{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:28:52Z","timestamp":1791613732272,"version":"4.3.4"},"reference-count":155,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.prp.2025.156283","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T16:20:22Z","timestamp":1761841222000},"page":"156283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Staphylococcal enterotoxins in cancer immunotherapy: An overview of translational advances and targeting strategies"],"prefix":"10.1016","volume":"276","author":[{"given":"Abbas Ali Imani","family":"Fooladi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russel J.","family":"Reiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Alimohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najma","family":"Farahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiavash","family":"Hushmandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.prp.2025.156283_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s44276-025-00141-6","article-title":"Cancer risk according to lifestyle risk score trajectories: a population-based cohort study","volume":"3","author":"Khong","year":"2025","journal-title":"BJC Rep."},{"issue":"6","key":"10.1016\/j.prp.2025.156283_bib3","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3390\/nu16060800","article-title":"Healthy lifestyle and cancer risk: modifiable risk factors to prevent cancer","volume":"16","author":"Marino","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.prp.2025.156283_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2022.154241","article-title":"Recent progress in cancer immunotherapy: overview of current status and challenges","volume":"241","author":"Darvishi","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2025.156283_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2021.153723","article-title":"Cancer immunotherapy: challenges and limitations","volume":"229","author":"Taefehshokr","year":"2022","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2025.156283_bib6","article-title":"Cancer immunotherapy focusing on the role of interleukins: a comprehensive and updated study","volume":"249","author":"Samadi","year":"2023","journal-title":"Pathol. Res Pr."},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib7","article-title":"Immunological-based approaches for cancer therapy","volume":"73","author":"Barros","year":"2018","journal-title":"Clinics"},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib8","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41392-021-00729-7","article-title":"Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence","volume":"6","author":"Xu","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.prp.2025.156283_bib9","first-page":"154","article-title":"The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas","volume":"26","author":"McCarthy","year":"2006","journal-title":"Iowa Orthop. J."},{"issue":"3","key":"10.1016\/j.prp.2025.156283_bib10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1046\/j.1464-410x.2001.02306.x","article-title":"A systematic review of intravesical bacillus Calmette-Guerin plus transurethral resection vs transurethral resection alone in Ta and T1 bladder cancer","volume":"88","author":"Shelley","year":"2001","journal-title":"BJU Int"},{"issue":"7","key":"10.1016\/j.prp.2025.156283_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202003572","article-title":"Bacteria-based cancer immunotherapy","volume":"8","author":"Huang","year":"2021","journal-title":"Adv. Sci."},{"issue":"6","key":"10.1016\/j.prp.2025.156283_bib12","first-page":"648","article-title":"Staphylococcal enterotoxins as good candidates for cancer immunotherapy: a systematic review","volume":"32","author":"Shivaee","year":"2020","journal-title":"Ann. Ig."},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1128\/CMR.13.1.16","article-title":"Exotoxins of Staphylococcus aureus","volume":"13","author":"Dinges","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"issue":"2","key":"10.1016\/j.prp.2025.156283_bib14","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1128\/CMR.12.2.224","article-title":"Clinical, microbial, and biochemical aspects of the exfoliative toxins causing staphylococcal scalded-skin syndrome","volume":"12","author":"Ladhani","year":"1999","journal-title":"Clin. Microbiol. Rev."},{"issue":"2","key":"10.1016\/j.prp.2025.156283_bib15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0147-619X(02)00157-9","article-title":"Mobile genetic elements and bacterial toxinoses: the superantigen-encoding pathogenicity islands of Staphylococcus aureus","volume":"49","author":"Novick","year":"2003","journal-title":"Plasmid"},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib16","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1128\/IAI.71.5.2827-2838.2003","article-title":"Genome diversification in Staphylococcus aureus: Molecular evolution of a highly variable chromosomal region encoding the Staphylococcal exotoxin-like family of proteins","volume":"71","author":"Fitzgerald","year":"2003","journal-title":"Infect. Immun."},{"issue":"12","key":"10.1016\/j.prp.2025.156283_bib17","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1086\/420852","article-title":"International Nomenclature Committee for Staphylococcal S. Standard nomenclature for the superantigens expressed by Staphylococcus","volume":"189","author":"Lina","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.prp.2025.156283_bib18","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fcimb.2012.00052","article-title":"Staphylococcal superantigens in colonization and disease","volume":"2","author":"Xu","year":"2012","journal-title":"Front. Cell Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib19","first-page":"4070419","article-title":"Molecular mechanisms contributing bacterial infections to the incidence of various types of cancer","volume":"2020","author":"Sheweita","year":"2020","journal-title":"Mediat. Inflamm."},{"issue":"6","key":"10.1016\/j.prp.2025.156283_bib20","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00262-017-1980-4","article-title":"Lipoteichoic acids from Staphylococcus aureus stimulate proliferation of human non-small-cell lung cancer cells in vitro","volume":"66","author":"Hattar","year":"2017","journal-title":"Cancer Immunol. Immunother."},{"issue":"2","key":"10.1016\/j.prp.2025.156283_bib21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/mco2.22","article-title":"Pulmonary Staphylococcus aureus infection regulates breast cancer cell metastasis via neutrophil extracellular traps (NETs) formation","volume":"1","author":"Qi","year":"2020","journal-title":"MedComm"},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/cbf.3396","article-title":"Inflammatory activation of microglia by Staphylococcus aureus caused phenotypic alterations and affected glioblastoma growth","volume":"37","author":"Zhang","year":"2019","journal-title":"Cell Biochem. Funct."},{"issue":"8","key":"10.1016\/j.prp.2025.156283_bib23","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.4049\/jimmunol.166.8.5129","article-title":"Fibronectin binding protein A of Staphylococcus aureus can mediate human T lymphocyte adhesion and coactivation","volume":"166","author":"Miyamoto","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.prp.2025.156283_bib24","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.3389\/fmicb.2020.02054","article-title":"The multivalent role of fibronectin-binding proteins A and B (FnBPA and FnBPB) of staphylococcus aureus in host infections","volume":"11","author":"Speziale","year":"2020","journal-title":"Front. Microbiol."},{"issue":"10","key":"10.1016\/j.prp.2025.156283_bib25","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.vaccine.2016.01.022","article-title":"Expression of fibronectin binding protein A (FnBPA) from Staphylococcus aureus at the cell surface of Lactococcus lactis improves its immunomodulatory properties when used as protein delivery vector","volume":"34","author":"Almeida","year":"2016","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.prp.2025.156283_bib26","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/14786419.2019.1585843","article-title":"Anti-adhesive activity of Aframomum melegueta major phenolics on lower respiratory tract pathogens","volume":"35","author":"El Dine","year":"2021","journal-title":"Nat. Prod. Res."},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib27","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.bbrc.2007.03.143","article-title":"Inhibition of breast cancer cell adhesion and bone metastasis by the extracellular adherence protein of Staphylococcus aureus","volume":"357","author":"Schneider","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.prp.2025.156283_bib28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1574-6968.2008.01218.x","article-title":"Staphylococcus saprophyticus ATCC 15305 is internalized into human urinary bladder carcinoma cell line 5637","volume":"285","author":"Szabados","year":"2008","journal-title":"FEMS Microbiol. Lett."},{"issue":"66","key":"10.1016\/j.prp.2025.156283_bib29","doi-asserted-by":"crossref","first-page":"7301","DOI":"10.1039\/c3cc43424a","article-title":"Metabolic glycoengineering of Staphylococcus aureus reduces its adherence to human T24 bladder carcinoma cells","volume":"49","author":"Memmel","year":"2013","journal-title":"Chem. Commun."},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.canlet.2008.02.007","article-title":"alpha-Toxin of Staphylococcus aureus overcomes acquired cisplatin-resistance in malignant mesothelioma cells","volume":"265","author":"Johansson","year":"2008","journal-title":"Cancer Lett."},{"issue":"3","key":"10.1016\/j.prp.2025.156283_bib31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.34172\/bi.2020.23","article-title":"Designing a light-activated recombinant alpha hemolysin for colorectal cancer targeting","volume":"10","author":"Alizadeh","year":"2020","journal-title":"Bioimpacts"},{"issue":"8","key":"10.1016\/j.prp.2025.156283_bib32","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.biocel.2013.05.011","article-title":"LukS-PV induces mitochondrial-mediated apoptosis and G0\/G1 cell cycle arrest in human acute myeloid leukemia THP-1 cells","volume":"45","author":"Bu","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.prp.2025.156283_bib33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.biocel.2015.01.007","article-title":"LukS-PV, a component of Panton-Valentine leukocidin, exerts potent activity against acute myeloid leukemia in vitro and in vivo","volume":"61","author":"Shan","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"4","key":"10.1016\/j.prp.2025.156283_bib34","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.bbrc.2019.10.181","article-title":"LukS-PV induces cell cycle arrest and apoptosis through p38\/ERK MAPK signaling pathway in NSCLC cells","volume":"521","author":"Qiang","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib35","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1186\/s12885-022-09680-4","article-title":"LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression","volume":"22","author":"Xu","year":"2022","journal-title":"BMC Cancer"},{"issue":"3","key":"10.1016\/j.prp.2025.156283_bib36","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/CAD.0000000000000866","article-title":"Quantitative proteomic analysis reveals that Luks-PV exerts antitumor activity by regulating the key proteins and metabolic pathways in HepG2 cells","volume":"31","author":"Zhao","year":"2020","journal-title":"AntiCancer Drugs"},{"issue":"6","key":"10.1016\/j.prp.2025.156283_bib37","article-title":"Staphylococcal enterotoxins as good candidates for cancer immunotherapy: a systematic review","volume":"32","author":"Shivaee","year":"2020","journal-title":"Ann. di Ig. Med. Prev. e di Comunit\u00e0"},{"key":"10.1016\/j.prp.2025.156283_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.micres.2017.08.006","article-title":"Apoptosis induced by Staphylococcus aureus toxins","volume":"205","author":"Zhang","year":"2017","journal-title":"Microbiol. Res."},{"issue":"19","key":"10.1016\/j.prp.2025.156283_bib39","doi-asserted-by":"crossref","first-page":"8945","DOI":"10.1073\/pnas.91.19.8945","article-title":"Monoclonal antibody-superantigen fusion proteins: tumor-specific agents for T-cell-based tumor therapy","volume":"91","author":"Dohlsten","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"16","key":"10.1016\/j.prp.2025.156283_bib40","doi-asserted-by":"crossref","first-page":"6294","DOI":"10.1074\/jbc.RA118.006742","article-title":"Design of split superantigen fusion proteins for cancer immunotherapy","volume":"294","author":"Golob-Urbanc","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.prp.2025.156283_bib41","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/BF01521342","article-title":"Immunotherapy of human colon cancer by antibody-targeted superantigens","volume":"41","author":"Dohlsten","year":"1995","journal-title":"Cancer Immunol. Immunother."},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib42","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1007\/s13277-013-0847-3","article-title":"Target expression of Staphylococcus enterotoxin A from an oncolytic adenovirus suppresses mouse bladder tumor growth and recruits CD3+ T cell","volume":"34","author":"Han","year":"2013","journal-title":"Tumour Biol."},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib43","doi-asserted-by":"crossref","DOI":"10.5812\/jjm.27297","article-title":"Staphylococcus aureus enterotoxin B down-regulates the expression of transforming growth factor-beta (TGF-beta) signaling transducers in human glioblastoma","volume":"9","author":"Akbari","year":"2016","journal-title":"Jundishapur J. Microbiol."},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib44","first-page":"3565","article-title":"Superantigen-activated mononuclear cells induce apoptosis in transitional cell carcinoma","volume":"25","author":"Perabo","year":"2005","journal-title":"Anticancer Res."},{"issue":"2","key":"10.1016\/j.prp.2025.156283_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055892","article-title":"Evaluation of a recombinant double mutant of staphylococcal enterotoxin B (SEB-H32Q\/K173E) with enhanced antitumor activity effects and decreased pyrexia","volume":"8","author":"Gu","year":"2013","journal-title":"PLOS One"},{"issue":"12","key":"10.1016\/j.prp.2025.156283_bib46","first-page":"2718","article-title":"Clinical application of highly agglutinative staphylococcin in cancer treatment updates of the literature","volume":"20","author":"Tian","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"1-2","key":"10.1016\/j.prp.2025.156283_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-013-1561-6","article-title":"Cytotoxicity of lymphocytes activated by superantigen toxic-shock-syndrome toxin-1 against colorectal cancer LoVo cells","volume":"376","author":"Wang","year":"2013","journal-title":"Mol. Cell Biochem."},{"issue":"4-6","key":"10.1016\/j.prp.2025.156283_bib48","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2119\/2006-00011.Jiang","article-title":"Targeting of hepatoma cell and suppression of tumor growth by a novel 12mer peptide fused to superantigen TSST-1","volume":"12","author":"Jiang","year":"2006","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib49","first-page":"101","article-title":"Integrative analysis of lncRNAs in kidney cancer to discover a new lncRNA (LINC00847) as a therapeutic target for staphylococcal enterotoxin tst gene","volume":"22","author":"Safarpour-Dehkordi","year":"2020","journal-title":"Cell J."},{"issue":"4","key":"10.1016\/j.prp.2025.156283_bib50","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2114478119","article-title":"Engineered human antibodies for the opsonization and killing of Staphylococcus aureus","volume":"119","author":"Chen","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.prp.2025.156283_bib51","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.2147\/IJN.S112560","article-title":"Functionalized immunostimulating complexes with protein A via lipid vinyl sulfones to deliver cancer drugs to trastuzumab-resistant HER2-overexpressing breast cancer cells","volume":"11","author":"Rodriguez-Serrano","year":"2016","journal-title":"Int. J. Nanomed."},{"issue":"4","key":"10.1016\/j.prp.2025.156283_bib52","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.sjbs.2020.01.017","article-title":"Purification and characterization of anti-tubercular and anticancer protein from Staphylococcus hominis strain MANF2: In silico structural and functional insight of peptide","volume":"27","author":"Khusro","year":"2020","journal-title":"Saudi J. Biol. Sci."},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010850","article-title":"Bacteria peptidoglycan promoted breast cancer cell invasiveness and adhesiveness by targeting toll-like receptor 2 in the cancer cells","volume":"5","author":"Xie","year":"2010","journal-title":"PLOS One"},{"issue":"9","key":"10.1016\/j.prp.2025.156283_bib54","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw3915","article-title":"Comment on \u201cA commensal strain of Staphylococcus epidermidis protects against skin neoplasia\u201d by Nakatsuji et al","volume":"5","author":"Kozmin","year":"2019","journal-title":"Sci. Adv."},{"issue":"3","key":"10.1016\/j.prp.2025.156283_bib55","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s11626-015-9978-8","article-title":"Anti-breast cancer effects of live, heat-killed and cytoplasmic fractions of Enterococcus faecalis and Staphylococcus hominis isolated from human breast milk","volume":"52","author":"Hassan","year":"2016","journal-title":"Vitr. Cell Dev. Biol. Anim."},{"issue":"7","key":"10.1016\/j.prp.2025.156283_bib56","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.3390\/jcm11072030","article-title":"Staphylococcus aureus-derived extracellular vesicles enhance the efficacy of endocrine therapy in breast cancer cells","volume":"11","author":"An","year":"2022","journal-title":"J. Clin. Med"},{"issue":"4","key":"10.1016\/j.prp.2025.156283_bib57","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/ijc.20941","article-title":"Preclinical evaluation of superantigen (staphylococcal enterotoxin B) in the intravesical immunotherapy of superficial bladder cancer","volume":"115","author":"Perabo","year":"2005","journal-title":"Int. J. Cancer"},{"issue":"2","key":"10.1016\/j.prp.2025.156283_bib58","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aao4502","article-title":"A commensal strain of Staphylococcus epidermidis protects against skin neoplasia","volume":"4","author":"Nakatsuji","year":"2018","journal-title":"Sci. Adv."},{"issue":"9","key":"10.1016\/j.prp.2025.156283_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12090570","article-title":"Bacterial toxins, current perspectives","volume":"12","author":"Popoff","year":"2020","journal-title":"Toxins"},{"issue":"6","key":"10.1016\/j.prp.2025.156283_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10060247","article-title":"Staphylococcus aureus isolates from bovine mastitis in eight countries: genotypes, detection of genes encoding different toxins and other virulence genes","volume":"10","author":"Monistero","year":"2018","journal-title":"Toxins"},{"issue":"6","key":"10.1016\/j.prp.2025.156283_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10060252","article-title":"Staphylococcus aureus toxins and their molecular activity in infectious diseases","volume":"10","author":"Oliveira","year":"2018","journal-title":"Toxins"},{"issue":"6","key":"10.1016\/j.prp.2025.156283_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11060321","article-title":"Exploring the role of staphylococcus aureus toxins in atopic dermatitis","volume":"11","author":"Seiti Yamada Yoshikawa","year":"2019","journal-title":"Toxins"},{"issue":"6","key":"10.1016\/j.prp.2025.156283_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11060356","article-title":"An eye on staphylococcus aureus toxins: roles in ocular damage and inflammation","volume":"11","author":"Astley","year":"2019","journal-title":"Toxins"},{"issue":"6","key":"10.1016\/j.prp.2025.156283_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11060307","article-title":"Genotypes, enterotoxin gene profiles, and antimicrobial resistance of staphylococcus aureus associated with foodborne outbreaks in Hangzhou, China","volume":"11","author":"Chen","year":"2019","journal-title":"Toxins"},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10050190","article-title":"Novel botulinum neurotoxins: exploring underneath the iceberg tip","volume":"10","author":"Azarnia Tehran","year":"2018","journal-title":"Toxins"},{"issue":"7","key":"10.1016\/j.prp.2025.156283_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11070418","article-title":"Rapid detection of botulinum neurotoxins-a review","volume":"11","author":"Hobbs","year":"2019","journal-title":"Toxins"},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10050208","article-title":"The expanding therapeutic utility of botulinum neurotoxins","volume":"10","author":"Fonfria","year":"2018","journal-title":"Toxins"},{"issue":"2","key":"10.1016\/j.prp.2025.156283_bib68","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10020055","article-title":"Botulinum toxin A for sialorrhoea associated with neurological disorders: evaluation of the relationship between effect of treatment and the number of glands treated","volume":"10","author":"Restivo","year":"2018","journal-title":"Toxins"},{"issue":"6","key":"10.1016\/j.prp.2025.156283_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10060224","article-title":"Botulinum toxin for central neuropathic pain","volume":"10","author":"Park","year":"2018","journal-title":"Toxins"},{"issue":"8","key":"10.1016\/j.prp.2025.156283_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11080459","article-title":"Mechanisms of botulinum toxin type A in","volume":"11","author":"Matak","year":"2019","journal-title":"Toxins"},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib71","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11010021","article-title":"Central effects of botulinum neurotoxin-evidence from human studies","volume":"11","author":"Weise","year":"2019","journal-title":"Toxins"},{"issue":"9","key":"10.1016\/j.prp.2025.156283_bib72","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11090491","article-title":"Immunogenicity associated with botulinum toxin treatment","volume":"11","author":"Bellows","year":"2019","journal-title":"Toxins"},{"issue":"3","key":"10.1016\/j.prp.2025.156283_bib73","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11030181","article-title":"Molecular docking and dynamics simulation studies predict Munc18b as a Target of Mycolactone: A Plausible Mechanism for Granule Exocytosis Impairment in Buruli Ulcer Pathogenesis","volume":"11","author":"Kwofie","year":"2019","journal-title":"Toxins"},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10050212","article-title":"Mechanisms of action and cell death associated with clostridium perfringens toxins","volume":"10","author":"Navarro","year":"2018","journal-title":"Toxins"},{"issue":"4","key":"10.1016\/j.prp.2025.156283_bib75","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10040151","article-title":"Colibactin: more than a new bacterial toxin","volume":"10","author":"Fa\u00efs","year":"2018","journal-title":"Toxins"},{"issue":"4","key":"10.1016\/j.prp.2025.156283_bib76","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10040163","article-title":"Epidemiology of helicobacter pylori and CagA-positive infections and global variations in gastric cancer","volume":"10","author":"Park","year":"2018","journal-title":"Toxins"},{"issue":"6","key":"10.1016\/j.prp.2025.156283_bib77","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3390\/toxins5061140","article-title":"J. Staphylococcus aureus \u03b1-toxin: nearly a century of intrigue","volume":"5","author":"Berube","year":"2013","journal-title":"Toxins"},{"issue":"3","key":"10.1016\/j.prp.2025.156283_bib78","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3390\/toxins8030072","article-title":"Targeting Staphylococcus aureus toxins: a potential form of anti-virulence therapy","volume":"8","author":"Kong","year":"2016","journal-title":"Toxins"},{"issue":"4","key":"10.1016\/j.prp.2025.156283_bib79","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1083\/jcb.200105081","article-title":"\u03b1-Toxin is a mediator of Staphylococcus aureus\u2013induced cell death and activates caspases via the intrinsic death pathway independently of death receptor signaling","volume":"155","author":"Bantel","year":"2001","journal-title":"J. Cell Biol."},{"issue":"11","key":"10.1016\/j.prp.2025.156283_bib80","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/sj.cdd.4401301","article-title":"Staphylococcus aureus alpha-toxin-induced cell death: predominant necrosis despite apoptotic caspase activation","volume":"10","author":"Essmann","year":"2003","journal-title":"Cell Death Differ."},{"issue":"7","key":"10.1016\/j.prp.2025.156283_bib81","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006293","article-title":"Membrane bound monomer of Staphylococcal alpha-hemolysin induces caspase activation and apoptotic cell death despite initiation of membrane repair pathway","volume":"4","author":"Srivastava","year":"2009","journal-title":"PLOS One"},{"key":"10.1016\/j.prp.2025.156283_bib82","article-title":"Selective Host Cell Death by Staphylococcus aureus: a strategy for bacterial persistence","volume":"11","author":"Missiakas","year":"2020","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.prp.2025.156283_bib83","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1172\/JCI22684","article-title":"Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils","volume":"115","author":"Genestier","year":"2005","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib84","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1473-3099(12)70238-4","article-title":"The role of the Panton-Valentine leucocidin toxin in staphylococcal disease: a systematic review and meta-analysis","volume":"13","author":"Shallcross","year":"2013","journal-title":"Lancet Infect. Dis."},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib85","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25010395","article-title":"Molecular characteristics and pathogenicity of staphylococcus aureus exotoxins","volume":"25","author":"Zhu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.prp.2025.156283_bib86","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.5740\/jaoacint.13-211","article-title":"Screening, detection, and serotyping methods for toxin genes and enterotoxins in Staphylococcus strains","volume":"97","author":"Hait","year":"2014","journal-title":"J. AOAC Int."},{"issue":"10","key":"10.1016\/j.prp.2025.156283_bib87","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.imbio.2006.05.006","article-title":"The superantigen staphylococcal enterotoxin A (SEA) and monoclonal antibody L243 share a common epitope but differ in their ability to induce apoptosis via MHC-II","volume":"211","author":"Gross","year":"2006","journal-title":"Immunobiology"},{"key":"10.1016\/j.prp.2025.156283_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-384730-0.00319-0","article-title":"Detection of staphylococcal enterotoxins","author":"Le Loir","year":"2014","journal-title":"Encycl. Food Microbiol."},{"key":"10.1016\/j.prp.2025.156283_bib89","series-title":"Staphylococcus Aureus as A Leading Cause of Foodborne Outbreaks Worldwide. Staphylococcus Aureus","first-page":"129","author":"Hennekinne","year":"2018"},{"issue":"4","key":"10.1016\/j.prp.2025.156283_bib90","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3390\/toxins14040249","article-title":"Multiplex detection of 24 staphylococcal enterotoxins in culture supernatant using liquid chromatography coupled to high-resolution mass spectrometry","volume":"14","author":"Lefebvre","year":"2022","journal-title":"Toxins"},{"issue":"12","key":"10.1016\/j.prp.2025.156283_bib91","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1080\/10408398.2017.1289149","article-title":"Staphylococcal enterotoxins and enterotoxin-like toxins with special reference to dairy products: an overview","volume":"58","author":"Benkerroum","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.prp.2025.156283_bib92","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijfoodmicro.2017.05.023","article-title":"Molecular and epidemiological characterization of staphylococcal foodborne outbreak of Staphylococcus aureus harboring seg, sei, sem, sen, seo, and selu genes without production of classical enterotoxins","volume":"256","author":"Umeda","year":"2017","journal-title":"Int. J. Food Microbiol."},{"issue":"3","key":"10.1016\/j.prp.2025.156283_bib93","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1128\/jb.85.3.715-716.1963","article-title":"Designation of staphylococcal enterotoxins","volume":"85","author":"Casman","year":"1963","journal-title":"J. Bacteriol."},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib94","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3390\/toxins12050347","article-title":"Prevalence and genetic diversity of staphylococcal enterotoxin (-like) genes sey, selw, selx, selz, sel26 and sel27 in community-acquired methicillin-resistant staphylococcus aureus","volume":"12","author":"Aung","year":"2020","journal-title":"Toxins"},{"issue":"10","key":"10.1016\/j.prp.2025.156283_bib95","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00587-20","article-title":"Genome sequencing of a historic Staphylococcus aureus collection reveals new enterotoxin genes and sheds light on the evolution and genomic organization of this key virulence gene family","volume":"203","author":"Dicks","year":"2021","journal-title":"J. Bacteriol."},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib96","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1128\/jb.90.5.1481-1485.1965","article-title":"Identification of a new enterotoxin as enterotoxin C","volume":"90","author":"Bergdoll","year":"1965","journal-title":"J. Bacteriol."},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib97","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1021\/bi00857a034","article-title":"Amino acid composition and terminal amino acids of staphylococcal enterotoxin C","volume":"6","author":"Huang","year":"1967","journal-title":"Biochemistry"},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib98","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1021\/bi00857a032","article-title":"Purification and partial characterization of enterotoxin C produced by Staphylococcus aureus strain 137","volume":"6","author":"Borja","year":"1967","journal-title":"Biochemistry"},{"issue":"6","key":"10.1016\/j.prp.2025.156283_bib99","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1128\/jb.94.6.1875-1882.1967","article-title":"Identification of a fourth staphylococcal enterotoxin, enterotoxin D","volume":"94","author":"Casman","year":"1967","journal-title":"J. Bacteriol."},{"issue":"6","key":"10.1016\/j.prp.2025.156283_bib100","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1348-0421.1972.tb00688.x","article-title":"Staphylococcal enterotoxin D. Immunological identification with purified toxin","volume":"16","author":"Igarashi","year":"1972","journal-title":"Jpn J. Microbiol."},{"issue":"7","key":"10.1016\/j.prp.2025.156283_bib101","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1128\/IAI.66.7.3337-3348.1998","article-title":"Identification and characterization of staphylococcal enterotoxin types G and I from Staphylococcus aureus","volume":"66","author":"Munson","year":"1998","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib102","doi-asserted-by":"crossref","first-page":"669","DOI":"10.4049\/jimmunol.166.1.669","article-title":"egc, a highly prevalent operon of enterotoxin gene, forms a putative nursery of superantigens in Staphylococcus aureus","volume":"166","author":"Jarraud","year":"2001","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.prp.2025.156283_bib103","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ijfoodmicro.2013.05.023","article-title":"egc characterization of enterotoxigenic Staphylococcus aureus isolates obtained from raw milk and cheese","volume":"165","author":"Vi\u00e7osa","year":"2013","journal-title":"Int. J. Food Microbiol."},{"issue":"9","key":"10.1016\/j.prp.2025.156283_bib104","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006549","article-title":"Staphylococcal enterotoxin-like X (SElX) is a unique superantigen with functional features of two major families of staphylococcal virulence factors","volume":"13","author":"Langley","year":"2017","journal-title":"PLOS Pathog."},{"issue":"6","key":"10.1016\/j.prp.2025.156283_bib105","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1084\/jem.187.6.823","article-title":"A mutational analysis of the binding of staphylococcal enterotoxins B and C3 to the T cell receptor beta chain and major histocompatibility complex class II","volume":"187","author":"Leder","year":"1998","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.prp.2025.156283_bib106","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/1074-7613(95)90088-8","article-title":"Multiple binding sites for bacterial superantigens on soluble class II MHC molecules","volume":"3","author":"Kozono","year":"1995","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib107","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1128\/IAI.71.5.2916-2919.2003","article-title":"Characterization of Staphylococcus aureus enterotoxin L","volume":"71","author":"Orwin","year":"2003","journal-title":"Infect. Immun."},{"issue":"47","key":"10.1016\/j.prp.2025.156283_bib108","doi-asserted-by":"crossref","first-page":"14033","DOI":"10.1021\/bi025977q","article-title":"Characterization of a novel staphylococcal enterotoxin-like superantigen, a member of the group V subfamily of pyrogenic toxins","volume":"41","author":"Orwin","year":"2002","journal-title":"Biochemistry"},{"issue":"Pt 8","key":"10.1016\/j.prp.2025.156283_bib109","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1099\/mic.0.2007\/011874-0","article-title":"agr function in clinical Staphylococcus aureus isolates","volume":"154","author":"Traber","year":"2008","journal-title":"Microbiology"},{"issue":"2","key":"10.1016\/j.prp.2025.156283_bib110","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.GPP3-0031-2018","article-title":"Regulation of Staphylococcus aureus Virulence","volume":"7","author":"Jenul","year":"2019","journal-title":"Microbiol. Spectr."},{"issue":"2","key":"10.1016\/j.prp.2025.156283_bib111","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.femsre.2003.09.003","article-title":"Regulation of virulence determinants in Staphylococcus aureus: complexity and applications","volume":"28","author":"Bronner","year":"2004","journal-title":"FEMS Microbiol. Rev."},{"issue":"8","key":"10.1016\/j.prp.2025.156283_bib112","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.fm.2009.06.007","article-title":"Differential temporal expression of the staphylococcal enterotoxins genes during cell growth","volume":"26","author":"Derzelle","year":"2009","journal-title":"Food Microbiol."},{"issue":"12","key":"10.1016\/j.prp.2025.156283_bib113","doi-asserted-by":"crossref","first-page":"5359","DOI":"10.3390\/toxins7124889","article-title":"Prophage-encoded staphylococcal enterotoxin a: regulation of production in staphylococcus aureus strains representing different sea regions","volume":"7","author":"Zeaki","year":"2015","journal-title":"Toxins"},{"issue":"23","key":"10.1016\/j.prp.2025.156283_bib114","doi-asserted-by":"crossref","first-page":"6841","DOI":"10.1128\/JB.185.23.6841-6851.2003","article-title":"Transcription of the toxin genes present within the staphylococcal phage \u03c6Sa3ms is intimately linked with the phage's life cycle","volume":"185","author":"Sumby","year":"2003","journal-title":"J. Bacteriol."},{"issue":"1-3","key":"10.1016\/j.prp.2025.156283_bib115","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s12026-014-8539-7","article-title":"Staphylococcal superantigens interact with multiple host receptors to cause serious diseases","volume":"59","author":"Stach","year":"2014","journal-title":"Immunol. Res."},{"issue":"3","key":"10.1016\/j.prp.2025.156283_bib116","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1574-695X.2011.00924.x","article-title":"Submucosal mast cells in the gastrointestinal tract are a target of staphylococcal enterotoxin type A","volume":"64","author":"Ono","year":"2012","journal-title":"FEMS Immunol. Med. Microbiol."},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib117","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007803","article-title":"Histamine release from intestinal mast cells induced by staphylococcal enterotoxin A (SEA) evokes vomiting reflex in common marmoset","volume":"15","author":"Ono","year":"2019","journal-title":"PLOS Pathog."},{"issue":"9","key":"10.1016\/j.prp.2025.156283_bib118","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrmicro3521","article-title":"Staphylococcal manipulation of host immune responses","volume":"13","author":"Thammavongsa","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib119","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s44149-021-00007-7","article-title":"Update on molecular diversity and multipathogenicity of staphylococcal superantigen toxins","volume":"1","author":"Hu","year":"2021","journal-title":"Anim. Dis."},{"issue":"7","key":"10.1016\/j.prp.2025.156283_bib120","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.14202\/vetworld.2022.1765-1771","article-title":"Cellular immune response of Staphylococcus aureus enterotoxin B in Balb\/c mice through intranasal infection","volume":"15","author":"Purwanasari","year":"2022","journal-title":"Vet. World"},{"issue":"7","key":"10.1016\/j.prp.2025.156283_bib121","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/1873-3468.14292","article-title":"Analyses of the complex formation of staphylococcal enterotoxin A and the human gp130 cytokine receptor","volume":"596","author":"Uzuncayir","year":"2022","journal-title":"FEBS Lett."},{"issue":"4","key":"10.1016\/j.prp.2025.156283_bib122","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/j.1365-2672.2007.03356.x","article-title":"Virulence genes of bovine Staphylococcus aureus from persistent and nonpersistent intramammary infections with different clinical characteristics","volume":"103","author":"Haveri","year":"2007","journal-title":"J. Appl. Microbiol."},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib123","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3168\/jds.2014-8044","article-title":"Genotypic and phenotypic characterization of Staphylococcus aureus causing persistent and nonpersistent subclinical bovine intramammary infections during lactation or the dry period","volume":"98","author":"Veh","year":"2015","journal-title":"J. Dairy Sci."},{"issue":"12","key":"10.1016\/j.prp.2025.156283_bib124","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.3390\/toxins6123552","article-title":"Staphylococcal enterotoxin H induced apoptosis of bovine mammary epithelial cells in vitro","volume":"6","author":"Liu","year":"2014","journal-title":"Toxins"},{"issue":"3","key":"10.1016\/j.prp.2025.156283_bib125","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3390\/toxins11030141","article-title":"Staphylococcal enterotoxin C is an important virulence factor for mastitis","volume":"11","author":"Fang","year":"2019","journal-title":"Toxins"},{"issue":"11","key":"10.1016\/j.prp.2025.156283_bib126","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00505-18","article-title":"Bovine Staphylococcus aureus superantigens stimulate the entire T cell repertoire of cattle","volume":"86","author":"Wilson","year":"2018","journal-title":"Infect. Immun."},{"issue":"10","key":"10.1016\/j.prp.2025.156283_bib127","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1128\/iai.65.10.4048-4054.1997","article-title":"Vbeta-dependent stimulation of bovine and human T cells by host-specific staphylococcal enterotoxins","volume":"65","author":"Deringer","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.prp.2025.156283_bib128","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.3389\/fimmu.2019.03008","article-title":"egc superantigens impair monocytes\/macrophages inducing cell death and inefficient activation","volume":"10","author":"Noli Truant","year":"2019","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.prp.2025.156283_bib129","doi-asserted-by":"crossref","first-page":"8350","DOI":"10.3168\/jds.2019-17444","article-title":"Staphylococcal enterotoxin M induced inflammation and impairment of bovine mammary epithelial cells","volume":"103","author":"Zhao","year":"2020","journal-title":"J. Dairy Sci."},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib130","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.prp.2025.156283_bib131","doi-asserted-by":"crossref","DOI":"10.4178\/epih.e2017006","article-title":"Cancer mortality-to-incidence ratio as an indicator of cancer management outcomes in organization for economic cooperation and development countries","volume":"39","author":"Choi","year":"2017","journal-title":"Epidemiol. Health"},{"key":"10.1016\/j.prp.2025.156283_bib132","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jcpo.2017.05.004","article-title":"Towards sustainable cancer care: reducing inefficiencies, improving outcomes\u2014a policy report from the All. Can initiative","volume":"13","author":"Wait","year":"2017","journal-title":"J. Cancer Policy"},{"issue":"20","key":"10.1016\/j.prp.2025.156283_bib133","first-page":"4702","article-title":"Treatment of intracranial tumors by systemic transfer of superantigen-activated tumor-draining lymph node T cells","volume":"56","author":"Inoue","year":"1996","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.prp.2025.156283_bib134","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/cmi.2015.88","article-title":"Inhibition of squamous cancer growth in a mouse model by Staphylococcal enterotoxin B-triggered Th9 cell expansion","volume":"14","author":"Miao","year":"2017","journal-title":"Cell Mol. Immunol."},{"issue":"4","key":"10.1016\/j.prp.2025.156283_bib135","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1007\/s13277-015-4334-x","article-title":"Tagging staphylococcal enterotoxin B (SEB) with TGFaL3 for breast cancer therapy","volume":"37","author":"Yousefi","year":"2016","journal-title":"Tumour Biol."},{"issue":"2","key":"10.1016\/j.prp.2025.156283_bib136","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.juro.2011.10.022","article-title":"Anti-angiogenic effects of the superantigen staphylococcal enterotoxin B and bacillus Calmette-Guerin immunotherapy for nonmuscle invasive bladder cancer","volume":"187","author":"Reis","year":"2012","journal-title":"J. Urol."},{"key":"10.1016\/j.prp.2025.156283_bib137","article-title":"Effects of Staphylococcus aureus enterotoxin type A on inducing the apoptosis in cervical cancer cell line","volume":"25","author":"Afzali","year":"2021","journal-title":"Gene Rep."},{"issue":"25","key":"10.1016\/j.prp.2025.156283_bib138","doi-asserted-by":"crossref","first-page":"4116","DOI":"10.1200\/JCO.2008.20.2515","article-title":"Phase I dose escalation, pharmacokinetic and pharmacodynamic study of naptumomab estafenatox alone in patients with advanced cancer and with docetaxel in patients with advanced non-small-cell lung cancer","volume":"27","author":"Borghaei","year":"2009","journal-title":"J. Clin. Oncol."},{"issue":"13","key":"10.1016\/j.prp.2025.156283_bib139","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1158\/1078-0432.CCR-15-0580","article-title":"A Randomized phase II\/III study of naptumomab estafenatox + IFN\u03b1 versus IFN\u03b1 in renal cell carcinoma: final analysis with baseline biomarker subgroup and trend analysis","volume":"22","author":"Hawkins","year":"2016","journal-title":"Clin. Cancer Res."},{"issue":"12","key":"10.1016\/j.prp.2025.156283_bib140","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1007\/s10529-008-9805-3","article-title":"In vivo induction of necrosis in mice fibrosarcoma via intravenous injection of type B staphylococcal enterotoxin","volume":"30","author":"Fooladi","year":"2008","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.prp.2025.156283_bib141","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10989-017-9595-3","article-title":"In silico analyses of staphylococcal enterotoxin B as a DNA vaccine for cancer therapy","volume":"24","author":"Jahangiri","year":"2018","journal-title":"Int. J. Pept. Res. Ther."},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib142","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1084\/jem.167.5.1697","article-title":"T cell stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells","volume":"167","author":"Fleischer","year":"1988","journal-title":"J. Exp. Med"},{"issue":"2","key":"10.1016\/j.prp.2025.156283_bib143","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1128\/AAC.45.2.460-463.2001","article-title":"Human antibodies to bacterial superantigens and their ability to inhibit T-cell activation and lethality","volume":"45","author":"LeClaire","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib144","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1084\/jem.190.1.53","article-title":"Anergy and cytokine-mediated suppression as distinct superantigen-induced tolerance mechanisms in vivo","volume":"190","author":"Miller","year":"1999","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.prp.2025.156283_bib145","doi-asserted-by":"crossref","first-page":"9737","DOI":"10.1074\/jbc.M110.212407","article-title":"Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock","volume":"286","author":"Varshney","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.prp.2025.156283_bib146","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/nrmicro2383","article-title":"Protein glycosylation in bacteria: sweeter than ever","volume":"8","author":"Nothaft","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib147","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jmb.2003.09.009","article-title":"Identification of the antigenic epitopes in staphylococcal enterotoxins A and E and design of a superantigen for human cancer therapy","volume":"333","author":"Erlandsson","year":"2003","journal-title":"J. Mol. Biol."},{"issue":"13","key":"10.1016\/j.prp.2025.156283_bib148","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1093\/emboj\/20.13.3306","article-title":"Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence","volume":"20","author":"Petersson","year":"2001","journal-title":"Embo J."},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib149","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/jmbi.2000.3725","article-title":"Conservation and variation in superantigen structure and activity highlighted by the three-dimensional structures of two new superantigens from Streptococcus pyogenes","volume":"299","author":"Arcus","year":"2000","journal-title":"J. Mol. Biol."},{"issue":"13","key":"10.1016\/j.prp.2025.156283_bib150","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1002\/j.1460-2075.1995.tb07300.x","article-title":"Characterization of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A","volume":"14","author":"Abrahms\u00e9n","year":"1995","journal-title":"Embo J."},{"issue":"1","key":"10.1016\/j.prp.2025.156283_bib151","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1006\/jmbi.1997.1577","article-title":"Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5 A resolution: implications for superantigen recognition by MHC class II molecules and T-cell receptors","volume":"277","author":"Papageorgiou","year":"1998","journal-title":"J. Mol. Biol."},{"issue":"3","key":"10.1016\/j.prp.2025.156283_bib152","first-page":"1622","article-title":"Superantigens, superantigen-like proteins and superantigen derivatives for cancer treatment","volume":"25","author":"Chen","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"5","key":"10.1016\/j.prp.2025.156283_bib153","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1182\/blood-2014-01-551184","article-title":"Staphylococcal enterotoxins stimulate lymphoma-associated immune dysregulation","volume":"124","author":"Krejsgaard","year":"2014","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.prp.2025.156283_bib154","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF01744942","article-title":"Bacterial superantigens as anti-tumour agents: induction of tumour cytotoxicity in human lymphocytes by staphylococcal enterotoxin A","volume":"33","author":"Lando","year":"1991","journal-title":"Cancer Immunol. Immunother."},{"issue":"15","key":"10.1016\/j.prp.2025.156283_bib155","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1182\/blood.2023021671","article-title":"Staphylococcus aureus induces drug resistance in cancer T cells in Sezary syndrome","volume":"143","author":"Vadivel","year":"2024","journal-title":"Blood"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033825004765?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033825004765?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:20:42Z","timestamp":1763367642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033825004765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":155,"alternative-id":["S0344033825004765"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2025.156283","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Staphylococcal enterotoxins in cancer immunotherapy: An overview of translational advances and targeting strategies","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2025.156283","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156283"}}