mollarasouli","year":"2022"},{"key":"10.1016\/j.prp.2024.155546_bib157","unstructured":"Alfa-Wali, M. (2013). Metabolic biomarkers of colorectal cancer."},{"key":"10.1016\/j.prp.2024.155546_bib158","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2397863","article-title":"Noninvasive biomarkers of colorectal cancer: role in diagnosis and personalised treatment perspectives","volume":"2018","author":"Pellino","year":"2018","journal-title":"Gastroenterol. Res. Pract."},{"issue":"22","key":"10.1016\/j.prp.2024.155546_bib159","doi-asserted-by":"crossref","first-page":"11761","DOI":"10.1021\/acs.chemrev.9b00437","article-title":"Disease detection with molecular biomarkers: from chemistry of body fluids to nature-inspired chemical sensors","volume":"119","author":"Broza","year":"2019","journal-title":"Chem. Rev."},{"issue":"15","key":"10.1016\/j.prp.2024.155546_bib160","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.3390\/ijms21155311","article-title":"Biomarkers in colorectal cancer: current research and future prospects","volume":"21","author":"Ogunwobi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib161","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3390\/ijms23020852","article-title":"Novel diagnostic biomarkers in colorectal cancer","volume":"23","author":"Zygulska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib162","doi-asserted-by":"crossref","first-page":"812","DOI":"10.3390\/cancers12040812","article-title":"Personalized medicine\u2014current and emerging predictive and prognostic biomarkers in colorectal cancer","volume":"12","author":"Koulis","year":"2020","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib163","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/jpm9010012","article-title":"The developing story of predictive biomarkers in colorectal cancer","volume":"9","author":"Boussios","year":"2019","journal-title":"J. Pers. Med."},{"issue":"10","key":"10.1016\/j.prp.2024.155546_bib164","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1158\/1078-0432.CCR-18-2523","article-title":"Evaluation of pharmacodynamic responses to cancer therapeutic agents using DNA damage markers","volume":"25","author":"Wilsker","year":"2019","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib165","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/23808993.2021.1876518","article-title":"GUCY2C as a biomarker to target precision therapies for patients with colorectal cancer","volume":"6","author":"Lisby","year":"2021","journal-title":"Expert Rev. Precis. Med. Drug Dev."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib166","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3233\/TUB-200069","article-title":"CA125: A superior prognostic biomarker for colorectal cancer compared to CEA, CA19-9 or CA242","volume":"43","author":"Bj\u00f6rkman","year":"2021","journal-title":"Tumor Biol."},{"key":"10.1016\/j.prp.2024.155546_bib167","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6567998","article-title":"Identification of APC mutation as a potential predictor for immunotherapy in colorectal cancer","volume":"2022","author":"Feng","year":"2022","journal-title":"J. Oncol."},{"key":"10.1016\/j.prp.2024.155546_bib168","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ejca.2021.01.015","article-title":"RAS as a positive predictive biomarker: focus on lung and colorectal cancer patients","volume":"146","author":"Malapelle","year":"2021","journal-title":"Eur. J. Cancer"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib169","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3390\/cells9010219","article-title":"KRAS and BRAF mutations as prognostic and predictive biomarkers for standard chemotherapy response in metastatic colorectal cancer: a single institutional study","volume":"9","author":"Garcia-Carbonero","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib170","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.1038\/s41598-019-43231-5","article-title":"miR-150-5p represses TP53 tumor suppressor gene to promote proliferation of colon adenocarcinoma","volume":"9","author":"Liu","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib171","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1080\/21655979.2021.1921551","article-title":"Identification of biomarkers related to Tumor-Infiltrating Lymphocytes (TILs) infiltration with gene co-expression network in colorectal cancer","volume":"12","author":"Liao","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.prp.2024.155546_bib172","article-title":"Optimizing fecal occult blood test (FOBT) colorectal cancer screening using gut bacteriome as a biomarker","author":"Chowdhury","year":"2023","journal-title":"Clin. Colorectal Cancer"},{"issue":"21","key":"10.1016\/j.prp.2024.155546_bib173","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.3390\/cancers13215568","article-title":"Faecal diagnostic biomarkers for colorectal Cancer","volume":"13","author":"Cruz","year":"2021","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib174","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-022-09473-9","article-title":"KCNQ1 and lymphovascular invasion are key features in a prognostic classifier for stage II and III colon cancer","volume":"22","author":"Uil","year":"2022","journal-title":"BMC Cancer"},{"issue":"8","key":"10.1016\/j.prp.2024.155546_bib175","doi-asserted-by":"crossref","first-page":"13128","DOI":"10.1002\/jcp.27983","article-title":"MSI-L\/EMAST is a predictive biomarker for metastasis in colorectal cancer patients","volume":"234","author":"Torshizi Esfahani","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"8","key":"10.1016\/j.prp.2024.155546_bib176","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/s41379-019-0265-1","article-title":"SATB2 and CDX2 are prognostic biomarkers in DNA mismatch repair protein deficient colon cancer","volume":"32","author":"Ma","year":"2019","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.prp.2024.155546_bib177","doi-asserted-by":"crossref","DOI":"10.1016\/j.gie.2024.06.015","article-title":"Development of an algorithm combining blood-based biomarkers, fecal immunochemical test, and age for population-based colorectal cancer screening","author":"Petersen","year":"2024","journal-title":"Gastrointest. Endosc."},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib178","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2023.100532","article-title":"Phenotypic heterogeneity analysis of APC-mutant colon cancer by proteomics and phosphoproteomics identifies RAI14 as a key prognostic determinant in East Asians and Westerners","volume":"22","author":"Zhang","year":"2023","journal-title":"Mol. Cell. Proteom."},{"issue":"7","key":"10.1016\/j.prp.2024.155546_bib179","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.3390\/cancers14071732","article-title":"Colorectal cancer: a review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies","volume":"14","author":"Hossain","year":"2022","journal-title":"Cancers"},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib180","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.soc.2017.11.010","article-title":"Surgical treatment of metastatic colorectal cancer","volume":"27","author":"Chakedis","year":"2018","journal-title":"Surg. Oncol. Clin."},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib181","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000446486","article-title":"Radiotherapy for colorectal cancer: current standards and future perspectives","volume":"32","author":"H\u00e4fner","year":"2016","journal-title":"Visc. Med."},{"issue":"15","key":"10.1016\/j.prp.2024.155546_bib182","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.2174\/0929867324666170111152436","article-title":"Colorectal cancer chemotherapy: the evolution of treatment and new approaches","volume":"24","author":"M McQuade","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.prp.2024.155546_bib183","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ejmech.2017.12.039","article-title":"Natural compounds and combination therapy in colorectal cancer treatment","volume":"144","author":"Rejhov\u00e1","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.prp.2024.155546_bib184","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jconrel.2021.06.008","article-title":"Treating colon cancers with a non-conventional yet strategic approach: an overview of various nanoparticulate systems","volume":"336","author":"Bhaskaran","year":"2021","journal-title":"J. Control. Release"},{"issue":"21","key":"10.1016\/j.prp.2024.155546_bib185","doi-asserted-by":"crossref","first-page":"11941","DOI":"10.3390\/ijms222111941","article-title":"Gene therapy targeting p53 and KRAS for colorectal cancer treatment: a myth or the way forward","volume":"22","author":"Hasbullah","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib186","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/1758834016646734","article-title":"Current targeted therapies in the treatment of advanced colorectal cancer: a review","volume":"8","author":"Moriarity","year":"2016","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.prp.2024.155546_bib187","series-title":"Abeloff's Clinical Oncology","first-page":"431","article-title":"Basics of radiation therapy","author":"Zeman","year":"2020"},{"key":"10.1016\/j.prp.2024.155546_bib188","doi-asserted-by":"crossref","first-page":"108","DOI":"10.53840\/ejpi.v10i1.91","article-title":"A short review on the imaging technology in radiation therapy","author":"Raja","year":"2023","journal-title":"e-J. Penyelid. Dan. Inov."},{"key":"10.1016\/j.prp.2024.155546_bib189","first-page":"151","article-title":"The evolution of radiation therapy in treating cancer","volume":"Vol. 34","author":"Abshire","year":"2018"},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib190","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/01466453211013514","article-title":"Occupational Radiological Protection in Brachytherapy","volume":"50","author":"Mourtada","year":"2021","journal-title":"Ann. ICRP"},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib191","first-page":"386","article-title":"Brachytherapy: an overview for clinicians","volume":"69","author":"Chargari","year":"2019","journal-title":"CA: A Cancer J. Clin."},{"key":"10.1016\/j.prp.2024.155546_bib192","first-page":"73","article-title":"Recent Therapeutic Strategies for the Treatment of Colon Cancer","volume":"Volume 2","author":"Sharma","year":"2021"},{"key":"10.1016\/j.prp.2024.155546_bib193","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-3-030-01443-8_9","article-title":"Interstitial brachytherapy-definitive and adjuvant","author":"Dyer","year":"2019","journal-title":"Radiat. Ther. Tech. Gynecol. Cancer.: A Compr. Pract. Guide"},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib194","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.suronc.2017.10.004","article-title":"Surgery-induced tumor growth in (metastatic) colorectal cancer","volume":"26","author":"Govaert","year":"2017","journal-title":"Surg. Oncol."},{"issue":"11","key":"10.1016\/j.prp.2024.155546_bib195","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.ejso.2018.08.003","volume":"44","author":"Montroni","year":"2018","journal-title":"Eur. J. Surg. Oncol."},{"issue":"12","key":"10.1016\/j.prp.2024.155546_bib196","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/codi.14342","article-title":"Variations in the management of significant polyps and early colorectal cancer: results from a multicentre observational study of 383 patients","volume":"20","author":"Dattani","year":"2018","journal-title":"Colorectal Dis."},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib197","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.surg.2017.10.057","article-title":"Management of the colorectal polyp referred for resection: a case-matched comparison of advanced endoscopic surgery and laparoscopic colectomy","volume":"163","author":"Gamaleldin","year":"2018","journal-title":"Surgery"},{"issue":"8","key":"10.1016\/j.prp.2024.155546_bib198","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1089\/lap.2015.0290","article-title":"Hybrid laparoendoscopic approaches to endoscopically unresectable colon polyps","volume":"26","author":"Aslani","year":"2016","journal-title":"J. Laparoendosc. Adv. Surg. Tech."},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib199","doi-asserted-by":"crossref","first-page":"513","DOI":"10.21037\/jgo-2019-ccm-09","article-title":"Surgical management of recurrent colon cancer","volume":"11","author":"Brown","year":"2020","journal-title":"J. Gastrointest. Oncol."},{"issue":"13","key":"10.1016\/j.prp.2024.155546_bib200","doi-asserted-by":"crossref","first-page":"6923","DOI":"10.3390\/ijms22136923","article-title":"The influence of cell cycle regulation on chemotherapy","volume":"22","author":"Sun","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib201","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/cas.13455","article-title":"DNA replication stress and cancer chemotherapy","volume":"109","author":"Kitao","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.prp.2024.155546_bib202","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107447","article-title":"5-fluorouracil and other fluoropyrimidines in colorectal cancer: past, present and future","volume":"206","author":"Vodenkova","year":"2020","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib203","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jcrpr.2017.02.002","article-title":"Nano drug delivery strategy of 5-fluorouracil for the treatment of colorectal cancer","volume":"4","author":"Chandran","year":"2017","journal-title":"J. Cancer Res. Pract."},{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib204","first-page":"10084","article-title":"Acriflavine enhances the antitumor activity of the chemotherapeutic drug 5\u2011fluorouracil in colorectal cancer cells","volume":"15","author":"Zargar","year":"2018","journal-title":"Oncol. Lett."},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib205","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3390\/nu10050560","article-title":"Frondoside a enhances the anti-cancer effects of oxaliplatin and 5-fluorouracil on colon cancer cells","volume":"10","author":"Attoub","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.prp.2024.155546_bib206","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00280-016-3139-y","article-title":"Irinotecan-and 5-fluorouracil-induced intestinal mucositis: insights into pathogenesis and therapeutic perspectives","volume":"78","author":"Ribeiro","year":"2016","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.prp.2024.155546_bib207","first-page":"383","article-title":"Traditional medicinal plants and their therapeutic potential against major cancer types","volume":"Volume 2","author":"Lee","year":"2018","journal-title":"Anticancer Plant.: Nat. Prod. Biotechnol. Implements"},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib208","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jtcme.2016.05.006","article-title":"Revival, modernization and integration of Indian traditional herbal medicine in clinical practice: importance, challenges and future","volume":"7","author":"Sen","year":"2017","journal-title":"J. Tradit. Complement. Med."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib209","doi-asserted-by":"crossref","DOI":"10.5530\/pres.14.2.15","article-title":"Traditional and herbal medicines: opportunities and challenges","volume":"14","author":"Saggar","year":"2022","journal-title":"Pharmacogn. Res."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2023.102627","article-title":"Comparative efficacy of epigallocatechin gallate and its nano-formulation in prostate cancer 3D spheroids model","volume":"35","author":"Alserihi","year":"2023","journal-title":"J. King Saud. Univ. - Sci."},{"key":"10.1016\/j.prp.2024.155546_bib211","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s12029-020-00385-0","article-title":"Anticancer effects of herbal medicine compounds and novel formulations: a literature review","volume":"51","author":"Abdulridha","year":"2020","journal-title":"J. Gastrointest. Cancer"},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib212","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s12029-020-00385-0","article-title":"Anticancer effects of herbal medicine compounds and novel formulations: a literature review","volume":"51","author":"Abdulridha","year":"2020","journal-title":"J. Gastrointest. Cancer"},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib213","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s12029-019-00299-6","article-title":"The anticancer efficiency of citrullus colocynthis toward the colorectal cancer therapy","volume":"51","author":"Abdulridha","year":"2020","journal-title":"J. Gastrointest. Cancer"},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib214","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.3748\/wjg.v22.i5.1745","article-title":"Colorectal cancer tumour markers and biomarkers: Recent therapeutic advances","volume":"22","author":"Lech","year":"2016","journal-title":"World J. Gastroenterol."},{"issue":"18","key":"10.1016\/j.prp.2024.155546_bib215","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.3390\/cancers15184570","article-title":"Prognostic biomarkers of cell proliferation in colorectal cancer (CRC): from immunohistochemistry to molecular biology techniques","volume":"15","author":"Kasprzak","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.prp.2024.155546_bib216","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.690499","article-title":"Cell therapy with TILs: training and taming T cells to fight cancer","volume":"12","author":"Kumar","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prp.2024.155546_bib217","series-title":"Immunotherapeutic approaches to treat cancer: Prospects and challenges","author":"Fred","year":"2021"},{"key":"10.1016\/j.prp.2024.155546_bib218","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.114003","article-title":"Understanding and improving cellular immunotherapies against cancer: from cell-manufacturing to tumor-immune models","volume":"179","author":"Ringquist","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib219","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.ymthe.2019.03.011","article-title":"Adoptive transfer of NKG2D CAR mRNA-engineered natural killer cells in colorectal cancer patients","volume":"27","author":"Xiao","year":"2019","journal-title":"Mol. Ther."},{"issue":"10","key":"10.1016\/j.prp.2024.155546_bib220","doi-asserted-by":"crossref","DOI":"10.3390\/bios13100926","article-title":"Current status and emerging trends in colorectal cancer screening and diagnostics","volume":"13","author":"Beniwal","year":"2023","journal-title":"Biosensors"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib221","first-page":"18","article-title":"Anticancer Chemotherapy and it's Anaesthetic Implications (Current Concepts)","volume":"53","author":"Gehdoo","year":"2009","journal-title":"Indian J. Anaesth."},{"key":"10.1016\/j.prp.2024.155546_bib222","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cobme.2018.09.003","article-title":"Oral non-viral gene delivery for applications in DNA vaccination and gene therapy","volume":"7","author":"Farris","year":"2018","journal-title":"Curr. Opin. Biomed. Eng."},{"issue":"18","key":"10.1016\/j.prp.2024.155546_bib223","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.2174\/1389557520666200730160911","article-title":"The potential application of novel drug delivery systems for phytopharmaceuticals and natural extracts\u2013current status and future perspectives","volume":"21","author":"Mahomoodally","year":"2021","journal-title":"Mini Rev. Med. Chem."},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib224","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1021\/acsabm.2c00002","article-title":"Recent progress in nanostructured smart drug delivery systems for cancer therapy: a review","volume":"5","author":"Khan","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.prp.2024.155546_bib225","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jconrel.2015.09.067","article-title":"Novel delivery approaches for cancer therapeutics","volume":"219","author":"Mitra","year":"2015","journal-title":"J. Control Release"},{"issue":"21","key":"10.1016\/j.prp.2024.155546_bib226","doi-asserted-by":"crossref","first-page":"8019","DOI":"10.3390\/ijms21218019","article-title":"Effect of physico-chemical properties of nanoparticles on their intracellular uptake","volume":"21","author":"Sabourian","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.prp.2024.155546_bib227","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.2741\/4552","article-title":"Endocytosis and membrane receptor internalization: implication of F-BAR protein Carom","volume":"22","author":"Xu","year":"2017","journal-title":"Front Biosci. (Landmark Ed. )"},{"issue":"7","key":"10.1016\/j.prp.2024.155546_bib228","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3109\/09687688.2010.521200","article-title":"Receptor-targeted nanocarriers for therapeutic delivery to cancer","volume":"27","author":"Yu","year":"2010","journal-title":"Mol. Membr. Biol."},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib229","article-title":"pH-Responsive Nanocarriers in Cancer Therapy","volume":"14","author":"AlSawaftah","year":"2022","journal-title":"Polym. (Basel)"},{"issue":"12","key":"10.1016\/j.prp.2024.155546_bib230","doi-asserted-by":"crossref","DOI":"10.3390\/jpm12121964","article-title":"Enhanced permeability and retention effect as a ubiquitous and epoch-making phenomenon for the selective drug targeting of solid tumors","volume":"12","author":"Islam","year":"2022","journal-title":"J. Pers. Med"},{"key":"10.1016\/j.prp.2024.155546_bib231","doi-asserted-by":"crossref","DOI":"10.1016\/j.amsu.2022.104493","article-title":"Dostarlimab: the miracle drug for the treatment of colorectal cancer","volume":"81","author":"Shuvo","year":"2022","journal-title":"Ann. Med. Surg."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib232","doi-asserted-by":"crossref","first-page":"9281","DOI":"10.1038\/s41598-020-66137-z","article-title":"Catalyst-free one-pot synthesis of densely substituted pyrazole-pyrazines as anti-colorectal cancer agents","volume":"10","author":"Xu","year":"2020","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib233","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.bbagen.2016.10.009","article-title":"Resveratrol induces mitochondrial respiration and apoptosis in SW620 colon cancer cells","volume":"1861","author":"Blanquer-Rossell\u00f3","year":"2017","journal-title":"Biochim. Et. Biophys. Acta (BBA) - Gen. Subj."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib234","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0304-3835(01)00655-3","article-title":"Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells","volume":"172","author":"Goel","year":"2001","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib235","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.phymed.2013.11.006","article-title":"Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol","volume":"21","author":"Romano","year":"2014","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib236","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1349-7006.2004.tb03230.x","article-title":"Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development","volume":"95","author":"Takahashi","year":"2004","journal-title":"Cancer Sci."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib237","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bbrc.2008.07.131","article-title":"Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis","volume":"375","author":"Yoshida","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib238","doi-asserted-by":"crossref","first-page":"257","DOI":"10.15430\/JCP.2013.18.3.257","article-title":"Kaempferol induces cell cycle arrest in HT-29 human colon cancer cells","volume":"18","author":"Cho","year":"2013","journal-title":"J. Cancer Prev."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib239","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.bbrc.2004.12.151","article-title":"Quercetin, a potent inhibitor against \u03b2-catenin\/Tcf signaling in SW480 colon cancer cells","volume":"328","author":"Park","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib240","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/(SICI)1097-0215(20000201)85:3<438::AID-IJC22>3.0.CO;2-F","article-title":"Quercetin inhibits p21-RAS expression in human colon cancer cell lines and in primary colorectal tumors","volume":"85","author":"Ranelletti","year":"2000","journal-title":"Int. J. Cancer"},{"issue":"8","key":"10.1016\/j.prp.2024.155546_bib241","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1002\/ddr.21590","article-title":"Artesunate suppresses inflammation and oxidative stress in a rat model of colorectal cancer","volume":"80","author":"Kumar","year":"2019","journal-title":"Drug Dev. Res."},{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib242","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/j.1349-7006.2012.02262.x","article-title":"Regulation of the metabolite profile by an APC gene mutation in colorectal cancer","volume":"103","author":"Yoshie","year":"2012","journal-title":"Cancer Sci."},{"issue":"7","key":"10.1016\/j.prp.2024.155546_bib243","doi-asserted-by":"crossref","first-page":"472","DOI":"10.4321\/S1130-01082005000700002","article-title":"Antisense gene therapy using anti-k-ras and antitelomerase oligonucleotides in colorectal cancer","volume":"97","author":"Lledo","year":"2005","journal-title":"Rev. Esp. De. Enferm. Dig."},{"issue":"29","key":"10.1016\/j.prp.2024.155546_bib244","doi-asserted-by":"crossref","first-page":"45199","DOI":"10.18632\/oncotarget.9900","article-title":"MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4","volume":"7","author":"Cheng","year":"2016","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib245","first-page":"33","article-title":"Chimeric antigen receptor\u2013modified T cells repressed solid tumors and their relapse in an established patient-derived colon carcinoma xenograft model","volume":"42","author":"Teng","year":"2019","journal-title":"J. Immunother. (Hagerstown, Md.: 1997)"},{"key":"10.1016\/j.prp.2024.155546_bib246","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.semcancer.2022.03.026","article-title":"Advancement of cancer immunotherapy using nanoparticles-based nanomedicine","volume":"86","author":"Gowd","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.prp.2024.155546_bib247","first-page":"1650","article-title":"Novel vesicular drug delivery systems: a review","volume":"11","author":"Myneni","year":"2021","journal-title":"J. Pharm. Res"},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib248","first-page":"1","article-title":"Vesicular drug delivery system: a novel approach","volume":"3","author":"Ashara","year":"2014","journal-title":"Mintage J. Pharm. Med Sci."},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib249","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e09394","article-title":"Liposomes: structure, composition, types, and clinical applications","volume":"8","author":"Nsairat","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.prp.2024.155546_bib250","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.biopha.2018.09.128","article-title":"A novel 5-Fluorouracil targeted delivery to colon cancer using folic acid conjugated liposomes","volume":"108","author":"Handali","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.prp.2024.155546_bib251","article-title":"Macrophage membrane-coated SN-38-encapsulated liposomes for efficient treatment of colorectal cancer","author":"Qi","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib252","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.jsps.2019.02.008","article-title":"The use of chitosan-coated flexible liposomes as a remarkable carrier to enhance the antitumor efficacy of 5-fluorouracil against colorectal cancer","volume":"27","author":"Alomrani","year":"2019","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.prp.2024.155546_bib253","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112317","article-title":"pH-responsive and folate-coated liposomes encapsulating irinotecan as an alternative to improve efficacy of colorectal cancer treatment","volume":"144","author":"Nunes","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.prp.2024.155546_bib254","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ejmech.2012.08.040","article-title":"Intravenous injection of hybrid liposomes suppresses the liver metastases in xenograft mouse models of colorectal cancer in vivo","volume":"57","author":"Ichihara","year":"2012","journal-title":"Eur. J. Med. Chem."},{"issue":"9","key":"10.1016\/j.prp.2024.155546_bib255","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12090855","article-title":"Transfersomes: a promising nanoencapsulation technique for transdermal drug delivery","volume":"12","author":"Opatha","year":"2020","journal-title":"Pharmaceutics"},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib256","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14040703","article-title":"Development of stable nano-sized transfersomes as a rectal colloid for enhanced delivery of cannabidiol","volume":"14","author":"Moqejwa","year":"2022","journal-title":"Pharmaceutics"},{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib257","doi-asserted-by":"crossref","first-page":"335","DOI":"10.22270\/jddt.v8i6.2029","article-title":"Noisomes: as novel vesicular drug delivery system","volume":"8","author":"Ray","year":"2018","journal-title":"J. Drug Deliv. Ther."},{"issue":"7","key":"10.1016\/j.prp.2024.155546_bib258","doi-asserted-by":"crossref","DOI":"10.3390\/ph15070816","article-title":"Targeting colorectal cancer cells with niosomes systems loaded with two anticancer drugs models; comparative in vitro and anticancer studies","volume":"15","author":"El-Far","year":"2022","journal-title":"Pharmaceuticals"},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib259","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1111\/jcmm.14943","article-title":"Pentamidine niosomes thwart S100B effects in human colon carcinoma biopsies favouring wtp53 rescue","volume":"24","author":"Seguella","year":"2020","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib260","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.xphs.2016.07.007","article-title":"Maximizing the therapeutic efficacy of imatinib mesylate\u2013loaded niosomes on human colon adenocarcinoma using Box-Behnken design","volume":"106","author":"Kassem","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.prp.2024.155546_bib261","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.heliyon.2023.e21400","article-title":"Targeted delivery of oxaliplatin via folate-decorated niosomal nanoparticles potentiates resistance reversion of colon cancer cells","volume":"9","author":"Abdulzehra","year":"2023","journal-title":"Heliyon"},{"issue":"6478","key":"10.1016\/j.prp.2024.155546_bib262","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.prp.2024.155546_bib263","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119035","article-title":"Exosome-mediated delivery of functionally active miRNA-375-3p mimic regulate epithelial mesenchymal transition (EMT) of colon cancer cells","volume":"269","author":"Rezaei","year":"2021","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib264","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1158\/0008-5472.CAN-18-0014","article-title":"M2 macrophage-derived exosomes promote cell migration and invasion in colon cancer","volume":"79","author":"Lan","year":"2019","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib265","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygeno.2023.110636","article-title":"SCARA5 in bone marrow stromal cell-derived exosomes inhibits colorectal cancer progression by inactivating the PI3K\/Akt pathway","volume":"115","author":"Fang","year":"2023","journal-title":"Genomics"},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib266","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygeno.2023.110646","article-title":"Exosomes-delivered PD-L1 siRNA and CTLA-4 siRNA protect against growth and tumor immune escape in colorectal cancer","volume":"115","author":"Li","year":"2023","journal-title":"Genomics"},{"key":"10.1016\/j.prp.2024.155546_bib267","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113690","article-title":"AS1411 aptamer-functionalized exosomes in the targeted delivery of doxorubicin in fighting colorectal cancer","volume":"155","author":"Hosseini","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib268","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11041114","article-title":"Cubosomes in drug delivery-a comprehensive review on its structural components, preparation techniques and therapeutic applications","volume":"11","author":"Sivadasan","year":"2023","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib269","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15020680","article-title":"Anti-tumor activity of orally administered gefitinib-loaded nanosized cubosomes against colon cancer","volume":"15","author":"El-Shenawy","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.prp.2024.155546_bib270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-018-4727-5","article-title":"Targeting colorectal cancer cell metabolism through development of cisplatin and metformin nano-cubosomes","volume":"18","author":"Saber","year":"2018","journal-title":"BMC Cancer"},{"issue":"8","key":"10.1016\/j.prp.2024.155546_bib271","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinthera.2017.05.082","article-title":"Pluronic based cubosomes enhance metformin cytotoxicity in colon cancer cell lines","volume":"39","author":"Magdy","year":"2017","journal-title":"Clin. Ther."},{"key":"10.1016\/j.prp.2024.155546_bib272","doi-asserted-by":"crossref","first-page":"723","DOI":"10.5530\/ijper.56.3.121","article-title":"Formulation, characterization, and evaluation of doxorubicin-loaded cubosome as a cytotoxic potentiator against HCT-116 colorectal cancer cells","volume":"56","author":"Almoshari","year":"2022","journal-title":"Indian J. Pharm. Educ. Res"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib273","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1080\/10717544.2022.2108938","article-title":"Development of nanocubosomes co-loaded with dual anticancer agents curcumin and temozolomide for effective colon cancer therapy","volume":"29","author":"Almoshari","year":"2022","journal-title":"Drug Deliv."},{"key":"10.1016\/j.prp.2024.155546_bib274","article-title":"Box Behnken optimization of cubosomes for enhancing the anticancer activity of metformin: design, characterization, and in-vitro cell proliferation assay on MDA-MB-231 breast and LOVO colon cancer cell lines","volume":"6","author":"Zaki","year":"2023","journal-title":"Int. J. Pharm.: X"},{"key":"10.1016\/j.prp.2024.155546_bib275","first-page":"113","article-title":"EMULSOMES: a lipid bases drug delivery system","volume":"10","author":"Gill","year":"2021","journal-title":"World J. Pharm. Res"},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib276","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9050419","article-title":"Piceatannol-loaded emulsomes exhibit enhanced cytostatic and apoptotic activities in colon cancer cells","volume":"9","author":"Alhakamy","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.prp.2024.155546_bib277","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fbioe.2020.00050","article-title":"Curcumin-and piperine-loaded emulsomes as combinational treatment approach enhance the anticancer activity of curcumin on HCT116 colorectal cancer model","volume":"8","author":"Bolat","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.prp.2024.155546_bib278","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e16561","article-title":"Overview of phytosomes in treating cancer: advancement, challenges, and future outlook","author":"Gaikwad","year":"2023","journal-title":"Heliyon"},{"issue":"9","key":"10.1016\/j.prp.2024.155546_bib279","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13091475","article-title":"Phytosomes as an Emerging Nanotechnology Platform for the Topical Delivery of Bioactive Phytochemicals","volume":"13","author":"Alharbi","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.prp.2024.155546_bib280","first-page":"148","article-title":"Formulation and characterization of chrysin loaded phytosomes and its cytotoxic effect against colorectal cancer cells","author":"Kudatarkar","year":"2022","journal-title":"Indian J. Pharm. Educ. Res."},{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib281","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1158\/0008-5472.CAN-07-6247","article-title":"Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis","volume":"68","author":"Singh","year":"2008","journal-title":"Cancer Res."},{"issue":"10","key":"10.1016\/j.prp.2024.155546_bib282","doi-asserted-by":"crossref","first-page":"6785","DOI":"10.1002\/jcp.26538","article-title":"Phytosomal curcumin inhibits tumor growth in colitis-associated colorectal cancer","volume":"233","author":"Marjaneh","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib283","doi-asserted-by":"crossref","DOI":"10.1016\/j.sjbs.2023.103874","article-title":"Evaluation of biogenically synthesized MgO NPs anticancer activity against breast cancer cells","volume":"31","author":"Rashid Khan","year":"2024","journal-title":"Saudi J. Biol. Sci."},{"issue":"7","key":"10.1016\/j.prp.2024.155546_bib284","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fmolb.2020.00193","article-title":"Nanoparticle-based drug delivery in cancer therapy and its role in overcoming drug resistance","volume":"2020","author":"Yao","year":"2020","journal-title":"Front Mol. Biosci."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib285","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s11671-021-03628-6","article-title":"Nanoparticles for cancer therapy: current progress and challenges","volume":"16","author":"Gavas","year":"2021","journal-title":"Nanoscale Res Lett."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib286","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s11671-021-03632-w","article-title":"Multifunctional gold nanoparticles for improved diagnostic and therapeutic applications: a review","volume":"16","author":"Sibuyi","year":"2021","journal-title":"Nanoscale Res. Lett."},{"issue":"8","key":"10.1016\/j.prp.2024.155546_bib287","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2022.102304","article-title":"Gold nanoparticles (AuNPs) and Rosmarinus officinalis extract and their potentials to prompt apoptosis and arrest cell cycle in HT-29 colon cancer cells","volume":"34","author":"Alshahrani","year":"2022","journal-title":"J. King Saud. Univ. - Sci."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib288","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2021.103039","article-title":"Anti-human colon cancer properties of a novel chemotherapeutic supplement formulated by gold nanoparticles containing Allium sativum L. leaf aqueous extract and investigation of its cytotoxicity and antioxidant activities","volume":"14","author":"Liu","year":"2021","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.prp.2024.155546_bib289","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110492","article-title":"Laser-triggered collaborative chemophotothermal effect of gold nanoparticles for targeted colon cancer therapy","volume":"130","author":"Zhang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.prp.2024.155546_bib290","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.sajb.2021.02.009","article-title":"Comparative therapeutic effects of Pituranthos tortuosus aqueous extract and phyto-synthesized gold nanoparticles on Helicobacter pylori, diabetic and cancer proliferation","volume":"139","author":"Abd El-Moaty","year":"2021","journal-title":"South Afr. J. Bot."},{"issue":"9","key":"10.1016\/j.prp.2024.155546_bib291","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17091534","article-title":"Silver nanoparticles: synthesis, characterization, properties, applications, and therapeutic approaches","volume":"17","author":"Zhang","year":"2016","journal-title":"Int J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.prp.2024.155546_bib292","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1016\/j.jksus.2020.09.024","article-title":"Green biosynthesis of silver nanoparticle using Commiphora myrrh extract and evaluation of their antimicrobial activity and colon cancer cells viability","volume":"32","author":"Alwhibi","year":"2020","journal-title":"J. King Saud. Univ. - Sci."},{"issue":"11","key":"10.1016\/j.prp.2024.155546_bib293","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1016\/j.sjbs.2020.09.021","article-title":"Green synthesis of silver nanoparticles using aqueous rhizome extract of Zingiber officinale and Curcuma longa: in-vitro anti-cancer potential on human colon carcinoma HT-29 cells","volume":"27","author":"Venkatadri","year":"2020","journal-title":"Saudi J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib294","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2022.101846","article-title":"Biological synthesis and characterization of Passiflora subpeltata Ortega aqueous leaf extract in silver nanoparticles and their evaluation of antibacterial, antioxidant, anti-cancer and larvicidal activities","volume":"34","author":"Loganathan","year":"2022","journal-title":"J. King Saud. Univ. - Sci."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib295","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2021.103500","article-title":"Ultrasonic green synthesis of silver nanoparticles mediated by Pectin: characterization and evaluation of the cytotoxicity, antioxidant, and colorectal carcinoma properties","volume":"15","author":"Wang","year":"2022","journal-title":"Arab. J. Chem."},{"issue":"7","key":"10.1016\/j.prp.2024.155546_bib296","doi-asserted-by":"crossref","DOI":"10.3390\/nano13071201","article-title":"Biogenic synthesis of Cu-Mn bimetallic nanoparticles using pumpkin seeds extract and their characterization and anticancer efficacy","volume":"13","author":"Alafaleq","year":"2023","journal-title":"Nanomaterials"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib297","doi-asserted-by":"crossref","DOI":"10.3390\/app12010141","article-title":"Copper nanoparticles: synthesis and characterization, physiology, toxicity and antimicrobial applications","volume":"12","author":"Crisan","year":"2022","journal-title":"Appl. Sci."},{"issue":"8","key":"10.1016\/j.prp.2024.155546_bib298","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1002\/cbf.3850","article-title":"Screening of Cu4O3 NPs efficacy and its anticancer potential against cervical cancer","volume":"41","author":"Zughaibi","year":"2023","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.prp.2024.155546_bib299","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.bbrc.2022.10.027","article-title":"Disulfiram-loaded hollow copper sulfide nanoparticles show anti-tumor effects in preclinical models of colorectal cancer","volume":"635","author":"Jiapaer","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.prp.2024.155546_bib300","doi-asserted-by":"crossref","unstructured":"Tabrez, S., Khan, A.U., Mirza, A.A., Suhail, M., Jabir, N.R., Zughaibi, T.A., et al. (2022). Biosynthesis of copper oxide nanoparticles and its therapeutic efficacy against colon cancer. 11(1), 1322-1331, doi:doi:\u300810.1515\/ntrev-2022-0081\u3009.","DOI":"10.1515\/ntrev-2022-0081"},{"key":"10.1016\/j.prp.2024.155546_bib301","first-page":"322","article-title":"Copper-cysteamine nanoparticle-mediated microwave dynamic therapy improves cancer treatment with induction of ferroptosis","volume":"24","author":"Zhou","year":"2023","journal-title":"Bioact. Mater."},{"issue":"12","key":"10.1016\/j.prp.2024.155546_bib302","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2018.e01077","article-title":"Biosynthesis of copper nanoparticles using aqueous Tilia extract: antimicrobial and anticancer activities","volume":"4","author":"Hassanien","year":"2018","journal-title":"Heliyon"},{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib303","doi-asserted-by":"crossref","first-page":"766","DOI":"10.2174\/1389201023666220821161737","article-title":"Biosynthesized cerium oxide nanoparticles CeO(2)NPs: recent progress and medical applications","volume":"24","author":"Humaira","year":"2023","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.prp.2024.155546_bib304","doi-asserted-by":"crossref","DOI":"10.1016\/j.inoche.2021.108800","article-title":"Biosynthesis of lead oxide and cerium oxide nanoparticles and their cytotoxic activities against colon cancer cell line","volume":"131","author":"Nazaripour","year":"2021","journal-title":"Inorg. Chem. Commun."},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib305","first-page":"194","article-title":"Anticancer effect of fluorouracil and gum-based cerium oxide nanoparticles on human malignant colon carcinoma cell line (Caco2)","volume":"25","author":"Keramati","year":"2023","journal-title":"Cell J."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib306","doi-asserted-by":"crossref","DOI":"10.1002\/aoc.5308","article-title":"Biosynthesis of cerium oxide nanoparticles and its cytotoxicity survey against colon cancer cell line","volume":"34","author":"Miri","year":"2020","journal-title":"Appl. Organomet. Chem."},{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib307","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1007\/s10904-023-02550-x","article-title":"Biogenic zinc oxide nanoparticles and their biomedical applications: a review","volume":"33","author":"Jha","year":"2023","journal-title":"J. Inorg. Organomet. Polym. Mater."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib308","first-page":"241","article-title":"Comparative study on anti-proliferative potentials of zinc oxide and aluminium oxide nanoparticles in colon cancer cells","volume":"90","author":"Subramaniam","year":"2019","journal-title":"Acta Biomed."},{"key":"10.1016\/j.prp.2024.155546_bib309","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.788527","article-title":"Cytotoxic potential of biogenic zinc oxide nanoparticles synthesized from swertia chirayita leaf extract on colorectal cancer cells","volume":"9","author":"Berehu","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.prp.2024.155546_bib310","article-title":"Anticancer and apoptotic activity of biologically synthesized zinc oxide nanoparticles against human colon cancer HCT-116\u00a0cell line- in vitro study","volume":"14","author":"Majeed","year":"2019","journal-title":"Sustain. Chem. Pharm."},{"key":"10.1016\/j.prp.2024.155546_bib311","doi-asserted-by":"crossref","unstructured":"Karimzadeh, M.R., Soltanian, S., Sheikhbahaei, M., & Mohamadi, N. (2020). Characterization and biological activities of synthesized zinc oxide nanoparticles using the extract of Acantholimon serotinum. 9(1), 722-733, doi:doi:\u300810.1515\/gps-2020-0058\u3009.","DOI":"10.1515\/gps-2020-0058"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib312","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s42269-023-01104-y","article-title":"Sustainable approaches for the synthesis of biogenic platinum nanoparticles","volume":"47","author":"Malode","year":"2023","journal-title":"Bull. Natl. Res. Cent."},{"issue":"12","key":"10.1016\/j.prp.2024.155546_bib313","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e11917","article-title":"Role of green synthesized platinum nanoparticles in cytotoxicity, oxidative stress, and apoptosis of human colon cancer cells (HCT-116)","volume":"8","author":"Alyami","year":"2022","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib314","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s41120-022-00060-7","article-title":"PLGA-based nanoparticles for the treatment of cancer: current strategies and perspectives","volume":"8","author":"Alvi","year":"2022","journal-title":"AAPS Open"},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib315","doi-asserted-by":"crossref","first-page":"971","DOI":"10.5530\/ijper.57.4.119","article-title":"Mucoadhesive chitosan-coated PLGA nanoparticles of ashwagandha extract for colon-targeted delivery","volume":"57","author":"Manjunath","year":"2023","journal-title":"Ind. J. Pharm. Edu. Res"},{"key":"10.1016\/j.prp.2024.155546_bib316","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-020-06803-7","article-title":"Enhanced antitumor efficacy in colon cancer using EGF functionalized PLGA nanoparticles loaded with 5-Fluorouracil and perfluorocarbon","volume":"20","author":"Wu","year":"2020","journal-title":"BMC Cancer"},{"issue":"17","key":"10.1016\/j.prp.2024.155546_bib317","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.3390\/polym14173577","article-title":"Apigenin Loaded Lipoid\u2013PLGA\u2013TPGS Nanoparticles for Colon Cancer Therapy: Characterization, Sustained Release, Cytotoxicity, and Apoptosis Pathways","volume":"14","author":"Alfaleh","year":"2022","journal-title":"Polymers"},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib318","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15020606","article-title":"Chitosan Surface-Modified PLGA Nanoparticles Loaded with Cranberry Powder Extract as a Potential Oral Delivery Platform for Targeting Colon Cancer Cells","volume":"15","author":"Mostafa","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.prp.2024.155546_bib319","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jconrel.2021.02.031","article-title":"Polymeric micelles in drug delivery: an insight of the techniques for their characterization and assessment in biorelevant conditions","volume":"332","author":"Ghezzi","year":"2021","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib320","article-title":"Treatment of colorectal cancer by anticancer and antibacterial\u00a0effects of hemiprotonic phenanthroline-phenanthroline+ with nanomicelle delivery","volume":"18","author":"Zhang","year":"2023","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.prp.2024.155546_bib321","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jconrel.2022.07.029","article-title":"Oral delivery of camptothecin-loaded multifunctional chitosan-based micelles is effective in reduce colorectal cancer","volume":"349","author":"Almeida","year":"2022","journal-title":"J. Control. Release"},{"issue":"10","key":"10.1016\/j.prp.2024.155546_bib322","first-page":"3025","article-title":"E\ufb03cient drug delivery and anticancer e\ufb00ect of micelles based on vitamin E succinate and chitosan derivatives","volume":"6","author":"Chen","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.prp.2024.155546_bib323","doi-asserted-by":"crossref","DOI":"10.1016\/j.reactfunctpolym.2021.104966","article-title":"Degradable pH-responsive polymer prodrug micelles with aggregation-induced emission for cellular imaging and cancer therapy","volume":"166","author":"Kalva","year":"2021","journal-title":"React. Funct. Polym."},{"key":"10.1016\/j.prp.2024.155546_bib324","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8844030","article-title":"Dendrimers: a new race of pharmaceutical nanocarriers","volume":"2021","author":"Mittal","year":"2021","journal-title":"BioMed. Res. Int."},{"issue":"18","key":"10.1016\/j.prp.2024.155546_bib325","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1080\/07391102.2020.1802344","article-title":"Surface modified PAMAM dendrimers with gallic acid inhibit, cell proliferation, cell migration and inflammatory response to augment apoptotic cell death in human colon carcinoma cells","volume":"39","author":"Priyadarshi","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"12","key":"10.1016\/j.prp.2024.155546_bib326","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1080\/03639045.2019.1680995","article-title":"Co-delivery of doxorubicin and TRAIL plasmid by modified PAMAM dendrimer in colon cancer cells, in vitro and in vivo evaluation","volume":"45","author":"Pishavar","year":"2019","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib327","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12030633","article-title":"Solid lipid nanoparticles: review of the current research on encapsulation and delivery systems for active and antioxidant compounds","volume":"12","author":"Subroto","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.prp.2024.155546_bib328","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117180","article-title":"Pectin co-functionalized dual layered solid lipid nanoparticle made by soluble curcumin for the targeted potential treatment of colorectal cancer","volume":"252","author":"Mohamed","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.prp.2024.155546_bib329","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ijbiomac.2020.02.132","article-title":"Oral delivery of pH-responsive alginate microbeads incorporating folic acid-grafted solid lipid nanoparticles exhibits enhanced targeting effect against colorectal cancer: a dual-targeted approach","volume":"151","author":"Rajpoot","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.prp.2024.155546_bib330","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115682","article-title":"Targeted delivery and apoptosis induction of trans-resveratrol-ferulic acid loaded chitosan coated folic acid conjugate solid lipid nanoparticles in colon cancer cells","volume":"231","author":"Senthil Kumar","year":"2020","journal-title":"Carbohydr. Polym."},{"issue":"8","key":"10.1016\/j.prp.2024.155546_bib331","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15082045","article-title":"Cytotoxic screening and enhanced anticancer activity of lippia alba and clinopodium nepeta essential oils-loaded biocompatible lipid nanoparticles against lung and colon cancer cells","volume":"15","author":"Rodenak-Kladniew","year":"2023","journal-title":"Pharmaceutics"},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib332","doi-asserted-by":"crossref","DOI":"10.5812\/jjnpp-135987","article-title":"Targeted solid lipid nanoparticles formulation for colon cancer treatment and cytotoxicity assessment using ht29 cell line. [research article]","volume":"18","author":"Moghimipour","year":"2023","journal-title":"Jundishapur J. Nat. Pharm. Prod."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib333","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3390\/pharmaceutics14010131","article-title":"Celecoxib-loaded solid lipid nanoparticles for colon delivery: formulation optimization and in vitro assessment of anti-cancer activity","volume":"14","author":"Alajami","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.prp.2024.155546_bib334","doi-asserted-by":"crossref","DOI":"10.1016\/j.onano.2022.100064","article-title":"Nanostructured lipid carriers and their potential applications for versatile drug delivery via oral administration","volume":"8","author":"Nguyen","year":"2022","journal-title":"OpenNano"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib335","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1080\/10717544.2022.2027573","article-title":"Combined and targeted drugs delivery system for colorectal cancer treatment: conatumumab decorated, reactive oxygen species sensitive irinotecan prodrug and quercetin co-loaded nanostructured lipid carriers","volume":"29","author":"Liu","year":"2022","journal-title":"Drug Deliv."},{"key":"10.1016\/j.prp.2024.155546_bib336","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.indcrop.2018.07.044","article-title":"The incorporation of Pterodon pubescens fruit oil into optimized nanostructured lipid carriers improves its effectiveness in colorectal cancer","volume":"123","author":"Outuki","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.prp.2024.155546_bib337","volume":"12","author":"Bhattacharya","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.prp.2024.155546_bib338","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2021.105033","article-title":"Tumor-targeted hyaluronic acid-mPEG modified nanostructured lipid carriers for cantharidin delivery: an in vivo and in vitro study","volume":"155","author":"Sun","year":"2021","journal-title":"Fitoterapia"},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib339","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15031021","article-title":"Design, synthesis, characterization, and evaluation of the anti-ht-29 colorectal cell line activity of novel 8-oxyquinolinate-platinum(II)-loaded nanostructured lipid carriers targeted with riboflavin","volume":"15","author":"Boztepe","year":"2023","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib340","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s12935-022-02605-y","article-title":"Recent advances in targeted drug delivery systems for resistant colorectal cancer","volume":"22","author":"Sharifi-Azad","year":"2022","journal-title":"Cancer Cell Int."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib341","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12951-020-00764-6","article-title":"An improved method in fabrication of smart dual-responsive nanogels for controlled release of doxorubicin and curcumin in HT-29 colon cancer cells","volume":"19","author":"Abedi","year":"2021","journal-title":"J. Nanobiotechnology"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib342","doi-asserted-by":"crossref","DOI":"10.3390\/nano11010144","article-title":"Development of a new hyaluronic acid based redox-responsive nanohydrogel for the encapsulation of oncolytic viruses for cancer immunotherapy","volume":"11","author":"Deng","year":"2021","journal-title":"Nanomaterials"},{"key":"10.1016\/j.prp.2024.155546_bib343","article-title":"Integrin receptor mediated pH-responsive nano-hydrogel based on histidine-modified poly(aminoethyl methacrylamide) as targeted cisplatin delivery system","volume":"62","author":"Entezar-Almahdi","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.prp.2024.155546_bib344","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/6640103","article-title":"Nanoemulsion: an emerging novel technology for improving the bioavailability of drugs","volume":"2023","author":"Preeti","year":"2023","journal-title":"Scientifica"},{"issue":"3","key":"10.1016\/j.prp.2024.155546_bib345","doi-asserted-by":"crossref","DOI":"10.3390\/colloids6030049","article-title":"Utilizing TPGS for optimizing quercetin nanoemulsion for colon cancer cells inhibition","volume":"6","author":"Enin","year":"2022","journal-title":"Colloids Interfaces"},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib346","doi-asserted-by":"crossref","DOI":"10.1049\/mna2.12161","article-title":"Evaluation of the biological activity of nanoemulsions fabricated by walnut oil (Juglans regia L.)","volume":"18","author":"Khezri","year":"2023","journal-title":"Micro Nano Lett."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib347","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/21691401.2023.2246145","article-title":"Anticancer potentials of metformin loaded coconut oil nanoemulsion on MCF-7, HepG2 and HCT-116 cell lines","volume":"51","author":"Alotaibi","year":"2023","journal-title":"Artif. Cells, Nanomed., Biotechnol."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib348","doi-asserted-by":"crossref","DOI":"10.3390\/colloids7040064","article-title":"Optimization of clove oil nanoemulsions: evaluation of antioxidant, antimicrobial, and anticancer properties","volume":"7","author":"Haro-Gonz\u00e1lez","year":"2023","journal-title":"Colloids Interfaces"},{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib349","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1049\/mna2.12115","article-title":"Anti-angiogenic and anticancer activities of the nanoemulsions synthesized from Trachyspermum ammi L. tincture against human colon adenorectal carcinoma cells","volume":"17","author":"Azaraz","year":"2022","journal-title":"Micro Nano Lett."},{"issue":"2","key":"10.1016\/j.prp.2024.155546_bib350","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s13205-022-03117-2","article-title":"Chemical investigation and screening of anti-cancer potential of Syzygium aromaticum L. bud (clove) essential oil nanoemulsion","volume":"12","author":"Abadi","year":"2022","journal-title":"3 Biotech"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib351","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1080\/10717544.2022.2096711","article-title":"Oxaliplatin-loaded nanoemulsion containing Teucrium polium L. essential oil induces apoptosis in Colon cancer cell lines through ROS-mediated pathway","volume":"29","author":"Al-Otaibi","year":"2022","journal-title":"Drug Deliv."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib352","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1080\/10717544.2022.2083724","article-title":"Self-emulsifying drug delivery systems: a novel approach to deliver drugs","volume":"29","author":"Salawi","year":"2022","journal-title":"Drug Deliv."},{"key":"10.1016\/j.prp.2024.155546_bib353","doi-asserted-by":"crossref","DOI":"10.1016\/j.rechem.2022.100385","article-title":"Preparation of Sorafenib tosylate self-emulsified drug delivery system and the effect on combination therapy with Bosutinib against HCT116\/SW1417 cells","volume":"4","author":"Bhattacharya","year":"2022","journal-title":"Results Chem."},{"key":"10.1016\/j.prp.2024.155546_bib354","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2021.117368","article-title":"Double w\/o\/w self-nano emulsifying drug delivery system of imatinib mesylate for colon cancer treatment","volume":"341","author":"Bhattacharya","year":"2021","journal-title":"J. Mol. Liq."},{"issue":"11","key":"10.1016\/j.prp.2024.155546_bib355","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14112384","article-title":"Development of guar gum-pectin-based colon targeted solid self-nanoemulsifying drug delivery system of xanthohumol","volume":"14","author":"Hanmantrao","year":"2022","journal-title":"Pharmaceutics"},{"issue":"5","key":"10.1016\/j.prp.2024.155546_bib356","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1016\/j.sjbs.2022.02.017","article-title":"A novel 5-Fluorocuracil multiple-nanoemulsion used for the enhancement of oral bioavailability in the treatment of colorectal cancer","volume":"29","author":"Ahmad","year":"2022","journal-title":"Saudi J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib357","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.xphs.2020.10.020","article-title":"Capsaicin loaded solid SNEDDS for enhanced bioavailability and anticancer activity: in-vitro, in-silico, and in-vivo characterization","volume":"110","author":"Bhagwat","year":"2021","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.prp.2024.155546_bib358","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2020.114774","article-title":"Design of absorption enhancer containing self-nanoemulsifying drug delivery system (SNEDDS) for curcumin improved anti-cancer activity and oral bioavailability","volume":"324","author":"Kanwal","year":"2021","journal-title":"J. Mol. Liq."},{"issue":"8","key":"10.1016\/j.prp.2024.155546_bib359","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14081576","article-title":"Novel drug delivery systems as an emerging platform for stomach cancer therapy","volume":"14","author":"Hani","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.prp.2024.155546_bib360","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jconrel.2021.08.050","article-title":"A single microbubble formulation carrying 5-fluorouridine, Irinotecan and oxaliplatin to enable FOLFIRINOX treatment of pancreatic and colon cancer using ultrasound targeted microbubble destruction","volume":"338","author":"Gao","year":"2021","journal-title":"J. Control. Release"},{"issue":"7","key":"10.1016\/j.prp.2024.155546_bib361","doi-asserted-by":"crossref","first-page":"7312","DOI":"10.1021\/acsnano.8b03674","article-title":"Ultrasound triggered conversion of porphyrin\/camptothecin-fluoroxyuridine triad microbubbles into nanoparticles overcomes multidrug resistance in colorectal cancer","volume":"12","author":"Chen","year":"2018","journal-title":"ACS Nano"},{"issue":"9","key":"10.1016\/j.prp.2024.155546_bib362","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ultrasmedbio.2023.05.013","article-title":"Treatment of liver metastases with focused ultrasound and microbubbles in patients with colorectal cancer receiving chemotherapy","volume":"49","author":"Haram","year":"2023","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.prp.2024.155546_bib363","doi-asserted-by":"crossref","unstructured":"Scheim, D., & Aldous, C. (2023). An NEJM randomized clinical trial finds a 50% reduction in colorectal cancer deaths after colonoscopy screening but concludes only minimal benefit.","DOI":"10.31219\/osf.io\/9yrfp"},{"key":"10.1016\/j.prp.2024.155546_bib364","doi-asserted-by":"crossref","DOI":"10.1016\/j.conctc.2023.101092","article-title":"Can butyrate prevent colon cancer? The AusFAP study: a randomised, crossover clinical trial","volume":"32","author":"Clarke","year":"2023","journal-title":"Contemp. Clin. Trials Commun."},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib365","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00384-023-04482-x","article-title":"Evaluating the oncological safety of neoadjuvant chemotherapy in locally advanced colon carcinoma: a systematic review and meta-analysis of randomised clinical trials and propensity-matched studies","volume":"38","author":"Davey","year":"2023","journal-title":"Int. J. Colorectal Dis."},{"issue":"15_suppl","key":"10.1016\/j.prp.2024.155546_bib366","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1200\/JCO.2019.37.15_suppl.3504","article-title":"FOxTROT: an international randomised controlled trial in 1052 patients (pts) evaluating neoadjuvant chemotherapy (NAC) for colon cancer","volume":"37","author":"Seymour","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.prp.2024.155546_bib367","article-title":"Efficacy and safety of intraoperative hyperthermic intraperitoneal chemotherapy for locally advanced colon cancer: a phase 3 randomized clinical trial","author":"Arjona-S\u00e1nchez","year":"2023","journal-title":"JAMA Surg."},{"issue":"8","key":"10.1016\/j.prp.2024.155546_bib368","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1200\/JCO.22.00046","article-title":"Preoperative chemotherapy for operable colon cancer: mature results of an international randomized controlled trial","volume":"41","author":"Morton","year":"2023","journal-title":"J. Clin. Oncol."},{"issue":"15","key":"10.1016\/j.prp.2024.155546_bib369","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1001\/jama.2023.4428","article-title":"Panitumumab vs bevacizumab added to standard first-line chemotherapy and overall survival among patients with RAS wild-type, left-sided metastatic colorectal cancer: a randomized clinical trial","volume":"329","author":"Watanabe","year":"2023","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib370","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1158\/2159-8290.CD-21-1117","article-title":"Reverse transcriptase inhibition disrupts repeat element life cycle in colorectal cancer","volume":"12","author":"Rajurkar","year":"2022","journal-title":"Cancer Discov."},{"issue":"14","key":"10.1016\/j.prp.2024.155546_bib371","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15143688","article-title":"The first cold atmospheric plasma phase I clinical trial for the treatment of advanced solid tumors: a novel treatment arm for cancer","volume":"15","author":"Canady","year":"2023","journal-title":"Cancers"},{"issue":"18","key":"10.1016\/j.prp.2024.155546_bib372","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1200\/JCO.19.03296","article-title":"Regorafenib plus nivolumab in patients with advanced gastric or colorectal cancer: an open-label, dose-escalation, and dose-expansion phase ib trial (REGONIVO, EPOC1603)","volume":"38","author":"Fukuoka","year":"2020","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib373","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/cam4.3630","article-title":"A phase 2 trial of trifluridine\/tipiracil plus nivolumab in patients with heavily pretreated microsatellite-stable metastatic colorectal cancer","volume":"10","author":"Patel","year":"2021","journal-title":"Cancer Med."},{"issue":"23","key":"10.1016\/j.prp.2024.155546_bib374","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1056\/NEJMoa2017699","article-title":"Pembrolizumab in microsatellite-instability\u2013high advanced colorectal cancer","volume":"383","author":"Andr\u00e9","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.prp.2024.155546_bib375","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.annonc.2022.07.1942","article-title":"Association of tumor-infiltrating lymphocytes with survival depends on primary tumor sidedness in stage III colon cancers (NCCTG N0147)[Alliance","volume":"33","author":"Saberzadeh-Ardestani","year":"2022","journal-title":"Ann. Oncol."},{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib376","doi-asserted-by":"crossref","first-page":"e494","DOI":"10.1093\/oncolo\/oyab070","article-title":"Marital status, living arrangement, and cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803 (Alliance)","volume":"27","author":"Lee","year":"2022","journal-title":"Oncologist"},{"issue":"13","key":"10.1016\/j.prp.2024.155546_bib377","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1001\/jama.2021.2454","article-title":"Effect of celecoxib vs placebo added to standard adjuvant therapy on disease-free survival among patients with stage III colon cancer: the CALGB\/SWOG 80702 (Alliance) randomized clinical trial","volume":"325","author":"Meyerhardt","year":"2021","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.prp.2024.155546_bib378","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.annonc.2020.10.480","article-title":"Oxaliplatin-based adjuvant chemotherapy duration (3 versus 6 months) for high-risk stage II colon cancer: the randomized phase III ACHIEVE-2 trial","volume":"32","author":"Yamazaki","year":"2021","journal-title":"Ann. Oncol."},{"issue":"12","key":"10.1016\/j.prp.2024.155546_bib379","doi-asserted-by":"crossref","first-page":"7855","DOI":"10.1007\/s00520-021-06371-x","article-title":"Neuropathy severity at the time of oxaliplatin treatment alteration in patients with colon cancer (Alliance A151912)","volume":"29","author":"Hertz","year":"2021","journal-title":"Support. Care Cancer"},{"key":"10.1016\/j.prp.2024.155546_bib380","article-title":"Feasibility and safety of laparoscopic complete mesocolic excision (CME) for right-sided colon cancer: short-term outcomes. A randomized clinical study","author":"Di Buono","year":"2021","journal-title":"LWW"},{"key":"10.1016\/j.prp.2024.155546_bib381","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.600715","article-title":"Vitamin C administration by intravenous infusion increases tumor ascorbate content in patients with colon cancer: a clinical intervention study. [Original Research]","volume":"10","author":"Dachs","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.prp.2024.155546_bib382","doi-asserted-by":"crossref","unstructured":"Takii, Y., Mizusawa, J., Kanemitsu, Y., Komori, K., Shiozawa, M., Ohue, M., et al. (2022). The Conventional Technique Versus the No-touch isolation technique for primary tumor resection in patients with colon cancer (JCOG1006): A Multicenter, open-label, randomized, phase III trial. LWW.","DOI":"10.1016\/j.annonc.2022.07.552"},{"issue":"6","key":"10.1016\/j.prp.2024.155546_bib383","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41416-020-01222-8","article-title":"Prognostic value of desmoplastic reaction characterisation in stage II colon cancer: prospective validation in a Phase 3 study (SACURA Trial)","volume":"124","author":"Ueno","year":"2021","journal-title":"Br. J. Cancer"},{"issue":"12","key":"10.1016\/j.prp.2024.155546_bib384","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1001\/jamasurg.2021.4992","article-title":"Sixty-day mortality of patients with metastatic colorectal cancer randomized to systemic treatment vs primary tumor resection followed by systemic treatment: the CAIRO4 Phase 3 randomized clinical trial","volume":"156","author":"van der Kruijssen","year":"2021","journal-title":"JAMA Surg."},{"issue":"4","key":"10.1016\/j.prp.2024.155546_bib385","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/jnci\/djaa124","article-title":"Sex and adverse events of adjuvant chemotherapy in colon cancer: an analysis of 34 640 patients in the ACCENT database","volume":"113","author":"Wagner","year":"2021","journal-title":"JNCI: J. Natl. Cancer Inst."},{"key":"10.1016\/j.prp.2024.155546_bib386","unstructured":"\u3008https:\/\/clinicaltrials.gov\/study\/NCT05279612?term=NCT05279612&rank=1\u3009\u3008\u3009(Accessed 16 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib387","unstructured":"\u3008https:\/\/clinicaltrials.gov\/study\/NCT03446157?cond=Colon%20Cancer&aggFilters=status:act&rank=6\u3009 (Accessed 16 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib388","unstructured":"\u3008https:\/\/clinicaltrials.gov\/study\/NCT02978612?cond=Colon%20Cancer&aggFilters=status:act&limit=50&page=1&rank=12\u3009 (Accessed 16 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib389","unstructured":"\u3008https:\/\/clinicaltrials.gov\/study\/NCT02467582?cond=Colon%20Cancer&aggFilters=status:act&limit=50&page=1&rank=13\u3009 (Accessed 16 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib390","unstructured":"\u3008https:\/\/clinicaltrials.gov\/study\/NCT01918527?cond=Colon%20Cancer&aggFilters=status:act&limit=50&page=1&rank=17\u3009 (Accessed 16 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib391","unstructured":"\u3008https:\/\/clinicaltrials.gov\/study\/NCT03883802?cond=Colon%20Cancer&aggFilters=status:act&limit=50&page=1&rank=18\u3009 (Accessed 16 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib392","unstructured":"\u3008https:\/\/clinicaltrials.gov\/study\/NCT02572141?cond=Colon%20Cancer&aggFilters=status:act&limit=50&page=1&rank=19\u3009 (Accessed 16 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib393","unstructured":"\u3008https:\/\/clinicaltrials.gov\/study\/NCT02138617?cond=Colon%20Cancer&aggFilters=status:act&limit=50&page=1&rank=20\u3009 (Accessed 16 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib394","unstructured":"\u3008https:\/\/clinicaltrials.gov\/study\/NCT03442569?cond=Colon%20Cancer&aggFilters=status:act&limit=50&page=1&rank=23\u3009 (Accessed 16 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib395","unstructured":"\u3008https:\/\/clinicaltrials.gov\/study\/NCT03168737?cond=Colon%20Cancer&aggFilters=status:act&limit=50&page=1&rank=25\u3009 (Accessed 16 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib396","unstructured":"\u3008https:\/\/clinicaltrials.gov\/study\/NCT03698461?cond=Colon%20Cancer&aggFilters=status:act&limit=50&page=1&rank=26\u3009 (Accessed 16 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib397","unstructured":"\u3008https:\/\/patents.google.com\/patent\/EP1804827B1\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment\u3009 (Accessed 17 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib398","unstructured":"\u3008https:\/\/patents.google.com\/patent\/US10821142B2\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment\u3009 (Accessed 17 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib399","unstructured":"\u3008https:\/\/patents.google.com\/patent\/JP5778708B2\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment\u3009 (Accessed 17 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib400","unstructured":"\u3008https:\/\/patents.google.com\/patent\/JP7254786B2\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment\u3009 (Accessed 17 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib401","unstructured":"\u3008https:\/\/patents.google.com\/patent\/JP5285012B2\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment\u3009 (Accessed 17 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib402","unstructured":"\u3008https:\/\/patents.google.com\/patent\/US9284275B2\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment&page=1\u3009 (Accessed 17 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib403","unstructured":"\u3008https:\/\/patents.google.com\/patent\/JP5635690B2\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment&page=1\u3009 (Accessed 17 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib404","unstructured":"\u3008https:\/\/patents.google.com\/patent\/JP5931336B2\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment&page=1\u3009 (Accessed 17 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib405","unstructured":"\u3008https:\/\/patents.google.com\/patent\/JP6999577B2\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment&page=1\u3009 (Accessed 17 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib406","unstructured":"\u3008https:\/\/patents.google.com\/patent\/CN107735104B\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment&page=1\u3009 (Accessed 17 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib407","unstructured":"\u3008https:\/\/patents.google.com\/patent\/US10772918B2\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment&page=1\u3009 (Accessed 17 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib408","unstructured":"\u3008https:\/\/patents.google.com\/patent\/US11344586B2\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment&page=2\u3009 (Accessed 17 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib409","unstructured":"\u3008https:\/\/patents.google.com\/patent\/US11648301B2\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment&page=2\u3009 (Accessed 18 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib410","unstructured":"\u3008https:\/\/patents.google.com\/patent\/US11345733B2\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment&page=3\u3009 (Accessed 18 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib411","unstructured":"\u3008https:\/\/patents.google.com\/patent\/KR101879926B1\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment&page=3\u3009 (Accessed 18 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib412","unstructured":"\u3008https:\/\/patents.google.com\/patent\/JP6544812B2\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment&page=3\u3009 (Accessed 18 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib413","unstructured":"\u3008https:\/\/patents.google.com\/patent\/JP6185971B2\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment&page=4\u3009 (Accessed 18 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib414","unstructured":"\u3008https:\/\/patents.google.com\/patent\/EP3204018B1\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment&page=4\u3009 (Accessed 18 November 2023)."},{"key":"10.1016\/j.prp.2024.155546_bib415","unstructured":"\u3008https:\/\/patents.google.com\/patent\/US10954305B2\/en?q\u3009\u3008=(colon+cancer%2c+treatment)&oq=colon+cancer%2c+treatment&page=4\u3009 (Accessed 19 November 2023)."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033824004576?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033824004576?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T13:42:02Z","timestamp":1727185322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033824004576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":415,"alternative-id":["S0344033824004576"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2024.155546","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel drug delivery systems in colorectal cancer: Advances and future prospects","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2024.155546","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155546"}}