{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:09:50Z","timestamp":1785510590029,"version":"3.56.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360807"],"award-info":[{"award-number":["82360807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["823714128"],"award-info":[{"award-number":["823714128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.prp.2026.156475","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:05:59Z","timestamp":1776351959000},"page":"156475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Identification of bioactive components in Wuji Wan and their protective effects against gastric ulcer via regulating PIK3CA-mediated PI3K\/AKT pathway"],"prefix":"10.1016","volume":"282","author":[{"given":"Guokun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanfen","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyue","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2026.156475_bib1","doi-asserted-by":"crossref","first-page":"123383","DOI":"10.1016\/j.biomaterials.2025.123383","article-title":"In vivo spatiotemporal acquisition of metabolic vibrational signatures for unraveling gastric ulcer genesis","volume":"322","author":"Cheng","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.prp.2026.156475_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2025.109934","article-title":"Integrating network pharmacology and in vivo pharmacological validation to explore the gastroprotective mechanism of Sotetsuflavone against indomethacin-induced gastric ulcer in rats: involvement of JAK2\/STAT3 pathway","volume":"142","author":"Tabaa","year":"2025","journal-title":"J. Nutr. Biochem"},{"key":"10.1016\/j.prp.2026.156475_bib3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.4103\/pm.pm_389_19","article-title":"Gastric ulcer healing activity against acidified ethanol-induced gastric ulcer and gastroprotective mechanisms of Zingiber simaoense rhizome ethanol extract in rats","volume":"16","author":"Laprasert","year":"2020","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.prp.2026.156475_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.117336","article-title":"Polysaccharides from Hippophae rhamnoides L. protected against ethanol-induced gastric ulcer in mice and its impact on metabolites and gut microbiota","volume":"221","author":"Li","year":"2025","journal-title":"Food Res. Int."},{"key":"10.1016\/j.prp.2026.156475_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.144755","article-title":"A pectic polysaccharide from wax gourd peel improves ethanol-induced gastric ulcer injury in mice via the PI3K\/AKT signaling pathway","volume":"316","author":"Luo","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.prp.2026.156475_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156642","article-title":"Revealing the gastric protective mechanism of Physochlaina physaloides (L) G. Don. with clinical orientation: PPAR\/NF-\u03baB signalling pathway activation","volume":"141","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.prp.2026.156475_bib7","doi-asserted-by":"crossref","first-page":"9845","DOI":"10.2147\/DDDT.S555188","article-title":"The gastroprotective effect of hydrogen-rich coral calcium in a mouse model of peptic ulcer disease","volume":"19","author":"Wu","year":"2025","journal-title":"Drug Des. Devel Ther."},{"key":"10.1016\/j.prp.2026.156475_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.948678","article-title":"Pharmacokinetic differences of Wuji Pill components in normal and chronic visceral hypersensitivity irritable bowel syndrome rats attributable to changes in tight junction and transporters","volume":"13","author":"Gong","year":"2022","journal-title":"Front Pharm."},{"key":"10.1016\/j.prp.2026.156475_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117901","article-title":"The active components and potential mechanisms of Wuji Wan in the treatment of ethanol-induced gastric ulcer: an integrated metabolomics, network pharmacology and experimental validation","volume":"326","author":"Wu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.prp.2026.156475_bib10","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/aps.2015.8","article-title":"Efficacy-oriented compatibility for component-based Chinese medicine","volume":"36","author":"Zhang","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.prp.2026.156475_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156423","article-title":"The effect of Yinhuang Hanhua dropping pill on acute pharyngitis via a systematic \u201cCompound-Target-Pathway\u201d analysis","volume":"139","author":"Zhao","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.prp.2026.156475_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111750","article-title":"Erianin reverses 5-FU resistance by targeting CALM1\/CAMKK2 and activating autophagy in colorectal cancer","author":"Zhou","year":"2025","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.prp.2026.156475_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114798","article-title":"Drug affinity responsive target stability (DARTS) accelerated small molecules target discovery: principles and application","volume":"194","author":"Ren","year":"2021","journal-title":"Biochem Pharm."},{"key":"10.1016\/j.prp.2026.156475_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102930","article-title":"Uncovering SOD3 and GPX4 as new targets of Benzo[\u03b1]pyrene-induced hepatotoxicity through Metabolomics and Chemical Proteomics","volume":"67","author":"Wang","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.prp.2026.156475_bib15","doi-asserted-by":"crossref","first-page":"116620","DOI":"10.1016\/j.carbpol.2020.116620","article-title":"Extraction, purification, and determination of the gastroprotective activity of glucomannan from bletilla striata","volume":"246","author":"Wang","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.prp.2026.156475_bib16","doi-asserted-by":"crossref","first-page":"xi84","DOI":"10.1016\/S0923-7534(20)32195-5","article-title":"Clinicopathological and molecular correlates of HER2 expression, PIK3CA mutations and EBV infection involved in the PI3K-AKT pathway in gastric cancer","volume":"23","author":"Sukawa","year":"2012","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.prp.2026.156475_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115282","article-title":"Uncovering the pharmacological mechanism of Wei-Tong-Xin against gastric ulcer based on network pharmacology combined with in vivo experiment validation","volume":"293","author":"Liu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.prp.2026.156475_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117340","article-title":"Integrated network pharmacology and metabolomics to investigate the effects and possible mechanisms of Dehydroevodiamine against ethanol-induced gastric ulcers","volume":"319","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.prp.2026.156475_bib19","doi-asserted-by":"crossref","first-page":"157226","DOI":"10.1016\/j.phymed.2025.157226","article-title":"QiShenYiQi pills ameliorated aspirin and clopidogrel-induced gastric hemorrhage via multi-target regulation","volume":"147","author":"Zhan","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.prp.2026.156475_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117793","article-title":"Treatment of gastric ulcer, traditional Chinese medicine may be a better choice","volume":"324","author":"Gong","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.prp.2026.156475_bib21","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.3748\/wjg.v29.i43.5848","article-title":"Chemical components and protective effects of Atractylodes japonica Koidz. ex Kitam against acetic acid-induced gastric ulcer in rats","volume":"29","author":"Zhen","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.prp.2026.156475_bib22","doi-asserted-by":"crossref","first-page":"17020","DOI":"10.3748\/wjg.v20.i45.17020","article-title":"Efficacy and safety of herbal medicines in treating gastric ulcer: a review","volume":"20","author":"Bi","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.prp.2026.156475_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2022.104302","article-title":"Unraveling the mystery of efficacy in Chinese medicine formula: new approaches and technologies for research on pharmacodynamic substances","volume":"15","author":"Li","year":"2022","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.prp.2026.156475_bib24","first-page":"484","article-title":"Unveiling secrets of traditional Chinese medicine: cutting-edge techniques in component analysis","volume":"17","author":"Zhou","year":"2025","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.prp.2026.156475_bib25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrd728","article-title":"Metabonomics: a platform for studying drug toxicity and gene function","volume":"1","author":"Nicholson","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.prp.2026.156475_bib26","article-title":"Differences between human plasma and serum metabolite profiles","volume":"6","author":"Yu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.prp.2026.156475_bib27","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1248\/bpb.b12-00799","article-title":"Plasma and serum from nonfasting men and women differ in their lipidomic profiles","volume":"36","author":"Ishikawa","year":"2013","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.prp.2026.156475_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120843","article-title":"Yinhuo Tang alleviates ionizing radiation injury via modulating PI3K-Akt signaling and metabolomics in mice","volume":"356","author":"Li","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.prp.2026.156475_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154360","article-title":"A discovery of clinically approved Panlongqi Tablet for repositioning to treat osteoarthritis by inhibiting PI3K\/AKT activation","volume":"105","author":"Wang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.prp.2026.156475_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155081","article-title":"Berberine ameliorate inflammation and apoptosis via modulating PI3K\/AKT\/NF\u03baB and MAPK pathway on dry eye","volume":"121","author":"Han","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.prp.2026.156475_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107452","article-title":"Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony","volume":"207","author":"Zhang","year":"2020","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.prp.2026.156475_bib32","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.3390\/molecules29092040","article-title":"Integrative genomics and bioactivity-guided isolation of novel antimicrobial compounds from streptomyces sp. KN37 in agricultural applications","volume":"29","author":"Zhao","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.prp.2026.156475_bib33","doi-asserted-by":"crossref","first-page":"D1670","DOI":"10.1093\/nar\/gkae973","article-title":"Generic Diagramming Platform (GDP): a comprehensive database of high-quality biomedical graphics","volume":"53","author":"Jiang","year":"2025","journal-title":"Nucleic Acids Res"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033826001287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033826001287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:33:26Z","timestamp":1785508406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033826001287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":33,"alternative-id":["S0344033826001287"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2026.156475","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of bioactive components in Wuji Wan and their protective effects against gastric ulcer via regulating PIK3CA-mediated PI3K\/AKT pathway","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2026.156475","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156475"}}