{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:29:09Z","timestamp":1792592949413,"version":"4.5.0"},"reference-count":156,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.prp.2025.156274","type":"journal-article","created":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:36:10Z","timestamp":1760884570000},"page":"156274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Role of C-reactive protein in cervical intraepithelial neoplasia\/cancer"],"prefix":"10.1016","volume":"276","author":[{"given":"Adriana","family":"Pedrea\u00f1ez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenddy","family":"Carrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.Hern\u00e1ndez","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Mosquera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2025.156274_bib1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"A global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"Cancer J. Clin."},{"key":"10.1016\/j.prp.2025.156274_bib2","first-page":"1004","article-title":"Vital signs: cervical cancer incidence, mortality, and screening \u2013United States, 2007- 2012","volume":"63","author":"Benard","year":"2014","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.prp.2025.156274_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101058","article-title":"In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: review","volume":"14","author":"Carrero","year":"2021","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.prp.2025.156274_bib4","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.3390\/cancers15194878","article-title":"The relationship between furin and chronic inflammation in the progression of cervical intraepithelial neoplasia to cancer: a Cross-Sectional study","volume":"15","author":"Afsar","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.prp.2025.156274_bib5","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000293648","article-title":"Serum C-reactive protein levels in patients with cervical neoplasia","volume":"27","author":"Wong","year":"1989","journal-title":"Gynecol. Obstet. Invest"},{"key":"10.1016\/j.prp.2025.156274_bib6","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2188\/jea.JE20200142","article-title":"High-sensitivity C-reactive protein and regression of Low-grade squamous intraepithelial lesion: the role of Low-grade inflammation in cervical carcinogenesis","volume":"31","author":"Ahn","year":"2021","journal-title":"J. Epidemiol."},{"key":"10.1016\/j.prp.2025.156274_bib7","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1097\/IGC.0000000000000153","article-title":"Twelve serum proteins progressively increase with disease stage in squamous cell cervical cancer patients","volume":"24","author":"Zhi","year":"2014","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.prp.2025.156274_bib8","article-title":"Prognostic significance of C-reactive protein in patients with cervical cancer: a meta-analysis","volume":"13","author":"Yang","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.prp.2025.156274_bib9","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ygyno.2007.06.001","article-title":"C-reactive protein is a prognostic parameter in patients with cervical cancer","volume":"107","author":"Polterauer","year":"2007","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.prp.2025.156274_bib10","first-page":"2259","article-title":"Association of C-reactive protein (CRP) gene polymorphisms, serum CRP levels and cervical cancer prognosis","volume":"31","author":"Polterauer","year":"2011","journal-title":"Anticancer Res"},{"key":"10.1016\/j.prp.2025.156274_bib11","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.31083\/j.ejgo4206180","article-title":"Prognostic value of combined glucose and C-reactive protein (CRP) in cervical cancer","volume":"42","author":"Bak\u0131r","year":"2021","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"10.1016\/j.prp.2025.156274_bib12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/path.1866","article-title":"HPV-mediated cervical carcinogenesis: concepts and clinical implications","volume":"208","author":"Snijders","year":"2006","journal-title":"J. Pathol."},{"key":"10.1016\/j.prp.2025.156274_bib13","doi-asserted-by":"crossref","first-page":"6764","DOI":"10.1074\/jbc.275.10.6764","article-title":"Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis","volume":"275","author":"Park","year":"2000","journal-title":"J. Boil. Chem."},{"key":"10.1016\/j.prp.2025.156274_bib14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.gene.2017.03.018","article-title":"Systematic identification of key genes and pathways in the development of invasive cervical cancer","volume":"618","author":"Niu","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.prp.2025.156274_bib15","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0140-6736(07)61416-0","article-title":"Human papillomavirus and cervical cancer","volume":"370","author":"Schiman","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.prp.2025.156274_bib16","first-page":"384","article-title":"Molecular events in cervical cancer development","volume":"55","author":"Balasubramaniam","year":"2019","journal-title":"Med. (Kaunas. )"},{"key":"10.1016\/j.prp.2025.156274_bib17","first-page":"1021","article-title":"An association of cervical inflammation with high-grade cervical neoplasia in women infected with oncogenic human papilloma virus (HPV)","volume":"10","author":"Castle","year":"2001","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.prp.2025.156274_bib18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s13669-015-0134-y","article-title":"Immunology of HPV infection","volume":"4","author":"Stanley","year":"2015","journal-title":"Curr. Obstet. Gynecol. Rep."},{"key":"10.1016\/j.prp.2025.156274_bib19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1034\/j.1600-065X.2002.18816.x","article-title":"Effective therapeutic anticancer vaccines based on precision guiding of cytolytic t lymphocytes","volume":"188","author":"Melief","year":"2002","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.prp.2025.156274_bib20","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cyto.2008.07.014","article-title":"Cytokines as a key component of cancer-related inflammation","volume":"43","author":"Germano","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.prp.2025.156274_bib21","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000445161","article-title":"Cytokines of cervical mucosa and human papilloma virus infection of the cervix: a descriptive study","volume":"60","author":"Daniilidis","year":"2016","journal-title":"Acta Cytol."},{"key":"10.1016\/j.prp.2025.156274_bib22","doi-asserted-by":"crossref","first-page":"753","DOI":"10.5306\/wjco.v5.i4.753","article-title":"Role of IL-10 and TGF- \u03b21 in local immunosuppression in HPV-associated cervical neoplasia","volume":"5","author":"Torres-Poveda","year":"2014","journal-title":"World J. Clin. Oncol."},{"key":"10.1016\/j.prp.2025.156274_bib23","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.7314\/APJCP.2014.15.9.3851","article-title":"Role of cytokines in genesis, progression and prognosis of cervical cancer","volume":"15","author":"Paradkar","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.prp.2025.156274_bib24","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1002\/cncr.24411","article-title":"Increased vascular endothelial growth factor expression, CD3-positive cell infiltration, and oxidative stress in premalignant lesions of the cervix","volume":"115","author":"Carrero","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.prp.2025.156274_bib25","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.2147\/OTT.S68286","article-title":"Angiogenesis and antiangiogenic agents in cervical cancer","volume":"7","author":"Tomao","year":"2014","journal-title":"Onco Targets Ther."},{"key":"10.1016\/j.prp.2025.156274_bib26","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s12935-018-0647-3","article-title":"Prognostic value of microvessel density in cervical cancer","volume":"18","author":"Hu","year":"2018","journal-title":"Cancer Cell. Int."},{"key":"10.1016\/j.prp.2025.156274_bib27","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.radonc.2009.01.002","article-title":"Higher serum C-reactive protein concentration and hypoalbuminemia are poor prognostic indicators in patients with esophageal cancer undergoing radiotherapy, radiotherapy oncol. J. eur. Soc. ther","volume":"92","author":"Wang","year":"2009","journal-title":"Radio. Oncol."},{"key":"10.1016\/j.prp.2025.156274_bib28","first-page":"908","article-title":"Creactive protein as a prognostic marker for advanced renal cell carcinoma treated with sunitinib","volume":"19","author":"Fujita","year":"2012","journal-title":"Int. J. Urol. Off. J. Jpn. Urol. Assoc."},{"key":"10.1016\/j.prp.2025.156274_bib29","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1002\/cncr.23461","article-title":"C-reactive protein as a prognostic marker for men with androgen-independent prostate cancer: results from the ASCENT trial","volume":"112","author":"Beer","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.prp.2025.156274_bib30","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1186\/1471-2407-11-489","article-title":"Prognostic significance of a systemic inflammatory response in patients receiving first-line palliative chemotherapy for recurred or metastatic gastric cancer","volume":"11","author":"Hwang","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.prp.2025.156274_bib31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10354-022-00981-8","article-title":"Significance of C-reactive protein in patients with chronic myelomonocytic leukemia","volume":"173","author":"Liang-Fonseca","year":"2023","journal-title":"Wien. Med. Wochenschr."},{"key":"10.1016\/j.prp.2025.156274_bib32","article-title":"The role of C-reactive protein in kidney, bladder, and prostate cancers","volume":"12","author":"O'Brian","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prp.2025.156274_bib33","doi-asserted-by":"crossref","first-page":"48487","DOI":"10.1074\/jbc.R400025200","article-title":"C-reactive protein","volume":"279","author":"Black","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.prp.2025.156274_bib34","doi-asserted-by":"crossref","first-page":"14283","DOI":"10.1074\/jbc.M114.555318","article-title":"Topological localization of monomeric C-reactive protein determines proinflammatory endothelial cell responses","volume":"289","author":"Li","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.prp.2025.156274_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.744129","article-title":"C-reactive protein and cancer: interpreting the differential bioactivities of its pentameric and monomeric, modified isoforms","volume":"12","author":"Potempa","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prp.2025.156274_bib36","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1093\/carcin\/bgq176","article-title":"The role of inflammation in HPV carcinogenesis","volume":"31","author":"Boccardo","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.prp.2025.156274_bib37","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/CEJ.0000000000000023","article-title":"Inflammation induced by human papillomavirus in cervical cancer and its implication in prevention","volume":"23","author":"Parida","year":"2014","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.prp.2025.156274_bib38","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1097\/01.AOG.0000292085.50987.f2","article-title":"Association of elevated C-reactive protein levels with animpaired prognosis in patients with surgically treated endometrial cancer","volume":"110","author":"Schmid","year":"2007","journal-title":"Obst. Gynecol."},{"key":"10.1016\/j.prp.2025.156274_bib39","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1158\/1078-0432.CCR-07-1044","article-title":"Serum C-reactive protein as independent prognostic variable in patients with ovarian cancer","volume":"14","author":"Hefler","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2025.156274_bib40","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2174\/1574893616666210708143556","article-title":"Cervical cancer metastasis and recurrence risk prediction based on deep convolutional neural network","volume":"17","author":"Ye","year":"2022","journal-title":"Curr. Bioinform"},{"key":"10.1016\/j.prp.2025.156274_bib41","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/sj.bjc.6603329","article-title":"Preoperative elevation of serum creactive protein is predictive for prognosis in myeloma bone disease after surgery","volume":"95","author":"Zahlten-Hinguranage","year":"2006","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.prp.2025.156274_bib42","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.3748\/wjg.v12.i23.3746","article-title":"Significance of preoperative C-reactive protein as a parameter of the perioperative course and long-term prognosis in squamous cell carcinoma and adenocarcinoma of the oesophagus","volume":"12","author":"Gockel","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.prp.2025.156274_bib43","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1002\/cncr.20976","article-title":"The impact of preoperative serum C-reactive protein on the prognosis of patients with hepatocellular carcinoma","volume":"103","author":"Hashimoto","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.prp.2025.156274_bib44","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1158\/0008-5472.CAN-05-3631","article-title":"A prospective study of serum C-reactive protein and colorectal cancer risk in men","volume":"66","author":"Gunter","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.prp.2025.156274_bib45","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.lungcan.2006.03.012","article-title":"Plasma fibrinogen and serum C-reactive protein are associated with non-small cell lung cancer","volume":"53","author":"Jones","year":"2006","journal-title":"Lung Cancer"},{"key":"10.1016\/j.prp.2025.156274_bib46","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/978-3-0348-0837-8_15","article-title":"The role of inflammation in cervical cancer","volume":"816","author":"Deivendran","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.prp.2025.156274_bib47","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.prp.2025.156274_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-48506-6","article-title":"Determinants of the level of circulating-tumor HPV16 DNA in patients with HPV-associated oropharyngeal cancer at the time of diagnosis","volume":"13","author":"Kentnowski","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2025.156274_bib49","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/0194599818800297","article-title":"C-reactive protein in HPV-Positive and HPV-Negative oropharyngeal cancer","volume":"160","author":"Johnson-Obaseki","year":"2019","journal-title":"Otolaryngol. Head. Neck Surg."},{"key":"10.1016\/j.prp.2025.156274_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/pore.2021.1609946","article-title":"Pretreatment C-Reactive Protein\/Albumin ratio is associated with poor survival in patients with 2018 FIGO stage IB-IIA HPV-Positive cervical cancer","volume":"27","author":"Jiang","year":"2021","journal-title":"Pathol. Oncol. Res."},{"issue":"00","key":"10.1016\/j.prp.2025.156274_bib51","article-title":"Impact of human papillomavirus on survival, inflammation, and immune function in patients with cervical cancer undergoing surgery","volume":"00","author":"Hua","year":"2023","journal-title":"South Asian J. Cancer"},{"key":"10.1016\/j.prp.2025.156274_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/PGP.0000000000000477","article-title":"Expression of HPV-induced DNA damage repair factors correlates with CIN progression","volume":"38","author":"Spriggs","year":"2019","journal-title":"Int. J. Gynecol. Pathol."},{"key":"10.1016\/j.prp.2025.156274_bib53","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1080\/10520295.2020.1800091","article-title":"Comparison of DNA damage and proliferative capacities in smear samples of HPV positive and negative patients by micronucleus counting and AgNOR staining","volume":"96","author":"Sancer","year":"2021","journal-title":"Biotech. Histochem"},{"key":"10.1016\/j.prp.2025.156274_bib54","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1161\/ATVBAHA.112.300276","article-title":"Association of oxidative DNA damage and C-reactive protein in women at risk for cardiovascular disease","volume":"32","author":"Noren Hooten","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.prp.2025.156274_bib55","doi-asserted-by":"crossref","first-page":"10293","DOI":"10.3390\/ijms251910293","article-title":"DNA damage in moderate and severe COVID-19 cases: relation to demographic, clinical, and laboratory parameters","volume":"25","author":"Harutyunyan","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.prp.2025.156274_bib56","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.prp.2015.01.002","article-title":"In situ increased chemokine expression in human cervical intraepithelial neoplasia","volume":"211","author":"Carrero","year":"2015","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2025.156274_bib57","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ejogrb.2018.07.023","article-title":"In situ expressions of protein 16 (p16 (CDKN2A)) and transforming growth factor beta-1 in patients with cervical intraepithelial neoplasia and cervical cancer","volume":"228","author":"Viloria","year":"2018","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.prp.2025.156274_bib58","first-page":"533","article-title":"Increased number of IL-2, IL-2 receptor and IL-10 positive cells in premalignant lesions of the cervix","volume":"49","author":"Mindiola","year":"2008","journal-title":"Invest. Clin."},{"key":"10.1016\/j.prp.2025.156274_bib59","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3389\/fimmu.2018.00754","article-title":"Role of C-Reactive protein at sites of inflammation and infection","volume":"9","author":"Sproston","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prp.2025.156274_bib60","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1161\/01.CIR.0000131160.94926.6E","article-title":"C-reactive protein promotes monocyte chemoattractant protein-1-mediated chemotaxis through upregulating CC chemokine receptor 2 expression in human monocytes","volume":"109","author":"Han","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.prp.2025.156274_bib61","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3892\/br.2017.949","article-title":"The combination of CRP isoforms with oxLDL decreases TNF-\u03b1 and IL-6 release by U937-derived macrophages","volume":"7","author":"Krayem","year":"2017","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.prp.2025.156274_bib62","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nrc2628","article-title":"Tumour necrosis factor and cancer","volume":"9","author":"Balkwill","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.prp.2025.156274_bib63","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1755-8794-1-29","article-title":"Characterization of global transcription profile of normal and HPV-immortalized keratinocytes and their response to TNF treatment","volume":"1","author":"Termini","year":"2008","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.prp.2025.156274_bib64","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1007\/s13277-013-1337-3","article-title":"Tumour necrosis factor alpha 308 G\/A is a risk marker for the progression from high-grade lesions to invasive cervical cancer","volume":"35","author":"Sousa","year":"2014","journal-title":"Tumour Biol."},{"key":"10.1016\/j.prp.2025.156274_bib65","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1161\/01.CIR.0000096055.62724.C5","article-title":"Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells","volume":"108","author":"Calabr\u00f3","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.prp.2025.156274_bib66","doi-asserted-by":"crossref","first-page":"9503","DOI":"10.1074\/jbc.271.16.9503","article-title":"STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6","volume":"271","author":"Zhang","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.prp.2025.156274_bib67","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1042\/CS20040315","article-title":"Inhibitory effect of pitavastatin (NK-104) on the C-reactive-protein- induced interleukin-8 production in human aortic endothelial cells","volume":"108","author":"Kibayashi","year":"2005","journal-title":"Clin. Sci."},{"key":"10.1016\/j.prp.2025.156274_bib68","doi-asserted-by":"crossref","DOI":"10.1126\/science.1281554","article-title":"Interleukin-8 as a macrophage-derived mediator of angiogenesis","volume":"258","author":"Koch","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.prp.2025.156274_bib69","first-page":"456","article-title":"The role of interleukin-8 in inflammation and mechanisms of regulation","volume":"64","author":"Bickel","year":"1993","journal-title":"J. Periodo"},{"key":"10.1016\/j.prp.2025.156274_bib70","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1161\/01.CIR.0000053731.05365.5A","article-title":"Coming of age of C-reactive protein using inflammation markers in cardiology","volume":"107","author":"Yeh","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.prp.2025.156274_bib71","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1161\/01.CIR.0000146846.00816.DD","article-title":"Opposing effects of C-reactive protein isoforms on shear-induced neutrophil-platelet adhesion and neutrophil aggregation in whole blood","volume":"110","author":"Khreiss","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.prp.2025.156274_bib72","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s13273-023-00360-3","article-title":"YTHDC1 inhibits cell proliferation and angiogenesis in cervical cancer by regulating m6A modification of SOCS4 mRNA","volume":"20","author":"Chen","year":"2024","journal-title":"Mol. Cell. Toxicol."},{"key":"10.1016\/j.prp.2025.156274_bib73","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1161\/01.CIR.102.18.2165","article-title":"Direct proinflammatory effect of C-reactive protein on human endothelial cells","volume":"102","author":"Pasceri","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.prp.2025.156274_bib74","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.21873\/invivo.12975","article-title":"Evaluation of CD4+:CD8+ ratio in patients with cervical cancer and the levels of inflammatory markers","volume":"36","author":"Salih","year":"2022","journal-title":"Vivo"},{"key":"10.1016\/j.prp.2025.156274_bib75","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1161\/01.ATV.0000168573.10844.ae","article-title":"Binding and internalization of C-reactive pro-tein by fcgamma receptors on human aortic endothelial cells mediates biological effects","volume":"26","author":"Devaraj","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.prp.2025.156274_bib76","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1161\/01.ATV.0000081637.36475.BC","article-title":"Interaction of oxidative stress and inflammatory response in coronary plaque instability: important role of C-reactive protein","volume":"23","author":"Kobayashi","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.prp.2025.156274_bib77","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cardiores.2007.04.027","article-title":"Fc\u03b3RIIa mediates C-reactive protein-induced inflammatory responses of human vascular smooth muscle cells by activating NADPH oxidase 4","volume":"75","author":"Ryu","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.prp.2025.156274_bib78","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.febslet.2014.01.008","article-title":"C-reactive protein induces G2\/M phase cell cycle arrest and apoptosis in monocytes through the upregulation of B-cell translocation gene 2 expression","volume":"588","author":"Kim","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.prp.2025.156274_bib79","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/ATVBAHA.113.301453","article-title":"TIS21 (\/BTG2\/PC3) as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule","volume":"33","author":"Tugal","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.prp.2025.156274_bib80","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1161\/01.CIR.0000136999.77584.A2","article-title":"C-reactive protein induces apoptosis in human coronary vascular smooth mus-cle cells","volume":"110","author":"Blaschke","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.prp.2025.156274_bib81","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1042\/bj3140547","article-title":"Induction of the mammalian stress response gene GADD153 by oxidative stress: role of AP-1 element","volume":"314","author":"Guyton","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.prp.2025.156274_bib82","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/cs1000275","article-title":"Role of GADD153 (growth arrest- and DNA damage-inducible gene 153) in vascular smooth muscle cell apoptosis","volume":"100","author":"Igase","year":"2001","journal-title":"Clin. Sci. (Lond. )."},{"key":"10.1016\/j.prp.2025.156274_bib83","doi-asserted-by":"crossref","first-page":"463","DOI":"10.4132\/KoreanJPathol.2012.46.5.463","article-title":"Expression of CHOP in squamous tumor of the uterine cervix","volume":"46","author":"Chu","year":"2012","journal-title":"Korean J. Pathol."},{"key":"10.1016\/j.prp.2025.156274_bib84","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1590\/S1807-59322010000600003","article-title":"Local lymphocytes and nitric oxide synthase in the uterine cervical stroma of patients with grade III cervical intraepithelial neoplasia","volume":"65","author":"Silva","year":"2010","journal-title":"Clin. (Sao Paulo)"},{"key":"10.1016\/j.prp.2025.156274_bib85","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejogrb.2007.06.015","article-title":"Local profile of cytokines and nitric oxide in patients with bacterial vaginosis and cervical intraepithelial neoplasia","volume":"138","author":"Tavares-Murta","year":"2008","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.prp.2025.156274_bib86","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s12985-024-02435-6","article-title":"High-risk human papillomavirus infection and cervical cytopathology: relationship with cervical nitric oxide levels","volume":"21","author":"El-Wakil","year":"2024","journal-title":"Virol. J."},{"key":"10.1016\/j.prp.2025.156274_bib87","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/j.1349-7006.2007.00497.x","article-title":"Nitrative and oxidative DNA damage in cervical intraepithelial neoplasia associated with human papilloma virus infection","volume":"98","author":"Hiraku","year":"2007","journal-title":"Cancer Sci."},{"key":"10.1016\/j.prp.2025.156274_bib88","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/00016340902807181","article-title":"Abnormal cervical cytology is associated with increased nitric oxide release in the uterine cervix","volume":"88","author":"Rahkola","year":"2009","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.prp.2025.156274_bib89","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1161\/01.CIR.0000029802.88087.5E","article-title":"A self-fulfilling prophecy C-reactive protein attenuates nitric oxide production and inhibits angiogenesis","volume":"106","author":"Verma","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.prp.2025.156274_bib90","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.atherosclerosis.2005.03.031","article-title":"Native pentameric C-reactive protein displays more potent pro-atherogenic activities in human aortic endothelial cells than modified C-reactive protein","volume":"184","author":"Devaraj","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.prp.2025.156274_bib91","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1161\/01.CIR.0000033116.22237.F9","article-title":"Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells","volume":"106","author":"Venugopal","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.prp.2025.156274_bib92","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.yjmcc.2007.08.015","article-title":"C-reactive protein decreases endothelial nitric oxide synthase activity via uncoupling","volume":"43","author":"Singh","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.prp.2025.156274_bib93","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.atherosclerosis.2007.06.013","article-title":"Native C-reactive protein induces endothelial dysfunction in ApoE\u2212\/\u2212 mice: implications for iNOS and reactive oxygen species","volume":"195","author":"Schwedler","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.prp.2025.156274_bib94","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.4161\/cc.8.23.10068","article-title":"C-reactive protein: how conformational changes influence inflammatory properties","volume":"8","author":"Eisenhardt","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.prp.2025.156274_bib95","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1161\/01.RES.0000183881.11739.CB","article-title":"Loss of pentameric symmetry in C-reactive protein induces interleukin-8 secretion through peroxynitrite signaling in human neutrophils","volume":"97","author":"Khreiss","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.prp.2025.156274_bib96","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1136\/ijgc-2020-001587","article-title":"Oxidative damage and antioxidants in cervical cancer","volume":"31","author":"Preci","year":"2021","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.prp.2025.156274_bib97","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.atherosclerosis.2004.08.007","article-title":"Association between novel oxidative stress markers and C-reactive protein among adults without clinical coronary heart disease","volume":"178","author":"Abramson","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.prp.2025.156274_bib98","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.amjhyper.2005.09.005","article-title":"Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension","volume":"19","author":"Cottone","year":"2006","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.prp.2025.156274_bib99","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s12012-020-09576-4","article-title":"Involvement of ROS\/NLRP3 inflammasome signaling pathway in Doxorubicin-Induced cardiotoxicity","volume":"20","author":"Wei","year":"2020","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.prp.2025.156274_bib100","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3892\/ol.2014.2195","article-title":"A1BG and C3 are overexpressed in patients with cervical intraepithelial neoplasia III","volume":"8","author":"Canales","year":"2014","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.prp.2025.156274_bib101","first-page":"101","article-title":"Serum complement levels in uterine cervical cancer patients and their relationship to Cell-Mediated immunity","volume":"11","author":"Gojobori","year":"1981","journal-title":"Jpn. J. Clin. Oncol."},{"key":"10.1016\/j.prp.2025.156274_bib102","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.3389\/fimmu.2018.02742","article-title":"MASP-1 and MASP-2 serum levels are associated with worse prognostic in cervical cancer progression","volume":"9","author":"Maestri","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prp.2025.156274_bib103","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.celrep.2014.02.014","article-title":"Autocrine effects of tumor-derived complement","volume":"6","author":"Cho","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.prp.2025.156274_bib104","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/ni.1655","article-title":"Modulation of the antitumor immune response by complement","volume":"9","author":"Markiewski","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.prp.2025.156274_bib105","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1172\/JCI90962","article-title":"The role of the complement system in cancer","volume":"127","author":"Afshar-Kharghan","year":"2017","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.prp.2025.156274_bib106","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.semcancer.2021.05.031","article-title":"Insights into the role of complement regulatory proteins in HPV mediated cervical carcinogenesis","volume":"86","author":"Khan","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.prp.2025.156274_bib107","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ejogrb.2023.07.014","article-title":"Human papillomavirus-mediated expression of complement regulatory proteins in human cervical cancer cells","volume":"288","author":"Khana","year":"2023","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.prp.2025.156274_bib108","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1158\/1541-7786.MCR-10-0225","article-title":"Cancer and the complement cascade","volume":"8","author":"Rutkowski","year":"2010","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.prp.2025.156274_bib109","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.smim.2013.04.001","article-title":"Complement inhibition in cancer therapy","volume":"25","author":"Pio","year":"2013","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.prp.2025.156274_bib110","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.4049\/jimmunol.112.6.2135","article-title":"Interaction of C-reactive protein complexes with the complement system I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin","volume":"112","author":"Kaplan","year":"1974","journal-title":"J. Immunol."},{"key":"10.1016\/j.prp.2025.156274_bib111","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/CIRCULATIONAHA.113.007124","article-title":"Dissociation of pentameric to monomeric C-reactive protein localises and aggravates inflammation: in vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy","volume":"130","author":"Thiele","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.prp.2025.156274_bib112","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.3390\/cancers13225767","article-title":"Activation of the complement system in patients with cancer cachexia","volume":"13","author":"Deng","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.prp.2025.156274_bib113","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1182\/blood.V78.10.2505.2505","article-title":"Complement activation in cancer patients undergoing immunotherapy with interleukin-2 (IL-2): binding of complement and C-reactive protein by IL-2-activated lymphocytes","volume":"78","author":"Vachino","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.prp.2025.156274_bib114","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s00262-014-1579-y","article-title":"Mannose-Binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) in women with malignant and benign ovarian tumours","volume":"63","author":"Swierzko","year":"2014","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.prp.2025.156274_bib115","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.595835","article-title":"C-Reactive protein and Cancer\u2014Diagnostic and therapeutic insights","volume":"11","author":"Hart","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prp.2025.156274_bib116","article-title":"Blockade of IL-6\/IL-6R signaling attenuates acute Antibody-Mediated rejection in a mouse cardiac transplantation model","volume":"12","author":"Ma","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.prp.2025.156274_bib117","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1089\/jir.2018.0169","article-title":"Changes of serum IL-6, IL-17, and complements in systemic lupus erythematosus patients","volume":"39","author":"Tang","year":"2019","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.prp.2025.156274_bib118","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adi0252","article-title":"A complement Atlas identifies interleukin-6-dependent alternative pathway dysregulation as a key druggable feature of COVID-19","volume":"15","author":"Van Damme","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.prp.2025.156274_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110698","article-title":"The role of interleukin 6 inhibitors in therapy of severe COVID-19","volume":"131","author":"Nasonov","year":"2020","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.prp.2025.156274_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2022.108982","article-title":"Complement activation by RPE cells preexposed to TNFalpha and IFNgamma","volume":"218","author":"Udsen","year":"2022","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.prp.2025.156274_bib121","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.imbio.2014.06.006","article-title":"Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF","volume":"219","author":"Nymo","year":"2014","journal-title":"Immunobiology"},{"key":"10.1016\/j.prp.2025.156274_bib122","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jhep.2014.08.050","article-title":"C5aR, TNF-alpha, and FGL2 contribute to coagulation and complement activation in virus-induced fulminant hepatitis","volume":"62","author":"Liu","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.prp.2025.156274_bib123","doi-asserted-by":"crossref","first-page":"832","DOI":"10.4049\/jimmunol.1500960","article-title":"TNF regulates essential alternative complement pathway components and impairs activation of protein c in human glomerular endothelial cells","volume":"196","author":"Sartain","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.prp.2025.156274_bib124","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1161\/01.RES.0000182677.89816.38","article-title":"Complement activation in angiotensin II-induced organ damage","volume":"97","author":"Shagdarsuren","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.prp.2025.156274_bib125","doi-asserted-by":"crossref","first-page":"80","DOI":"10.47102\/annals-acadmedsg.2022290","article-title":"Immune and coagulation profiles in 3 adults with multisystem inflammatory syndrome","volume":"52","author":"Yap","year":"2023","journal-title":"Ann. Acad. Med. Singap."},{"key":"10.1016\/j.prp.2025.156274_bib126","doi-asserted-by":"crossref","first-page":"H1643","DOI":"10.1152\/ajpheart.00938.2008","article-title":"CRP is a novel ligand for the oxidized LDL receptor LOX-1","volume":"296","author":"Shih","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.prp.2025.156274_bib127","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1373\/clinchem.2008.119750","article-title":"Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects","volume":"55","author":"Fujita","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.prp.2025.156274_bib128","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/01.RES.0000147309.54227.42","article-title":"C-reactive protein enhances LOX-1 expression in human aortic endothelial cells: relevance of LOX-1 to C-reactive protein-induced endothelial dysfunction","volume":"95","author":"Li","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.prp.2025.156274_bib129","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1158\/1078-0432.CCR-17-2472","article-title":"The highly metastatic nature of uterine cervical\/endometrial cancer displaying tumor-related leukocytosis: clinical and preclinical investigations","volume":"24","author":"Sasano","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2025.156274_bib130","doi-asserted-by":"crossref","first-page":"dju147","DOI":"10.1093\/jnci\/dju147","article-title":"Uterine cervical cancer displaying tumor-related leukocytosis: a distinct clinical entity with radio resistant feature","volume":"106","author":"Mabuchi","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.prp.2025.156274_bib131","doi-asserted-by":"crossref","first-page":"8774","DOI":"10.1038\/s41598-025-91858-4","article-title":"Roles of C-reactive protein and LOX-1 on cancer and myeloid-derived suppressor cells in the progression of uterine cervical cancer","volume":"15","author":"Maeda","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2025.156274_bib132","doi-asserted-by":"crossref","DOI":"10.15190\/d.2023.18","article-title":"Role of C-reactive protein in disease progression, diagnosis and management","volume":"11","author":"Ali","year":"2023","journal-title":"Discov. (Craiova)"},{"key":"10.1016\/j.prp.2025.156274_bib133","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1080\/10408363.2022.2050886","article-title":"Systematic review and meta-analysis of C-reactive protein as a biomarker in breast cancer","volume":"59","author":"Mikkelsen","year":"2022","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.prp.2025.156274_bib134","first-page":"161","article-title":"C-reactive protein is a predictor of prognosis of prostate cancer: a systematic review and Meta-Analysis","volume":"50","author":"Liao","year":"2020","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.prp.2025.156274_bib135","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1237729","article-title":"C-reactive protein: a target for therapy to reduce inflammation","volume":"14","author":"Rizo-T\u00e9llez","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prp.2025.156274_bib136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00705-020-04860-8","article-title":"Tetracycline and viruses: a possible treatment for COVID-19?","volume":"166","author":"Mosquera-Sulbaran","year":"2020","journal-title":"Arch. Virol."},{"key":"10.1016\/j.prp.2025.156274_bib137","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2174\/1871526514666140827101231","article-title":"Antioxidant response of osteoblasts to doxycycline in an inflammatory model induced by C-reactive protein and interleukin-6","volume":"14","author":"Tilakaratne","year":"2014","journal-title":"Infect. Disord. Drug Targets"},{"key":"10.1016\/j.prp.2025.156274_bib138","article-title":"Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in db\/db mice","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2025.156274_bib139","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1042\/CS20110234","article-title":"Activator protein-1 (AP-1) signalling in human atherosclerosis: results of a systematic evaluation and intervention study","volume":"122","author":"Meijer","year":"2012","journal-title":"Clin. Sci. (Lond. )."},{"key":"10.1016\/j.prp.2025.156274_bib140","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1067\/mva.2001.117891","article-title":"Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study","volume":"34","author":"Mosorin","year":"2001","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.prp.2025.156274_bib141","doi-asserted-by":"crossref","first-page":"262","DOI":"10.14219\/jada.archive.2011.0165","article-title":"The effect of subantimicrobial- dose-doxycycline periodontal therapy on serum biomarkers of systemic inflammation: a randomized, doublemasked, placebo-controlled clinical trial","volume":"142","author":"Payne","year":"2011","journal-title":"J. Am. Dent. Assoc."},{"key":"10.1016\/j.prp.2025.156274_bib142","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000325206","article-title":"Angiotensin II induces the expression of c - reactive protein via MAPK-dependent signal pathway in U937 macrophages","volume":"27","author":"Li","year":"2011","journal-title":"Cell. Physiol. Biochem"},{"key":"10.1016\/j.prp.2025.156274_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106749","article-title":"Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19","volume":"86","author":"Zhang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.prp.2025.156274_bib144","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2017-221078","article-title":"GSK2586184, a JAK1 selective inhibitor, in two patients with ulcerative colitis","volume":"2017","author":"De Vries","year":"2017","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.prp.2025.156274_bib145","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0002-9343(01)01115-9","article-title":"Beta-blockers are associated with lower C-reactive protein concentrations in patients with coronary artery disease","volume":"112","author":"Jenkins","year":"2002","journal-title":"Am. J. Med."},{"key":"10.1016\/j.prp.2025.156274_bib146","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1081\/JDI-120039821","article-title":"Effects of cebecoxib on highsensitivity C-reactive protein in chronic peritoneal dialysis patients","volume":"26","author":"Kim","year":"2004","journal-title":"Ren. Fail"},{"key":"10.1016\/j.prp.2025.156274_bib147","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1111\/j.1538-7836.2004.01017.x","article-title":"CADET study investigators. A randomized comparison of the effects of aspirin and clopidogrel on thrombotic risk factors and C-reactive protein following myocardial infarction: the CADET trial","volume":"11","author":"Woodward","year":"2004","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.prp.2025.156274_bib148","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.amjcard.2005.01.092","article-title":"Comparison of the effects of ramipril versus telmisartan in reducing serum levels of high-sensitivity C-reactive protein and oxidized low-density lipoprotein cholesterol in patients with type 2 diabetes mellitus","volume":"95","author":"Koulouris","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.prp.2025.156274_bib149","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/jama.291.9.1132","article-title":"High-intensity statin treatment for coronary heart disease","volume":"291","author":"Sacks","year":"2004","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.prp.2025.156274_bib150","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0891-5849(00)00420-2","article-title":"Alpha-tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients","volume":"29","author":"Devaraj","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.prp.2025.156274_bib151","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.clinthera.2005.05.006","article-title":"Efficacy and tolerability of combination therapy with valsartan plus hydrochlorothiazide compared with amlodipine monotherapy in hypertensive patients with other cardiovascular risk factors: the VAST study","volume":"27","author":"Ruilope","year":"2005","journal-title":"Clin. Ther."},{"key":"10.1016\/j.prp.2025.156274_bib152","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/01.CIR.0000025403.20953.23","article-title":"Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus","volume":"106","author":"Haffner","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.prp.2025.156274_bib153","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1038\/s41598-024-52413-9","article-title":"Network pharmacology combined with experimental verification to explore the potential mechanism of naringenin in the treatment of cervical cancer","volume":"14","author":"Zhou","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2025.156274_bib154","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119126","article-title":"Chrysotoxine regulates ferroptosis and the PI3K\/AKT\/mTOR pathway to prevent cervical cancer","volume":"338","author":"Zhou","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.prp.2025.156274_bib155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2025.101322","article-title":"From foe to friend: rewiring oncogenic pathways through artificial selenoprotein to combat immune-resistant tumor","author":"You","year":"2025","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.prp.2025.156274_bib156","doi-asserted-by":"crossref","first-page":"5997","DOI":"10.1038\/s41467-025-61112-6","article-title":"Small-molecule-induced liquid-liquid phase separation suppresses the carcinogenesis of \u03b2-catenin","volume":"16","author":"Yan","year":"2025","journal-title":"Nat. Commun."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033825004674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033825004674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:21:04Z","timestamp":1763367664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033825004674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":156,"alternative-id":["S0344033825004674"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2025.156274","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of C-reactive protein in cervical intraepithelial neoplasia\/cancer","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2025.156274","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156274"}}