{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:29:12Z","timestamp":1788481752332,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373368"],"award-info":[{"award-number":["82373368"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2024JC-YBQN-0834"],"award-info":[{"award-number":["2024JC-YBQN-0834"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2024JC-YBMS-684"],"award-info":[{"award-number":["2024JC-YBMS-684"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.prp.2025.156096","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T13:04:17Z","timestamp":1751375057000},"page":"156096","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["SPARC promotes malignant progression and predicts poor prognosis in cervical squamous cell carcinoma"],"prefix":"10.1016","volume":"272","author":[{"given":"Qingge","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.prp.2025.156096_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.prp.2025.156096_bib2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ijgo.12749","article-title":"Revised FIGO staging for carcinoma of the cervix uteri","volume":"145","author":"Bhatla","year":"2019","journal-title":"Int. J. Gynaecol. Obstet."},{"issue":"1(1","key":"10.1016\/j.prp.2025.156096_bib3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/ijgo.13865","article-title":"Cancer of the cervix uteri: 2021 update","volume":"155","author":"Bhatla","year":"2021","journal-title":"Int. J. Gynaecol. Obstet."},{"issue":"14","key":"10.1016\/j.prp.2025.156096_bib4","doi-asserted-by":"crossref","first-page":"11386","DOI":"10.3390\/ijms241411386","article-title":"Epithelial-Mesenchymal Transition (EMT)","volume":"24","author":"Manfioletti","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.prp.2025.156096_bib5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.yexcr.2018.04.014","article-title":"Cadherin profiling for therapeutic interventions in Epithelial Mesenchymal Transition (EMT) and tumorigenesis","volume":"368","author":"Pal","year":"2018","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.prp.2025.156096_bib6","article-title":"Inhibition of ITGA2 suppresses cervical tumorigenesis and metastasis by targeting the AKT\/mTOR signaling pathway","volume":"12","author":"Luo","year":"2024","journal-title":"Genes Dis."},{"issue":"12","key":"10.1016\/j.prp.2025.156096_bib7","article-title":"Radiotherapy-associated cellular senescence and EMT alterations contribute to distinct disease relapse patterns in locally advanced cervical cancer","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.prp.2025.156096_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155429","article-title":"E2F1 modulates RCCD1 expression to participate in the initiation and progression of EMT in colorectal cancer","volume":"260","author":"Han","year":"2024","journal-title":"Pathol. Res Pract."},{"issue":"6","key":"10.1016\/j.prp.2025.156096_bib9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.drup.2008.08.005","article-title":"SPARC in cancer biology: its role in cancer progression and potential for therapy","volume":"11","author":"Tai","year":"2008","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.prp.2025.156096_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.775743","article-title":"SPARC overexpression promotes liver cancer cell proliferation and tumor growth","volume":"8","author":"Gao","year":"2021","journal-title":"Front Mol. Biosci."},{"key":"10.1016\/j.prp.2025.156096_bib11","unstructured":"Alcaraz L.B., Mallavialle A., Mollevi C., Boissi\u00e8re-Michot F., Mansouri H., Simony-Lafontaine J., Laurent-Matha V., Chard\u00e8s T., Jacot W., Turtoi A., Roger P., Guiu S., Liaudet-Coopman E. SPARC in cancer-associated fibroblasts is an independent poor prognostic factor in non-metastatic triple-negative breast cancer and exhibits pro-tumor activity."},{"issue":"4","key":"10.1016\/j.prp.2025.156096_bib12","doi-asserted-by":"crossref","first-page":"794","DOI":"10.4149\/neo_2022_211002N1401","article-title":"Methylation-mediated expression of SPARC is correlated with tumor progression and poor prognosis of breast cancer","volume":"69","author":"Li","year":"2022","journal-title":"Neoplasma"},{"issue":"11","key":"10.1016\/j.prp.2025.156096_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.70972","article-title":"SPARC promotes aerobic glycolysis and 5-fluorouracil resistance in colorectal cancer through the STAT3\/HK2 axis","volume":"14","author":"Xiang","year":"2025","journal-title":"Cancer Med."},{"issue":"10","key":"10.1016\/j.prp.2025.156096_bib14","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/s41419-024-07153-z","article-title":"Tumor-secreted LCN2 impairs gastric cancer progression via autocrine inhibition of the 24p3R\/JNK\/c-Jun\/SPARC axis","volume":"15","author":"Huang","year":"2024","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.prp.2025.156096_bib15","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1158\/0008-5472.CAN-23-2889","article-title":"SPARC stabilizes ApoE to induce cholesterol-dependent invasion and sorafenib resistance in hepatocellular carcinoma","volume":"84","author":"Wan","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2025.156096_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.155053","article-title":"Osteonectin (SPARC) prognostic value in prostate cancer","volume":"254","author":"Chekhun","year":"2024","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2025.156096_bib17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jconrel.2021.12.035","article-title":"SPARC-mediated long-term retention of nab-paclitaxel in pediatric sarcomas","volume":"342","author":"Pascual-Pasto","year":"2022","journal-title":"J. Control Release"},{"key":"10.1016\/j.prp.2025.156096_bib18","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jconrel.2023.12.057","article-title":"Modulating the tumoral SPARC content to enhance albumin-based drug delivery for cancer therapy","volume":"366","author":"Zheng","year":"2024","journal-title":"J. Control Release"},{"issue":"2","key":"10.1016\/j.prp.2025.156096_bib19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/cac2.12629","article-title":"Advances in cervical cancer: current insights and future directions","volume":"45","author":"Xu","year":"2025","journal-title":"Cancer Commun (Lond)"},{"issue":"7","key":"10.1016\/j.prp.2025.156096_bib20","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/s41571-024-00904-z","article-title":"Epidemiology of HPV-associated cancers past, present and future: towards prevention and elimination","volume":"21","author":"Malag\u00f3n","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.prp.2025.156096_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155426","article-title":"The activation of Piezo1 channel promotes invasion and migration via the release of extracellular ATP in cervical cancer","volume":"260","author":"Liao","year":"2024","journal-title":"Pathol. Res. Pract."},{"issue":"16","key":"10.1016\/j.prp.2025.156096_bib22","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1158\/0008-5472.CAN-21-0163","article-title":"Castration-induced downregulation of SPARC in stromal cells drives neuroendocrine differentiation of prostate cancer","volume":"81","author":"Enriquez","year":"2021","journal-title":"Cancer Res."},{"issue":"13","key":"10.1016\/j.prp.2025.156096_bib23","doi-asserted-by":"crossref","first-page":"6173","DOI":"10.7150\/thno.58254","article-title":"A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment","volume":"11","author":"Alcaraz","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.prp.2025.156096_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.138747","article-title":"Modulating the blood-brain barrier in CNS disorders: a review of the therapeutic implications of secreted protein acidic and rich in cysteine (SPARC)","volume":"288","author":"Yang","year":"2025","journal-title":"Int J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.prp.2025.156096_bib25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3892\/mmr.2024.13355","article-title":"SPOCK: Master regulator of malignant tumors (Review)","volume":"30","author":"Xiao","year":"2024","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.prp.2025.156096_bib26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.21037\/atm-20-7272","article-title":"MiR-29c-3p inhibits epithelial-mesenchymal transition to inhibit the proliferation, invasion and metastasis of cervical cancer cells by targeting SPARC","volume":"9","author":"Zou","year":"2021","journal-title":"Ann. Transl. Med."},{"issue":"1","key":"10.1016\/j.prp.2025.156096_bib27","first-page":"853","article-title":"miR-211 inhibits proliferation, invasion and migration of cervical cancer via targeting SPARC","volume":"16","author":"Qu","year":"2018","journal-title":"Oncol. Lett."},{"issue":"4","key":"10.1016\/j.prp.2025.156096_bib28","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1158\/0008-5472.CAN-13-2800","article-title":"Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma","volume":"74","author":"Aguilera","year":"2014","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.prp.2025.156096_bib29","first-page":"751","article-title":"Loss of SPARC in bladder cancer enhances carcinogenesis and progression","volume":"123","author":"Said","year":"2013","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.prp.2025.156096_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2025.155873","article-title":"Tiny messengers, big Impact: Exosomes driving EMT in oral cancer","volume":"268","author":"Mivehchi","year":"2025","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2025.156096_bib31","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.semcancer.2024.06.001","article-title":"RNA regulatory mechanisms controlling TGF-\u03b2 signaling and EMT in cancer","volume":"102-103","author":"Bracken","year":"2024","journal-title":"Semin Cancer Biol."},{"issue":"1","key":"10.1016\/j.prp.2025.156096_bib32","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12943-025-02338-2","article-title":"Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025","volume":"24","author":"Allgayer","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.prp.2025.156096_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.138800","article-title":"Chitosan and hyaluronic acid in colorectal cancer therapy: a review on EMT regulation, metastasis, and overcoming drug resistance","volume":"289","author":"Han","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.prp.2025.156096_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155229","article-title":"A comprehensive review of lncRNA CRNDE in cancer progression and pathology, with a specific glance at the epithelial-mesenchymal transition (EMT) process","volume":"256","author":"Jasim","year":"2024","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2025.156096_bib35","doi-asserted-by":"crossref","unstructured":"Journal of Cancer. Retraction: MiR-211-5p Inhibits the Biological Behaviors of Colorectal Cancer via SPARC-Related Growth Factor Pathways. J Cancer. 2022 Apr 26;13(8):2418.","DOI":"10.7150\/jca.73906"},{"issue":"6","key":"10.1016\/j.prp.2025.156096_bib36","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3892\/ol.2021.12746","article-title":"SPARC promotes pancreatic cancer cell proliferation and migration through autocrine secretion into the extracellular milieu","volume":"21","author":"Pan","year":"2021","journal-title":"Oncol. Lett."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033825002894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033825002894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:30:43Z","timestamp":1778747443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033825002894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":36,"alternative-id":["S0344033825002894"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2025.156096","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SPARC promotes malignant progression and predicts poor prognosis in cervical squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2025.156096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156096"}}