{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:21:16Z","timestamp":1767993676580,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","award":["2024SRP071"],"award-info":[{"award-number":["2024SRP071"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2023A03J0814"],"award-info":[{"award-number":["2023A03J0814"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.prp.2025.156329","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T16:45:01Z","timestamp":1765471501000},"page":"156329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Primary Rosai-Dorfman disease of lung and mediastinum: A clinicopathological and immunohistochemical study of five cases"],"prefix":"10.1016","volume":"278","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9630-9034","authenticated-orcid":false,"given":"Jilong","family":"Qin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Sing","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xina","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2025.156329_bib1","first-page":"63","article-title":"Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity","volume":"87","author":"Rosai","year":"1969","journal-title":"Arch. Pathol."},{"key":"10.1016\/j.prp.2025.156329_bib2","unstructured":"Y. Natkunam, S. Rossi, E.G. Demicco, B. Wilheim, H. Zelger, B.M. Wenig, et al., Histiocytic\/Dendritic cell neoplasms - Rosai-Dorfman Disease. In: Chan J., Coupland S.E. (eds). WHO Classification of Haematolymphoid Tumours, 5th edition, 2024. pp. 660\u2013679."},{"key":"10.1016\/j.prp.2025.156329_bib3","article-title":"Tracheobronchial involvement of rosai-dorfman disease: case report and review of the literature","volume":"95","author":"Boissi\u00e8re","year":"2016","journal-title":"Medicine"},{"key":"10.1016\/j.prp.2025.156329_bib4","unstructured":"K. El-Kersh, R.L. Perez, J. Guardiola, Pulmonary IgG4+ Rosai-Dorfman disease, BMJ Case Rep. 2013 (2013) bcr2012008324. https:\/\/doi: 10.1136\/bcr-2012-008324."},{"key":"10.1016\/j.prp.2025.156329_bib5","first-page":"927","article-title":"Unusual life-threatening Rosai-Dorfman disease of the trachea: role of NF-\u03baB","volume":"65","author":"Zhou","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.prp.2025.156329_bib6","first-page":"37","article-title":"Rosai-Dorfman disease with pulmonary involve-ment mimicking bronchogenic carcinoma","volume":"15","author":"Al-Maghrabi","year":"2020","journal-title":"J. Cardiothorac. Surg."},{"key":"10.1016\/j.prp.2025.156329_bib7","first-page":"212","article-title":"An extremely rare case of Rosai-Dorfman disease in the thymus","volume":"16","author":"Shen","year":"2021","journal-title":"J. Cardiothorac. Surg."},{"key":"10.1016\/j.prp.2025.156329_bib8","first-page":"61","article-title":"Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): a rare case of subglottic narrowing","volume":"106","author":"Courteney-Harris","year":"1992","journal-title":"J. Laryngol. Otol."},{"key":"10.1016\/j.prp.2025.156329_bib9","first-page":"937","article-title":"Rosai-dorfman disease of the lung overlapping with IgG4-related disease: the difficulty in its differential diagnosis","volume":"56","author":"Hasegawa","year":"2017","journal-title":"Intern Med."},{"key":"10.1016\/j.prp.2025.156329_bib10","article-title":"Primary Rosai-Dorfman disease of the thymus and lung: a clinicopathological and immunohistochemical study of three cases","volume":"234","author":"Oramas","year":"2022","journal-title":"Pathol. Res. Pr."},{"key":"10.1016\/j.prp.2025.156329_bib11","first-page":"82","article-title":"Primary diffuse Rosai-Dorfman disease in central airway: a case report and literature review","volume":"23","author":"Wu","year":"2023","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.prp.2025.156329_bib12","first-page":"166","article-title":"Mediastinal Rosai-Dorfman disease with KRAS mutation case report and literature review","volume":"19","author":"Zhang","year":"2024","journal-title":"J. Cardiothorac. Surg."},{"key":"10.1016\/j.prp.2025.156329_bib13","first-page":"284","article-title":"Primary unifocal thymic Rosai-Dorfman disease: an extremely rare challenge in diagnostic practice","volume":"18","author":"Liu","year":"2023","journal-title":"J. Cardiothorac. Surg."},{"key":"10.1016\/j.prp.2025.156329_bib14","first-page":"173","article-title":"Rosai-Dorfman disease manifesting as a solitary mass with fat in the thymus a case report","volume":"19","author":"Liu","year":"2024","journal-title":"J. Cardiothorac. Surg."},{"key":"10.1016\/j.prp.2025.156329_bib15","first-page":"351","article-title":"Thymic Rosai-Dorfmann disease: a case report","volume":"19","author":"Liu","year":"2024","journal-title":"J. Cardiothorac. Surg."},{"key":"10.1016\/j.prp.2025.156329_bib16","first-page":"1","article-title":"How i diagnose Rosai-Dorfman disease","volume":"160","author":"Ravindran","year":"2023","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.prp.2025.156329_bib17","first-page":"908","article-title":"Rosai-Dorfman disease of the lung","volume":"64","author":"Ali","year":"2009","journal-title":"Thorax"},{"key":"10.1016\/j.prp.2025.156329_bib18","article-title":"Rosai-Dorfman disease differentiated from a posterior mediastinal tumour: a case report","volume":"2024","author":"Hirai","year":"2024","journal-title":"J. Surg. Case Rep."},{"key":"10.1016\/j.prp.2025.156329_bib19","first-page":"717","article-title":"Soft tissue Rosai-Dorfman disease of the posterior mediastinum","volume":"35","author":"Costa","year":"2009","journal-title":"J. Bras. Pneumol."},{"key":"10.1016\/j.prp.2025.156329_bib20","first-page":"132","article-title":"Rosai-Dorfman disease of the trachea: an extremely rare benign tumor","volume":"27","author":"Santosham","year":"2019","journal-title":"Asian Cardiovasc. Thorac. Ann."},{"key":"10.1016\/j.prp.2025.156329_bib21","article-title":"Rosai-Dorfman disease: rare presentation as isolated mediastinal and hilar lymphadenopathy","volume":"10","author":"Lateef","year":"2018","journal-title":"Cureus"},{"key":"10.1016\/j.prp.2025.156329_bib22","first-page":"1344","article-title":"Intrathoracic manifestations of Rosai-Dorfman disease","volume":"104","author":"Cartin-Ceba","year":"2010","journal-title":"Respir. Med"},{"key":"10.1016\/j.prp.2025.156329_bib23","first-page":"19","article-title":"Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity","volume":"7","author":"Foucar","year":"1990","journal-title":"Semin Diagn. Pathol."},{"key":"10.1016\/j.prp.2025.156329_bib24","first-page":"1","article-title":"Diagnostic value of endobronchial ultrasound-guided intranodal forceps biopsies combined with rapid on-site evaluation for mediastinal\/hilar lymph node disease","volume":"85","author":"Wang","year":"2024","journal-title":"Br. J. Hosp. Med."},{"key":"10.1016\/j.prp.2025.156329_bib25","first-page":"35","article-title":"Mayo clinic histiocytosis working group. Rosai-Dorfman disease displays a unique monocyte-macrophage phenotype characterized by expression of OCT2","volume":"45","author":"Ravindran","year":"2021","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.prp.2025.156329_bib26","first-page":"527","article-title":"Rosai-Dorfman disease between proliferation and neoplasia","volume":"14","author":"Elbaz","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.prp.2025.156329_bib27","first-page":"1367","article-title":"Mutually exclusive recurrent KRAS and MAP2K1 mutations in Rosai-Dorfman disease","volume":"30","author":"Garces","year":"2017","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.prp.2025.156329_bib28","first-page":"837","article-title":"Cyclin D1 expression and novel mutational findings in Rosai-Dorfman disease","volume":"186","author":"Baraban","year":"2019","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.prp.2025.156329_bib29","first-page":"36","article-title":"Cyclin D1 expression in Rosai-Dorfman disease: a near-constant finding that is not invariably associated with mitogen-activated protein kinase\/extracellular signal-regulated kinase pathway activation","volume":"121","author":"Garces","year":"2022","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.prp.2025.156329_bib30","first-page":"183","article-title":"Immunohistological recognition of cyclin D1 expression by non-lymphoid cells among lymphoid neoplastic cells","volume":"122","author":"Abdulla","year":"2014","journal-title":"APMIS"},{"key":"10.1016\/j.prp.2025.156329_bib31","first-page":"396","article-title":"NRAS mutations may be involved in the pathogenesis of cutaneous Rosai Dorfman disease: a pilot study","volume":"10","author":"Wu","year":"2021","journal-title":"Biology"},{"key":"10.1016\/j.prp.2025.156329_bib32","first-page":"394","article-title":"Rosai-Dorfman disease harboring an activating KRAS K117N missense mutation","volume":"10","author":"Shanmugam","year":"2016","journal-title":"Head. Neck Pathol."},{"key":"10.1016\/j.prp.2025.156329_bib33","article-title":"Cigarette smoke extract-treated mouse airway epithelial cells-derived exosomal LncRNA MEG3 promotes M1 macrophage polarization and pyroptosis in chronic obstructive pulmonary disease by upregulating TREM-1 via m6A methylation","volume":"24","author":"Wang","year":"2024","journal-title":"Immune Netw."},{"key":"10.1016\/j.prp.2025.156329_bib34","first-page":"5516","article-title":"Protection against cigarette smoke-induced chronic obstructive pulmonary disease via activation of the SIRT1\/FoxO1 axis by targeting microRNA-132","volume":"16","author":"Shen","year":"2024","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.prp.2025.156329_bib35","first-page":"1213","article-title":"IgG4-related disease and Rosai-Dorfman-Destombes disease","volume":"398","author":"Chen","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.prp.2025.156329_bib36","first-page":"16","article-title":"Focal Rosai-Dorfman disease coexisting with lymphoma in the same anatomic site: a localized histiocytic proliferation associ-ated with MAPK\/ERK pathway activation","volume":"32","author":"Garces","year":"2019","journal-title":"Mod. Pathol."},{"issue":"63","key":"10.1016\/j.prp.2025.156329_bib37","article-title":"Phenotypic intrafamilial variability including H syndrome and Rosai-Dorfman disease associated with the same c.1088G > A mutation in the SLC29A3 gene","volume":"15","author":"Chouk","year":"2021","journal-title":"Hum. Genom."},{"key":"10.1016\/j.prp.2025.156329_bib38","first-page":"62","article-title":"Systemic histiocytosis (Langerhans Cell Histiocytosis, Erdheim-Chester Disease, Destombes-Rosai-Dorfman Disease): from oncogenic mutations to inflamma-tory disorders","volume":"21","author":"Papo","year":"2019","journal-title":"Curr. Oncol. Rep."},{"key":"10.1016\/j.prp.2025.156329_bib39","first-page":"5531","article-title":"Extranodal rosai-dorfman disease of the bone treated with surgery and radiotherapy","volume":"6","author":"Paryani","year":"2014","journal-title":"Rare Tumors"},{"key":"10.1016\/j.prp.2025.156329_bib40","first-page":"323","article-title":"Lung involvement in destombes-Rosai-Dorfman disease: clinical and radiological features and response to the MEK inhibitor cobimetinib","volume":"157","author":"Moyon","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.prp.2025.156329_bib41","first-page":"95","article-title":"Ceftazidime\/avibactam versus polymyxin B in carbapenem-resistant Klebsiella pneumoniae infections: a propensity score-matched multicenter real-world study","volume":"53","author":"Zhuang","year":"2025","journal-title":"Infection"},{"key":"10.1016\/j.prp.2025.156329_bib42","first-page":"238","article-title":"Lnc-TMEM132D-AS1 as a potential therapeutic target for acquired resistance to osimertinib in non-small-cell lung cancer","volume":"19","author":"Wang","year":"2023","journal-title":"Mol. Omics"},{"key":"10.1016\/j.prp.2025.156329_bib43","article-title":"CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1\/ECT2 pathway","volume":"154","author":"Wen","year":"2023","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.prp.2025.156329_bib44","article-title":"COPZ1 regulates ferroptosis through NCOA4-mediated ferritinophagy in lung adenocarcinoma","volume":"1868","author":"Wu","year":"2024","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.prp.2025.156329_bib45","first-page":"1046","article-title":"Elucidating the mechanism of buyanghuanwu decoction acting on pulmonary fibrosis based on network pharmacology and animal studies","volume":"27","author":"Xing","year":"2024","journal-title":"Comb. Chem. High. Throughput Screen"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033825005229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033825005229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:39:46Z","timestamp":1767973186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033825005229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":45,"alternative-id":["S0344033825005229"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2025.156329","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Primary Rosai-Dorfman disease of lung and mediastinum: A clinicopathological and immunohistochemical study of five cases","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2025.156329","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"156329"}}