{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:35:32Z","timestamp":1791992132028,"version":"4.4.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072864"],"award-info":[{"award-number":["82072864"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.prp.2025.156224","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T01:23:34Z","timestamp":1757467414000},"page":"156224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["METTL3 promotes ovarian cancer progression through YTHDF2-dependent degradation of GATA4"],"prefix":"10.1016","volume":"275","author":[{"family":"Di Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2025.156224_bib1","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.prp.2025.156224_bib2","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20231967","article-title":"Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer","volume":"221","author":"Murphy","year":"2024","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.prp.2025.156224_bib3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13148-023-01440-w","article-title":"Early diagnosis of ovarian cancer based on methylation profiles in peripheral blood cell-free DNA: a systematic review","volume":"15","author":"Terp","year":"2023","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.prp.2025.156224_bib4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12943-024-01967-3","article-title":"Drug resistance in ovarian cancer: from mechanism to clinical trial","volume":"23","author":"Wang","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.prp.2025.156224_bib5","article-title":"RNA epigenetic modifications in ovarian cancer: the changes, chances, and challenges","volume":"14","author":"Ye","year":"2023","journal-title":"Wiley Inter. Rev. RNA"},{"key":"10.1016\/j.prp.2025.156224_bib6","doi-asserted-by":"crossref","DOI":"10.1007\/s10495-025-02094-0","article-title":"YTHDF1-mediated m6A modification promotes cisplatin resistance in ovarian cancer via the FZD7\/Wnt\/beta-catenin pathway","author":"Miao","year":"2025","journal-title":"Apoptosis"},{"key":"10.1016\/j.prp.2025.156224_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41417-025-00898-5","article-title":"ALKBH5-mediated m6A regulates the alternative splicing events of SRSF10 in ovarian cancer","author":"Li","year":"2025","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.prp.2025.156224_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155168","article-title":"Transcription factor RELA promotes hepatocellular carcinoma progression by promoting the transcription of m6A modulator METTL3","volume":"255","author":"Wu","year":"2024","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2025.156224_bib9","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.molcel.2019.04.025","article-title":"Where, when, and how: Context-Dependent functions of RNA methylation writers, readers, and erasers","volume":"74","author":"Shi","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.prp.2025.156224_bib10","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/s41580-023-00654-3","article-title":"Publisher correction: Reading, writing and erasing mRNA methylation","volume":"24","author":"Zaccara","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.prp.2025.156224_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2025.156107","article-title":"Expression of m6A-related factors in pulmonary sarcomatoid carcinoma","volume":"272","author":"Chen","year":"2025","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2025.156224_bib12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ygyno.2023.11.034","article-title":"m6A-modified RIPK4 facilitates proliferation and cisplatin resistance in epithelial ovarian cancer","volume":"180","author":"Yin","year":"2024","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.prp.2025.156224_bib13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12967-024-04929-x","article-title":"m(6)A methylation-mediated regulation of LncRNA MEG3 suppresses ovarian cancer progression through miR-885-5p and the VASH1 pathway","volume":"22","author":"Li","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.prp.2025.156224_bib14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41417-020-00222-3","article-title":"METTL3-mediated maturation of miR-126-5p promotes ovarian cancer progression via PTEN-mediated PI3K\/Akt\/mTOR pathway","volume":"28","author":"Bi","year":"2021","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.prp.2025.156224_bib15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ygyno.2022.12.005","article-title":"Oncogenic SIRT7 inhibits GATA4 transcriptional activity and activates the wnt signaling pathway in ovarian cancer","volume":"171","author":"Li","year":"2023","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.prp.2025.156224_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006454","article-title":"Loss of GATA4 and GATA6 expression specifies ovarian cancer histological subtypes and precedes neoplastic transformation of ovarian surface epithelia","volume":"4","author":"Cai","year":"2009","journal-title":"PLOS One"},{"key":"10.1016\/j.prp.2025.156224_bib17","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1038\/s41467-019-11036-9","article-title":"De sousa lopes, Single-cell reconstruction of follicular remodeling in the human adult ovary","volume":"10","author":"Fan","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.prp.2025.156224_bib18","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1158\/1078-0432.CCR-22-0296","article-title":"Single-Cell RNA sequencing reveals the tissue architecture in human High-Grade serous ovarian cancer","volume":"28","author":"Xu","year":"2022","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2025.156224_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adm7506","article-title":"Cellular Atlas of the human ovary using morphologically guided spatial transcriptomics and single-cell sequencing","volume":"10","author":"Jones","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.prp.2025.156224_bib20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00280-023-04533-8","article-title":"Tumor-associated macrophages promote cisplatin resistance in ovarian cancer cells by enhancing WTAP-mediated N6-methyladenosine RNA methylation via the CXCL16\/CXCR6 axis","volume":"92","author":"Hong","year":"2023","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.prp.2025.156224_bib21","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1038\/s41388-022-02411-w","article-title":"PLAA suppresses ovarian cancer metastasis via METTL3-mediated m(6)A modification of TRPC3 mRNA","volume":"41","author":"Shen","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2025.156224_bib22","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.1111\/jcmm.15063","article-title":"METTL3\/YTHDF2 m(6) a axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer","volume":"24","author":"Xie","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.prp.2025.156224_bib23","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1158\/1541-7786.MCR-22-0509","article-title":"Downregulation of iNOS\/NO promotes Epithelial-Mesenchymal transition and metastasis in colorectal cancer","volume":"21","author":"Du","year":"2023","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.prp.2025.156224_bib24","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/tox.23960","article-title":"Transcriptome characteristics of epithelial cells from advanced non-small cell lung cancer were revealed by single-cell RNA sequencing","volume":"39","author":"Qiu","year":"2024","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.prp.2025.156224_bib25","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1161\/CIRCULATIONAHA.123.067504","article-title":"Cardiac reprogramming and Gata4 overexpression reduce fibrosis and improve diastolic dysfunction in heart failure with preserved ejection fraction","volume":"151","author":"Yamada","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.prp.2025.156224_bib26","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.7150\/ijbs.97091","article-title":"TRIM50 inhibits glycolysis and the malignant progression of gastric cancer by ubiquitinating PGK1","volume":"20","author":"Gu","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.prp.2025.156224_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.155047","article-title":"METTL3\/YTHDF1 m(6)A axis promotes tumorigenesis by enhancing DDR2 expression in ovarian cancer","volume":"253","author":"Zhi","year":"2024","journal-title":"Pathol. Res. Pract."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033825004170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033825004170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:37:23Z","timestamp":1760503043000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033825004170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":27,"alternative-id":["S0344033825004170"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2025.156224","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"METTL3 promotes ovarian cancer progression through YTHDF2-dependent degradation of GATA4","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2025.156224","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"156224"}}