{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:47:55Z","timestamp":1786996075225,"version":"build-2736575974"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Secretaria de Ciencia Humanidades Tecnologia e Innovacion","doi-asserted-by":"publisher","award":["CF-2023-I-1083"],"award-info":[{"award-number":["CF-2023-I-1083"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.prp.2025.156256","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:17:45Z","timestamp":1759731465000},"page":"156256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The interplay of NAD+, hyperuricemia, and renal damage: A scientific review"],"prefix":"10.1016","volume":"275","author":[{"given":"Laura Gabriela","family":"S\u00e1nchez-Lozada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Garc\u00eda-Arroyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Gonzaga-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar Emiliano","family":"Aparicio-Trejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Cuevas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Reyes-Leo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Rodr\u00edguez-Iturbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2025.156256_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1526482","article-title":"Global, regional, and national burden of chronic kidney disease, 1990-2021: a systematic analysis for the global burden of disease study 2021","volume":"16","author":"Xie","year":"2025","journal-title":"Front Endocrinol."},{"issue":"7","key":"10.1016\/j.prp.2025.156256_bib2","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/humu.24211","article-title":"New cases that expand the genotypic and phenotypic spectrum of congenital NAD deficiency disorder","volume":"42","author":"Szot","year":"2021","journal-title":"Hum. Mutat."},{"issue":"1","key":"10.1016\/j.prp.2025.156256_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s42255-019-0161-5","volume":"2","author":"Katsyuba","year":"2020","journal-title":"Nat. Metab."},{"issue":"6","key":"10.1016\/j.prp.2025.156256_bib4","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1053\/j.ajkd.2017.12.009","article-title":"Hyperuricemia, acute and chronic kidney disease, hypertension, and cardiovascular disease: report of a scientific workshop organized by The National kidney foundation","volume":"71","author":"Johnson","year":"2018","journal-title":"Am. J. Kidney Dis."},{"issue":"2","key":"10.1016\/j.prp.2025.156256_bib5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3390\/ijerph18020387","article-title":"Prevalence of hyperuricemia and the use of allopurinol in older Poles\u2014Results from a Population-Based PolSenior study","volume":"18","author":"Winder","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"3","key":"10.1016\/j.prp.2025.156256_bib6","article-title":"MdLC. relationship of hyperuricemia with metabolic alterations and cardiovascular risk factors in a population of Mexican young adults","volume":"155","author":"Kammar-Garc\u00eda","year":"2019","journal-title":"Gac. M\u00e9d. M\u00e9xico"},{"issue":"2","key":"10.1016\/j.prp.2025.156256_bib7","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1007\/s11357-023-00936-w","article-title":"Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort","volume":"46","author":"Murata","year":"2024","journal-title":"Geroscience"},{"issue":"6","key":"10.1016\/j.prp.2025.156256_bib8","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cmet.2016.05.006","article-title":"CD38 dictates Age-Related NAD decline and mitochondrial dysfunction through an SIRT3-Dependent mechanism","volume":"23","author":"Camacho-Pereira","year":"2016","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.prp.2025.156256_bib9","doi-asserted-by":"crossref","first-page":"927","DOI":"10.14336\/AD.2019.0820","article-title":"Sirtuins and their biological relevance in aging and Age-Related diseases","volume":"11","author":"Zhao","year":"2020","journal-title":"Aging Dis."},{"issue":"2","key":"10.1016\/j.prp.2025.156256_bib10","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1089\/ars.2017.7269","article-title":"Role of nicotinamide adenine dinucleotide and related precursors as therapeutic targets for Age-Related degenerative diseases: rationale, biochemistry, pharmacokinetics, and outcomes","volume":"30","author":"Braidy","year":"2019","journal-title":"Antioxid. Redox Signal."},{"issue":"5","key":"10.1016\/j.prp.2025.156256_bib11","doi-asserted-by":"crossref","DOI":"10.1152\/ajpregu.00238.2021","article-title":"Sirtuin deficiency and the adverse effects of fructose and uric acid synthesis","volume":"322","author":"Rodriguez-Iturbe","year":"2022","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.prp.2025.156256_bib12","article-title":"Autophagy in disease management: exploring the potential of natural products as targeted therapies","volume":"272","author":"Eissa","year":"2025","journal-title":"Pathol. Res Pr."},{"issue":"9","key":"10.1016\/j.prp.2025.156256_bib13","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1073\/pnas.0712145105","article-title":"A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy","volume":"105","author":"Lee","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.prp.2025.156256_bib14","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1080\/15548627.2016.1257467","article-title":"NAD(+): the convergence of DNA repair and mitophagy","volume":"13","author":"Fang","year":"2017","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.prp.2025.156256_bib15","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.cell.2014.03.026","article-title":"Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)\/SIRT1 reduction","volume":"157","author":"Fang","year":"2014","journal-title":"Cell"},{"issue":"5-6","key":"10.1016\/j.prp.2025.156256_bib16","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1101\/gad.335109.119","article-title":"Interplay between compartmentalized NAD+ synthesis and consumption: a focus on the PARP family","volume":"34","author":"Cohen","year":"2020","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.prp.2025.156256_bib17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41581-019-0216-6","article-title":"NAD(+) homeostasis in renal health and disease","volume":"16","author":"Ralto","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.prp.2025.156256_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155447","article-title":"Ataxia-Telangiectasia mutated (ATM) gene signaling pathways in human cancers and their therapeutic implications","volume":"260","author":"Varadhan","year":"2024","journal-title":"Pathol. Res Pract."},{"issue":"4","key":"10.1016\/j.prp.2025.156256_bib19","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.cmet.2016.09.004","article-title":"NAD(+) replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair","volume":"24","author":"Fang","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.prp.2025.156256_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/acel.70093","article-title":"Nicotinamide riboside supplementation benefits in patients with werner syndrome: a double-blind randomized crossover Placebo-controlled trial","author":"Shoji","year":"2025","journal-title":"Aging Cell"},{"issue":"2","key":"10.1016\/j.prp.2025.156256_bib21","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/mds.29645","article-title":"Long-Term nicotinamide riboside use improves coordination and eye movements in ataxia telangiectasia","volume":"39","author":"Presterud","year":"2024","journal-title":"Mov. Disord."},{"key":"10.1016\/j.prp.2025.156256_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2018.05.006","article-title":"NAD metabolism: implications in aging and longevity","volume":"47","author":"Yaku","year":"2018","journal-title":"Ageing Res. Rev."},{"issue":"4","key":"10.1016\/j.prp.2025.156256_bib23","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.cmet.2019.09.001","article-title":"NAD(+) in brain aging and neurodegenerative disorders","volume":"30","author":"Lautrup","year":"2019","journal-title":"Cell Metab."},{"issue":"10","key":"10.1016\/j.prp.2025.156256_bib24","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1681\/ASN.2010010046","article-title":"Sirtuins and their relevance to the kidney","volume":"21","author":"Hao","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"issue":"7","key":"10.1016\/j.prp.2025.156256_bib25","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1681\/ASN.2017111218","article-title":"Sirtuins in renal health and disease","volume":"29","author":"Morigi","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.prp.2025.156256_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13649","article-title":"Association of metabolic syndrome and chronic kidney disease","volume":"25","author":"Scurt","year":"2024","journal-title":"Obes. Rev."},{"issue":"8","key":"10.1016\/j.prp.2025.156256_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104975","article-title":"NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease","volume":"299","author":"Myakala","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.prp.2025.156256_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.trsl.2016.12.004","article-title":"The metabolic syndrome and chronic kidney disease","volume":"183","author":"Zhang","year":"2017","journal-title":"Transl. Res."},{"issue":"1","key":"10.1016\/j.prp.2025.156256_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13878","article-title":"The risk for chronic kidney disease in metabolically healthy obese patients: a systematic review and meta-analysis","volume":"53","author":"Kanbay","year":"2023","journal-title":"Eur. J. Clin. Investig."},{"issue":"5","key":"10.1016\/j.prp.2025.156256_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/biom11050730","article-title":"NADH\/NAD(+) redox imbalance and diabetic kidney disease","volume":"11","author":"Yan","year":"2021","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.prp.2025.156256_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010137","article-title":"Roles of NAD(+) in acute and chronic kidney diseases","volume":"24","author":"Morevati","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.prp.2025.156256_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11092560","article-title":"The role of NAD(+) in metabolic regulation of adipose tissue: implications for Obesity-Induced insulin resistance","volume":"11","author":"Ruskovska","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.prp.2025.156256_bib33","article-title":"NAD(+) homeostasis in diabetic kidney disease","volume":"8","author":"Xu","year":"2021","journal-title":"Front Med."},{"issue":"1","key":"10.1016\/j.prp.2025.156256_bib34","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.153019","article-title":"Cell stress response impairs de novo NAD+ biosynthesis in the kidney","volume":"7","author":"Bignon","year":"2022","journal-title":"JCI Insight"},{"issue":"9","key":"10.1016\/j.prp.2025.156256_bib35","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/s41591-018-0138-z","article-title":"De novo NAD(+) biosynthetic impairment in acute kidney injury in humans","volume":"24","author":"Poyan Mehr","year":"2018","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.prp.2025.156256_bib36","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1111\/jcmm.14285","article-title":"Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation","volume":"23","author":"Zheng","year":"2019","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.prp.2025.156256_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/toxins13010050","article-title":"Nicotinamide attenuates the progression of renal failure in a mouse model of Adenine-Induced chronic kidney disease","volume":"13","author":"Kumakura","year":"2021","journal-title":"Toxins"},{"issue":"6","key":"10.1016\/j.prp.2025.156256_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0252554","article-title":"Effect of NAD+ boosting on kidney ischemia-reperfusion injury","volume":"16","author":"Morevati","year":"2021","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.prp.2025.156256_bib39","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1681\/ASN.2016040385","article-title":"Nicotinamide mononucleotide, an NAD(+) precursor, rescues Age-Associated susceptibility to AKI in a sirtuin 1-Dependent manner","volume":"28","author":"Guan","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.prp.2025.156256_bib40","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000510943","article-title":"Nicotinamide supplementation attenuates renal interstitial fibrosis via boosting the activity of sirtuins","volume":"7","author":"Zhen","year":"2021","journal-title":"Kidney Dis."},{"key":"10.1016\/j.prp.2025.156256_bib41","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.3389\/fphys.2021.649547","article-title":"Nicotinamide mononucleotide attenuates renal interstitial fibrosis after AKI by suppressing tubular DNA damage and senescence","volume":"12","author":"Jia","year":"2021","journal-title":"Front. Physiol."},{"issue":"3","key":"10.1016\/j.prp.2025.156256_bib42","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s42255-023-00761-7","article-title":"NAD+ precursor supplementation prevents mtRNA\/RIG-I-dependent inflammation during kidney injury","volume":"5","author":"Doke","year":"2023","journal-title":"Nat. Metab."},{"issue":"5","key":"10.1016\/j.prp.2025.156256_bib43","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.181443","article-title":"NAD+ prevents chronic kidney disease by activating renal tubular metabolism","volume":"10","author":"Jones","year":"2025","journal-title":"JCI Insight"},{"key":"10.1016\/j.prp.2025.156256_bib44","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cellsig.2017.10.014","article-title":"Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-kappaB signaling suppression","volume":"42","author":"Shu","year":"2018","journal-title":"Cell Signal."},{"key":"10.1016\/j.prp.2025.156256_bib45","article-title":"Application of CD38 monoclonal antibody in kidney disease","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.prp.2025.156256_bib46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/BOR.0000000000000679","article-title":"Asymptomatic hyperuricemia: is it really asymptomatic?","volume":"32","author":"Yip","year":"2020","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.prp.2025.156256_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.649505","article-title":"Urate crystals; beyond joints","volume":"8","author":"Ahmad","year":"2021","journal-title":"Front. Med."},{"issue":"10","key":"10.1016\/j.prp.2025.156256_bib48","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1001\/jamacardio.2019.3201","article-title":"Dual-Energy computed tomography detection of cardiovascular monosodium urate deposits in patients with gout","volume":"4","author":"Klauser","year":"2019","journal-title":"JAMA Cardiol."},{"issue":"4 (1","key":"10.1016\/j.prp.2025.156256_bib49","article-title":"Fructose induced hyperuricemia as a causal mechanism of nonalcoholic liver disease","volume":"46","author":"Abdelmalek","year":"2007","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.prp.2025.156256_bib50","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.2337\/db12-1814","article-title":"Sugar, uric acid, and the etiology of diabetes and obesity","volume":"62","author":"Johnson","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.prp.2025.156256_bib51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000484274","article-title":"The pathophysiology of uric acid on renal diseases","volume":"192","author":"Sanchez-Lozada","year":"2018","journal-title":"Contrib. Nephrol."},{"issue":"4","key":"10.1016\/j.prp.2025.156256_bib52","first-page":"458","article-title":"Relationship between hyperuricemia, HSP70 and NLRP3 inflammasome in arterial hypertension","volume":"93","author":"Rodr\u00edguez-Iturbe","year":"2023","journal-title":"Arch. Cardiol. Mex."},{"key":"10.1016\/j.prp.2025.156256_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155330","article-title":"Release of damaged mitochondrial DNA: a novel factor in stimulating inflammatory response","volume":"258","author":"Li","year":"2024","journal-title":"Pathol. Res Pract."},{"issue":"4","key":"10.1016\/j.prp.2025.156256_bib54","doi-asserted-by":"crossref","first-page":"F1134","DOI":"10.1152\/ajprenal.00104.2008","article-title":"Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia","volume":"295","author":"Sanchez-Lozada","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"5","key":"10.1016\/j.prp.2025.156256_bib55","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1111\/j.1523-1755.2005.00273.x","article-title":"Hyperuricemia induces endothelial dysfunction","volume":"67","author":"Khosla","year":"2005","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.prp.2025.156256_bib56","doi-asserted-by":"crossref","DOI":"10.1152\/ajprenal.00283.2001","article-title":"Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism","volume":"282","author":"Mazzali","year":"2002","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"4","key":"10.1016\/j.prp.2025.156256_bib57","doi-asserted-by":"crossref","first-page":"F1238","DOI":"10.1152\/ajprenal.00164.2006","article-title":"Effects of acute and chronic L-arginine treatment in experimental hyperuricemia","volume":"292","author":"Sanchez-Lozada","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"6","key":"10.1016\/j.prp.2025.156256_bib58","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1161\/01.HYP.0000072820.07472.3B","article-title":"Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2","volume":"41","author":"Kanellis","year":"2003","journal-title":"Hypertension"},{"issue":"3-4","key":"10.1016\/j.prp.2025.156256_bib59","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1159\/000345509","article-title":"Uric Acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrations","volume":"121","author":"Sanchez-Lozada","year":"2012","journal-title":"Nephron Exp. Nephrol."},{"key":"10.1016\/j.prp.2025.156256_bib60","doi-asserted-by":"crossref","DOI":"10.1038\/srep39884","article-title":"Soluble uric acid activates the NLRP3 inflammasome","volume":"7","author":"Braga","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2025.156256_bib61","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bbrc.2021.10.010","article-title":"CD38 activation by monosodium urate crystals contributes to inflammatory responses in human and murine macrophages","volume":"581","author":"Wen","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"13","key":"10.1016\/j.prp.2025.156256_bib62","doi-asserted-by":"crossref","first-page":"10839","DOI":"10.3390\/ijms241310839","article-title":"Accumulation of renal fibrosis in hyperuricemia rats is attributed to the recruitment of mast cells, activation of the TGF-\u03b21\/Smad2\/3 pathway, and aggravation of oxidative stress","volume":"24","author":"Zhang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.prp.2025.156256_bib63","doi-asserted-by":"crossref","DOI":"10.1002\/dvg.23529","article-title":"Epithelial\u2013mesenchymal plasticity in kidney fibrosis","volume":"62","author":"Hadpech","year":"2023","journal-title":"Genesis"},{"issue":"20","key":"10.1016\/j.prp.2025.156256_bib64","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.16995","article-title":"Pharmacologic targeting ERK1\/2 attenuates the development and progression of hyperuricemic nephropathy in rats","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2025.156256_bib65","doi-asserted-by":"crossref","unstructured":"Kang D.-H. Hyperuricemia and Progression of Chronic Kidney Disease: Role of Phenotype Transition of Renal Tubular and Endothelial Cells. 2018 [cited 5\/27\/2025]. In: Uric Acid in Chronic Kidney Disease [Internet]. S.Karger AG, [cited 5\/27\/2025]; [0]. Available from: https:\/\/doi.org\/10.1159\/000484278.","DOI":"10.1159\/000484278"},{"issue":"5","key":"10.1016\/j.prp.2025.156256_bib66","doi-asserted-by":"crossref","DOI":"10.1152\/ajprenal.00560.2012","article-title":"Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease","volume":"304","author":"Ryu","year":"2013","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"9","key":"10.1016\/j.prp.2025.156256_bib67","doi-asserted-by":"crossref","first-page":"15563","DOI":"10.1002\/jcp.28203","article-title":"Uric acid induced epithelial\u2212mesenchymal transition of renal tubular cells through PI3K\/p-Akt signaling pathway","volume":"234","author":"Xiong","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.prp.2025.156256_bib68","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10735-017-9720-9","article-title":"Uric acid activates NRLP3 inflammasome in an in-vivo model of epithelial to mesenchymal transition in the kidney","volume":"48","author":"Romero","year":"2017","journal-title":"J. Mol. Histol."},{"issue":"1","key":"10.1016\/j.prp.2025.156256_bib69","article-title":"Telmisartan attenuates uric acid-induced epithelial-mesenchymal transition in renal tubular cells","volume":"2019","author":"Zha","year":"2019","journal-title":"Biomed. Res. Int."},{"issue":"4","key":"10.1016\/j.prp.2025.156256_bib70","doi-asserted-by":"crossref","DOI":"10.1152\/ajprenal.00480.2018","article-title":"Blockade of ERK1\/2 by U0126 alleviates uric acid-induced EMT and tubular cell injury in rats with hyperuricemic nephropathy","volume":"316","author":"Tao","year":"2019","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"4","key":"10.1016\/j.prp.2025.156256_bib71","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000481668","article-title":"Retracted paper - high uric acid-induced epithelial-mesenchymal transition of renal tubular epithelial cells via the TLR4\/NF-kB signaling pathway","volume":"46","author":"Liu","year":"2017","journal-title":"Am. J. Nephrol."},{"issue":"12","key":"10.1016\/j.prp.2025.156256_bib72","doi-asserted-by":"crossref","first-page":"13334","DOI":"10.1096\/fj.201901148R","article-title":"Uric acid induced the phenotype transition of vascular endothelial cells via induction of oxidative stress and glycocalyx shedding","volume":"33","author":"Ko","year":"2019","journal-title":"FASEB J."},{"issue":"48","key":"10.1016\/j.prp.2025.156256_bib73","doi-asserted-by":"crossref","first-page":"40732","DOI":"10.1074\/jbc.M112.399899","article-title":"Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver","volume":"287","author":"Lanaspa","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.prp.2025.156256_bib74","doi-asserted-by":"crossref","DOI":"10.4238\/gmr.15028644","article-title":"Effect of uric acid on mitochondrial function and oxidative stress in hepatocytes","volume":"15","author":"Yang","year":"2016","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.prp.2025.156256_bib75","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/535686","article-title":"Renal oxidative stress induced by long-term hyperuricemia alters mitochondrial function and maintains systemic hypertension","volume":"2015","author":"Cristobal-Garcia","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"11","key":"10.1016\/j.prp.2025.156256_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048801","article-title":"Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver","volume":"7","author":"Lanaspa","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.prp.2025.156256_bib77","doi-asserted-by":"crossref","DOI":"10.1177\/03000605211021752","article-title":"The rho kinase signaling pathway participates in tubular mitochondrial oxidative injury and apoptosis in uric acid nephropathy","volume":"49","author":"Su","year":"2021","journal-title":"J. Int. Med. Res."},{"issue":"2","key":"10.1016\/j.prp.2025.156256_bib78","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s12020-016-0896-7","article-title":"SIRT1 prevents hyperuricemia via the PGC-1\u03b1\/PPAR\u03b3-ABCG2 pathway","volume":"53","author":"Wang","year":"2016","journal-title":"Endocrine"},{"issue":"20","key":"10.1016\/j.prp.2025.156256_bib79","doi-asserted-by":"crossref","first-page":"18426","DOI":"10.1074\/jbc.M301295200","article-title":"Intra-Mitochondrial Poly(ADP-Ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress","volume":"278","author":"Du","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.prp.2025.156256_bib80","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202402831R","article-title":"Uric acid promotes aortic valve calcification via mediating valve interstitial cell osteogenic differentiation and endothelial dysfunction","volume":"39","author":"Zhang","year":"2025","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.prp.2025.156256_bib81","doi-asserted-by":"crossref","first-page":"6565","DOI":"10.1021\/acs.jafc.3c07655","article-title":"Piperine improves hyperuricemic nephropathy by inhibiting URAT1\/GLUT9 and the AKT-mTOR pathway","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"10.1016\/j.prp.2025.156256_bib82","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1161\/ATVBAHA.119.313224","article-title":"Soluble uric acid promotes atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated inflammation","volume":"40","author":"Kimura","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.prp.2025.156256_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2022.166374","article-title":"Kidney and plasma metabolomics provide insights into the molecular mechanisms of urate nephropathy in a mouse model of hyperuricemia","volume":"1868","author":"Li","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.prp.2025.156256_bib84","doi-asserted-by":"crossref","first-page":"7161","DOI":"10.1038\/s41598-023-34426-y","article-title":"Exploring the mechanism underlying hyperuricemia using comprehensive research on multi-omics","volume":"13","author":"Liu","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2025.156256_bib85","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.96962.3","article-title":"Functional identification of soluble uric acid as an endogenous inhibitor of CD38","volume":"13","author":"Wen","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.prp.2025.156256_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155617","article-title":"PARP inhibitors in ovarian cancer: mechanisms, resistance, and the promise of combination therapy","volume":"263","author":"Bhatia","year":"2024","journal-title":"Pathol. Res Pract."},{"issue":"4","key":"10.1016\/j.prp.2025.156256_bib87","doi-asserted-by":"crossref","DOI":"10.4172\/2324-9110.1000165","article-title":"NAD+ in cancer prevention and treatment: pros and cons","volume":"5","author":"Poljsak","year":"2016","journal-title":"J. Clin. Exp. Oncol."},{"issue":"9","key":"10.1016\/j.prp.2025.156256_bib88","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11091637","article-title":"Current uncertainties and future challenges regarding NAD+ boosting strategies","volume":"11","author":"Polj\u0161ak","year":"2022","journal-title":"Antioxidants"},{"issue":"5","key":"10.1016\/j.prp.2025.156256_bib89","doi-asserted-by":"crossref","DOI":"10.3390\/biom10050687","article-title":"Possible adverse effects of High-Dose nicotinamide: mechanisms and safety assessment","volume":"10","author":"Hwang","year":"2020","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.prp.2025.156256_bib90","doi-asserted-by":"crossref","first-page":"F106","DOI":"10.1152\/ajprenal.00126.2009","article-title":"Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure","volume":"297","author":"Cho","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.prp.2025.156256_bib91","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bbagen.2009.10.009","article-title":"Niacin improves renal lipid metabolism and slows progression in chronic kidney disease","volume":"1800","author":"Cho","year":"2010","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033825004492?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033825004492?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:46:41Z","timestamp":1760503601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033825004492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":91,"alternative-id":["S0344033825004492"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2025.156256","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The interplay of NAD+, hyperuricemia, and renal damage: A scientific review","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2025.156256","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156256"}}