{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:11:24Z","timestamp":1771546284686,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.prp.2026.156362","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:59:50Z","timestamp":1768291190000},"page":"156362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Trilobatin ameliorates ulcerative colitis by reducing inflammation and enhancing intestinal barrier function via regulating HMGB1-mediated TLR4\/NF-\u03baB signaling pathway"],"prefix":"10.1016","volume":"280","author":[{"given":"Tao","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2026.156362_bib1","doi-asserted-by":"crossref","unstructured":"Kang, C., et al., Colon-Targeted Trans-Cinnamic Acid Ameliorates Rat Colitis by Activating GPR109A. 2022. 15(1).","DOI":"10.3390\/pharmaceutics15010041"},{"key":"10.1016\/j.prp.2026.156362_bib2","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.biopha.2018.12.063","article-title":"CTGF-mediated ERK signaling pathway influences the inflammatory factors and intestinal flora in ulcerative colitis","volume":"111","author":"Song","year":"2019","journal-title":"Biomed. Pharm."},{"issue":"4","key":"10.1016\/j.prp.2026.156362_bib3","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/ecco-jcc\/jjy181","article-title":"A molecular targeted immunotherapeutic strategy for ulcerative colitis via dual-targeting nanoparticles delivering miR-146b to intestinal macrophages","volume":"13","author":"Deng","year":"2019","journal-title":"J. Crohns Colitis"},{"issue":"11","key":"10.1016\/j.prp.2026.156362_bib4","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1093\/ibd\/izz066","article-title":"Improving the quality of inpatient ulcerative colitis management: promoting evidence-based practice and reducing care variation with an inpatient protocol","volume":"25","author":"Lewin","year":"2019","journal-title":"Inflamm. Bowel Dis."},{"issue":"9","key":"10.1016\/j.prp.2026.156362_bib5","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3748\/wjg.v25.i9.1142","article-title":"Conventional therapy for moderate to severe inflammatory bowel disease: a systematic literature review","volume":"25","author":"Dami\u00e3o","year":"2019","journal-title":"World J. Gastroenterol."},{"issue":"12","key":"10.1016\/j.prp.2026.156362_bib6","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1080\/17474124.2018.1545574","article-title":"Adverse events in IBD therapy: the 2018 update","volume":"12","author":"Quezada","year":"2018","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.prp.2026.156362_bib7","article-title":"Trilobatin, a natural food additive, exerts anti-type 2 diabetes effect mediated by Nrf2\/ARE and IRS-1\/GLUT2 signaling pathways","volume":"13","author":"Shi","year":"2022","journal-title":"Front Pharm."},{"key":"10.1016\/j.prp.2026.156362_bib8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3389\/fnmol.2018.00267","article-title":"Trilobatin protects against oxidative injury in neuronal PC12 cells through regulating mitochondrial ROS homeostasis mediated by AMPK\/Nrf2\/Sirt3 signaling pathway","volume":"11","author":"Gao","year":"2018","journal-title":"Front Mol. Neurosci."},{"key":"10.1016\/j.prp.2026.156362_bib9","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.foodchem.2014.06.022","article-title":"Trilobatin attenuates the LPS-mediated inflammatory response by suppressing the NF-\u03baB signaling pathway","volume":"166","author":"Fan","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.prp.2026.156362_bib10","doi-asserted-by":"crossref","unstructured":"He, X.Q., et al., Prevention of Ulcerative Colitis in Mice by Sweet Tea (Lithocarpus litseifolius) via the Regulation of Gut Microbiota and Butyric-Acid-Mediated Anti-Inflammatory Signaling. 2022. 14(11).","DOI":"10.3390\/nu14112208"},{"issue":"10","key":"10.1016\/j.prp.2026.156362_bib11","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/aps.2017.185","article-title":"Artemisinin analogue SM934 ameliorates DSS-induced mouse ulcerative colitis via suppressing neutrophils and macrophages","volume":"39","author":"Yan","year":"2018","journal-title":"Acta Pharm. Sin."},{"issue":"6","key":"10.1016\/j.prp.2026.156362_bib12","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/s41401-019-0335-4","article-title":"Oroxindin inhibits macrophage NLRP3 inflammasome activation in DSS-induced ulcerative colitis in mice via suppressing TXNIP-dependent NF-\u03baB pathway","volume":"41","author":"Liu","year":"2020","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.prp.2026.156362_bib13","doi-asserted-by":"crossref","unstructured":"Ding, A. and X. Wen, Dandelion root extract protects NCM460 colonic cells and relieves experimental mouse colitis. 2018. 72(4): p. 857-866.","DOI":"10.1007\/s11418-018-1217-7"},{"issue":"18","key":"10.1016\/j.prp.2026.156362_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24183390","article-title":"Trilobatin, a novel SGLT1\/2 inhibitor, selectively induces the proliferation of human hepatoblastoma cells","volume":"24","author":"Wang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.prp.2026.156362_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175291","article-title":"Trilobatin alleviates non-alcoholic fatty liver disease in high-fat diet plus streptozotocin-induced diabetic mice by suppressing NLRP3 inflammasome activation","volume":"933","author":"Zhang","year":"2022","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.prp.2026.156362_bib16","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ebiom.2019.06.033","article-title":"Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway","volume":"45","author":"Nunes","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.prp.2026.156362_bib17","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.ijbiomac.2020.10.259","article-title":"Scutellaria baicalensis Georgi polysaccharide ameliorates DSS-induced ulcerative colitis by improving intestinal barrier function and modulating gut microbiota","volume":"166","author":"Cui","year":"2021","journal-title":"Int J. Biol. Macromol."},{"key":"10.1016\/j.prp.2026.156362_bib18","doi-asserted-by":"crossref","unstructured":"Yin, S., et al., Artesunate ameliorates DSS-induced ulcerative colitis by protecting intestinal barrier and inhibiting inflammatory response. 2020. 43(2): p. 765-776.","DOI":"10.1007\/s10753-019-01164-1"},{"issue":"1","key":"10.1016\/j.prp.2026.156362_bib19","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1080\/21691401.2019.1577877","article-title":"Inonotus obliquus polysaccharide ameliorates dextran sulphate sodium induced colitis involving modulation of Th1\/Th2 and Th17\/Treg balance","volume":"47","author":"Chen","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"issue":"2","key":"10.1016\/j.prp.2026.156362_bib20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4196\/kjpp.2016.20.2.147","article-title":"Curcumin protects against the intestinal ischemia-reperfusion injury: involvement of the tight junction protein ZO-1 and TNF-\u03b1 related mechanism","volume":"20","author":"Tian","year":"2016","journal-title":"Korean J. Physiol. Pharm."},{"issue":"7","key":"10.1016\/j.prp.2026.156362_bib21","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1007\/s10620-019-05580-z","article-title":"Effects and mechanism of constitutive TL1A expression on intestinal mucosal barrier in DSS-induced colitis","volume":"64","author":"Yang","year":"2019","journal-title":"Dig. Dis. Sci."},{"issue":"1","key":"10.1016\/j.prp.2026.156362_bib22","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1038\/s41598-023-29649-y","article-title":"Intestinal epithelial barrier integrity investigated by label-free techniques in ulcerative colitis patients","volume":"13","author":"Quansah","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2026.156362_bib23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.intimp.2019.04.052","article-title":"Regulating effect of baicalin on IKK\/IKB\/NF-kB signaling pathway and apoptosis-related proteins in rats with ulcerative colitis","volume":"73","author":"Shen","year":"2019","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.prp.2026.156362_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109847","article-title":"Puerarin inhibits inflammation and oxidative stress in dextran sulfate sodium-induced colitis mice model","volume":"124","author":"Jeon","year":"2020","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.prp.2026.156362_bib25","doi-asserted-by":"crossref","unstructured":"Wang, R., et al., Maggot Extracts Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis via the Activation of Nrf2. 2019. 2019: p. 4703253.","DOI":"10.1155\/2019\/4703253"},{"key":"10.1016\/j.prp.2026.156362_bib26","doi-asserted-by":"crossref","unstructured":"Gao, J.M., et al., Trilobatin rescues cognitive impairment of Alzheimer's disease by targeting HMGB1 through mediating SIRT3\/SOD2 signaling pathway. 2022. 43(10): p. 2482-2494.","DOI":"10.1038\/s41401-022-00888-5"},{"issue":"12","key":"10.1016\/j.prp.2026.156362_bib27","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1097\/WNR.0000000000001680","article-title":"MicroRNA-488 inhibits neural inflammation and apoptosis in spinal cord injury through restraint on the HMGB1\/TLR4\/NF-\u03baB signaling pathway","volume":"32","author":"Niu","year":"2021","journal-title":"Neuroreport"},{"issue":"6","key":"10.1016\/j.prp.2026.156362_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066527","article-title":"Dipotassium Glycyrrhizate Inhibits HMGB1-Dependent Inflammation and Ameliorates Colitis in Mice","volume":"8","author":"Vitali","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.prp.2026.156362_bib29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.yexcr.2018.05.012","article-title":"Glycyrrhizin ameliorates inflammatory pain by inhibiting microglial activation-mediated inflammatory response via blockage of the HMGB1-TLR4-NF-kB pathway","volume":"369","author":"Sun","year":"2018","journal-title":"Exp. Cell Res"},{"key":"10.1016\/j.prp.2026.156362_bib30","article-title":"A microsatellite DNA-derived oligodeoxynucleotide attenuates lipopolysaccharide-induced acute lung injury in mice by inhibiting the HMGB1-TLR4-NF-\u03baB signaling pathway","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.prp.2026.156362_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106794","article-title":"Anemoside B4 prevents acute ulcerative colitis through inhibiting of TLR4\/NF-\u03baB\/MAPK signaling pathway","volume":"87","author":"Ma","year":"2020","journal-title":"Int Immunopharmacol."},{"issue":"4","key":"10.1016\/j.prp.2026.156362_bib32","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1002\/tox.23457","article-title":"Anti-ulcerative effects of wogonin on ulcerative colitis induced by dextran sulfate sodium via Nrf2\/TLR4\/NF-\u03baB signaling pathway in BALB\/c mice","volume":"37","author":"Zhou","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.prp.2026.156362_bib33","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3389\/fmicb.2020.00497","article-title":"Obacunone protects against ulcerative colitis in mice by modulating gut microbiota, attenuating TLR4\/NF-\u03baB signaling cascades, and improving disrupted epithelial Barriers","volume":"11","author":"Luo","year":"2020","journal-title":"Front. Microbiol."},{"issue":"6","key":"10.1016\/j.prp.2026.156362_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0305926","article-title":"Trilobatin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice via the NF-kappaB pathway and alterations in gut microbiota","volume":"19","author":"Wang","year":"2024","journal-title":"PLoS One"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033826000130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033826000130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T23:40:40Z","timestamp":1771544440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033826000130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":34,"alternative-id":["S0344033826000130"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2026.156362","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trilobatin ameliorates ulcerative colitis by reducing inflammation and enhancing intestinal barrier function via regulating HMGB1-mediated TLR4\/NF-\u03baB signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2026.156362","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"156362"}}